Norovirus derived immunogenic compositions and methods

ABSTRACT

The invention relates to chimeric norovirus VP1 proteins containing the S-domain of VP1 of a first norovirus strain and a P-domain that contains at least a portion of the P-domain of VP1 of a second norovirus strain. The invention also relates to nucleic acids that encode the chimeric VP1 proteins, virus-like particles that contain a chimeric norovirus VP1 protein, and to immunogenic compositions.

RELATED APPLICATIONS

This application is a continuation of Ser. No. 14/946,324, filed Nov.19, 2015, which is a continuation of U.S. patent application Ser. No.13/808,157, filed Mar. 20, 2013, which is abandoned and which is theU.S. National Phase of International Application No. PCT/US2011/042979,filed Jul. 5, 2011 and published in English, which claims the benefit ofU.S. Patent Application No. 61/361,581 filed on Jul. 6, 2010, thecomplete contents of which are hereby incorporated by reference.

REFERENCE TO SEQUENCE LISTING SUBMITTED ELECTRONICALLY

This application contains a Sequence Listing which has been submittedelectronically in ASCII format and which is incorporated by reference inits entirety. Said ASCII file is named 54021_Sequence_Listing.txt, is139,000 bytes in size and was created on Jul. 5, 2011.

Noroviruses (formerly known as Norwalk-like viruses, NVLs, or Norwalkviruses) are the primary etiological agents of acute viralgastroenteritis in adults and children. noroviruses are highlyinfectious and spread by ingestion of contaminated food, such as oystersand water. Noroviruses also spread rapidly by person-to-persontransmission through the fecal-oral route in semiclosed communities,such as hospitals, schools, nursing homes, and cruise ships. Thesecharacteristics make noroviruses a major public health concern. Forexample, in the United States alone, noroviruses cause greater than 95%of viral gastroenteritis outbreaks and an estimated 23 million cases ofgastroenteritis per year (Fankhauser et al. (2002) J. Infect Dis,186:1-7; MMWR Morb. Mortal Weekly Rep. (2000) 49:207-211).

The symptoms of norovirus infection include diarrhea and vomiting aswell as fever, headaches, chills and stomach-aches. The cause of suchsymptoms may be related to the binding of noroviruses to carbohydratereceptors of intestinal epithelial cells, which results in an imbalancein ion transfer (Marionneau et al. (2002) Gastroenterology122:1967-1977; Hutson et al. (2003) J. Virol. 77:405-415). Extremelycontagious, noroviruses can cause disease by infection with as few as 10virions. Although otherwise healthy, people infected with norovirusesmay recover within 2-4 days, they may still shed virus for up to 2 weeksafter the onset of symptoms. Approximately 30-40% of infected people mayremain symptom-free but spread infection by shedding of virus to otherswho may be more susceptible to infection (Hutson et al. (2004) TrendsMicrobiol. 12(6):279-287).

Noroviruses are members of the Caliciviridae family of small,non-enveloped, icosahedral viruses, 27-40 nm in diameter, containing asingle-strand of positive-sense RNA. Phylogenic studies show that thegenus Norovirus is made up of at least 40 diverse virus strainscategorized into 5 genogroups, GI-GV, on the basis of sequencesimilarity. Among these 5 genogroups, GI and GII are the most importantgenogroups for human infection. Each genogroup is further divided intogenotypes. Currently, GI includes 8 distinct genotypes and GII has atleast 17 different genotypes. At the genomic level, strains in agenogroup have 51-56% nucleotide sequence identity, and strains in agenotype have 69-70% nucleotide sequence similarity (Donaldson et al.,Nat. Rev. Microbiol. 2010 Feb. 2. [e-pub ahead of print]).

Norovirus RNA includes three open reading frames (ORFs), which encodethe structural and non-structural proteins of the virus. The majorstructural protein of noroviruses is viral protein 1 (VP1). It isexclusively encoded by ORF2 of the norovirus RNA and forms the noroviruscapsid structure. The norovirus capsid is made up of 180 copies of VP1monomers. When VP1 is expressed recombinantly, it can self-assemble intoan icosahedral capsid structure that lacks a viral genome and is knownas virus-like particle (VLP).

X-ray crystallography studies have revealed that each capsid protein,VP1, is made up of two distinct domains, the shell (S) domain and theprotruding (P) domain. These two domains are tethered together by ashort flexible linker or hinge. The S-domains of the VP1 monomerscollectively form the core of the norovirus VLP, and the P-domainsextend radially on the surface of VLP and include the bulk of the knownantigenic epitopes of norovirus. The P domain (aa 226-530, Norwalkstrain numbering) is divided into two subdomains, P1 and P2. The P2domain is located at the outermost surface of the virion (or VLP)radially and is considered to be hypervariable in sequence. (See, e.g.,Chen et al. (2004) J. Virol. 78:6469-6479). The P2 domain is the leastconserved region of VP1 among norovirus strains and is thought to playan important role in receptor binding and immune reactivity. (Kitamotoet al. (2002) J. Clin. Microbiol. 40:2459-2465; Prasad et al. (1999)Science 286:287-290; Tan et al. (2003) J. Virol. 77:12562-12571; Whiteet al. (1996) J. Virol. 70:6589-6597; Vance et al. (2005) J. GeneralVirol. 86:2799-2806). Structural studies have shown diversity in theshape and size of the P2 subdomains of different noroviruses, consistentwith the observed sequence variability of the P2 subdomains. Chen et al.(2004) J. Virology 78(12):6469-6479.

The expression and self-assembly of Norwalk virus VLPs was firstdemonstrated using the baculovirus-infected insect cell expressionsystem (Jiang et al. (1992) J. Virol. 66:6527-6532) and then using aVenezuelan equine encephalitis vector-infected mammalian cell expressionsystem (Baric et al. (2002) J. Virol. 76:3025-3030). When expressed athigh levels in eukaryotic expression systems, the VP1 monomers inNorwalk virus, and certain other noroviruses, self-assemble into VLPsthat structurally mimic native norovirus virions. VLPs preserve theauthentic conformation of the viral capsid protein but lack norovirusgenetic material. When injected into animals, norovirus VLPs can elicitan appropriate host immune response.

Despite what is known about the antigenic properties of norovirus, thedevelopment of an effective vaccine against norovirus has been slow andchallenging. There are several reasons why it has been a challenge todevelop a norovirus vaccine that is effective against a broad range ofnorovirus strains, including field isolates from different genogroupsand genotypes. One reason has been the complex antigenic diversity thatexists among different norovirus strains. Genotypic variations canresult in new ligand-binding characteristics and antigenic properties(Donaldson et al., Nat. Rev. Microbiol. 2010 Feb. 2. [e-pub ahead ofprint]). A second reason is the sequential replacement of the dominantcirculating norovirus strains (Siebenga et al. (2007) J. Virol81:9932-9941). A third reason is the lack of a cell culture model forhuman noroviruses, preventing the development of a neutralization assay.A fourth reason is the lack of an animal model for human noroviruses,limiting preclinical testing of vaccine efficacy and impeding researchto understand norovirus pathogensis and immunity (Donaldson et al.(2010) Nature Rev. Microbiol. 8:231-241).

To present immunodominant norovirus epitopes as vaccines, previously,VLPs containing either one type of VP1 protein from only one norovirusstrain (also known as monovalent VLPs) or a mixture of non-chimeric VP1proteins from two or more norovirus strains (also known as multivalentVLPs) have been prepared. See, e.g., WO2009039229. Monovalent VLPs maybe less effective against a broad range of norovirus strains thanmultivalent VLPs. Current multivalent VLPs may be constrained in therange of VP1's from different strains that can be co-assembled due totheir differences in VP1-VP1 interaction surfaces between strains.Because of these problems, neither of the above-mentioned vaccinesystems are suitable for rapid customization against the new norovirusesthat emerge due to viral evolution.

Noroviruses undergo progressive changes in antigenic type, with newantigenic variants replacing older antigenic variants. Therefore, it islikely that there will be a need to periodically change the straincomposition of a norovirus vaccine, as is done today for seasonalinfluenza vaccines. The assembly of VLPs from VP1 of different norovirusstrains occurs with different levels of efficiency, and the resultingVLPs have different levels of yield and stability. This variabilitybetween strains would impede the speed, reliability, and facility ofneeded strain changes in a norovirus vaccine composition.

Therefore, there remains a need for an improved norovirus vaccinedevelopment approach that allows for rapid changes in the straincomposition of efficiently prepared, stable, and properly presentednorovirus immunogenic materials from any desired norovirus strain,including new field and/or clinical isolates.

SUMMARY OF THE INVENTION

The present invention, in part, provides immunogenic compositionscomprising norovirus antigens and materials and methods that can be usedfor rapid development of such compositions. The norovirus antigens ofthe invention comprise chimeric norovirus VP1 proteins in which all or aportion of the P-domain is replaced with all or a portion of a P-domainfrom a different norovirus strain.

In one aspect the invention relates to a chimeric norovirus viralprotein 1 (VP1), which contains the S-domain of VP1 from a firstnorovirus strain and at least a portion of the P-domain of VP1 from asecond norovirus strain, and optionally, a linker peptide that operablylinks the S-domain and the P-domain. When present, the linker peptidecan be any suitable linker, such as the linker peptide of the VP1 fromthe first norovirus strain, from the second norovirus strain, or from athird norovirus strain. The chimeric VP1 can have a structure accordingto Formula (I):A-S-L-P-B  (I).

In Formula (I), A and B are independently absent or any desired aminoacid sequence; S is the S-domain of VP1 from a first norovirus strain; Lis absent or a linker peptide; and P is a norovirus VP1 P-domain;wherein at least a portion of the P-domain is from a second norovirusstrain.

In some embodiments, P is the P-domain from a second norovirus strain.In other embodiments, P comprises a P1-subdomain, or portion thereof,from the first norovirus strain and a P2-subdomain from a secondnorovirus strain.

The chimeric VP1 protein can contain portions, e.g., S-domain, P-domain,from any desired norovirus strain, such as the norovirus strains listedin Table 1. In some embodiments, the S-domain is from the Snow Mountainstrain. In these embodiments, the P-domain or a portion thereof (e.g.,P2 subdomain) can be from any other norovirus strain, such as thoselisted in Table 1. In particular embodiments, the S-domain is from theSnow Mountain strain and the P-domain or a portion thereof (e.g., P2subdomain) is from a different norovirus strain from genogroup GII, anorovirus strain from genogroup GI or a norovirus strain from genogroupGIV. In more particular embodiments, the S-domain is from the SnowMountain strain and the P-domain or a portion thereof (e.g., P2subdomain) is from Norwalk virus, GII.4.2006a, or New Orleans.

In another aspect, the invention relates to a norovirus virus likeparticle (VLP) comprising a chimeric VP1 protein as described herein.The VLP can be monovalent or multivalent. The multivalent VLP cancomprise two or more different chimeric VP1 protein as described herein.The multivalent VLP can comprise a chimeric VP1 protein as describedherein and a naturally occurring norovirus VP1 protein.

The invention also relates to recombinant nucleic acids that encode achimeric norovirus VP1 protein as described herein. The recombinantnucleic acid can be, for example, RNA or DNA, and if desired, cancomprise a vector. In some embodiments, the recombinant nucleic acid isself-replicating, such as a self-replicating RNA.

In another aspect, the invention relates to immunogenic compositionscomprising a chimeric norovirus VP1 protein as described herein, a VLPas described herein or combinations thereof. The invention also relatesto an immunogenic composition comprising a recombinant nucleic acid thatencodes encode a chimeric norovirus VP1 protein as described herein.

In another aspect, the invention relates to a recombinant host cellcomprising a recombinant nucleic acid that encodes encode a chimericnorovirus VP1 protein as described herein. The host cell can be, forexample, insect cells, mammalian cells, avian cells, bacteria, yeastcells, Tetrahymena cells and combinations thereof.

The invention also relates to a method of producing a chimeric norovirusVP1 protein and/or VLP, comprising culturing a recombinant host cell asdescribed herein under conditions whereby the recombinant nucleic acidis expressed and chimeric VP1 protein is produced. In some embodiments,the recombinant host cell is maintained under conditions suitable forformation of VLPs. In some embodiments, the method further comprisesisolating the chimeric norovirus VP1 protein and/or VLPs from theculture media and/or the recombinant host cells.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 depicts the diagram for vector pMADC5 suitable for subcloning andamplification of the chimeric VP1 oligonucleotides of the invention.

FIG. 2 depicts the diagram of a vector pBS24.1 suitable for expressionof chimeric VP1 proteins and VLPs in S. cerevisiae.

FIG. 3 is an amino acid alignment of VP1 proteins from three differentnorovirus strains, Norwalk (norw) genotype G1.1 (SEQ ID NO: 11), SnowMountain (snow) genotype GII.2 (SEQ ID NO: 12), and 2006a (g2.4) GII.4(SEQ ID NO: 13). As shown, the shell domain (S-domain) is residues1-221, the linker peptide is residues 222-230, and the protruding domain(P-domain) is residues 231-530.

FIG. 4A depicts the nucleotide sequence (SEQ ID NO:14) of ORF2 innorovirus strain Snow Mountain, which encodes the VP1 protein in thatstrain. FIG. 4B show the translated amino acid sequence (SEQ ID NO:12)of VP protein encoded by ORF2 of Snow Mountain.

FIG. 5 depicts a nucleic acid (SEQ ID NO:15) encoding a chimeric VP1protein whose S-domain is derived from the Snow Mountain strain, andP-domain is derived from the Norwalk strain.

FIG. 6 depicts a nucleic acid (SEQ ID NO:16) encoding a chimeric VP1protein whose S-domain is derived from the Snow Mountain strain, andP-domain is derived from the GII.4 2006a strain.

FIG. 7 shows 24 schematic representations of the primary structure ofexemplary chimeric VP1 proteins of the invention. The variables A, S, L,P1-1, P2, P1-2, and B are as described herein.

FIGS. 8A-8E show a multiple amino acid alignment of VP1 sequences ofseveral norovirus strains. See, Hansman et al. (2006) J. GeneralVirology 87:909-919. The following regions are indicated in thesefigures: N-terminal region (line); S-domain (filled box), P₁₋₁-subdomain(open box); P₂-subdomain (XXX); P₁₋₂-subdomain (open box) and C-terminalregion (line). Asterisks indicate conserved amino acids. The sequencesdepicted are from the following norovirus strains: #8 (SEQ ID NO:17)(AB058547, a GI/11 strain); SeV (SEQ ID NO:18) (AB031013, a GI/1strain); 258 (SEQ ID NO:19) (AB078335, a GI/2 strain); 645 (SEQ IDNO:20) (BD011871, a GI/3 strain); CV (SEQ ID NO:21) (AB042808, a GI/4strain); WUG1 (SEQ ID NO:22) (AB081723, a GI/8 strain); HV (SEQ IDNO:23) (U07611, a GII/1 strain); 485 (SEQ ID NO:24) (DQ093065, a GII/1strain); Ina (SEQ ID NO:25) (AB195225, a GII/2 strain); 809 (SEQ IDNO:26) (BD011876, a GII/3 strain); Sh5 (SEQ ID NO:27) (AB195226, a GII/3strain); 18-3 (SEQ ID NO:28) (DQ093062, a GII/3 strain); 336 (SEQ IDNO:29) (DQ093063, a GII/3 strain); 1152 (SEQ ID NO:30) (DQ0930); 104(SEQ ID NO:31) (AB078336, a GII/4 strain); 754 (SEQ ID NO:32) (BD011877,a GII/5 strain); 7k (SEQ ID NO:33) (AB078337, GII/6 strain); 445 (SEQ IDNO:34) (DQ093064, a GII/6 strain); 10-25 (SEQ ID NO:35) (9BD011881, aGII/7 strain); U25 (SEQ ID NO:36) (AB039780, a GII/8 strain); 026 (SEQID NO:37) (AF504671, a GII/10 strain); CHV (SEQ ID NO:38) (AB032758, aGII/12 strain); 47 (SEQ ID NO:39) (AB078334, a GII/14 strain); Hiro (SEQID NO:40) (AB044366, a GII/12 strain); Alph23 (SEQ ID NO:41) (DQ093067,a GII/17 strain).

FIG. 9 is a table showing amino acid residues identified by Chakavartyet al. (2005) J. Virology, 79(1):554-568, from S and P domains, thatdistinguish different known and suggested antigenic norovirus strainsand classes.

FIG. 10A is an X-ray structure of Norwalk virus-like particles with theS-domain (internal) in dark gray and the P-domain (external) in lightgrey. FIG. 10B is a view of a single monomer colored as in FIG. 10A.

FIG. 11A is an image depicting a purified protein of Snow Mountain VLPs.FIG. 11B is an electron micrograph of Snow Mountain VLPs.

FIG. 12A is an image depicting a purified protein of SnowMountain/Norwalk VLP chimera. FIG. 12B is an electron micrograph of SnowMountain/Norwalk chimeric VLPs.

DETAILED DESCRIPTION OF THE INVENTION

The present invention provides compositions and methods for productionand use of chimeric norovirus VP1 proteins. The invention furtherprovides immunogenic compositions that include norovirus VLPs comprisingsaid chimeric VP1 proteins in which the S-domain is derived from a firstnorovirus strain and all or part of the P-domain is derived from asecond norovirus strain.

Other aspects of the present invention include nucleic acids andpolypeptides, and methods for preparing and purifying such nucleic acidsand polypeptides. These aspects of the invention together with the VLPsof the invention and their use in immunogenic compositions and methodsof using such compositions in the treatment or prevention of norovirusare described in more detail below.

I. Definitions

All scientific and technical terms used in this application havemeanings commonly used in the art unless otherwise specified. As used inthis application, the following words or phrases have the meaningsspecified.

As used herein, “a”, “an” and “the” include singular and pluralreferences unless the content clearly dictates otherwise. Thus, forexample, reference to “a polynucleotide” includes a mixture of two ormore such polynucleotides, and the like.

The term “about” in relation to a numerical value x means, for example,x+10%.

As used herein, the terms “norovirus” and “Norwalk-like virus” refer tomembers of the genus norovirus of the family Caliciviridae ofpositive-sense, single-stranded RNA, nonenveloped viruses (Green et al.,Human Caliciviruses, in Fields Virology Vol. 1, pp. 841-874 (Knipe andHowley, editors-in-chief 4th ed., Lippincott Williams & Wilkins 2001)).The term norovirus includes strains in all genogroups of the virus.Currently, norovirus strains are divided into five genogroups (GI-GV),which are subdivided into at least 20 genetic clusters or genotypes. Inparticular, the term norovirus includes, but is not limited to, thespecies Norwalk virus (NV), Lordsdale virus (LV), Mexico virus (MV),Hawaii virus (HV), Snow Mountain virus (SMV), Desert Shield virus (DSV),and Southhampton virus (SV). A large number of norovirus isolates havebeen partially or completely sequenced. See, e.g., the GenBank database(ncbi.nlm.nih.gov), the Taxonomy Database at National Center forBiotechnology Information (ncbi.nlm.nih.gov) or the PathoSystemsResource Integration Center Database on Caliciviridae(patric.vbi.vt.edu). The term norovirus also includes isolates notcharacterized at the time of filing.

The terms “polypeptide” and “protein” refer to a polymer of amino acidresidues and are not limited to a minimum length of the product. Thus,peptides, oligopeptides, dimers, multimers, and the like, are includedwithin the definition. Both full-length proteins and fragments thereofare encompassed by the definition. The terms also include postexpressionmodifications of the polypeptide, for example, glycosylation,acetylation, phosphorylation and the like. Furthermore, for purposes ofthe present invention, a “polypeptide” refers to a protein whichincludes modifications, such as deletions, additions and substitutions(generally conservative in nature), to the native sequence, so long asthe protein maintains the desired activity. These modifications may bedeliberate, as through site-directed mutagenesis, or may be accidental,such as through mutations of hosts which produce the proteins or errorsdue to PCR amplification.

“Substantially purified” generally refers to isolation of a substance(compound, polynucleotide, protein, polypeptide, polypeptidecomposition) such that the substance comprises the majority percent ofthe sample in which it resides. Typically in a sample, a substantiallypurified component comprises 50%, preferably 80%-85%, more preferably90-95% of the sample. Techniques for purifying polynucleotides andpolypeptides of interest are well-known in the art and include, forexample, ion-exchange chromatography, affinity chromatography andsedimentation according to density.

By “isolated” is meant, when referring to a polypeptide, that theindicated molecule is separate and discrete from the whole organism withwhich the molecule is found in nature or is present in the substantialabsence of other biological macro-molecules of the same type. The term“isolated” with respect to a polynucleotide is a nucleic acid moleculedevoid, in whole or part, of sequences normally associated with it innature; or a sequence, as it exists in nature, but having heterologoussequences in association therewith; or a molecule disassociated from thechromosome.

“Recombinant” as used herein to describe a nucleic acid molecule means apolynucleotide of genomic, cDNA, viral, semisynthetic, or syntheticorigin which, by virtue of its origin or manipulation, is not associatedwith all or a portion of the polynucleotide with which it is associatedin nature. The term “recombinant” as used with respect to a protein orpolypeptide means a polypeptide produced by expression of a recombinantpolynucleotide. In general, the gene of interest is cloned and thenexpressed in transformed organisms, as described further below. The hostorganism expresses the foreign gene to produce the protein underexpression conditions.

The term “transformation” refers to the insertion of an exogenouspolynucleotide into a host cell, irrespective of the method used for theinsertion. For example, direct uptake, transfection, transduction orf-mating are included. The exogenous polynucleotide may be maintained asa non-integrated vector, for example, a plasmid, or alternatively, maybe integrated into the host genome.

“Recombinant host cells”, “host cells,” “cells”, “cell lines,” “cellcultures”, and other such terms denoting microorganisms or highereukaryotic cell lines cultured as unicellular entities refer to cellswhich can be, or have been, used as recipients for recombinant vector orother transferred DNA, and include the original progeny of the originalcell which has been transfected.

A “coding sequence” or a sequence which “encodes” a selectedpolypeptide, is a nucleic acid molecule which is transcribed (in thecase of DNA) and translated (in the case of mRNA) into a polypeptide invive when placed under the control of appropriate regulatory sequences(or “control elements”). The boundaries of the coding sequence can bedetermined by a start codon at the 5′ (amino) terminus and a translationstop codon at the 3′ (carboxy) terminus. A coding sequence can include,but is not limited to, cDNA from viral, procaryotic or eucaryotic mRNA,genomic DNA sequences from viral or procaryotic DNA or RNA, and evensynthetic DNA sequences. A transcription termination sequence may belocated 3′ to the coding sequence.

Typical “control elements,” include, but are not limited to,transcription promoters, transcription enhancer elements, transcriptiontermination signals, polyadenylation sequences (located 3′ to thetranslation stop codon), sequences for optimization of initiation oftranslation (located 5′ to the coding sequence), and translationtermination sequences.

The term “nucleic acid” includes DNA and RNA, and also their analogues,such as those containing modified backbones (e.g. phosphorothioates,etc.), and also peptide nucleic acids (PNA), etc. The invention includesnucleic acids comprising sequences complementary to those describedabove (e.g. for antisense or probing purposes).

The term “self-replicating” refers to a nucleic acid molecule thatencodes a polymerase, contains nucleotide sequence elements that enablethat polymerase to replicate the nucleic acid molecule and, preferably,also encodes a desired polypeptide, such as a chimeric norovirus VP1.Preferably, the self-replication nucleic acid is a self-replicating RNAmolecule. For example, a self-replicating RNA molecule can be based onan alphavirus genome, and encode nonstructural proteins that can directreplication of the RNA molecule, contains a replication recognitionsequence sufficient to allow replication of the RNA molecule, and alsoencode a desired target polypeptide, such as such as a chimericnorovirus VP1. Optionally, one or more structural viral genes (e.g.,capsid and/or envelope glycoproteins) are deleted or omitted from theself-replicating RNA molecule. Suitable alphaviruses that can be used toproduce self-replicating RNA molecules include Sindbis virus. Semlikiforest virus, Eastern Equine Encephalitis virus, Venezuelan equineencephalitis virus and the like. (See, e.g., EP 1 751 289 B1; Ying etal. (1999) Nat. Med. 5(7):823-827; Racanelli et al. (2004) Immunity,20(1):47-58, regarding self-replicating RNA molecules.)

“Operably linked” refers to an arrangement of elements wherein thecomponents so described are configured so as to perform their usualfunction. Thus, a given promoter operably linked to a coding sequence iscapable of effecting the expression of the coding sequence when theproper enzymes are present. The promoter need not be contiguous with thecoding sequence, so long as it functions to direct the expressionthereof. Thus, for example, intervening untranslated yet transcribedsequences can be present between the promoter sequence and the codingsequence and the promoter sequence can still be considered “operablylinked” to the coding sequence.

“Encoded by” refers to a nucleic acid sequence which codes for apolypeptide sequence, wherein the polypeptide sequence or a portionthereof contains an amino acid sequence of at least 3 amino acids.

“Expression cassette” or “expression construct” refers to an assemblywhich is capable of directing the expression of the sequence(s) orgene(s) of interest. An expression cassette generally includes controlelements, as described above, such as a promoter which is operablylinked to (so as to direct transcription of) the sequence(s) or gene(s)of interest, and often includes a polyadenylation sequence as well.Within certain embodiments of the invention, the expression cassettedescribed herein may be contained within a plasmid construct. Inaddition to the components of the expression cassette, the plasmidconstruct may also include, one or more selectable markers, a signalwhich allows the plasmid construct to exist as single-stranded DNA(e.g., a M13 origin of replication), at least one multiple cloning site,and a “mammalian” origin of replication (e.g., a SV40 or adenovirusorigin of replication).

“Purified polynucleotide” refers to a polynucleotide of interest orfragment thereof which is essentially free, e.g., contains less thanabout 50%, preferably less than about 70%, and more preferably less thanabout at least 90%, of the protein with which the polynucleotide isnaturally associated. Techniques for purifying polynucleotides ofinterest are well-known in the art and include, for example, disruptionof the cell containing the polynucleotide with a chaotropic agent andseparation of the polynucleotide(s) and proteins by ion-exchangechromatography, affinity chromatography and sedimentation according todensity.

A “vector” is capable of transferring nucleic acid sequences to targetcells (e.g., viral vectors, non-viral vectors, particulate carriers, andliposomes). Typically, “vector construct,” “expression vector,” and“gene transfer vector,” mean any nucleic acid construct capable ofdirecting the expression of a nucleic acid of interest and which cantransfer nucleic acid sequences to target cells. Thus, the term includescloning and expression vehicles, as well as viral vectors.

As used herein, the term “epitope” generally refers to the site on anantigen which is recognized by a T-cell receptor and/or an antibody. Itmay be a short peptide derived from or as part of a protein antigen. Thethree-dimensional structure of the epitope may or may not be importantfor its function. However the term is also intended to include peptideswith glycopeptides and carbohydrate epitopes. Several different epitopesmay be carried by a single antigenic molecule. The term “epitope” alsoincludes modified sequences of amino acids or carbohydrates whichstimulate responses which recognize the whole organism. It isadvantageous if the selected epitope is an epitope of an infectiousagent, which causes the infectious disease.

For a description of various norovirus capsid epitopes, see, e.g., Hardyet al., U.S. Patent Application Publication No. 2005/0152911;incorporated herein by reference in its entirety. In particular, Hardyet al. have identified epitopes of the Norwalk virus capsid protein atresidues 133-137 and of the Snow Mountain virus capsid protein atresidues 319-327, comprising the following sequences: WTRGSHNL, (SEQ IDNO:1), WTRGGHGL, (SEQ ID NO:2), WTRGQHQL (SEQ ID NO:3), or WLPAPIDKL(SEQ ID NO:4). Immunogenic polypeptides comprising such capsid epitopesand nucleic acids encoding them may be used in the practice of theinvention.

As used herein, the term “T cell epitope” refers generally to thosefeatures of a peptide structure which are capable of inducing a T cellresponse and a “B cell epitope” refers generally to those features of apeptide structure which are capable of inducing a B cell response.

An “immunological response” to an antigen or composition is thedevelopment in a subject of a humoral and/or a cellular immune responseto an antigen present in the composition of interest. For purposes ofthe present invention, a “humoral immune response” refers to an immuneresponse mediated by antibody molecules, while a “cellular immuneresponse” is one mediated by T-lymphocytes and/or other white bloodcells. One important aspect of cellular immunity involves anantigen-specific response by cytolytic T-cells (“CTL”s). CTLs havespecificity for peptide antigens that are presented in association withproteins encoded by the major histocompatibility complex (MHC) andexpressed on the surfaces of cells. CTLs help induce and promote thedestruction of intracellular microbes, or the lysis of cells infectedwith such microbes. Another aspect of cellular immunity involves anantigen-specific response by helper T-cells. Helper T-cells act to helpstimulate the function, and focus the activity of, nonspecific effectorcells against cells displaying peptide antigens in association with MHCmolecules on their surface. A “cellular immune response” also refers tothe production of cytokines, chemokines and other such moleculesproduced by activated T-cells and/or other white blood cells, includingthose derived from CD4+ and CD8+ T-cells.

An immunogenic composition or vaccine that elicits a cellular immuneresponse may serve to sensitize a vertebrate subject by the presentationof antigen in association with MHC molecules at the cell surface. Thecell-mediated immune response is directed at, or near, cells presentingantigen at their surface. In addition, antigen-specific T-lymphocytescan be generated to allow for the future protection of an immunizedhost.

The ability of a particular antigen to stimulate a cell-mediatedimmunological response may be determined by a number of assays, such asby lymphoproliferation (lymphocyte activation) assays, CTL cytotoxiccell assays, or by assaying for T-lymphocytes specific for the antigenin a sensitized subject. Such assays are well known in the art. See.e.g., Erickson et al. (1993) J. Immunol. 151:4189-4199; Doe et al.(1994) Eur. J. Immunol. 24:2369-2376. Recent methods of measuringcell-mediated immune response include measurement of intracellularcytokines or cytokine secretion by T-cell populations, or by measurementof epitope specific T-cells (e.g., by the tetramer technique) (reviewedby McMichael, A. J. and O'Callaghan, C. A. (1998) J. Exp. Med.187(9)1367-1371; Mcheyzer-Williams, M. G. et al. (1996), Immunol. Rev.150:5-21; Lalvani, A. et al. (1997) J. Exp. Med. 186:859-865).

Thus, an immunological response as used herein may be one thatstimulates the production of antibodies (e.g., neutralizing antibodiesthat block bacterial toxins and pathogens such as viruses entering cellsand replicating by binding to toxins and pathogens, typically protectingcells from infection and destruction). The antigen of interest may alsoelicit production of CTLs. Hence, an immunological response may includeone or more of the following effects: the production of antibodies byB-cells; and/or the activation of suppressor T-cells and/ormemory/effector T-cells directed specifically to an antigen or antigenspresent in the composition or vaccine of interest. These responses mayserve to neutralize infectivity, and/or mediate antibody-complement, orantibody dependent cell cytotoxicity (ADCC) to provide protection to animmunized host. Such responses can be determined using standardimmunoassays. The innate immune system of mammals also recognizes andresponds to molecular features of pathogenic organisms via activation ofToll-like receptors and similar receptor molecules on immune cells. Uponactivation of the innate immune system, various non-adaptive immuneresponse cells. are activated to, e.g., produce various cytokines,lymphokines and chemokines. Cells activated by an innate immune responseinclude immature and mature Dendritic cells of the monocyte andplasmacytoid lineage (MDC, PDC), as well as gamma, delta, alpha and betaT cells and B cells and the like. Thus, the present invention alsocontemplates an immune response wherein the immune response involvesboth an innate and adaptive response.

An “immunogenic composition” is a composition that comprises anantigenic molecule where administration of the composition to a subjectresults in the development in the subject of a humoral and/or a cellularimmune response to the antigenic molecule of interest.

The terms “immunogenic” protein or polypeptide refer to an amino acidsequence which elicits an immunological response as described above. An“immunogenic” protein or polypeptide, as used herein, includes thefull-length natural or recombinant sequence of the protein in question,including the precursor and mature forms, analogs thereof, orimmunogenic fragments thereof.

A norovirus polynucleotide, oligonucleotide, nucleic acid, protein,polypeptide, or peptide, as defined above, is a molecule derived from anorovirus, respectively, including, without limitation, any of thevarious isolates of norovirus. The molecule need not be physicallyderived from the particular isolate in question, but may besynthetically or recombinantly produced.

In particular, the genomes of norovirus strains contain three openreading frames: ORF1, which is transcribed into a polyprotein; ORF2,which is transcribed into the major capsid protein VP1; and ORF3, whichis transcribed into the minor structural protein VP2. In norovirusstrain Norwalk, the boundaries of the polypeptide domains within the VP1protein are as follows: the shell (S) domain formed by amino acidresidues 1-221, a flexible hinge region at amino acid residues 222-230,and the protruding (P) domain formed by amino residues 231-530. TheP-domain is further divided into two subdomains, P1 and thehypervariable P2, which extends farthest out from the capsid shell andcontains the putative receptor-binding sites (Choi, et al. (2008) Proc.Natl. Aacd. Sci. USA 105:9175-9180, Prasad et al. (1999) Science286:287-290). Although, the foregoing numbering is relative to thepolyprotein amino acid sequence of Norwalk strain (SEQ ID NO: 11), it isto be understood that the corresponding amino acid positions insequences obtained from other genotypes and isolates of norovirus arealso intended to be encompassed by the present invention. For example,see FIG. 3. Any one of the polypeptides encoding the full-length VP1 orVP2, as well as variants thereof, immunogenic fragments thereof, andnucleic acids encoding such polypeptides, variants or immunogenicfragments can be used in the practice of the invention.

Nucleic acid and protein sequences for a number of norovirus isolatesare known. Representative norovirus VP1 and VP2 sequences are presentedin FIGS. 4A-4B and 5A-5B. Additional representative sequences, includingsequences of ORF1, ORF2, ORF3, and their encoded polypeptides fromnorovirus isolates are listed in the National Center for BiotechnologyInformation (NCBI) database. See, for example, GenBank entries:norovirus genogroup 1 strain Hu/NoV/West Chester/2001/USA, GenBankAccession No. AY502016; norovirus genogroup 2 strain Hu/NoV/BraddockHeights/1999/USA, GenBank Accession No. AY502015; norovirus genogroup 2strain Hu/NoV/Fayette/1999/USA, GenBank Accession No. AY502014;norovirus genogroup 2 strain Hu/NoV/Fairfield/1999/USA, GenBankAccession No. AY502013; norovirus genogroup 2 strainHu/NoV/Sandusky/1999/USA, GenBank Accession No. AY502012; norovirusgenogroup 2 strain Hu/NoV/Canton/1999/USA, GenBank Accession No.AY502011; norovirus genogroup 2 strain Hu/NoV/Tiffin/1999/USA, GenBankAccession No. AY502010; norovirus genogroup 2 strainHu/NoV/CS-E1/2002/USA, GenBank Accession No. AY50200; norovirusgenogroup 1 strain Hu/NoV/Wisconsin/2001/USA, GenBank Accession No.AY502008; norovirus genogroup 1 strain Hu/NoV/CS-841/2001/USA, GenBankAccession No. AY502007; norovirus genogroup 2 strainHu/NoV/Hiram/2000/USA, GenBank Accession No. AY502006; norovirusgenogroup 2 strain Hu/NoV/Tontogany/1999/USA, GenBank Accession No.AY502005; Norwalk virus, complete genome, GenBank Accession No.NC-001959; norovirus Hu/GI/Otofuke/1979/JP genomic RNA, complete genome,GenBank Accession No. AB187514; norovirus Hu/Hokkaido/133/2003/JP,GenBank Accession No. AB212306; norovirus Sydney 2212, GenBank AccessionNo. AY588132; Norwalk virus strain SN2000JA, GenBank Accession No.AB190457; Lordsdale virus complete genome, GenBank Accession No. X86557;Norwalk-like virus genomic RNA, Gifu′96, GenBank Accession No. AB045603;Norwalk virus strain Vietnam 026, complete genome, GenBank Accession No.AF504671; norovirus Hu/GII.4/2004/N/L, GenBank Accession No. AY883096;norovirus Hu/GII/Hokushin/03/JP, GenBank Accession No. AB195227;norovirus Hu/GII/Kamo/03/JP, GenBank Accession No. AB195228; norovirusHu/GII/Sinsiro/97/JP, GenBank Accession No. AB195226; norovirusHu/GII/Ina/02JP, GenBank Accession No. AB195225; norovirusHu/NLV/GII/Neustrelitz260/2000/DE, GenBank Accession No. AY772730;norovirus Hu/NLV/Dresden174/pUS-NorII/1997/GE, GenBank Accession No.AY741811; norovirus Hu/NLV/Oxford/B2S16/2002/UK, GenBank Accession No.AY587989; norovirus Hu/NLV/Oxford/B4S7/2002/UK, GenBank Accession No.AY587987; norovirus Hu/NLV/Witney/B7S2/2003/UK, GenBank Accession No.AY588030; norovirus Hu/NLV/Banbury/B9S23/2003/UK, GenBank Accession No.AY588029; norovirus Hu/NLV/ChippingNorton/2003/UK, GenBank Accession No.AY588028; norovirus Hu/NLV/Didcot/B9S2/2003/UK, GenBank Accession No.AY588027; norovirus Hu/NLV/Oxford/B8S5/2002/UK, GenBank Accession No.AY588026; norovirus Hu/NLV/Oxford/B6S4/2003/UK, GenBank Accession No.AY588025; norovirus Hu/NLV/Oxford/B6S5/2003/UK, GenBank Accession No.AY588024; norovirus Hu/NLV/Oxford/B5S23/2003/UK, GenBank Accession No.AY588023; norovirus Hu/NLV/Oxford/B6S2/2003/UK, GenBank Accession No.AY588022; norovirus Hu/NLV/Oxford/B6S6/2003/UK, GenBank Accession No.AY588021; Norwalk-like virus isolate Bo/Thirsk10/00/UK, GenBankAccession No. AY126468; Norwalk-like virus isolate Bo/Penrith55/00/UK,GenBank Accession No. AY126476; Norwalk-like virus isolateBo/Aberystwyth24/00/UK, GenBank Accession No. AY126475; Norwalk-likevirus isolate Bo/Dumfries/94/UK, GenBank Accession No. AY126474;norovirus NLV/IF2036/2003/Iraq, GenBank Accession No. AY675555;norovirus NLV/IF1998/2003/Iraq, GenBank Accession No. AY675554;norovirus NLV/BUDS/2002/USA, GenBank Accession No. AY660568; norovirusNLV/Paris Island/2003/USA, GenBank Accession No. AY652979; Snow Mountainvirus, complete genome, GenBank Accession No. AY134748; Norwalk-likevirus NLV/Fort Lauderdale/S60/1998/US, GenBank Accession No. AF414426;Hu/norovirus/hiroshima/1999/JP(9912-02F), GenBank Accession No.AB044366; Norwalk-like virus strain 11MSU-MW, GenBank Accession No.AY274820; Norwalk-like virus strain B-1SVD, GenBank Accession No.AY274819; norovirus genogroup 2 strain Hu/NoV/Farmington Hills/2002/USA,GenBank Accession No. AY502023; norovirus genogroup 2 strainHu/NoV/CS-G4/2002/USA, GenBank Accession No. AY502022; norovirusgenogroup 2 strain Hu/NoV/CS-G2/2002/USA, GenBank Accession No.AY502021; norovirus genogroup 2 strain Hu/NoV/CS-G12002/USA, GenBankAccession No. AY502020; norovirus genogroup 2 strainHu/NoV/Anchorage/2002/USA, GenBank Accession No. AY502019; norovirusgenogroup 2 strain Hu/NoV/CS-D1/2002/CAN, GenBank Accession No.AY502018; norovirus genogroup 2 strain Hu/NoV/Germanton/2002/USA,GenBank Accession No. AY502017; Human calicivirusNLV/GII/Langen1061/2002/DE, complete genome, GenBank Accession No.AY485642; Murine norovirus 1 polyprotein, GenBank Accession No.AY228235; Norwalk virus, GenBank Accession No. AB067536; Humancalicivirus NLV/Mex7076/1999, GenBank Accession No. AF542090; Humancalicivirus NLV/Oberhausen 455/01/DE, GenBank Accession No. AF539440;Human calicivirus NLV/Herzberg 385/01/DE, GenBank Accession No.AF539439; Human calicivirus NLV/Boxer/2001/US, GenBank Accession No.AF538679; Norwalk-like virus genomic RNA, complete genome, GenBankAccession No. AB081723; Norwalk-like virus genomic RNA, complete genome,isolate:Saitama U201, GenBank Accession No. AB039782; Norwalk-like virusgenomic RNA, complete genome, isolate:Saitama U18, GenBank Accession No.AB039781; Norwalk-like virus genomic RNA, complete genome,isolate:Saitama U25, GenBank Accession No. AB039780; Norwalk virusstrain:U25GII, GenBank Accession No. AB067543; Norwalk virus strain:U201GII, GenBank Accession No. AB067542; Norwalk-like viruses strain416/97003156/1996/LA, GenBank Accession No. AF080559; Norwalk-likeviruses strain 408/97003012/1996/FL, GenBank Accession No. AF080558;Norwalk-like virus NLV/Burwash Landing/331/1995/US, GenBank AccessionNo. AF414425; Norwalk-like virus NLV/Miami Beach/326/1995/US, GenBankAccession No. AF414424; Norwalk-like virus NLV/White River/290/1994/US,GenBank Accession No. AF414423; Norwalk-like virus NLV/NewOrleans/306/1994/US. GenBank Accession No. AF414422; Norwalk-like virusNLV/Port Canaveral/301/1994/US, GenBank Accession No. AF414421;Norwalk-like virus NLV/Honolulu/314/1994/US, GenBank Accession No.AF414420; Norwalk-like virus NLV/Richmond/283/1994/US, GenBank AccessionNo. AF414419; Norwalk-like virus NLV/Westover/302/1994/US, GenBankAccession No. AF414418; Norwalk-like virus NLV/UK3-17/12700/1992/GB,GenBank Accession No. AF414417; Norwalk-like virus NLV/Miami/81/1986/US,GenBank Accession No. AF414416; Snow Mountain strain, GenBank AccessionNo. U70059; Desert Shield virus DSV395, GenBank Accession No. U04469;Norwalk virus, complete genome, GenBank Accession No. AF093797; Hawaiicalicivirus, GenBank Accession No. U07611; Southampton virus, GenBankAccession No. L07418; Norwalk virus (SRSV-KY-89/89/J), GenBank AccessionNo. L23828; Norwalk virus (SRSV-SMA/76/US), GenBank Accession No.L23831; Camberwell virus, GenBank Accession No. U46500; Humancalicivirus strain Melksham, GenBank Accession No. X81879; Humancalicivirus strain MX, GenBank Accession No. U22498; Minireovirus TV24,GenBank Accession No. U02030; and Norwalk-like virusNLV/Gwynedd/273/1994/US, GenBank Accession No. AF414409; all of whichsequences (as entered by the date of filing of this application) areherein incorporated by reference. Additional norovirus sequences aredisclosed in the following patent publications: WO 05/030806, WO00/79280, JP2002020399, US2003129588, U.S. Pat. No. 6,572,862, WO94/05700, and WO 05/032457, all of which are herein incorporated byreference in their entireties. See also Green et al. (2000) J. Infect.Dis. 181(Suppl. 2):S322-S330; Wang et al. (1994) J. Virol. 68:5982-5990;Chen et al. (2004) J. Virol. 78: 6469-6479; Chakravarty et al. (2005) J.Virol. 79: 554-568; and Fankhauser et al. (1998) J. Infect. Dis.178:1571-1578; for sequence comparisons and a discussion of geneticdiversity and phylogenetic analysis of noroviruses.

As used herein, the terms “major capsid protein” or “major capsidpolypeptide” or “VP1” in reference to a norovirus refer to a polypeptidecomprising a sequence homologous or identical to the ORF2-encodedpolypeptide of a norovirus, and includes sequences displaying at leastabout 70-100% or about 80-100% amino acid sequence identity thereto,including any percent identity within this range, such as 71, 72, 73,74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91,92, 93, 94, 95, 96, 97, 98, 99, 100% amino acid sequence identitythereto.

As used herein, the terms “minor structural protein” or “minorstructural polypeptide” or “VP2” or “small basic protein” in referenceto a norovirus refer to a polypeptide comprising a sequence homologousor identical to the ORF3-encoded polypeptide of a norovirus, andincludes sequences displaying at least about 70-100% or about 80-100%amino acid sequence identity thereto, including any percent identitywithin this range, such as 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81,82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99,100% amino acid sequence identity thereto.

As used herein, the term “virus-like particle” or “VLP” refers to anonreplicating, noninfectious viral shell, that contains a viral capsidbut lack all or part of the viral genome, in particular, the replicativeand infectious components of the viral genome. VLPs are generallycomposed of one or more viral proteins, such as, but not limited tothose proteins referred to as capsid, coat, shell, surface, structuralproteins (e.g., VP1, VP2). norovirus VLPs can form spontaneously uponrecombinant expression of VP1 in an appropriate expression system.Methods for producing particular VLPs are known in the art and discussedmore fully below. The presence of VLPs following recombinant expressionof viral proteins can be detected using conventional techniques known inthe art, such as by electron microscopy, biophysical characterization,and the like. For example, VLPs can be isolated by density gradientcentrifugation and/or identified by characteristic density banding.Alternatively, cryoelectron microscopy can be performed on vitrifiedaqueous samples of the VLP preparation in question, and images recordedunder appropriate exposure conditions. Negative stained electronmicroscopy can be performed on norovirus or norovirus VLP samples aftercoating with an electron-dense negative contrast agent, such as uranylacetate, uranuyl formate, or phosphotungstic acid.

As used herein, a “biological sample” refers to a sample of tissue orfluid isolated from a subject, including but not limited to, forexample, blood, plasma, serum, fecal matter, urine, bone marrow, bile,spinal fluid, lymph fluid, samples of the skin, external secretions ofthe skin, respiratory, intestinal, and genitourinary tracts, tears,saliva, milk, blood cells, organs, biopsies and also samples of in vitrocell culture constituents including but not limited to conditioned mediaresulting from the growth of cells and tissues in culture medium, e.g.,recombinant cells, and cell components. In particular, norovirus may beobtained from biological samples such as vomit or diarrhea fromindividuals infected with the viruses.

By “subject” is meant any member of the subphylum chordata, including,without limitation, humans and other primates, including non-humanprimates such as chimpanzees and other apes and monkey species; farmanimals such as cattle, sheep, pigs, goats and horses; domestic mammalssuch as dogs and cats; laboratory animals including rodents such asmice, rats and guinea pigs; birds, including domestic, wild and gamebirds such as chickens, turkeys and other gallinaceous birds, ducks,geese, and the like. The term does not denote a particular age. Thus,both adult and newborn individuals are intended to be covered.

“Homology” refers to the percent identity between two polynucleotide ortwo polypeptide moieties. Two nucleic acid, or two polypeptide sequencesare “substantially homologous” to each other when the sequences exhibitat least about 50% sequence identity, preferably at least about 75%sequence identity, more preferably at least about 80%-85% sequenceidentity, more preferably at least about 90% sequence identity, and mostpreferably at least about 95%-98% sequence identity over a definedlength of the molecules. As used herein, substantially homologous alsorefers to sequences showing complete identity to the specified sequence.

In general, “identity” refers to an exact nucleotide-to-nucleotide oramino acid-to-amino acid correspondence of two polynucleotides orpolypeptide sequences, respectively. Percent identity can be determinedby a direct comparison of the sequence information between two moleculesby aligning the sequences, counting the exact number of matches betweenthe two aligned sequences, dividing by the length of the shortersequence, and multiplying the result by 100. Readily available computerprograms can be used to aid in the analysis, such as ALIGN, Dayhoff, M.O. in Atlas of Protein Sequence and Structure M. O. Dayhoff ed., 5Suppl. 3:353-358, National biomedical Research Foundation, Washington,D.C., which adapts the local homology algorithm of Smith and Waterman(1981) Advances in Appl. Math. 2:482-489 for peptide analysis. Programsfor determining nucleotide sequence identity are available in theWisconsin Sequence Analysis Package, Version 8 (available from GeneticsComputer Group, Madison, Wis.) for example, the BESTFIT, FASTA and GAPprograms, which also rely on the Smith and Waterman algorithm. Theseprograms are readily utilized with the default parameters recommended bythe manufacturer and described in the Wisconsin Sequence AnalysisPackage referred to above. For example, percent identity of a particularnucleotide sequence to a reference sequence can be determined using thehomology algorithm of Smith and Waterman with a default scoring tableand a gap penalty of six nucleotide positions.

Another method of establishing percent identity in the context of thepresent invention is to use the MPSRCH package of programs copyrightedby the University of Edinburgh, developed by John F. Collins and ShaneS. Sturrok, and distributed by IntelliGenetics, Inc. (Mountain View,Calif.). From this suite of packages the Smith-Waterman algorithm can beemployed where default parameters are used for the scoring table (forexample, gap open penalty of 12, gap extension penalty of one, and a gapof six). From the data generated the “Match” value reflects “sequenceidentity.” Other suitable programs for calculating the percent identityor similarity between sequences are generally known in the art, forexample, another alignment program is BLAST, used with defaultparameters. For example, BLASTN and BLASTP can be used using thefollowing default parameters: genetic code=standard; filter-none;strand-both; cutoff=60; expect-10; Matrix=BLOSUM62; Descriptions=50sequences; sort by=HIGH SCORE; Databases-non-redundant,GenBank+EMBL+DDBJ+PDB+GenBank CDS translations+Swissprotein+Spupdate+PIR. Details of these programs are readily available.

Alternatively, homology can be determined by hybridization ofpolynucleotides under conditions which form stable duplexes betweenhomologous regions, followed by digestion with single-stranded-specificnuclease(s), and size determination of the digested fragments. DNAsequences that are substantially homologous can be identified in aSouthern hybridization experiment under, for example, stringentconditions, as defined for that particular system. Defining appropriatehybridization conditions is within the skill of the art.

Amino acid substitutions, when present in the chimeric VP1 proteins, arepreferably conservative in nature, i.e., substitutions in which a firstamino acid is replaced with a second amino acid that have similarproperties based on their side chains. Specifically, amino acids aregenerally divided into four families and substitutions with families areconsidered to be conservative substitutions. The four families are: (1)acidic amino acids—aspartate and glutamate; (2) basic aminoacids—lysine, arginine, histidine; (3) non-polar amino acids—alanine,valine, leucine, isoleucine, proline, phenylalanine, methionine,tryptophan; and (4) uncharged polar amino acids—glycine, asparagine,glutamine, cysteine, serine, threonine, tyrosine. Phenylalanine,tryptophan, and tyrosine are sometimes classified as aromatic aminoacids.

By “therapeutically effective amount” in the context of the immunogeniccompositions is meant an amount of an immunogen (e.g., chimeric VP1protein, VLP, or nucleic acid encoding an antigen) which will induce animmunological response, either for antibody production or for treatmentor prevention of norovirus infection or disease. Such a response willgenerally result in the development in the subject of anantibody-mediated and/or a secretory or cellular immune response to thecomposition. Usually, such a response includes but is not limited to oneor more of the following effects; the production of antibodies from anyof the immunological classes, such as immunoglobulins A, D, E, G or M;the proliferation of B and T lymphocytes; the provision of activation,growth and differentiation signals to immunological cells; expansion ofhelper T cell, suppressor T cell, and/or cytotoxic T cell and/or γδTcell populations.

For purposes of the present invention, an “effective amount” of anadjuvant will be that amount which enhances an immunological response toa coadministered antigen or nucleic acid encoding an antigen.

As used herein, “treatment” refers to any of (i) the prevention ofinfection or reinfection or disease, (ii) the reduction or eliminationof symptoms, and (iii) the substantial or complete elimination of thepathogen in question. Treatment may be effected prophylactically (priorto infection) or therapeutically (following infection).

II. Modes of Carrying Out the Invention

The invention described herein is not limited to particularlyexemplified molecules or process parameters as such may vary. Theterminology used herein is for the purpose of describing particularaspects, features and embodiments of the invention only, and is notintended to be limiting. In addition, the practice of the presentinvention will employ conventional methods of virology, microbiology,molecular biology, recombinant DNA techniques and immunology all ofwhich are within the ordinary skill of the art. Such techniques areexplained fully in the literature. See, e.g., Sambrook, et al.,Molecular Cloning: A Laboratory Manual (3rd Edition, 2000); DNA Cloning:A Practical Approach, vol. I & II (D. Glover, ed.); OligonucleotideSynthesis (N. Gait, ed., 1984); A Practical Guide to Molecular Cloning(1984); and Fundamental Virology, 4th Edition, 2001 (B. N. Fields and D.M. Knipe, eds.); Handbook of Experimental Immunology, Vols. I-IV (D. M.Weir and C. C. Blackwell eds., Blackwell Scientific Publications); A. L.Lehninger, Biochemistry (Worth Publishers, Inc., current addition);Methods In Enzymology (S. Colowick and N. Kaplan eds., Academic Press,Inc.). Although a number of methods and materials similar or equivalentto those described herein can be used in the practice of the presentinvention, the preferred materials and methods are described herein. Inaddition, all publications, patents and patent applications citedherein, whether supra or infra, are hereby incorporated by reference intheir entireties.

The present invention is, in part, based on the discovery that all or aportion of the P-domain of the VP1 protein of a first norovirus straincan be replaced with all or the corresponding portion of the P-domain ofa second norovirus strain, and that when expressed, such chimeric VP1proteins can self-assemble into VLPs. It has also been discovered thatVLPs that contain any desired VP1 P-domain, even P-domains from VP1proteins of norovirus strains that are not expressed well in recombinanthost cells and therefore do not readily form VLPs. This is accomplishedby preparing a chimeric VP1 protein that contains the S-domain of a VP1from a norovirus strain that is well expressed and, therefore, canreadily form VLPs, and all or a portion of the P-domain of a VP1 proteinof any other desired norovirus strain. Accordingly, the presentinvention provides chimeric norovirus VP1 proteins, and norovirus VLPs,that contain all or a portion of any desired P-domain. Now, chimericnorovirus VP1 proteins, and norovirus VLPs, that contain all or aportion of any P-domain, including P-domains from emerging norovirusstrains can be produced relatively easily and rapidly.

Therefore, the present invention provides compositions and methods forrapid generation of immunogenic compositions that can be used to inducean immune response in a subject, that preferably can protect the subjectfrom norovirus infection and/or norovirus disease. The inventionprovides immunogenic compositions comprising chimeric norovirus VP1protein in the form of monomers or in the form of VLPs. The chimericnorovirus VP1 proteins contain the VP1 S-domain from a first norovirusstrain and all or a portion of the VP1 P-domain from a second norovirusstrain.

The norovirus VLPs of the present invention can be monovalent, and becomposed of a single type of chimeric VP1 protein. Such monovalent VLPscontain multiple copies of a single VP1 P-domain from a single norovirusstrain. If desired, the norovirus VLP of the present invention can bemultivalent, and be composed of two or more different chimeric VP1proteins. Preferably, the two or more different chimeric VP1 proteinscontain the VP1 S-domain from the same norovirus strain, but VP1P-domains from different norovirus strains.

In addition, the immunogenic compositions of the present invention canfurther comprise one or more adjuvants or nucleic acids encodingadjuvants, wherein immunogenic polypeptides and/or VLPs are mixed orco-expressed with adjuvants. Immunogenic compositions may also compriseadditional antigens other than norovirus antigens, such as antigens thatcan be used in immunization against pathogens that cause diarrhealdiseases.

Also provided are immunogenic compositions that comprise a nucleic acidmolecule that encodes a chimeric norovirus VP1, such as an RNA moleculeor a self-replicating RNA molecule. Such compositions can beadministered to a subject and the encoded chimeric norovirus VP1 can beproduced in the subject, preferably in the form of a VLP.

In order to further understand other aspects of the present invention,including nucleic acids, polypeptides and/or VLPs and methods for theirpreparation, purification and use in the treatment or prevention ofnorovirus infection, more detailed discussions are provided below.

A. Polypeptides and VLPs

The chimeric norovirus VP1 protein contains the S-domain of VP1 of afirst norovirus strain and a P-domain that contains at least a portionof the P-domain of VP1 of a second norovirus strain. The S-domain andthe P-domain of the chimeric norovirus VP1 protein are generally joinedthrough a linker peptide, as they are in naturally occurring VP1proteins. The linker peptide can allow the chimeric VP1 protein to foldproperly, so that it self-assembles to form VLPs. The linker peptide canbe any suitable amino acid sequence, such as the linker peptide from theVP1 protein of the first norovirus strain, the second norovirus strainor a third norovirus strain. The first, second, and third norovirusstrains can be any desired norovirus strains, such as any of the strainslisted in Table 1. For example, the first norovirus strain can be theSnow Mountain strain, and the second norovirus strain can be any otherstrain, such as the Norwalk strain or the 2006a strain.

If desired, the amino acid sequence of the S domain, linker and/or Pdomain of a chimeric VP1 may differ from the corresponding naturallyoccurring amino acid sequence by one or more amino acid replacement,addition or deletion (e.g., mutation, substitution, insertion, deletion,truncation and the like). Such sequence changes should not prevent thechimeric VP1 proteins from folding properly and self-assembling intoVLPs. Generally, it is acceptable for amino acid sequences to vary(including by addition or deletion of one or more amino acids) fromnaturally occurring sequences in areas that are not highly conserved.For example, as shown in FIGS. 8A-8B alignment of the amino acidsequences of several norovirus VP1 proteins reveals that the S domain ishighly conserved whereas the P domain, and the P2 subdomain inparticular, is more variable. Accordingly, amino acid sequence variationcan be introduced, if desired, into the amino-terminal region,carboxy-terminal region, and P domain. Some amino acid sequencevariations can also be introduced into the S domain and/or P1 subdomain,preferably at nonconserved positions, which are not marked with anasterisk in FIG. 8A.

The VP1 proteins of some norovirus strains are difficult to produce inhigh yields by recombinant expression in host cells, such as yeast.However, when the chimeric norovirus VP1 protein contains an S-domainfrom a strain that is a high expressor (such as the Snow Mountain strainwhere expression can be >40 mg per liter of yeast cells) in a desiredhost cell, such as yeast cells, the chimeric protein can be produced inhigh yield in that host cell even if the P-domain is from a strain thatis not well expressed. For example, the secreted soluble expression ofNorwalk P-domain can be increased greater than 5-fold by generating achimeric construct as described with a Snow Mountain S-domain.Accordingly, the chimeric VP1 proteins of the invention can be used tomake VLPs that contain the VP1 P-domain from strains that are not wellexpressed in host cells, and therefore do not readily form VLPs. Thus,it is generally preferred that the S-domain is from the VP1 protein of astrain that is well expressed in a desired host cell, such as yeastcells. Preferably, the high expressor norovirus strain is a strain whoseVP1 protein can be produced recombinantly in a host cell, preferablyyeast, in a quantity of at least about 5 mg/liter of cells, at leastabout 10 mg/liter of cells, at least about 15 mg/liter of cells, atleast about 20 mg/liter of cells, at least about 25 mg/liter of cells,at least about 30 mg/liter of cells, at least about 35 mg/liter ofcells, or at least about 40 mg/liter of cells.

The chimeric norovirus VP1 protein can have a structure according toFormula I:A-S-L-P-B  (I)

wherein,

A and B are independently absent or any desired amino acid sequence;

S is the S-domain of VP1 of a first norovirus strain;

L is a linker peptide or absent; and

P is a norovirus VP1 P-domain, wherein at least a portion of P is fromthe P-domain of a second norovirus strain.

The linker peptide (L) can be any amino acid sequence that allows thechimeric VP1 protein to fold properly and to self-assemble to form aVLP. Suitable linker peptides include the linker peptide from the VP11protein of the first norovirus strain, the second norovirus strain or athird norovirus strain. Alternatively, the linker peptide (L) can be ashort amino acid sequence that permits the chimeric protein to foldproperly and self-assemble into VLPs, e.g., 20 or fewer amino acids(i.e., 20, 19, 18, 17, 16, 15, 14, 13, 12, 11, 10, 9, 8, 7, 6, 5, 4, 3,2, 1 amino acids), preferably about 9 amino acids. Examples of suitablelinker peptides (L) include poly-glycine linkers (Gly, where n=2, 3, 4,5, 6, 7, 8, 9, 10 or more (SEQ ID NO:5)), and (GGGS)n wherein n=1, 2, 3or 4 (SEQ ID NO:6), and highly charged linkers, such as (SRSK)n whereinn=1, 2, 3 or 4 (SEQ ID NO:7). Preferably, L is the linker peptide fromthe VP1 protein of the first norovirus strain, the second norovirusstrain or a third norovirus strain.

A and B, when present, are independently any desired amino acidsequence, such as, a sequence of about 1-500 amino acids, about 1-250amino acids, about 1-100 amino acids, about 1-50 amino acids, about 1-40amino acids, about 1-30 amino acids, about 1-20 amino acids, about 1-10amino acids, or about 1-5 amino acids. For example, A and B can be oneor more amino acids that are added to the chimeric protein to facilitateor as a result of cloning, or to facilitate protein purification such asan epitope tag or a histidine tag (His_(n) where n=3, 4, 5, 6, 7, 8, 9,10 (SEQ ID NO:8)). An epitope tag could consist of a strong T cellepitope or a modified epitope designed to improve the immunogenicity ofthe protein. These additional residues could comprise a modified TLRagonist as part of an immunomodulator strategy. If desired, A and/or Bcan comprise immunogenic fragments including, for example, the heatshock proteins or fragments, such as those disclosed in U.S. PublicationNo. 20060264609, or viral and bacterial antigens, such as thosedisclosed in U.S. Pat. No. 7,527,801. Alternately, A and/or B cancomprise a full length protein, for example a recombinant protein thatis to be displayed on a norovirus VP1 fusion protein, or that is to beused to display norovirus VP1 or portion thereof. In some embodiments, Aand B are both absent.

As described herein, the P-domain of VP1 comprises a P¹ subdomain and aP² subdomain. Thus, in the formulas disclosed herein, P can be depictedas P¹-P², wherein P¹ is the P¹ subdomain and P² is the P² subdomain.

In the primary structure of the P-domain, the P² subdomain amino acidsare inserted into the sequence of the P¹ subdomain amino acids, and theprimary structure has the formula P¹-1-P²-P¹-2, where P¹-1 is theamino-terminal portion of the sequence of the P¹ subdomain, P¹-2 is theremainder of the sequence of the P¹ subdomain, and P² is the sequence ofthe P² subdomain.

In some exemplary embodiments, the chimeric norovirus VP1 protein can beof Formula I, wherein S is from a first norovirus strain, and P is froma second norovirus strain. In such embodiments, L can be any suitablelinker, such as the natural linker from the first norovirus strain orthe second norovirus strain, or be absent.

As described herein, the chimeric norovirus VP1 protein can contain aP-domain in which a portion of the P-domain is from the same strain asthe S domain, and a portion of the P-domain is from a different strain.The portion from the different stain can be the P¹ domain or a portionthereof, the P² domain or a portion thereof and any combination ofportions of the P¹ domain and the P² domain. Preferably, the portionfrom the different strain is the P² domain or a portion thereof. Forexample, in some embodiments, the chimeric norovirus VP1 protein canhave a structure according to Formula II or Formula III.A-S-L-P¹-P²-B  (II)A-S-P¹-P²-B  (III)

In Formulas II and III, the variables A, S, L and B are as described inFormula I, P¹ is the P¹ domain of VP1 and P² is the P² domain of VP1,and at least one of P¹ and P² is from a norovirus stain different fromthe strain that provides S. In some embodiments, S and P¹ are from afirst norovirus stain and P² is from a second norovirus strain. In otherembodiments, S and P² are from a first norovirus strain and P¹ is from asecond norovirus strain. In such embodiments, the linker L, if present,can be any suitable linker, such as the linker from the first norovirusstrain or the second norovirus strain. In some embodiments, the chimericnorovirus VP1 protein is of Formula II wherein S, L and P¹ are from afirst norovirus strain and P² is from a second norovirus strain. Thisdescription of exemplary embodiments encompassed by Formulas II and IIIis illustrative of chimeric norovirus VP1 proteins that contain aP-domain in which a portion of the P domain is from the same strain asthe S domain, and a portion of the P domain is from a different strain.

In some embodiments, the chimeric norovirus VP1 protein has a structureaccording to any one of Formulas IV and XVII: S_(NV)-L-P_(SMV) (IV),S_(SMV)-L-P_(NV) (V), S_(NV)-P_(DSV) (VI), S_(SMV)-L-P_(DSV) (VII),S_(NV)-L-P_(GI) (VIII), S_(NV)-L-P_(GII) (IX), S_(NV)-L-P_(GIII) (X),S_(NV)-L-P_(GIV) (XI), S_(NV)-L-PV (XII), S_(SMV)-L-P_(GI) (XIII),S_(NV)-L-P_(GII) (XIV), S_(SMV)-L-P_(GIII) (XV), S_(SMV)-L-P_(GIV)(XVI), S_(SMV)-L-P_(GV) (XVII), where P represents the P-domain,including the P¹ and P² subdomains, where the subscript indicates thatthe S-domain or the P-domain is from the following strains: NV, Norwalkstrain; SMV, Snow Mountain strain; DSV, Desert Storm strain; and GI,GII, GIII, GIV and GV are any norovirus from genogroups GI, GII, GIII,GIV and GV, respectively.

In particular embodiments, the chimeric norovirus VP1 protein comprisesan S-domain from the VP1 of Snow Mountain strain, the linker peptidefrom the VP1 of Snow Mountain strain, and a P-domain that contains atleast a portion of the P-domain of the VP1 of another norovirus strain.In more particular embodiments, the P-domain or portion thereof is fromthe VP1 of the Norwalk strain, 2006a strain, or the New Orleans strain.

In some embodiments, the chimeric norovirus VP1 protein has a primarystructure according to Formula XVIII:A-S_(First)-L-P1-1_((First))-P2_((Second))-P1-2_((First))-B  (XVIII),In formula XVIII, the subscripts First and Second indicate that thedomain is from a first strain or a second strain, respectively. Incertain examples, the chimeric norovirus VP1 protein has a primarystructure according to any one of Formulas XIX-XLVI:A-S_(NV)-L-P¹-1_(NV)-P² _((SMV))-P₁-2_((NV))-B (XIX),A-S_(SMV)-L-P¹-1_((SMV))-P2_((NV))-P1-2_((SMV))-B (XX),A-S_(NV)-L-P¹-1_((NV))-P2_((DSV))-P1-2_((NV))-B (XXI),A-S_(SMV)-L-P¹-1_((SMV))-P2_((DSV))-P1-2_((SMV))-B (XXII),A-S_(NV)-L-P¹-1_((NV))-P2_((NV))-P1-2_((NV))-B (XXIII),A-S_(NV)-L-P¹-1_((NV))-P2_((GII))-P1-2_((NV))-B (XXIV),A-S_(NV)-L-P¹-1_((NV))-P2_((GIII))-P1-2_((NV))-B (XXV),A-S_(NV)-L-P¹-1_((NV))-P2_((GIV))-P1-2_((NV))-B (XXVI),A-S_(NV)L-P¹-1_((NV))-P2_((GV))-P1-2_((NV))-B (XXVII).A-S_(SMV)-L-P¹-1_((SMV))-P2_((GI))-P1-2_((SMV))-B (XXVIII),A-S_(SMV)-L-P¹-1_((SMV))-P2_((GII))-P1-2_((SMV))-B (XXIX),A-S_(SMV)-L-P¹-1_((SMV))-P2_((GIII))-P1-2_((SMV))-B (XXX),A-S_(SMV)-L-P¹-1_((SMV))-P2_((GIV))-P1-2_((SMV))-B (XXXI),A-S_(SMV)-L-P¹1_((SMV))-P2_((GV))-P1-2_((SMV))-B (XXXII),A-S_(NV)-L-P¹-1_((NV))-P2_((SMV))-B (XXXIII),A-S_(SMV)-L-P¹-1_((SMV))-P2_((NV))-B (XXXIV),A-S_(NV)-L-P¹-1_((NV))-P2_((DSV))-B (XXXV),A-S_(SMV)-L-P¹-1_((SMV))-P2_((SMV))-B (XXXVI),A-S_(NV)-L-P¹-1_((NV))-P2_((GI))-B (XXXVII),A-S_(NV)-L-P¹-1_((NV))-P2_((GII))-B (XXXVIII),A-S_(NV)-L-P¹-1_((NV))-P2_((GIII))-B (XXXIX),A-S_(NV)-L-P¹-1_((NV))-P2_((GIV))-B (XL),A-S_(NV)-L-P¹-1_((NV))-P2_((GV))-B (XLI),A-S_(SMV)-L-P¹-1_((SMV))-P2_((GI))-B (XLII),A-S_(SMV)-L-P¹-1_((SMV))-P2_((GII))-B (XLIII),A-S_(SMV)-L-P¹-1_((SMV))-P2_((GIII))-B (XLIV),A-S_(SMV)-L-P¹-1_((SMV))-P2_((GIV))-B (XLV),A-S_(SMV)-L-P¹-1_((SMV))-P2_((GV))-B (XLVI), wherein the subscriptindicates that the S-domain or the P-subdomain is from the followingstrains: NV, Norwalk strain; SMV, Snow Mountain strain; DSV, DesertStorm strain; and GI, GII, GIII, GIV and GV are any norovirus fromgenogroups GI, GII, GIII, GIV and GV, respectively.

By following the teachings of this invention, a vast number of differentchimeric VP1 proteins can be produced by recombinant means usingstandard procedures. The amino acid sequences of VP1 proteins, and thenucleotide sequences encoding them, from the different strains ofnorovirus can be obtained from the GenBank database (ncbi.nlm.nih.gov),the Taxonomy Database at National Center for Biotechnology Information(ncbi.nlm.nih.gov) or the PathoSystems Resource Integration CenterDatabase on Caliciviridae (patric.vbi.vt.edu).

When the chimeric VP1 proteins of the invention are produced byexpression in a host cell, such as yeast cells, they can self-assembleinto VLPs. This is particularly the case for chimeric VP1 proteins thatcontain an S-domain of VP1 of a norovirus strain that is well expressedin the host cell, such as the S-domain of the Snow Mountain strain.Thus, the present invention further provides VLPs that contain achimeric VP1. The VLPs can be monovalent or bivalent or multivalent.Monovalent VLPs contain a chimeric VP1 protein and only one P-domain. Insome embodiments, the monovalent VLP can contain a chimeric VP1 and anaturally occurring VP1 that each contain the same P-domain. Preferredmonovalent VLPs are composed of multiple copies (e.g., 180 copies) of asingle chimeric VP1 protein. Accordingly, in certain embodiments, themonovalent VLPs of the invention include 180 copies of a single chimericVP1 of any one of Formulas I-XLVI, for example.

Bivalent and multivalent VLPs contain a chimeric VP1 protein and atleast 2 different P-domains. For example, in some embodiments, abivalent VLP can contain a chimeric VP1 that contains a first P-domainand a naturally occurring VP1 that contains a second P-domain. In suchembodiments, it is preferred that the S-domain in the chimeric VP1 andin naturally occurring VP1 is the same. In other embodiments, thebivalent or multivalent VLP contains two or more different chimeric VP1proteins that contain P-domains from different strains. Preferably thetwo or more chimeric VP1 proteins contain the same S-domain.

In certain other embodiments, the bivalent or multivalent VLPs of theinvention include two or more chimeric VP1 proteins selected from thegroup consisting of chimeric VP1 proteins according to Formulas I-XLVI,for example.

If desired, the amino acid sequence of one or both of the S- andP-domains (including P-subdomains) of a chimeric VP1 can be altered (byinsertion, deletion, mutation, substitution) to include one or moreamino acid insertion(s), deletion(s), mutation(s) or substitution(s)that render the amino acid sequence of the domain or subdomain differentfrom the corresponding naturally occurring amino acid sequence, forexample by up to about 20%, up to about 1%, up to about 2%, up to about3%, up to about 4%, up to about 5%, up to about 10%, up to about 15%, orup to about 20% over the length of the amino acid sequence of the domainor subdomain.

As shown in FIGS. 8A-8E, alignment of naturally occurring VP1 amino acidsequences demonstrates that the N-terminal region (aa 1-49), S-domain(aa 50-225) and P₁₋₁ subdomain (aa 226-278) amino acid sequences aremore conserved (asterisks indicate conserved amino acids) than the aminoacid sequence of the P2 subdomain (aa 279-405), P1-2 domain (aa 406-520)and C-terminal region (Hansman et al. (2006) J. General Virology 87:909-919). Because conserved amino acid residues are often important forproper folding or function, it is preferred that any amino acid sequencealterations that are present are not introduced at conserved positions.For example, conserved amino acids in the S-domain may be important forproper folding and formation of VLPs. Therefore, in the chimeric VP1proteins of the present invention, conserved amino acid residues arepreferably not deleted or replaced.

Thus, in some embodiments, the S-domain of the chimeric VP1 protein ofthe invention can have at least about 70-100% or about 80-100% aminoacid sequence identity to a naturally occurring S-domain, including anypercent identity within this range, such as at least about 70, at leastabout 71, at least about 72, at least about 73, at least about 74, atleast about 75, at least about 76, at least about 77, at least about 78,at least about 79, at least about 80, at least about 81, at least about82, at least about 83, at least about 84, at least about 85, at leastabout 86, at least about 87, at least about 88, at least about 89, atleast about 90, at least about 91, at least about 92, at least about 93,at least about 94, at least about 95, at least about 96, at least about97, at least about 98, at least about 99, or 100% amino acid sequenceidentity. Alternatively or in addition, the P1-1-subdomain of thechimeric VP1 protein of the invention can have at least about 70-100% orabout 80-100% amino acid sequence identity relative to a naturallyoccurring P1-1-subdomain, including any percent identity within thisrange, such as at least about 70, at least about 71, at least about 72,at least about 73, at least about 74, at least about 75, at least about76, at least about 77, at least about 78, at least about 79, at leastabout 80, at least about 81, at least about 82, at least about 83, atleast about 84, at least about 85, at least about 86, at least about 87,at least about 88, at least about 89, at least about 90, at least about91, at least about 92, at least about 93, at least about 94, at leastabout 95, at least about 96, at least about 97, at least about 98, atleast about 99, or 100% amino acid sequence identity. Alternatively orin addition, the P₂-subdomain of the chimeric VP1 protein of theinvention can have at least about 70-100% or about 80-100% amino acidsequence identity to a naturally occurring P₂-subdomain, including anypercent identity within this range, such as at least about 70, at leastabout 71, at least about 72, at least about 73, at least about 74, atleast about 75, at least about 76, at least about 77, at least about 78,at least about 79, at least about 80, at least about 81, at least about82, at least about 83, at least about 84, at least about 85, at leastabout 86, at least about 87, at least about 88, at least about 89, atleast about 90, at least about 91, at least about 92, at least about 93,at least about 94, at least about 95, at least about 96, at least about97, at least about 98, at least about 99, or 100% amino acid sequenceidentity. Alternatively or in addition, the P1-2-subdomain of thechimeric VP1 protein of the invention can have at least about 70-100% orabout 80-100% amino acid sequence identity to a naturally occurringP1-2-subdomain, including any percent identity within this range, suchas at least about 70, at least about 71, at least about 72, at leastabout 73, at least about 74, at least about 75, at least about 76, atleast about 77, at least about 78, at least about 79, at least about 80,at least about 81, at least about 82, at least about 83, at least about84, at least about 85, at least about 86, at least about 87, at leastabout 88, at least about 89, at least about 90, at least about 91, atleast about 92, at least about 93, at least about 94, at least about 95,at least about 96, at least about 97, at least about 98, at least about99, or 100% amino acid sequence identity.

The S-domains of the VP1 proteins of the invention are full-length ornear full-length relative to a naturally occurring S-domain. Truncationat either N- or C-terminals or both and internal deletions, areacceptable provided that the ability to form VLPs under conditions thatfavor VLP formation is preserved. Accordingly, the S-domain may comprisethe full-length sequence, fragments, truncated and partial sequences, aswell as analogs and precursor forms of the reference or native S-domain.In some embodiments, the S-domain of the VP1 proteins of the inventionis truncated at its N-terminal end by 5, 10, 15, 20, 25, 30, 35, 40, 45or 50 amino acid residues. Alternatively or in addition, the S-domain ofthe VP1 proteins of the invention can be truncated at its C-terminal endby 5, 10, 15, 20, 25, 30, 35, 40, 45 or 50 amino acid residues.Alternatively or in addition, the S-domain of the VP1 proteins of theinvention can contain an internal deletion of 5, 10, 15, 20, 25, 30, 35,40, 45 or 50 amino acid residues in length.

The P1-1-subdomains of the VP1 proteins of the invention are full-lengthor near full-length relative to a naturally occurring P1-1-subdomain,with sequence truncation at either N- or C-terminals or both and/or withinternal deletions. Accordingly, the P1-1-subdomain may comprise thefull-length sequence, fragments, truncated and partial sequences, aswell as analogs and precursor forms of the naturally occurringP1-1-domain. In some embodiments, the P1-1-subdomain of the VP1 proteinsof the invention is truncated at its N-terminal end by 1, 2, 3, 4, 5, 6,7, 8, 9 or 10 amino acid residues. Alternatively, or in addition, theP1-1-subdomain of the VP1 proteins of the invention can be truncated atits C-terminal end by 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 amino acidresidues. Alternatively or in addition, the P1-1-subdomain of the VP1proteins of the invention can contain an internal deletion of 1, 2, 3,4, 5, 6, 7, 8, 9 or 10 amino acid residues in length.

The P2-subdomains of the VP proteins of the invention are full-length ornear full-length relative to the naturally occurring P2-subdomain, withsequence truncation at either N- or C-terminals or both and/or withinternal deletions. Accordingly, the P2-subdomain may comprise thefull-length sequence, fragments, truncated and partial sequences, aswell as analogs and precursor forms of the naturally occurringP2-domain. In some embodiments, the P2-subdomain of the VP1 proteins ofthe invention is truncated at its N-terminal end by 1 to about 26 aminoacids, such as 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 16, 20, 24 or 26 aminoacid residues. Alternatively, or in addition, the P2-subdomain of theVP1 proteins of the invention can be truncated at its C-terminal end by1 to about 26 amino acids, such as 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12,16, 20, 24 or 26 amino acid residues. Alternatively, or in addition, theP2-subdomain of the VP1 proteins of the invention can contain aninternal deletion of 1 to about 26 amino acids, such as 1, 2, 3, 4, 5,6, 7, 8, 9, 10, 12, 16, 20, 24 or 26 amino acid residues.

The P1-2-subdomains of the VP1 proteins of the invention are full-lengthor near full-length relative to the native or reference P1-2-subdomain,with sequence truncation at either N- or C-terminals or both and/or withinternal deletions. Accordingly, the P1-2-subdomain may comprise thefull-length sequence, fragments, truncated and partial sequences, aswell as analogs and precursor forms of the naturally occurringP1-2-domain. In some embodiments, the P1-2-subdomain of the VP1 proteinsof the invention is truncated at its N-terminal end by 1 to about 26amino acids, such as 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 16, 20, 24 or 26amino acid residues. Alternatively, or in addition, the P1-2-subdomainof the VP1 proteins of the invention can be truncated at its C-terminalend by 1 to about 26 amino acids, such as 1, 2, 3, 4, 5, 6, 7, 8, 9, 10,12, 16, 20, 24 or 26 amino acid residues. Alternatively or in addition,the P1-2-subdomain of the VP1 proteins of the invention can contain aninternal deletion of 1 to about 26 amino acids, such as 1, 2, 3, 4, 5,6, 7, 8, 9, 10, 12, 16, 20, 24 or 26 amino acid residues.

In some embodiments, the P-domains (including P1-1, P2 and P1-2subdomains) of the chimeric VP1 proteins of the invention can includeamino acid sequence insertions or replacements that are portions ofother polypeptides, such as polypeptides that are displayed on thechimeric VP1. For example, the P-domain can be fused to anotherpolypeptide or portion of another polypeptide. For example, in Formula IB can be an amino acid sequence of another polypeptide that is displayedon the chimeric VP1. In such situations, the other polypeptide can bedisplayed on the surface of a VLP that contains the chimeric VP1protein.

The chimeric VP1 proteins of the invention can be produced by expressionin suitable recombinant host cells, such as yeast cells, using anysuitable methods, including those described herein.

B. Nucleic Acids

The invention further provides recombinant nucleic acids that encode thechimeric norovirus VP1 proteins described herein. These nucleic acidscontain a first nucleotide sequence that encodes the S-domain of VP1 ofa first norovirus strain, a second nucleotide sequence that encodes aP-domain that contains at least a portion of the P-domain of a secondnorovirus strain, and optionally, third, forth and fifth nucleotidesequences that encode a linker peptide, and amino acid sequences A andB, respectively. The nucleic acid sequences are operably linked so thatthe nucleic acid can be transcribed and/or translated to produce achimeric VP1 protein that self assembles into a VLP. Any suitablenucleic acid sequences that encode the S-domain and the P-domain of VP1from desired norovirus strains can be used. For example, nucleic acidsthat have the same nucleotide sequences as the corresponding sequencesin ORF2 in the genome of the desired norovirus strain, or codonoptimized variants thereof that are optimized for recombinant expressionin a desired host cell, such as yeast cells, can be used.

A representative norovirus ORF2 sequence from the Snow Mountain strainis known and is presented in FIG. 4A. The nucleotide sequences of ORF2of many other norovirus strains are known in the art, such as the ORF2sequences of Norwalk virus, GenBank Accession No. M87661, Hawaii virus;GenBank Accession No. U07611, and sequences disclosed in the followingpatent publications: WO 05/030806, WO 00/79280, JP2002020399,US2003129588, U.S. Pat. No. 6,572,862, WO 94/05700, and WO 05/032457.See also Green et al. (2000) J. Infect. Dis. 181(Suppl. 2):S322-330;Wang et al. (1994) J. Virol. 68:5982-5990; Chen et al. (2004) J. Virol.78: 6469-6479; Chakravarty et al. (2005) J. Virol. 79: 554-568; andFankhauser et al. (1998) J. Infect. Dis. 178:1571-1578; for sequencecomparisons of different norovirus strains. Further information aboutnucleotide sequences of noroviruses can be obtained from the GenBankdatabase (ncbi.nlm.nih.gov), the Taxonomy Database at National Centerfor Biotechnology Information (ncbi.nlm.nih.gov) or the PathoSystemsResource Integration Center Database on Caliciviridae(patric.vbi.vt.edu).

In some aspects, the recombinant nucleic acids encode a chimeric VP1protein described herein, such as a chimeric VP1 protein according toFormula I. For example, the recombinant nucleic acid can include acoding sequence according to Formula LIVA′-S′-L′-P′-B′  (XLVII)

wherein,

A′ and B′ are independently absent or a nucleotide sequence encoding anydesired amino acid sequence;

S′ is a nucleotide sequence encoding the S-domain of VP1 of a firstnorovirus strain;

L′ is absent or a nucleotide sequence encoding a linker peptide and;

P′ is a nucleotide sequence encoding a norovirus VP1 P-domain, whereinat least a portion of P is from the P-domain of a second norovirusstrain.

The linker peptide encoded by L′, and the amino acid sequences encodedby A′, S′, P′ and B′ are as described herein for L, A, S, P, and B,respectively.

In particular embodiments, the recombinant nucleic acid contains acoding sequence that encodes a chimeric VP1 protein according to any oneof Formulas I-XLVI.

In other particular embodiments, the recombinant nucleic acid contains acoding sequence that encodes a chimeric VP1 protein have any of theprimary structures shown in FIG. 7.

Representative recombinant nucleic acids that encode chimeric VP1proteins that contain the S-sequence from Snow Mountain strain and theP-sequence from Norwalk stain; or the S-sequence from Snow Mountainstrain and the P-sequence from GII.4 2006a.OPTI:P strain are shown inFIGS. 5 and 6 respectively. In the case of the Snow Mountain sequence,the S-domain encompasses residues 1-216 and the linker includes residues217 to 226. For Norwalk the P-sequence encompassed residues 231-530. Forthe 2006a sequence, the P-sequence encompassed residues 227-541.Additional representative norovirus sequences are Norwalk virus, GenBankAccession No. M87661, Snow Mountain virus, GenBank Accession No. U70059;Snow Mountain virus, GenBank Accession No. AY134748, Hawaii virus;GenBank Accession No. U07611, and sequences disclosed in the followingpatent publications: WO 05/030806, WO 00/79280, JP2002020399,US2003129588, U.S. Pat. No. 6,572,862, WO 94/05700, and WO 05/032457.See also Green et al. (2000) J. Infect. Dis. 181(Suppl. 2):S322-330;Wang et al. (1994) J. Virol. 68:5982-5990; Chen et al. (2004) J. Virol.78:6469-6479; Chakravarty et al. (2005) J. Virol. 79:554-568; andFankhauser et al. (1998) J. Infect. Dis. 178:1571-1578; for sequencecomparisons of different norovirus strains.

A nucleic acid encoding a chimeric VP1 protein can be RNA or DNA, can beconstructed using any suitable method (e.g. by chemical synthesis, usingrecombinant DNA technology) and can take various forms (e.g. singlestranded, double stranded, vectors, etc.). Many suitable methods forproducing recombinant constructs are well-known and conventional in theart. For example, the recombinant nucleic acids can be produced from twoor more oligonucleotides comprising sequences encoding portions of thechimeric VP1 protein or by ligating oligonucleotides to form a codingsequence for the full-length chimeric VP1 protein using standardmolecular biology techniques. See, e.g., U.S. Pat. Nos. 6,632,601 and6,630,298. Preferably, nucleic acids are prepared in substantially pureform (i.e. substantially free from other host cell or non host cellnucleic acids).

Polynucleotides that encode VP1 proteins of interest can be isolatedfrom a genomic library derived from viral RNA, present in, for example,stool or vomit samples from an infected individual. Alternatively,norovirus nucleic acids can be isolated from infected humans or othermammals or from stool or vomit samples collected from infectedindividuals as described in e.g., Estes et al. U.S. Pat. No. 6,942,865;Guntapong et al. (2004) Jpn J. Infect. Dis. 57:276-278; Harrington etal. (2004) J. Virol. 78:3035-3045; Fankhauser et al. (1998) J. Infect.Dis. 178:1571-1578; and Dolin et al. (1971) J. Infect. Dis. 123:307-312.Porcine viruses can be grown in LLC-PK cells in the presence ofintestinal fluid containing bile acids (Chang et al. (2004) Proc. Natl.Acad. Sci. U.S.A. 101:8733-8738). An amplification method such as PCRcan be used to amplify polynucleotides from either norovirus genomic RNAor cDNA encoding therefore. Alternatively, polynucleotides can bechemically synthesized. The nucleotide sequence can be designed with theappropriate codons for the particular amino acid sequence desired.Preferably, synthetic constructs will contain codons optimized forexpression in the intended host cell in which the chimeric VP1 proteinwill be produced. The complete sequence of the polynucleotide ofinterest can be assembled from overlapping oligonucleotides prepared bystandard methods and assembled into a complete coding sequence. See,e.g., Edge (1981) Nature 292:756; Nambair et al. (1984) Science223:1299; Jay et al. (1984) J. Biol. Chem. 259:6311; Stemmer et al.(1995) Gene 164:49-53. The polynucleotides can be RNA or single- ordouble-stranded DNA. Preferably, the polynucleotides are isolated freeof other components, such as proteins and lipids.

Alternatively, particular nucleotide sequences can be obtained fromvectors harboring the desired sequences or synthesized completely or inpart using various oligonucleotide synthesis techniques known in theart, such as site-directed mutagenesis and polymerase chain reaction(PCR) techniques where appropriate. See, e.g., Sambrook, supra. Inparticular, one method of obtaining nucleotide sequences encoding thedesired sequences is by annealing complementary sets of overlappingsynthetic oligonucleotides, followed by ligation with an appropriate DNAligase and amplification of the ligated nucleotide sequence via PCR.See, e.g., Jayaraman et al. (1991) Proc. Natl. Acad. Sci. USA88:4084-4088. Additionally, oligonucleotide directed synthesis (Jones etal. (1986) Nature 54:75-82), oligonucleotide directed mutagenesis ofpre-existing nucleotide regions (Riechmann et al. (1988) Nature332:323-327 and Verhoeyen et al. (1988) Science 239:1534-1536), andenzymatic filling-in of gapped oligonucleotides using T4 DNA polymerase(Queen et al. (1989) Proc. Natl. Acad. Sci. USA 86:10029-10033) can beused.

Recombinant constructs encoding chimeric VP1 proteins can be prepared insuitable vectors, such as expression vectors, using conventionalmethods. The recombinant construct, such as an expression vector,includes a nucleic acid sequence which encodes a chimeric norovirus VP1protein. The recombinant construct can be in the form of DNA, RNA, andcan be either single or double stranded. For example, the construct canbe in the form of a plasmid. A number of suitable vectors for expressionof recombinant proteins in a desired host cell are well-known andconventional in the art. Suitable vectors can contain a number ofcomponents, including, but not limited to one or more of the following:an origin of replication; a selectable marker gene; one or moreexpression control elements, such as a transcriptional control element(e.g., a promoter, an enhancer, a terminator), and/or one or moretranslation signals; and a signal sequence or leader sequence fortargeting to the secretory pathway in a selected host cell (e.g., ofmammalian origin or from a heterologous mammalian or non-mammalianspecies). For example, for expression in insect cells a suitablebaculovirus expression vector, such as pFastBac (Invitrogen), is used toproduce recombinant baculovirus particles. The baculovirus particles areamplified and used to infect insect cells to express recombinantprotein. For expression in mammalian cells, a vector that will driveexpression of the construct in the desired mammalian host cell (e.g.,Chinese hamster ovary cells) is used. Similarly, for expression inyeast, a vector that will drive expression in the desired yeast hostcell (e.g., Saccharomyces cerevisiae, Candida albicans, Candida maltosa,Hansenual polymorpha, Kluyveromyces fragilis, Kluyveromyces lactis,Pichia guillerimondii, Pichia pastoris, Schizosaccharomyces pombe andYarrowia lipolytica) is used.

Viral vectors can be used for the production of VLPs of the invention ineukaryotic cells, such as those derived from the pox family of viruses,including vaccinia virus and avian poxvirus. Additionally, a vacciniabased infection/transfection system, as described in Tomei et al. (1993)J. Virol. 67:4017-4026 and Selby et al. (1993) J. Gen. Virol.74:1103-1113, will also find use with the present invention. In thissystem, cells are first infected in vitro with a vaccinia virusrecombinant that encodes the bacteriophage T7 RNA polymerase. Thispolymerase displays exquisite specificity in that it only transcribestemplates bearing T7 promoters. Following infection, cells aretransfected with the DNA of interest, driven by a T7 promoter. Thepolymerase expressed in the cytoplasm from the vaccinia virusrecombinant transcribes the transfected DNA into RNA which is thentranslated into protein by the host translational machinery.Alternately, T7 can be added as a purified protein or enzyme as in the“Progenitor” system (Studier and Moffatt (1986) J. Mol. Biol.189:113-130). The method provides for high level, transient, cytoplasmicproduction of large quantities of RNA and its translation product(s).

The recombinant nucleic acids can be in the form of, or components of, avectored expression system, such as a self-replicating nucleic acidmolecule (e.g., RNA), an alphavirus particle, an alphavirus replicon,and the like.

If desired, the vector can include a detectable marker. For example, thedetectable marker can be a polypeptide that confers resistance to one ormore antibiotics. Additional information about the vectors of theinvention is provided below in section C.

C. Production of Viral-Like Particles (VLPs) & Host Cells for Same

The invention further provides recombinant host cells that contain anucleic acid that encodes a chimeric norovirus VP1 protein, and methodsfor producing a chimeric norovirus VP1 protein and VLPs that contain thechimeric VP1 protein. The chimeric VP1 proteins can be produced usingany suitable method. Generally, they are produced by expression ofrecombinant constructs that encode the chimeric VP1 protein in suitablerecombinant host cells, such as insect cells (e.g., Aedes aegypti,Autographa californica, Bombyx mori, Drosophila melanogaster, Spodopterafrugiperda, and Trichoplusia ni), mammalian cells (e.g., human,non-human primate, horse, cow, sheep, dog, cat, and rodent (e.g.,hamster), avian cells (e.g., chicken, duck, and geese, bacteria (e.g.,E. coli, Bacillus subtilis, and Streptococcus spp.), yeast cells (e.g.,Saccharomyces cerevisiae, Candida albicans, Candida maltosa, Hansenualpolymorpha, Kluyveromyces fragilis, Kluyveromyces lactis, Pichiaguillerimondii, Pichia pastoris, Schizosaccharomyces pombe and Yarrowialipolytica), Tetrahymena cells (e.g., Tetrahymena thermophila) orcombinations thereof. Many suitable insect cells and mammalian cells arewell-known in the art. Suitable insect cells include, for example, Sf9cells, Sf21 cells, Tn5 cells, Schneider S2 cells, and High Five cells (aclonal isolate derived from the parental Trichoplusia ni BTI-TN-5B1-4cell line (Invitrogen)). Suitable mammalian cells include, for example,Chinese hamster ovary (CHO) cells, human embryonic kidney cells (HEK293cells, typically transformed by sheared adenovirus type 5 DNA), NIH-3T3cells, 293-T cells, Vero cells, HeLa cells, PERC.6 cells (ECACC depositnumber 96022940), Hep G2 cells, MRC-5 (ATCC CCL-171), WI-38 (ATCCCCL-75), fetal rhesus lung cells (ATCC CL-160), Madin-Darby bovinekidney (“MDBK”) cells, Madin-Darby canine kidney (“MDCK”) cells (e.g.,MDCK (NBL2), ATCC CCL34; or MDCK 33016, DSM ACC 2219), baby hamsterkidney (BHK) cells, such as BHK21-F, HKCC cells, and the like. Suitableavian cells include, for example, chicken embryonic stem cells (e.g.,EBx® cells), chicken embryonic fibroblasts, chicken embryonic germcells, duck cells (e.g., AGE1.CR and AGE1.CR.pIX cell lines (ProBioGen)which are described, for example, in Vaccine 27:4975-4982 (2009) andWO2005/042728), EB66 cells, and the like.

Suitable insect cell expression systems, such as baculovirus systems,are known to those of skill in the art and described in, e.g., Summersand Smith, Texas Agricultural Experiment Station Bulletin No. 1555(1987). Materials and methods for baculovirus/insect cell expressionsystems are commercially available in kit form from, inter alia,Invitrogen, San Diego Calif. Avian cell expression systems are alsoknown to those of skill in the art and described in, e.g., U.S. Pat.Nos. 5,340,740; 5,656,479; 5,830,510; 6,114,168; and 6,500,668; EuropeanPatent No. EP 0787180B; European Patent Publication No. EP1500699; WO03/043415; and WO 03/076601. Similarly, yeast, bacterial and mammaliancell expression systems are also known in the art and described in,e.g., Yeast Genetic Engineering (Barr et al., eds., 1989) Butterworths,London.

In some aspects, the method for producing a chimeric norovirus VPprotein comprises culturing a host cell transformed with a recombinantnucleic acid that encodes a chimeric VP1 protein under conditionssuitable for expression of the nucleic acid, whereby a chimericnorovirus VP1 protein is produced. Chimeric VP1 proteins canself-assemble to form VLPs, and preferably the host cell is maintainedunder conditions suitable for VLP formation. Conditions suitable for theformation of VLPs are well known and easily determined by a person ofordinary skill in the art. See. e.g., U.S. Pat. No. 7,527,801, whichdescribes the production of viral particles in yeast cells(Saccharomyces cerevisiae) and insect cells (SF9), and Taube, S. et al.(2005) Archives of Virology 150:1425-1431, which describes theproduction of VLPs in HEK293T cells. If desired, the method can furtherinclude the step of isolating or purifying the chimeric norovirus VP1protein, VLPs containing the chimeric VP1 protein, or a combinationthereof from the culture media or cells. In some preferred embodiments,the host cell used to produce the chimeric VP1 protein and/or VLPscontaining the chimeric VP1 protein is a yeast cell, insect cell, or acombination thereof.

The invention also provides methods for the production of multivalentVLPs. Multivalent VLPs can be prepared by maintaining a host cell thatcontains recombinant nucleic acids encoding two different chimeric VLPs.For example, this can be accomplished using a bicistronic expressionvector, such as pCDC.7 for expression in yeast. Alternatively, two ormore monovalent VLPs can be prepared, and optionally purified, and thenmixed to produce a formulation of VLPs that is multivalent.

The norovirus chimeric VP1 proteins, and VLPs, can also be produced byexpression of a recombinant nucleic acid molecule that encodes anorovirus chimeric VP1 proteins, e.g., in the form of or as a componentof a vectored expression system, by the cells of a mammal followingadministration of the recombinant nucleic acid to the mammal.

D. Isolation and Purification of VLPs

The present invention further provides a method of isolating orpurifying norovirus VLPs from culture media, host cells or a combinationthereof. Preferably, the VLPs are isolated or purified directly from thehost cell culture media, i.e., conditioned culture media. However, ifdesired, the host cells can be recovered, for example by centrifugation,a host cell homogenate or lysate can be formed using any suitablemethods, and VLPs can be isolated. Suitable chemical, physical ormechanical means, which lyse the cells yet keep the VLPs substantiallyintact are known in the art and are described in, e.g., ProteinPurification Applications: A Practical Approach, (E. L. V. Harris and S.Angal, Eds., 1990).

VLPs can be isolated from culture media or host cells, e.g., a celllysate or homogenate, using any suitable method. Suitable methods thatmaintain the integrity of VLPs, such as, density gradientcentrifugation, e.g., sucrose gradients, PEG-precipitation, pelleting,and the like (see, e.g., Kirnbauer et al. (1993) J. Virol.67:6929-6936), as well as standard purification techniques including,e.g., ion exchange and gel filtration chromatography can be used.Centrifugation, on a sucrose cushion or sucrose gradient is convenientmethod for isolating VLPs from VP1 monomers or oligomers and from othercellular components. These methods can be used singly, consecutively andintegrated into a larger purification scheme. For example, VLPs that arepurified on a sucrose cushion or gradient can then be further purifiedif desired, for example, using ion exchange chromatography, sizeexclusion chromatography or any other suitable method. In a particularexample, norovirus virus-like particles (VLPs) can be purified from themedia of yeast cells expressing the norovirus VP1 protein. A low speedspin (15,000×g) can be performed on the media to remove extra cells orcellular debris. Following this step a high speed spin (100,000×g)through a 40% sucrose cushion can be performed to separate thevirus-like particles from free protein and other material. The pelletcontaining the VLPs can be resuspended in buffer (50 mM Tris pH 7.5, 100mM NaCl) and loaded onto an ion exchange column. The VLPs can be elutedfrom the column using a salt gradient. Finally, the eluted fractionscontaining the VLPs can be concentrated and buffer exchanged into alower salt buffer (20 mM Tris pH 7.5, 100 mM NaCl) and stored at 4°Celsius until needed.

E. Immunogenic Compositions

As described earlier, the invention also provides immunogeniccompositions comprising one or more chimeric VP1 proteins, preferably inthe form of a VLP. Two or more different chimeric VP1 proteins,monovalent VLPs, or multivalent VLPs may be mixed together to produce amultivalent immunogenic composition that contains two or more differentVP1 P-domains.

The immunogenic compositions may comprise a mixture of chimeric VP1proteins, VLPs and nucleic acids, which in turn may be delivered usingthe same or different vehicles. Antigens may be administeredindividually or in combination, in e.g., prophylactic (i.e., to preventinfection) or therapeutic (to treat infection) immunogenic compositions.The immunogenic composition may be given more than once (e.g., a “prime”administration followed by one or more “boosts”) to achieve the desiredeffects. The same composition can be administered in one or more primingand one or more boosting steps. Alternatively, different compositionscan be used for priming and boosting.

The immunogenic composition may further comprise one or more otherantigens, from a norovirus or from another pathogen, if desired. Forexample, a combination immunogenic composition can contain a norovirusVLP that comprises a chimeric VP1 protein and one or more antigens fromanother pathogen, such as a bacterial, viral or fungal pathogen. Forexample, the immunogenic composition of the invention can comprise anorovirus VLP that comprises a chimeric VP1 protein as described herein,and one or more rotavirus antigens such as a live attenuated rotavirus(e.g., ROTARIX (rotavirus vaccine, live, oral; GlaxoSmithKline)), one ormore live reassortant rotaviruses (e.g., ROTATEQ (rotavirus vaccine,live, oral, pentavalent; Merck), ROTASHIELD (rotavirus vaccine, live,oral, tetravalent; Wyeth-Lederle)), non-human rotaviruses (e.g., lamb(Lanzhou), bovine, rhesus), reassortant rotaviruses (e.g., human-bovine,human-lamb, human-rhesus), inactivated rotavirus (e.g., heatinactivated), rotavirus subunits (e.g., VP2, VP4, VP6, VP7, or anycombination thereof), rotavirus subunit VLP or vaccines.

In another aspect, the immunogenic composition comprises a recombinantnucleic acid molecule that encodes a norovirus chimeric VP1 protein. Ifdesired, such immunogenic compositions can contain a suitable nucleicacid delivery system, such as liposomes, lipoplexes, emulsions(nanoemulsions, microemulsions), particles (nanoparticles,microparticles), a vector, such as a viral particle, a replicon, and thelike.

The immunogenic compositions generally include one or more“pharmaceutically acceptable excipients or vehicles” such as water,saline, glycerol, ethanol, and the like singly or in combination.Immunogenic compositions will typically, in addition to the componentsmentioned above, comprise one or more “pharmaceutically acceptablecarriers.” These include any carrier which does not itself induce theproduction of antibodies harmful to the individual receiving thecomposition. Suitable carriers typically are large, slowly metabolizedmacromolecules such as proteins, polysaccharides, polylactic acids,polyglycolic acids, polymeric amino acids, amino acid copolymers, andlipid aggregates (such as oil droplets or liposomes). Such carriers arewell known to those of ordinary skill in the art. Additionally, anauxiliary substance, such as a wetting or emulsifying agent, pHbuffering substance, and the like, may be present. A thorough discussionof pharmaceutically acceptable components is available in Gennaro (2000)Remington: The Science and Practice of Pharmacy. 20th ed., ISBN:0683306472.

Pharmaceutically acceptable salts can also be used in immunogeniccompositions of the invention, for example, mineral salts such ashydrochlorides, hydrobromides, phosphates, or sulfates, as well as saltsof organic acids such as acetates, proprionates, malonates, orbenzoates.

If desired, antigens can be adsorbed to, entrapped within or otherwiseassociated with liposomes and particulate carriers such aspoly(D,L-lactide co-glycolide) (PLG) microparticles or nanoparticles.Antigens can be conjugated to a carrier protein in order to enhanceimmunogenicity. See Ramsay et al. (2001) Lancet 357(9251):195-196;Lindberg (1999) Vaccine 17 Suppl 2:S28-36; Buttery & Moxon (2000) J RColl Physicians Lond 34:163-168; Ahmad & Chapnick (1999) Infect Dis ClinNorth Am 13:113-133, vii; Goldblatt (1998) J. Med. Microbiol.47:563-567; European patent 0 477 508; U.S. Pat. No. 5,306,492;WO98/42721; Conjugate Vaccines (eds. Cruse et al.) ISBN 3805549326,particularly vol. 10:48-114; Hermanson (1996) Bioconjugate TechniquesISBN: 0123423368 or 012342335X.

Immunogenic compositions of the present invention may be administered inconjunction with other immunoregulatory agents. For example, animmunogenic composition of the invention can include an adjuvant.Preferred adjuvants include, but are not limited to, one or more of thefollowing types of adjuvants described below. Immunogenic compositionsof the present invention may also be pre-mixed with an adjuvant beforeadministration.

Alum

In one embodiment, the adjuvant for use in the present invention is alum(aluminum potassium sulfate (AlK(SO₄)₂)), or an alum derivative, such asthat formed in-situ by mixing an antigen in phosphate buffer with alum,followed by titration and precipitation with a base such as ammoniumhydroxide or sodium hydroxide.

Retinoic Acid

In one embodiment, the adjuvant for use in the present invention isretinoic acid, the oxidized form of Vitamin A, with only partial vitaminA function.

MF59C.1

In one embodiment, the adjuvant for use in the present invention isMF59C.1, an oil-in-water emulsion (squalene) in citrate buffer. MF59C. Ihas been shown to be an effective adjuvant and enhance the production ofhigh titers of neutralizing antibodies against parvovirus B19 (Ballou etal. (2003) JID, 187:675-678).

Mineral Containing Compositions

Mineral containing compositions suitable for use as adjuvants in theinvention include mineral salts, such as aluminum salts and calciumsalts. Suitable mineral salts include hydroxides (e.g. oxyhydroxides),phosphates (e.g. hydroxyphosphates, orthophosphates), sulfates, etc.(e.g. see chapters 8 & 9 of Vaccine Design . . . (1995) eds. Powell &Newman. ISBN: 030644867X. Plenum.), or mixtures of different mineralcompounds (e.g. a mixture of a phosphate and a hydroxide adjuvant,optionally with an excess of the phosphate), with the compounds takingany suitable form (e.g. gel, crystalline, amorphous, etc.), and withadsorption to the salt(s) being preferred. The mineral containingcompositions may also be formulated as a particle of metal salt(WO00/23105).

The adjuvants known as “aluminium hydroxide” are typically aluminiumoxyhydroxide salts, which are usually at least partially crystalline.Aluminium oxyhydroxide, which can be represented by the formula AlO(OH),can be distinguished from other aluminium compounds, such as aluminiumhydroxide Al(OH)₃, by infrared (IR) spectroscopy, in particular by thepresence of an adsorption band at 1070 cm⁻¹ and a strong shoulder at3090-3100 cm⁻¹ [chapter 9 of Vaccine Design . . . (1995) eds. Powell &Newman. ISBN: 030644867X. Plenum.] The degree of crystallinity of analuminum hydroxide adjuvant is reflected by the width of the diffractionband at half height (WHH), with poorly-crystalline particles showinggreater line broadening due to smaller crystallite sizes. The surfacearea increases as WHH increases, and adjuvants with higher WHH valueshave been seen to have greater capacity for antigen adsorption. Afibrous morphology (e.g. as seen in transmission electron micrographs)is typical for aluminum hydroxide adjuvants. The pI of aluminiumhydroxide adjuvants is typically about 11 i.e. the adjuvant itself has apositive surface charge at physiological pH. Adsorptive capacities ofbetween 1.8-2.6 mg protein per mg Al⁺⁺⁺ at pH 7.4 have been reported foraluminium hydroxide adjuvants.

The adjuvants known as “aluminium phosphate” are typically aluminiumhydroxyphosphates, often also containing a small amount of sulfate (i.e.aluminium hydroxyphosphate sulfate). They may be obtained byprecipitation, and the reaction conditions and concentrations duringprecipitation influence the degree of substitution of phosphate forhydroxyl in the salt. Hydroxyphosphates generally have a PO₄/Al molarratio between 0.3 and 1.2. Hydroxyphosphates can be distinguished fromstrict AlPO₄ by the presence of hydroxyl groups. For example, an IRspectrum band at 3164 cm⁻¹ (e.g. when heated to 200° C.) indicates thepresence of structural hydroxyls [ch. 9 of Vaccine Design . . . (1995)eds. Powell & Newman. ISBN: 030644867X. Plenum.].

The PO₄/Al³⁺ molar ratio of an aluminium phosphate adjuvant willgenerally be between 0.3 and 1.2, preferably between 0.8 and 1.2, andmore preferably 0.95±0.1. The aluminium phosphate will generally beamorphous, particularly for hydroxyphosphate salts. A typical adjuvantis amorphous aluminium hydroxyphosphate with PO₄/Al molar ratio between0.84 and 0.92, included at 0.6 mg Al³⁺/ml. The aluminium phosphate willgenerally be particulate (e.g. plate-like morphology as seen intransmission electron micrographs). Typical diameters of the particlesare in the range 0.5-20 μm (e.g. about 5-10 μm) after any antigenadsorption. Adsorptive capacities of between 0.7-1.5 mg protein per mgAl⁺⁺⁺ at pH 7.4 have been reported for aluminium phosphate adjuvants.

The point of zero charge (PZC) of aluminium phosphate is inverselyrelated to the degree of substitution of phosphate for hydroxyl, andthis degree of substitution can vary depending on reaction conditionsand concentration of reactants used for preparing the salt byprecipitation. PZC is also altered by changing the concentration of freephosphate ions in solution (more phosphate=more acidic PZC) or by addinga buffer such as a histidine buffer (makes PZC more basic). Aluminiumphosphates used according to the invention will generally have a PZC ofbetween 4.0 and 7.0, more preferably between 5.0 and 6.5 e.g. about 5.7.

Suspensions of aluminium salts used to prepare compositions of theinvention may contain a buffer (e.g. a phosphate or a histidine or aTris buffer), but this is not always necessary. The suspensions arepreferably sterile and pyrogen-free. A suspension may include freeaqueous phosphate ions e.g. present at a concentration between 1.0 and20 mM, preferably between 5 and 15 mM, and more preferably about 10 mM.The suspensions may also comprise sodium chloride.

In one embodiment, an adjuvant component includes a mixture of both analuminium hydroxide and an aluminium phosphate. In this case there maybe more aluminium phosphate than hydroxide e.g. a weight ratio of atleast 2:1 e.g. ≥5:1, ≥6:1, ≥7:1, ≥8:1, ≥9:1, etc.

The concentration of Al⁺⁺⁺ in a composition for administration to apatient is preferably less than 10 mg/ml e.g. ≤5 mg/ml, ≤4 mg/ml, ≤3mg/ml, ≤2 mg/ml, ≤1 mg/ml, etc. A preferred range is between 0.3 and 1mg/ml. A maximum of <0.85 mg/dose is preferred.

Oil-Emulsions

Oil emulsion compositions suitable for use as adjuvants in the inventioninclude squalene-water emulsions, such as MF59 [Chapter 10 of VaccineDesign . . . (1995) eds. Powell & Newman. ISBN: 030644867X. Plenum.] (5%Squalene, 0.5% Tween 80, and 0.5% Span 85, formulated into submicronparticles using a microfluidizer). Complete Freund's adjuvant (CFA) andincomplete Freund's adjuvant (IFA) may also be used.

Various suitable oil-in-water emulsions are known, and they typicallyinclude at least one oil and at least one surfactant, with the oil(s)and surfactant(s) being biodegradable (metabolisable) and biocompatible.The oil droplets in the emulsion are generally less than 5 μm indiameter, and advantageously the emulsion comprises oil droplets with asub-micron diameter, with these small sizes being achieved with amicrofluidiser to provide stable emulsions. Droplets with a size lessthan 220 nm are preferred as they can be subjected to filtersterilization.

The invention can be used with oils such as those from an animal (suchas fish) or vegetable source. Sources for vegetable oils include nuts,seeds and grains. Peanut oil, soybean oil, coconut oil, and olive oil,the most commonly available, exemplify the nut oils. Jojoba oil can beused e.g. obtained from the jojoba bean. Seed oils include saffloweroil, cottonseed oil, sunflower seed oil, sesame seed oil and the like.In the grain group, corn oil is the most readily available, but the oilof other cereal grains such as wheat, oats, rye, rice, teff, triticaleand the like may also be used. 6-10 carbon fatty acid esters of glyceroland 1,2-propanediol, while not occurring naturally in seed oils, may beprepared by hydrolysis, separation and esterification of the appropriatematerials starting from the nut and seed oils. Fats and oils frommammalian milk are metabolizable and may therefore be used in thepractice of this invention. The procedures for separation, purification,saponification and other means necessary for obtaining pure oils fromanimal sources are well known in the art. Most fish containmetabolizable oils which may be readily recovered. For example, codliver oil, shark liver oils, and whale oil such as spermaceti exemplifyseveral of the fish oils which may be used herein. A number of branchedchain oils are synthesized biochemically in 5-carbon isoprene units andare generally referred to as terpenoids. Shark liver oil contains abranched, unsaturated terpenoid known as squalene,2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene. Otherpreferred oils are the tocopherols (see below). Oil in water emulsionscomprising squalene are particularly preferred. Mixtures of oils can beused.

Surfactants can be classified by their ‘HLB’ (hydrophile/lipophilebalance). Preferred surfactants of the invention have a HLB of at least10, preferably at least 15, and more preferably at least 16. Theinvention can be used with surfactants including, but not limited to:the polyoxyethylene sorbitan esters surfactants (commonly referred to asthe Tweens), especially polysorbate 20 and polysorbate 80; copolymers ofethylene oxide (EO), propylene oxide (PO), and/or butylene oxide (BO),sold under the DOWFAX™ tradename, such as linear EO/PO block copolymers;octoxynols, which can vary in the number of repeating ethoxy(oxy-1,2-ethanediyl) groups, with octoxynol-9 (Triton X-100, ort-octylphenoxypolyethoxyethanol) being of particular interest;(octylphenoxy)polyethoxyethanol (IGEPAL CA-630/NP-40); phospholipidssuch as phosphatidylcholine (lecithin); polyoxyethylene fatty ethersderived from lauryl, cetyl, stearyl and oleyl alcohols (known as Brijsurfactants), such as triethyleneglycol monolauryl ether (Brij 30); andsorbitan esters (commonly known as the SPANs), such as sorbitantrioleate (Span 85) and sorbitan monolaurate. Preferred surfactants forincluding in the emulsion are Tween 80 (polyoxyethylene sorbitanmonooleate), Span 85 (sorbitan trioleate), lecithin and Triton X-100. Asmentioned above, detergents such as Tween 80 may contribute to thethermal stability seen in the examples below.

Mixtures of surfactants can be used e.g. Tween 80/Span 85 mixtures. Acombination of a polyoxyethylene sorbitan ester such as polyoxyethylenesorbitan monooleate (Tween 80) and an octoxynol such ast-octylphenoxypolyethoxyethanol (Triton X-100) is also suitable. Anotheruseful combination comprises laureth 9 plus a polyoxyethylene sorbitanester and/or an octoxynol.

Preferred amounts of surfactants (% by weight) are: polyoxyethylenesorbitan esters (such as Tween 80) 0.01 to 1%, in particular about 0.1%;octyl- or nonylphenoxy polyoxyethanols (such as Triton X-100, or otherdetergents in the Triton series) 0.001 to 0.1%, in particular 0.005 to0.02%; polyoxyethylene ethers (such as laureth 9) 0.1 to 20%, preferably0.1 to 10% and in particular 0.1 to I % or about 0.5%.

Specific oil-in-water emulsion adjuvants useful with the inventioninclude, but are not limited to:

-   -   A submicron emulsion of squalene, Tween 80, and Span 85. The        composition of the emulsion by volume can be about 5% squalene,        about 0.5% polysorbate 80 and about 0.5% Span 85. In weight        terms, these ratios become 4.3% squalene, 0.5% polysorbate 80        and 0.48% Span 85. This adjuvant is known as ‘MF59’. The MF59        emulsion advantageously includes citrate ions e.g. 10 mM sodium        citrate buffer.    -   An emulsion comprising squalene, an α-tocopherol, and        polysorbate 80. These emulsions may have from 2 to 10% squalene,        from 2 to 10% tocopherol and from 0.3 to 3% Tween 80, and the        weight ratio of squalene:tocopherol is preferably ≤1 (e.g. 0.90)        as this provides a more stable emulsion. Squalene and Tween 80        may be present volume ratio of about 5:2, or at a weight ratio        of about 11:5. One such emulsion can be made by dissolving Tween        80 in PBS to give a 2% solution, then mixing 90 ml of this        solution with a mixture of (5 g of DL-α-tocopherol and 5 ml        squalene), then microfluidising the mixture. The resulting        emulsion may have submicron oil droplets e.g. with an average        diameter of between 100 and 250 nm, preferably about 180 nm.    -   An emulsion of squalene, a tocopherol, and a Triton detergent        (e.g. Triton X-100). The emulsion may also include a 3d-MPL (see        below). The emulsion may contain a phosphate buffer.    -   An emulsion comprising a polysorbate (e.g. polysorbate 80), a        Triton detergent (e.g. Triton X-100) and a tocopherol (e.g. an        α-tocopherol succinate). The emulsion may include these three        components at a mass ratio of about 75:11:10 (e.g. 750 μg/ml        polysorbate 80, 110 μg/ml Triton X-100 and 100 μg/ml        α-tocopherol succinate), and these concentrations should include        any contribution of these components from antigens. The emulsion        may also include squalene. The emulsion may also include a        3d-MPL (see below). The aqueous phase may contain a phosphate        buffer.    -   An emulsion of squalane, polysorbate 80 and poloxamer 401        (“Pluronic™ L121”). The emulsion can be formulated in phosphate        buffered saline, pH 7.4. This emulsion is a useful delivery        vehicle for muramyl dipeptides, and has been used with        threonyl-MDP in the “SAF-1” adjuvant (0.05-1% Thr-MDP, 5%        squalane, 2.5% Pluronic L121 and 0.2% polysorbate 80). It can        also be used without the Thr-MDP, as in the “AF” adjuvant (5%        squalane, 1.25% Pluronic L121 and 0.2% polysorbate 80).        Microfluidisation is preferred.    -   An emulsion comprising squalene, an aqueous solvent, a        polyoxyethylene alkyl ether hydrophilic nonionic surfactant        (e.g. polyoxyethylene (12) cetostearyl ether) and a hydrophobic        nonionic surfactant (e.g. a sorbitan ester or mannide ester,        such as sorbitan monoleate or ‘Span 80’). The emulsion is        preferably thermoreversible and/or has at least 90% of the oil        droplets (by volume) with a size less than 200 nm. The emulsion        may also include one or more of: alditol; a cryoprotective agent        (e.g. a sugar, such as dodecylmaltoside and/or sucrose); and/or        an alkylpolyglycoside. Such emulsions may be lyophilized.    -   An emulsion having from 0.5-50% of an oil, 0.1-10% of a        phospholipid, and 0.05-5% of a non-ionic surfactant. Preferred        phospholipid components are phosphatidylcholine,        phosphatidylethanolamine, phosphatidylserine,        phosphatidylinositol, phosphatidylglycerol, phosphatidic acid,        sphingomyelin and cardiolipin. Submicron droplet sizes are        advantageous.    -   A submicron oil-in-water emulsion of a non-metabolisable oil        (such as light mineral oil) and at least one surfactant (such as        lecithin, Tween 80 or Span 80). Additives may be included, such        as QuilA saponin, cholesterol, a saponin-lipophile conjugate        (such as GPI-0100, produced by addition of aliphatic amine to        desacylsaponin via the carboxyl group of glucuronic acid),        dimethyidioctadecylammonium bromide and/or        N,N-dioctadecyl-N,N-bis (2-hydroxyethyl)propanediamine.    -   An emulsion comprising a mineral oil, a non-ionic lipophilic        ethoxylated fatty alcohol, and a non-ionic hydrophilic        surfactant (e.g. an ethoxylated fatty alcohol and/or        polyoxyethylene-polyoxypropylene block copolymer) (see        WO2006/113373).    -   An emulsion comprising a mineral oil, a non-ionic hydrophilic        ethoxylated fatty alcohol, and a non-ionic lipophilic surfactant        (e.g. an ethoxylated fatty alcohol and/or        polyoxyethylene-polyoxypropylene block copolymer) (see        WO2006/13373).    -   An emulsion in which a saponin (e.g. QuilA or QS21) and a sterol        (e.g. a cholesterol) are associated as helical micelles.

Antigens (VLPs) and adjuvants in a composition will typically be inadmixture at the time of delivery to a patient. The emulsions may bemixed with antigen (VLP) during manufacture, or extemporaneously, at thetime of delivery. Thus the adjuvant and antigen (VLP) may be keptseparately in a packaged or distributed vaccine, ready for finalformulation at the time of use. The antigen (VLP) will generally be inan aqueous form, such that the vaccine is finally prepared by mixing twoliquids. The volume ratio of the two liquids for mixing can vary (e.g.between 5:1 and 1:5) but is generally about 1:1.

Saponin Formulations (see chapter 22 of Vaccine Design . . . (1995) eds.Powell & Newman. ISBN: 030644867X. Plenum.).

Saponin formulations may also be used as adjuvants in the invention.Saponins are a heterogeneous group of sterol glycosides and triterpenoidglycosides that are found in the bark, leaves, stems, roots and evenflowers of a wide range of plant species. Saponin from the bark of theQuillaia saponaria Molina tree have been widely studied as adjuvants.Saponin can also be commercially obtained from Smilax ornata(sarsaprilla), Gypsophilla paniculata (brides veil), and Saponariaofficianalis (soap root). Saponin adjuvant formulations include purifiedformulations, such as QS21, as well as lipid formulations, such asISCOMs. QS21 is marketed as Stimulon™.

Saponin compositions have been purified using HPLC and RP-HPLC. Specificpurified fractions using these techniques have been identified,including QS7, QS17, QS18, QS21, QH-A, QH-B and QH-C. Preferably, thesaponin is QS21. A method of production of QS21 is disclosed in U.S.Pat. No. 5,057,540. Saponin formulations may also comprise a sterol,such as cholesterol.

Combinations of saponins and cholesterols can be used to form uniqueparticles called immunostimulating complexes (ISCOMs) (chapter 23 ofVaccine Design . . . (1995) eds. Powell & Newman. ISBN: 030644867X.Plenum.). ISCOMs typically also include a phospholipid such asphosphatidylethanolamine or phosphatidylcholine. Any known saponin canbe used in ISCOMs. Preferably, the ISCOM includes one or more of QuilA,QHA & QHC. ISCOMs are further described in WO96/33739. Optionally, theISCOMS may be devoid of additional detergent.

Virosomes and Virus Like Particles (VLPs)

Virosomes and virus-like particles (VLPs) can also be used as adjuvantsin the invention. These structures generally contain one or moreproteins from a virus optionally combined or formulated with aphospholipid. They are generally non-pathogenic, non-replicating andgenerally do not contain any of the native viral genome. The viralproteins may be recombinantly produced or isolated from whole viruses.These viral proteins suitable for use in virosomes or VLPs includeproteins derived from influenza virus (such as HA or NA), Hepatitis Bvirus (such as core or capsid proteins), Hepatitis E virus, measlesvirus, Sindbis virus, Rotavirus, Foot-and-Mouth Disease virus,Retrovirus, Norwalk virus, human Papilloma virus, HIV, RNA-phages,Qβ-phage (such as coat proteins), GA-phage, fr-phage, AP205 phage, andTy (such as retrotransposon Ty protein p1).

Bacterial or Microbial Derivatives

Adjuvants suitable for use in the invention include bacterial ormicrobial derivatives such as non-toxic derivatives of enterobacteriallipopolysaccharide (LPS), Lipid A derivatives, immunostimulatoryoligonucleotides and ADP-ribosylating toxins and detoxified derivativesthereof.

Non-toxic derivatives of LPS include monophosphoryl lipid A (MPL) and3-O-deacylated MPL (3dMPL). 3dMPL is a mixture of 3 de-O-acylatedmonophosphoryl lipid A with 4, 5 or 6 acylated chains. A preferred“small particle” form of 3 De-O-acylated monophosphoryl lipid A isdisclosed in EP-A-0689454. Such “small particles” of 3dMPL are smallenough to be sterile filtered through a 0.22 μm membrane (EP-A-0689454).Other non-toxic LPS derivatives include monophosphoryl lipid A mimics,such as aminoalkyl glucosaminide phosphate derivatives e.g. RC-529.

Lipid A derivatives include derivatives of lipid A from Escherichia colisuch as OM-174. OM-174 is described for example in Meraldi et al. (2003)Vaccine 21:2485-2491 and Pajak et al. (2003) Vaccine 21:836-842.

Immunostimulatory oligonucleotides suitable for use as adjuvants in theinvention include nucleotide sequences containing a CpG motif (adinucleotide sequence containing an unmethylated cytosine linked by aphosphate bond to a guanosine). Double-stranded RNAs andoligonucleotides containing palindromic or poly(dG) sequences have alsobeen shown to be immunostimulatory.

The CpG's can include nucleotide modifications/analogs such asphosphorothioate modifications and can be double-stranded orsingle-stranded. References Kandimalla et al. (2003) Nucleic AcidsResearch 31:2393-2400; WO02/26757, and WO99/62923 disclose possibleanalog substitutions e.g. replacement of guanosine with2′-deoxy-7-deazaguanosine. The adjuvant effect of CpG oligonucleotidesis further discussed in Krieg (2003) Nature Medicine 9:831-835;McCluskie et al. (2002) FEMS Immunology and Medical Microbiology32:179-185; WO98/40100; U.S. Pat. Nos. 6,207,646; 6,239,116; and6,429,199.

The CpG sequence may be directed to TLR9, such as the motif GTCGTT orTTCGTT (Kandimalla et al. (2003) Biochemical Society Transactions 31(part 3):654-658). The CpG sequence may be specific for inducing a Th1immune response, such as a CpG-A ODN, or it may be more specific forinducing a B cell response, such a CpG-B ODN. CpG-A and CpG-B ODNs arediscussed in Blackwell et al. (2003) J Immunol 170:4061-4068; Krieg(2002) Trends Immunol 23:64-65 and WO01/95935. Preferably, the CpG is aCpG-A ODN.

Preferably, the CpG oligonucleotide is constructed so that the 5′ end isaccessible for receptor recognition. Optionally, two CpG oligonucleotidesequences may be attached at their 3′ ends to form “immunomers”. See,for example, Kandimalla et al. (2003) Biochemical Society Transactions31 (part 3):654-658 & Kandimalla et al. (2003) BBRC 306:948-953; Bhagatet al. (2003) BBRC 300:853-861 and WO03/035836.

A particularly useful adjuvant based around immunostimulatoryoligonucleotides is known as IC-31™ (Schellack et al. (2006) Vaccine24:5461-5472). Thus an adjuvant used with the invention may comprise amixture of (i) an oligonucleotide (e.g. between 15-40 nucleotides)including at least one (and preferably multiple) CpI motifs (i.e. acytosine linked to an inosine to form a dinucleotide), and (ii) apolycationic polymer, such as an oligopeptide (e.g. between 5-20 aminoacids) including at least one (and preferably multiple) Lys-Arg-Lystripeptide sequence(s). The oligonucleotide may be a deoxynucleotidecomprising 26-mer sequence 5′-(IC)₁₃-3′ (SEQ ID NO:9). The polycationicpolymer may be a peptide comprising 11-mer amino acid sequenceKLKLLLLLKLK (SEQ ID NO:10).

Bacterial ADP-ribosylating toxins and detoxified derivatives thereof maybe used as adjuvants in the invention. Preferably, the protein isderived from E. coli (E. coli heat labile enterotoxin “LT”), cholera(“CT”), or pertussis (“PT”). The use of detoxified ADP-ribosylatingtoxins as mucosal adjuvants is described in WO95/17211 and as parenteraladjuvants in WO98/42375. The toxin or toxoid is preferably in the formof a holotoxin, comprising both A and B subunits. Preferably, the Asubunit contains a detoxifying mutation; preferably the B subunit is notmutated. Preferably, the adjuvant is a detoxified LT mutant such asLT-K63, LT-R72, and LT-G192. The use of ADP-ribosylating toxins anddetoxified derivatives thereof, particularly LT-K63 and LT-R72, asadjuvants can be found in Beignon et al. (2002) Infect Immun70:3012-3019; Pizza et al. (2001) Vaccine 19:2534-2541; Pizza et al.(2000) Int J Med Microbiol 290:455-461; Scharton-Kersten et al. (2000)Infect Immun 68:5306-5313; Ryan et al. (1999) Infect Immun 67:6270-6280;Partidos et al. (1999) Immunol Lett 67:209-216; Peppoloni et al. (2003)Expert Rev Vaccines 2:285-293; Pine et al. (2002) J Control Release85:263-270 and Tebbey et al. (2000) Vaccine 18:2723-34. A useful CTmutant is or CT-E29H. Numerical reference for amino acid substitutionsis preferably based on the alignments of the A and B subunits ofADP-ribosylating toxins set forth in Domenighini et al. (1995) MolMicrobiol 15:1165-1167, specifically incorporated herein by reference inits entirety.

Human Immunomodulators

Human immunomodulators suitable for use as adjuvants in the inventioninclude cytokines, such as interleukins (e.g. IL-1, IL-2, IL-4, IL-5,IL-6, IL-7, IL-12, etc.) (WO99/40936 and WO99/44636), interferons (e.g.interferon-γ), macrophage colony stimulating factor, and tumor necrosisfactor. A preferred immunomodulator is IL-12.

Bioadhesives and Mucoadhesives

Bioadhesives and mucoadhesives may also be used as adjuvants in theinvention. Suitable bioadhesives include esterified hyaluronic acidmicrospheres (Singh et al. (2001) J. Cont. Release 70:267-276) ormucoadhesives such as cross-linked derivatives of poly(acrylic acid),polyvinyl alcohol, polyvinyl pyrollidone, polysaccharides andcarboxymethylcellulose. Chitosan and derivatives thereof may also beused as adjuvants in the invention (WO99/27960).

Microparticles

Microparticles may also be used as adjuvants in the invention.Microparticles (i.e. a particle of ˜100 nm to ˜150 μm in diameter, morepreferably ˜200 nm to ˜30 μm in diameter, and most preferably ˜500 nm to˜10 μm in diameter) formed from materials that are biodegradable andnon-toxic (e.g. a poly(α-hydroxy acid), a polyhydroxybutyric acid, apolyorthoester, a polyanhydride, a polycaprolactone, etc.), withpoly(lactide-co-glycolide) are preferred, optionally treated to have anegatively-charged surface (e.g. with SDS) or a positively-chargedsurface (e.g. with a cationic detergent, such as CTAB).

Liposomes (Chapters 13 & 14 of Vaccine Design . . . (1995) eds. Powell &Newman. ISBN: 030644867X. Plenum.).

Examples of liposome formulations suitable for use as adjuvants aredescribed in U.S. Pat. Nos. 6,090,406, 5,916,588 and EP A 0626169.

Polyoxyethylene Ether and Polyoxyethylene Ester Formulations

Adjuvants suitable for use in the invention include polyoxyethyleneethers and polyoxyethylene esters (WO99/52549). Such formulationsfurther include polyoxyethylene sorbitan ester surfactants incombination with an octoxynol (WO01/21207) as well as polyoxyethylenealkyl ethers or ester surfactants in combination with at least oneadditional non-ionic surfactant such as an octoxynol (WO01/21152).Preferred polyoxyethylene ethers are selected from the following group:polyoxyethylene-9-lauryl ether (laureth 9), polyoxyethylene-9-steorylether, polyoxytheylene-8-steoryl ether, polyoxyethylene-4-lauryl ether,polyoxyethylene-35-lauryl ether, and polyoxyethylene-23-lauryl ether.

Polyphosphazene (PCPP)

PCPP formulations are described, for example, in Andrianov et al. (1998)Biomaterials 19: 109-115 and Payne et al. (1998) Adv Drug DeliveryReview 31:185-196.

Muramyl Peptides

Examples of muramyl peptides suitable for use as adjuvants in theinvention include N-acetyl-muramyl-L-threonyl-D-isoglutamine (thr-MDP),N-acetyl-normuramyl-L-alanyl-D-isoglutamine (nor-MDP), andN-acetylmuramyl-L-alanyl-D-isoglutaminyl-L-alanine-2-(1′-2′-dipalmitoyl-sn-glycero-3-hydroxyphosphoryloxy)-ethylamineMTP-PE).

Imidazoquinolone Compounds

Examples of imidazoquinolone compounds suitable for use as adjuvants inthe invention include Imiquamod and its homologues (e.g. “Resiquimod3M”), described further in Stanley (2002) Clin Exp Dermatol 27:571-577and Jones (2003) Curr Opin Investig Drugs 4:214-218.

Benzonaphthyridines

Examples of benzonaphthyridine compounds suitable for use as adjuvantsin the invention are described in WO 2009/111337.

Lipopeptides

Lipopeptides (i.e., compounds comprising one or more fatty acid residuesand two or more amino acid residues) are known to have immunostimulatingcharacter. Lipopeptides based on glycerylcysteine are particularlysuitable for use as adjuvants in the invention. Specific examples ofsuch peptides include compounds of the following formula:

in which each of R¹ and R² represents a saturated or unsaturated,aliphatic or mixed aliphatic-cycloaliphatic hydrocarbon radical havingfrom 8 to 30, preferably 11 to 21, carbon atoms that is optionally alsosubstituted by oxygen functions, R³ represents hydrogen or the radicalR₁—CO—O—CH₂— in which R¹ has the same meaning as above, and X representsan amino acid bonded by a peptide linkage and having a free, esterifiedor amidated carboxy group, or an amino acid sequence of from 2 to 10amino acids of which the terminal carboxy group is in free, esterifiedor amidated form. In certain embodiments, the amino acid sequencecomprises a D-amino acid, for example, D-glutamic acid (D-Glu) orD-gamma-carboxy-glutamic acid (D-Gla).

Bacterial lipopeptides generally recognize TLR2, without requiring TLR6to participate. (TLRs operate cooperatively to provide specificrecognition of various triggers, and TLR2 plus TLR6 together recognizepeptidoglycans, while TLR2 recognizes lipopeptides without TLR6.) Theseare sometimes classified as natural lipopeptides and syntheticlipopeptides. Synthetic lipopeptides tend to behave similarly, and areprimarily recognized by TLR2.

Lipopeptides suitable for use as adjuvants in the invention includecompounds with the following formula:

where the chiral center labeled * and the one labeled *** are both inthe R configuration;

the chiral center labeled ** is either in the R or S configuration;

each R^(1a) and R^(1b) is independently an aliphatic orcycloaliphatic-aliphatic hydrocarbon group having 7-21 carbon atoms,optionally substituted by oxygen functions, or one of R^(1a) and R^(1b),but not both, is H;

R² is an aliphatic or cycloaliphatic hydrocarbon group having 1-21carbon atoms and optionally substituted by oxygen functions;

n is 0 or 1;

As represents either —O-Kw-CO— or —NH-Kw-CO—, where Kw is an aliphatichydrocarbon group having 1-12 carbon atoms;

As¹ is a D- or L-alpha-amino acid;

Z¹ and Z² each independently represent —OH or the N-terminal radical ofa D- or L-alpha amino acid of an amino-(lower alkane)-sulfonic acid orof a peptide having up to 6 amino acids selected from the D- and L-alphaaminocarboxylic acids and amino-lower alkyl-sulfonic acids; and

Z³ is H or —CO—Z⁴, where Z⁴ is —OH or the N-terminal radical of a D- orL-alpha amino acid of an amino-(lower alkane)-sulfonic acid or of apeptide having up to 6 amino acids selected from the D and L-alphaaminocarboxylic acids and amino-lower alkyl-sulfonic acids; or an esteror amide formed from the carboxylic acid of such compounds. Suitableamides include —NH₂ and NH(lower alkyl), and suitable esters includeC1-C4 alkyl esters. (lower alkyl or lower alkane, as used herein, refersto C₁-C₆ straight chain or branched alkyls).

Such compounds are described in more detail in U.S. Pat. No. 4,666,886.An example of a lipopeptide compound suitable for use as an adjuvant inthe invention is a lipopeptide with the following formula:

Another example of a lipopeptide species is called LP40, and is anagonist of TLR2. Akdis et al. (2003) Eur. J. Immunology, 33: 2717-2726.

These are related to a known class of lipopeptides from E. coli,referred to as murein lipoproteins. Certain partial degradation productsof those proteins called murein lipopeptides are described in Hantke etal. (1973) Eur. J. Biochem., 34: 284-296. These comprise a peptidelinked to N-acetyl muramic acid and are thus related to Muramylpeptides, which are described in Baschang, et al., Tetrahedron (1989)45(20): 6331-6360.

The invention may also comprise combinations of aspects of one or moreof the adjuvants identified above. For example, the following adjuvantcompositions may be used in the invention: (1) a saponin and anoil-in-water emulsion (WO99/1241); (2) a saponin (e.g. QS21)+a non-toxicLPS derivative (e.g. 3dMPL) (WO94/00153); (3) a saponin (e.g. QS21)+anon-toxic LPS derivative (e.g. 3dMPL)+a cholesterol; (4) a saponin (e.g.QS21)+3dMPL+IL-12 (optionally+a sterol) (WO98/57659); (5) combinationsof 3dMPL with, for example, QS21 and/or oil-in-water emulsions (Europeanpatent applications 0835318, 0735898 and 0761231); (6) SAF, containing10% squalane, 0.4% Tween 80™, 5% pluronic-block polymer L121, andthr-MDP, either microfluidized into a submicron emulsion or vortexed togenerate a larger particle size emulsion; (7) Ribi™ adjuvant system(RAS), (Ribi Immunochem) containing 2% squalene, 0.2% Tween 80, and oneor more bacterial cell wall components from the group consisting ofmonophosphorylipid A (MPL), trehalose dimycolate (TDM), and cell wallskeleton (CWS), preferably MPL+CWS (Detox™); and (8) one or more mineralsalts (such as an aluminum salt)+a non-toxic derivative of LPS (such as3dMPL).

Other substances that act as immunostimulating agents are disclosed inchapter 7 of Vaccine Design . . . (1995) eds. Powell & Newman. ISBN:030644867X. Plenum. The use of an aluminium hydroxide and/or aluminiumphosphate adjuvant is useful, particularly in children, and antigens aregenerally adsorbed to these salts. Squalene-in-water emulsions are alsopreferred, particularly in the elderly. Useful adjuvant combinationsinclude combinations of Th1 and Th2 adjuvants such as CpG and alum orresiquimod and alum. A combination of aluminium phosphate and 3dMPL maybe used.

In some embodiments, the invention is an immunogenic composition thatcontains a parvovirus VLP that contains VP1 and VP2, as describedherein, and an adjuvant, such as MF59. The VLP and the adjuvant (e.g,MF59) can be premixed and provided as a single composition, or can beprovided as separate components that are to be mixed prior toadministration.

E. Administration

Compositions of the invention (e.g., compositions that contain noroviruschimeric VP1 proteins, VLPs, and nucleic acids that encode noroviruschimeric VP1 proteins) will generally be administered directly to apatient. Direct delivery may be accomplished by parenteral injection(e.g. subcutaneously, intraperitoneally, intravenously, intramuscularly,or to the interstitial space of a tissue), or mucosally, such as byrectal, oral (e.g. tablet, spray), vaginal, topical, transdermal (Seee.g. WO099/27961) or transcutaneous (See e.g. WO02/074244 andWO02/064162), intranasal (See e.g. WO03/028760), ocular, aural,pulmonary or other mucosal administration. Transdermal delivery can beachieved, for example, using microneedles. Immunogenic compositions canalso be administered topically by direct transfer to the surface of theskin. Topical administration can be accomplished without utilizing anydevices, or by contacting naked skin with the immunogenic compositionutilizing a bandage or a bandage-like device (see, e.g., U.S. Pat. No.6,348,450).

Preferably the mode of administration is parenteral, mucosal or acombination of mucosal and parenteral immunizations. Even morepreferably, the mode of administration is parenteral, mucosal or acombination of mucosal and parenteral immunizations in a total of 1-2vaccinations 1-3 weeks apart. Preferably the route of administrationincludes but is not limited to oral delivery, intra-muscular deliveryand a combination of oral and intramuscular delivery.

It has already been demonstrated that mucosal and systemic immuneresponses to antigens from mucosal pathogens, such as Helicobacterpylori antigens can be enhanced through mucosal priming followed bysystemic boosting immunizations (see Vajdy et al. (2003) Immunology 110:86-94). In some embodiments, the method for treating or preventing aninfection by a norovirus, comprises mucosally administering to a subjectin need thereof a first immunogenic composition comprising one or morenorovirus antigens followed by parenterally administering atherapeutically effective amount of a second immunogenic compositioncomprising one or more norovirus antigens.

The immunogenic composition may be used to elicit systemic and/ormucosal immunity, preferably to elicit an enhanced systemic and/ormucosal immunity.

Preferably the immune response is characterized by the induction of aserum IgG and/or intestinal IgA immune response.

As noted above, prime-boost methods are preferably employed where one ormore gene delivery vectors and/or polypeptide antigens are delivered ina “priming” step and, subsequently, one or more second gene deliveryvectors and/or polypeptide antigens are delivered in a “boosting” step.In certain embodiments, priming and boosting with one or more genedelivery vectors or polypeptide antigens described herein is followed byadditional boosting with one or more polypeptide-containing compositions(e.g., polypeptides comprising norovirus antigens).

In any method involving co-administration, the various compositions canbe delivered in any order. Thus, in embodiments including delivery ofmultiple different compositions or molecules, the nucleic acids need notbe all delivered before the polypeptides. For example, the priming stepmay include delivery of one or more polypeptides and the boostingcomprises delivery of one or more nucleic acids and/or one or morepolypeptides. Multiple polypeptide administrations can be followed bymultiple nucleic acid administrations or polypeptide and nucleic acidadministrations can be performed in any order. Thus, one or more of thegene delivery vectors described herein and one or more of thepolypeptides described herein can be co-administered in any order andvia any administration route. Therefore, any combination ofpolynucleotides and polypeptides described herein can be used to elicitan immune reaction.

(i). Dosage Regime

Dosage treatment can be according to a single dose schedule or amultiple dose schedule. Multiple doses may be used in a primaryimmunization schedule and/or in a booster immunization schedule. In amultiple dose schedule, the various doses may be given by the same ordifferent routes, e.g. a parenteral prime and mucosal boost, a mucosalprime and parenteral boost, etc.

Preferably the dosage regime enhances the avidity of the antibodyresponse leading to antibodies with a neutralizing characteristic.

In some cases there is a correlation between serum antibody levels andprotection from disease caused by norovirus. For example, in multiplechallenge studies, serum antibody levels were associated with protectionafter repeated (2-3) oral challenges with high doses of Norwalk virus(Johnson et al. (1990) J. Infect. Dis. 161:18-21). In another study, 18of 23 infants without pre-existing antibodies developed gastroenteritiscaused by human Caliciviruses, whereas 15 of 18 with pre-existingantibody levels did not become ill (Ryder et al. (1985) J. Infect. Dis.151:99-105). In yet another study, 47% of persons with a baselineNorwalk antibody titre of less than 1:100 developed Norwalk infectioncompared to 13% of persons with a baseline antibody titre of greaterthan 1:100 (p<0.001) (Ryder et al. (1985) J. Infect. Dis. 151:99-105).Because some individuals do not produce the receptor for certainnorovirus strains and are, therefore, inherently resistant to thosenorovirus strains, anomalous results can be seen in which the presenceof antibody correlates with susceptibility to certain strains ratherthan with protection. See, Parrino et al. (1997) N. Engl. J. Med.297:86-89.

Chimeric norovirus VP1 proteins and VLPs as described above can beadministered to a mammal, such as a mouse, baboon, chimpanzee, or human,to activate norovirus-specific T cells in vivo. Administration can be byany means known in the art, including parenteral, intranasal,intramuscular or subcutaneous injection, including injection using abiological ballistic gun, as discussed above.

A composition of the invention comprising a chimeric norovirus VP1protein or VLP is administered in a manner compatible with theparticular composition used and in an amount which is effective toinduce an immune response (e.g., a T cell response and/or a humoralresponse), preferably a protective immune response.

Norovirus-specific T cell responses can be measured by, Inter alia, a51Cr release assay, a lymphoproliferation assay, or by intracellularstaining for IFN-γ. The proteins can be administered either to a mammalwhich is not infected with a norovirus or can be administered to anorovirus-infected mammal. The particular dosages of the fusion proteinsin a composition will depend on many factors including, but not limitedto, the species, age, and general condition of the mammal to which thecomposition is administered, and the mode of administration of thecomposition. An effective amount of the composition of the invention canbe readily determined using only routine experimentation. In vitro andin vivo models can be employed to identify appropriate doses. Generally,0.5, 0.75, 1.0, 1.5, 2.0, 2.5, 5 or 10 mg of a norovirus polypeptide orVLP will be administered to a large mammal, such as a baboon,chimpanzee, or human. If desired, co-stimulatory molecules or adjuvantscan also be provided before, after, or together with the compositions.

Immune responses of the mammal generated by the delivery of acomposition of the invention, including activation of norovirus-specificT cells, can be enhanced by varying the dosage, route of administration,or boosting regimens. Compositions of the invention may be given in asingle dose schedule, or preferably in a multiple dose schedule in whicha primary course of vaccination includes 1-10 separate doses, followedby other doses given at subsequent time intervals required to maintainand/or reinforce an immune response, for example, at 1-4 months for asecond dose, and if needed, a subsequent dose or doses after severalmonths.

F. Tests to Determine the Efficacy of an Immune Response

One way of checking efficacy of therapeutic treatment involvesmonitoring infection after administration of the compositions of theinvention. Another way of checking efficacy of prophylactic treatmentinvolves monitoring immune responses both systemically (such asmonitoring the level of IgG1 and IgG2a production) and mucosally (suchas monitoring the level of IgA production) against the antigens in thecompositions of the invention after administration of the composition.Typically, serum specific antibody responses are determinedpost-immunization but pre-challenge whereas mucosal specific antibodyresponses are determined post-immunization and post-challenge.

Another way of assessing the immunogenicity of the component proteins ofthe immunogenic compositions of the present invention is to express theproteins recombinantly and to screen patient sera or mucosal secretionsby immunoblot. A positive reaction between the protein and the patientserum indicates that the patient has previously mounted an immuneresponse to the protein in question—that is, the protein is animmunogen. This method may also be used to identify immunodominantproteins and/or epitopes.

In vivo efficacy models include a human challenge model, which issupported by the NIH and the Center for Disease Control (CDC) (see forexample, Lindesmith et al. (2003) Nat. Med. 9: 548-553 and Lindesmith etal. (2005) J. Virol. 79: 2900-2909).

The immune response may be one or both of a TH1 immune response and aTH2 response. The immune response may be an improved or an enhanced oran altered immune response. The immune response may be one or both of asystemic and a mucosal immune response. Preferably the immune responseis an enhanced systemic and/or mucosal response.

An enhanced systemic and/or mucosal immunity is reflected in an enhancedTH1 and/or TH2 immune response. Preferably, the enhanced immune responseincludes an increase in the production of IgG1 and/or IgG2a and/or IgA.Preferably the mucosal immune response is a TH2 immune response.Preferably, the mucosal immune response includes an increase in theproduction of IgA.

Activated TH2 cells enhance antibody production and are therefore ofvalue in responding to extracellular infections. Activated TH2 cells maysecrete one or more of IL-4, IL-5, IL-6, and IL-10. A TH2 immuneresponse may result in the production of IgG1, IgE, IgA and memory Bcells for future protection.

A TH2 immune response may include one or more of an increase in one ormore of the cytokines associated with a TH2 immune response (such asIL-4, IL-5, IL-6 and IL-10), or an increase in the production of IgG1,IgE, IgA and memory B cells. Preferably, the enhanced TH2 immuneresponse will include an increase in IgG1 production.

A TH1 immune response may include one or more of an increase in CTLs, anincrease in one or more of the cytokines associated with a TH 1 immuneresponse (such as IL-2, IFNγ, and TNFβ), an increase in activatedmacrophages, an increase in NK activity, or an increase in theproduction of IgG2a. Preferably, the enhanced TH1 immune response willinclude an increase in IgG2a production.

Immunogenic compositions of the invention, in particular, immunogeniccomposition comprising one or more antigens of the present invention maybe used either alone or in combination with other antigens optionallywith an immunoregulatory agent capable of eliciting a Th1 and/or Th2response.

The invention also comprises an immunogenic composition comprising oneor more immunoregulatory agents, such as a mineral salt, such as analuminium salt and an oligonucleotide containing a CpG motif. Mostpreferably, the immunogenic composition includes both an aluminium saltand an oligonucleotide containing a CpG motif. Alternatively, theimmunogenic composition includes an ADP ribosylating toxin, such as adetoxified ADP ribosylating toxin and an oligonucleotide containing aCpG motif. Preferably, the one or more immunoregulatory agents includean adjuvant. The adjuvant may be selected from one or more of the groupconsisting of a TH1 adjuvant and TH2 adjuvant, further discussed above.

The immunogenic compositions of the invention will preferably elicitboth a cell mediated immune response as well as a humoral immuneresponse in order to effectively address an infection. This immuneresponse will preferably induce long lasting (e.g., neutralizing)antibodies and a cell mediated immunity that can quickly respond uponexposure to one or more infectious antigens.

G. Use of the Immunogenic Compositions as Medicaments

The invention also provides a composition of the invention for use as amedicament, in particular for making or for use as a vaccine. Themedicament is preferably able to raise an immune response in a mammal(i.e. it is an immunogenic composition) and is more preferably avaccine. The invention also provides the use of the compositions of theinvention in the manufacture of a medicament for raising an immuneresponse in a mammal. The medicament is preferably a vaccine. Preferablythe vaccine is used to prevent and/or treat an intestinal infection suchas gastroenteritis, preferably acute gastroenteritis. Thegastroenteritis may result from an imbalance in ion and/or watertransfer resulting in both watery diarrhea and/or intestinalperistalisis and/or motility. The gastroenteritis may also result invomiting.

The invention provides methods for inducing or increasing an immuneresponse using the compositions described above. The immune response ispreferably protective and can include antibodies and/or cell-mediatedimmunity (including systemic and mucosal immunity). Immune responsesinclude booster responses.

The invention also provides a method for raising an immune response in amammal comprising the step of administering an effective amount of acomposition of the invention. The immune response is preferablyprotective and preferably involves antibodies and/or cell-mediatedimmunity. Preferably, the immune response includes one or both of a TH1immune response and a TH2 immune response. The method may raise abooster response.

The mammal is preferably a human. Where the immunogenic composition,preferably a vaccine, is for prophylactic use, the human is preferably achild (e.g. an infant or toddler, pre-schooler, such as a child one yearor less, from one to three, or four, or five, or six, or seven, oreight, or nine, or ten years onwards), a teenager, an elderly person(e.g., about 60 years old or older) or a person in a high risk group,such as military personnel, travelers, healthcare workers, child care(day care) providers, and food handlers. The immunogenic composition orvaccine can also be administered to such individuals for therapeuticuse. A vaccine intended for children may also be administered to adults(e.g. to assess safety, dosage, immunogenicity, etc.).

Other target groups for the immunogenic compositions (e.g., vaccines) ofthe present invention include: transplant and immunocompromisedindividuals; adults and children in, e.g., USA, Canada and Europeincluding but not limited to the following: food handlers; healthcareworkers such as but not limited to hospital and nursing home personnel;day care providers; travelers, including cruise ship travelers; militarypersonnel; and pediatric and/or elderly populations as discussed above.

(i). Norovirus Specific T Cells

Norovirus-specific T cells, which are activated by the chimeric VP1proteins or VLPs expressed in vivo or in vitro, preferably recognize anepitope of the P-domain of the VP1. Norovirus-specific T cells can beCD8+ or CD4+.

Norovirus-specific CD8+ T cells can be cytotoxic T lymphocytes (CTL)which can kill norovirus-infected cells that display any of theseepitopes complexed with an MHC class I molecule. Norovirus-specific CD8+T cells can be detected by, for example, 51Cr release assays. 51Crrelease assays measure the ability of norovirus-specific CD8+ T cells tolyse target cells displaying one or more of these epitopes.Norovirus-specific CD8+ T cells which express antiviral agents, such asIFN-γ, are also contemplated herein and can also be detected byimmunological methods, preferably by intracellular staining for IFN-γ orlike cytokine after in vitro stimulation with one or more of thenorovirus polypeptides, such as those described herein.

Norovirus-specific CD4+ T cells can be detected by a lymphoproliferationassay. Lymphoproliferation assays measure the ability ofnorovirus-specific CD4+ T cells to proliferate in response to, e.g., aVP1.

(ii) Methods of Activating Norovirus-Specific T Cells

The chimeric norovirus VP1 proteins and VLPs can be used to activatenorovirus-specific T cells either in vitro or in vivo. Activation ofnorovirus-specific T cells can be used, inter alia, to provide modelsystems to optimize CTL responses to norovirus and to provideprophylactic or therapeutic treatment against norovirus infection. Forin vitro activation, proteins are preferably supplied to T cells via aplasmid or a viral vector, such as an adenovirus vector, as describedabove.

Polyclonal populations of T cells can be derived from the blood, andpreferably from peripheral lymphoid organs, such as lymph nodes, spleen,or thymus, of mammals that have been infected with a norovirus.Preferred mammals include mice, chimpanzees, baboons, and humans.Infection with norovirus serves to expand the number of activatednorovirus-specific T cells in the mammal. The norovirus-specific T cellsderived from the mammal can then be restimulated in vitro by adding, anorovirus immunogenic polypeptide, and/or fusion protein according tothe present invention. The norovirus-specific T cells can then be testedfor, inter alia, proliferation, the production of IFN-γ, and the abilityto lyse target cells displaying, for example, VP1 polypeptide epitopesin vitro.

H. Kits

The invention also provides kits comprising one or more containers ofimmunogenic compositions of the invention. Compositions can be in liquidform or can be lyophilized, as can individual antigens. Suitablecontainers for the compositions include, for example, bottles, vials,syringes, and test tubes. Containers can be formed from a variety ofmaterials, including glass or plastic. A container may have a sterileaccess port (for example, the container may be an intravenous solutionbag or a vial having a stopper pierceable by a hypodermic injectionneedle).

The kit can further comprise a second container comprising apharmaceutically-acceptable buffer, such as phosphate-buffered saline,Ringer's solution, or dextrose solution. It can also contain othermaterials useful to the end-user, including other pharmaceuticallyacceptable formulating solutions such as buffers, diluents, filters,needles, and syringes or other delivery device. The kit may furtherinclude a third component comprising an adjuvant.

The kit can also comprise a package insert containing writteninstructions for methods of inducing immunity or for treatinginfections. The package insert can be an unapproved draft package insertor can be a package insert approved by the Food and Drug Administration(FDA) or other regulatory body.

The invention also provides a delivery device pre-filled with theimmunogenic compositions of the invention.

III. Experimental

Below are examples of specific embodiments for carrying out the presentinvention. The examples are offered for illustrative purposes only, andare not intended to limit the scope of the present invention in any way.

Example 1 Expression Constructs for Snow Mountain/Norwalk Chimeric VP1Proteins

Constructs for production of chimeric norovirus VP1 proteins, and VLPscontaining the chimeric proteins, Saccharomyces cerevisiae strain AD3were created by cloning sequences encoding chimeric VP1 proteins intothe yeast expression vector pBS24.1. The pBS24.1 vector is described indetail in commonly owned U.S. patent application serial No. 382,805,filed Jul. 19, 1989, which application is hereby incorporated byreference in its entirety herein. The pBS24.1 vector contains the2-micron sequence for autonomous replication in yeast and the yeastgenes leu2d and URA3 as selectable markers. The β-lactamase gene and theColE1 origin of replication, required for plasmid replication inbacteria, are also present in this expression vector. Regulation ofexpression was put under the control of a hybrid ADH2/GAPDH promoter(described in U.S. Pat. No. 6,183,985) and an alpha-factor terminator.

The constructs were created and utilized for expression of Snow Mountain(SMV0/Norwalk VP1 proteins included the polynucleotide sequence shown inFIG. 6 (SEQ ID NO:16). To do that, a fragment corresponding to theS-domain of the a previously generated Snow Mountain gene, excised byrestriction enzymes HindIII and Acc651, was ligated to a fragmentcorresponding to the P-domain of Norwalk gene that was generated usingrestriction enzymes Alw211 and SalI. This new chimeric DNA was ligatedinto a pMADC5 subcloning vector (FIG. 1) at the HindIII-SalI site andamplified. The amplified fragment (shown in FIG. 5) was then cloned intothe expression vector pBS24.1 (FIG. 2), at the BamHI+SalI site, forexpression of the SMV/Norwalk chimeric VP1 protein in S. cervisiaestrain AD3.

Example 2 Expression Constructs for Snow Mountain/GII4.2006a Chimeras

In this example, expression vector pBS24.1 was used in production ofSnow Mountain/GII.4.2006a VLPs (SMV/GII.4.2006a/chimeras) inSaccharomyces cerevisiae strain AD3. The coding sequence that wasutilized for the expression of chimeric SMV/GII.4.2006a VP1 proteins isshown in FIG. 7. The coding sequence was generated using syntheticoligonucleotides, based on the cDNA sequences of VP1 S- and P-domains ofSnow Mountain and GII.4.2006a viruses.

In this example, a fragment corresponding to the S-domain of apreviously generated Snow Mountain gene, excised by restriction enzymesHindIII and Acc651, was ligated to a fragment corresponding to theP-domain of the GII.4.2006a gene that was generated using restrictionenzymes Xbal-SalI. This new chimeric DNA was ligated into a pMADC5subcloning vector (FIG. 1) at the HindIII-SalI site and amplified. Theamplified fragment (shown in FIG. 6) was then cloned into the expressionvector pBS24.1 (FIG. 2), at the BamHI+SalI site, for expression of theSMV/Norwalk chimeric VP1 protein in S. cervisiae strain AD3.

Example 3 Expression of Chimeric VLPs in Yeast

S. cerevisiae strain AD3 (MATa, leu2, ura3-52, prb1-1122, pep4-3,prc1-407, gal2, [cir0], ::pDM15(pGAP/ADR1::G418R), ::Yip5ΔleuAD) wastransformed with the expression plasmids described above. Before thetransformation, the yeast cells were streaked on YEPD (yeast extractbactopeptone 2% glucose) plates and a single colony was selected forpreparation of competent cells for transformation.

Yeast transformation was performed using the Invitrogen S.c. EasyComp™Transformation Kit. After transformation, several Ura-transformants werestreaked onto Ura-8% glucose plates in order to obtain single colonies.The single colonies were subsequently patched onto Leu-8% glucose platesto increase the plasmid copy number. Leu-starter cultures were grown for24 hours at 30° C. and then diluted 1:20 in YEPD (yeast extractbactopeptone 2% glucose) or Veggie (Novagen Veggie Peptone and VeggieYeast Extract) media. Cells were grown for 48-72 hours at 30° C. toallow depletion of the glucose in the media and then harvested.Induction occurred upon depletion of glucose from the media. This systemprovided a high cell mass before the foreign genes were induced.

Example 4 Purification of Chimeric VLPs

Norovirus virus-like particles (VLPs) were purified from the media ofyeast cells expressing the norovirus chimeric VP1 protein. A low speedspin (15,000×g) was performed on the media to remove extra cells orcellular debris. Following this step, the supernatant was subjected to afour hour high speed spin (100,000×g) through a 40% sucrose cushion toseparate the virus-like particles from free protein and other material.The pellet containing the VLPs was resuspended in buffer (50 mM Tris pH7.5, 100 mM NaCl) and loaded onto a Capto™ Q column and eluted with highsalt. The VLPs were eluted from the column during a gradient ofincreasing salt. Finally, the eluted fraction containing the VLPs wereconcentrated and buffer exchanged into a lower salt buffer (20 mM TrispH 7.5, 100 mM NaCl) and stored at 4° C. until use.

TABLE 1 Norovirus Strains Norovirus genus Norwalk virus Chitta virusCamberwell virus Hawaii calicivirus Chiba virus Maryland calicivirus 1Norovirus genogroup 1 Desert Shield virus NorovirusHu/GI/KE/230207-1/2007/SGP Norovirus genogroup G1 unidentified NorovirusHu/GI/KE/230207-2/2007/SGP subgroup Norovirus Hu/GI/KE/230207-3/2007/SGPHuman calicivirus Norovirus Hu/GI/KE/240407-1/2007/SGPHU/NLV/Birmingham/93/UK Norovirus Hu/GI/KE/240407-2/2007/SGP Humancalicivirus Norovirus Hu/GI/KE/270607-1/2007/SGPHU/NLV/Koblenz/433/2000/DE Norovirus Hu/GI/KE/270607-2/2007/SGP Humancalicivirus HU/NLV/Musgrove/89/UK Norovirus Hu/GI/KE/270607-3/2007/SGPHuman calicivirus HU/NLV/Rbh/93/UK Norovirus Hu/GI/KE/290507-1/2007/SGPHuman calicivirus Norovirus Hu/GI/KE/290507-2/2007/SGPHU/NLV/Sindlesham/95/UK Norovirus Hu/GI/KE/290507-3/2007/SGP Humancalicivirus HU/NLV/Thistlehall/90/UK NorovirusHu/GI/KS/200307-1/2007/SGP Human calicivirus HU/NLV/Valetta/95/MaltaNorovirus Hu/GI/KS/200307-2/2007/SGP Human calicivirusHU/NLV/Whiterose/96/UK Norovirus Hu/GI/KS/200307-3/2007/SGP Humancalicivirus Norovirus Hu/GI/KS/230107-1/2007/SGP HU/NLV/Winchester/94/UKNorovirus Hu/GI/KS/230107-2/2007/SGP Human calicivirusHU/NLV/Wortley/90/UK Norovirus Hu/GI/KS/230107-3/2007/SGP Humancalicivirus NLV/Stav/95/Nor Norovirus Hu/GI/KS/230207-1/2007/SGP Humancalicivirus Norovirus Hu/GI/KS/230207-2/2007/SGPNLV/Wyoming/US/genogroup 1 Norovirus Hu/GI/KS/240407-1/2007/SGPNorovirus clam/GI/Shijimi1/JPN Norovirus Hu/GI/KS/240407-2/2007/SGPNorovirus clam/GI/Shijimi11/JPN Norovirus Hu/GI/KS/270607-1/2007/SGPNorovirus clam/GI/Shijimi12a/JPN Norovirus Hu/GI/KS/270607-2/2007/SGPNorovirus clam/GI/Shijimi12b/JPN Norovirus Hu/GI/KS/270607-3/2007/SGPNorovirus clam/GI/Shijimi12c/JPN Norovirus Hu/GI/KS/290507-1/2007/SGPNorovirus clam/GI/Shijimi12d/JPN Norovirus Hu/GI/KS/290507-2/2007/SGPNorovirus clam/GI/Shijimi13/JPN Norovirus Hu/GI/Marina48/2001/BotswanaNorovirus clam/GI/Shijimi16a/JPN Norovirus Hu/GI/Marina60/2003/BotswanaNorovirus clam/GI/Shijimi16b/JPN Norovirus Hu/GI/N9/2003/Irl Norovirusclam/GI/Shijimi16c/JPN Norovirus Hu/GI/NoV360/2004/CAN Norovirusclam/GI/Shijimi16d/JPN Norovirus Hu/GI/NoV69/2004/CAN Norovirusclam/GI/Shijimi17/JPN Norovirus Hu/GI/NoV730/2004/CAN Norovirusclam/GI/Shijimi18/JPN Norovirus Hu/GI/NoV748/2004/CAN Norovirusclam/GI/Shijimi19a/JPN Norovirus Hu/GI/Nsk-D81/2009/RUS Norovirusclam/GI/Shijimi19b/JPN Norovirus Hu/GI/Orstad/749/2004/NOR Norovirusclam/GI/Shijimi2/JPN Norovirus Hu/GI/Osaka1115/2006/JPN Norovirusclam/GI/Shijimi20a/JPN Norovirus Hu/GI/Osaka896/2006/JPN Norovirusclam/GI/Shijimi20b/JPN Norovirus Hu/GI/Oslo/1504/2002/NOR Norovirusclam/GI/Shijimi21/JPN Norovirus Hu/GI/Oslo/776/2004/NOR Norovirusclam/GI/Shijimi22/JPN Norovirus Hu/GI/R1D-011106/2006/SGP Norovirusclam/GI/Shijimi23/JPN Norovirus Hu/GI/R1D-111206/2006/SGP Norovirusclam/GI/Shijimi25a/JPN Norovirus Hu/GI/R1D-201106/2006/SGP Norovirusclam/GI/Shijimi25b/JPN Norovirus Hu/GI/R1U-031006/2006/SGP Norovirusclam/GI/Shijimi26/JPN Norovirus Hu/GI/R1U-111206/2006/SGP Norovirusclam/GI/Shijimi28/JPN Norovirus Hu/GI/R2D-011106/2006/SGP Norovirusclam/GI/Shijimi29/JPN Norovirus Hu/GI/R2D-111206/2006/SGP Norovirusclam/GI/Shijimi30/JPN Norovirus Hu/GI/R2D-150806/2006/SGP Norovirusclam/GI/Shijimi31/JPN Norovirus Hu/GI/R2D-220606/2006/SGP Norovirusclam/GI/Shijimi4/JPN Norovirus Hu/GI/R2D-240706/2006/SGP Norovirusclam/GI/Shijimi5/JPN Norovirus Hu/GI/R2U-031006/2006/SGP Norovirusclam/GI/Shijimi6/JPN Norovirus Hu/GI/R2U-111206-1/2006/SGP Norovirusclam/GI/Shijimi7/JPN Norovirus Hu/GI/R2U-111206-2/2006/SGP Norovirusclam/GI/Shijimi8/JPN Norovirus Hu/GI/R2U-150806/2006/SGP Norovirusclam/GI/Shijimi9/JPN Norovirus Hu/GI/R2U-201106/2006/SGP NorovirusCor/Gunma/Apr-3/GI/2004/JP Norovirus Hu/GI/R2U-220606-1/2006/SGPNorovirus Cor/Gunma/Apr-4/GI/2004/JP NorovirusHu/GI/R2U-220606-2/2006/SGP Norovirus Cor/Gunma/Dec-1/GI/2004/JPNorovirus Hu/GI/R3D-251006/2006/SGP Norovirus Cor/Gunma/Dec-2/GI/2004/JPNorovirus Hu/GI/R3U-251006-1/2006/SGP NorovirusCor/Gunma/Dec-3/GI/2004/JP Norovirus Hu/GI/R3U-251006-2/2006/SGPNorovirus Cor/Gunma/Dec-4/GI/2004/JP NorovirusHu/GI/R3U-251006-3/2006/SGP Norovirus Cor/Gunma/Dec-5/GI/2004/JPNorovirus Hu/GI/R3U-251006-4/2006/SGP NorovirusCor/Gunma/Feb-2/GI/2004/JP Norovirus Hu/GI/R3U-251006-5/2006/SGPNorovirus Cor/Gunma/Feb-3/GI/2004/JP NorovirusHu/GI/Shenzhen193-06/2006/CHN Norovirus Cor/Gunma/Feb-5/GI/2004/JPNorovirus Hu/GI/Shenzhen197-06/2006/CHN NorovirusCor/Gunma/Jan-1/GI/2004/JP Norovirus Hu/GI/Shenzhen198-06/2006/CHNNorovirus Cor/Gunma/Jan-2/GI/2004/JP NorovirusHu/GI/Shenzhen199-06/2006/CHN Norovirus Cor/Gunma/Jun-2/GI/2004/JPNorovirus Hu/GI/Shenzhen200-06/2006/CHN NorovirusCor/Gunma/Mar-1/GI/2004/JP Norovirus Hu/GI/Shenzhen202-06/2006/CHNNorovirus Cor/Gunma/May-1/GI/2004/JP NorovirusHu/GI/Shenzhen84-06/2006/CHN Norovirus Cor/Gunma/May-3/GI/2004/JPNorovirus Hu/GI/SI-2002/2006/SVN Norovirus Cor/Gunma/May-4/GI/2004/JPNorovirus Hu/GI/Skovde/IV8406/2002/SE NorovirusCor/Gunma/Nov-1/GI/2004/JP Norovirus Hu/GI/SL4450/2005/Arg NorovirusCor/Gunma/Nov-2/GI/2004/JP Norovirus Hu/GI/Stavanger/754/2004/NORNorovirus Cor/Gunma/Oct-2/GI/2004/JP NorovirusHu/GI/Stockholm/IV1353/2002/SE Norovirus env/GGI/956/2007/ITA NorovirusHu/GI/Trondheim/4448/2000/NOR Norovirus GI/103/2005/RJ/BRA NorovirusHu/GI/UE/200307-1/2007/SGP Norovirus GI/104/2005/RJ/BRA NorovirusHu/GI/UE/200307-2/2007/SGP Norovirus GI/110/2005/RJ/BRA NorovirusHu/GI/UE/230107-1/2007/SGP Norovirus GI/56/2005/RJ/BRA NorovirusHu/GI/UE/230107-2/2007/SGP Norovirus GI/57/2005/RJ/BRA NorovirusHu/GI/UE/230107-3/2007/SGP Norovirus GI/Lopburi105/2006/THA NorovirusHu/GI/UE/230107-4/2007/SGP Norovirus groundwater/GI/HE-a-1/2007/KORNorovirus Hu/GI/UE/230207-1/2007/SGP Norovirusgroundwater/GI/HE-b-1/2007/KOR Norovirus Hu/GI/UE/230207-2/2007/SGPNorovirus groundwater/GI/HE-c-1/2007/KOR NorovirusHu/GI/UE/230207-3/2007/SGP Norovirus groundwater/GI/SS-c-1/2007/KORNorovirus Hu/GI/UE/240407-1/2007/SGP Norovirusgroundwater/GI/SS-f-1/2007/KOR Norovirus Hu/GI/UE/240407-2/2007/SGPNorovirus Han Norovirus Hu/GI/UE/270607-1/2007/SGPRiver/GI/Dukpoong/Aug01/2005/KOR Norovirus Hu/GI/UE/270607-2/2007/SGPNorovirus Han Norovirus Hu/GI/UE/270607-3/2007/SGPRiver/GI/Dukpoong/Feb01/2006/KOR Norovirus Hu/GI/UE/290507-1/2007/SGPNorovirus Han Norovirus Hu/GI/UE/290507-2/2007/SGPRiver/GI/Dukpoong/Feb02/2006/KOR Norovirus Hu/GI/UE/290507-3/2007/SGPNorovirus Han Norovirus Hu/GI/Uppsala/IV11029/2002/SERiver/GI/Dukpoong/Jul01/2005/KOR Norovirus Hu/GI/US/200307-1/2007/SGPNorovirus Han Norovirus Hu/GI/US/200307-2/2007/SGPRiver/GI/Dukpoong/Jul02/2005/KOR Norovirus Hu/GI/US/230107-1/2007/SGPNorovirus Han Norovirus Hu/GI/US/230107-2/2007/SGPRiver/GI/Dukpoong/May01/2006/KOR Norovirus Hu/GI/US/230107-3/2007/SGPNorovirus Han Norovirus Hu/GI/US/230207-1/2007/SGPRiver/GI/Jamsil/Oct01/2005/KOR Norovirus Hu/GI/US/230207-2/2007/SGPNorovirus Han Norovirus Hu/GI/US/230207-3/2007/SGPRiver/GI/Jamsil/Oct02/2005/KOR Norovirus Hu/GI/US/240407-1/2007/SGPNorovirus Han Norovirus Hu/GI/US/240407-2/2007/SGPRiver/GI/Kyoungan/Feb01/2006/KOR Norovirus Hu/GI/US/240407-3/2007/SGPNorovirus Han Norovirus Hu/GI/US/270607-1/2007/SGPRiver/GI/Kyoungan/Feb02/2006/KOR Norovirus Hu/GI/US/270607-2/2007/SGPNorovirus Han Norovirus Hu/GI/US/270607-3/2007/SGPRiver/GI/Kyoungan/Jan01/2006/KOR Norovirus Hu/GI/US/290507-1/2007/SGPNorovirus Han Norovirus Hu/GI/US/290507-2/2007/SGPRiver/GI/Kyoungan/Jul01/2005/KOR Norovirus Hu/GI/US/290507-3/2007/SGPNorovirus Han Norovirus Hu/GI/Water-1B/2004/South KoreaRiver/GI/Kyoungan/Jul02/2005/KOR Norovirus Hu/GI/Water-2B/2004/SouthKorea Norovirus Han Norovirus Hu/GI/Water-A/2004/South KoreaRiver/GI/Kyoungan/May01/2006/KOR Norovirus Hu/GI4/51059/Jilin/06/CHNNorovirus Han Norovirus Hu/GI4/51296/Anhui/06/CHNRiver/GI/Sungnae/Jan01/2006/KOR Norovirus Hu/Gunma/3/GI/JP Norovirus HanNorovirus Hu/Gunma/4/GI/JP River/GI/Sungnae/Jul01/2005/KOR NorovirusHu/Gunma/5/GI/JP Norovirus Han Norovirus Hu/Mashhad4/GGI/IranRiver/GI/Sungnae/Jul02/2005/KOR Norovirus Hu/NFL-1107V6/GI/07-2004/CANNorovirus Han Norovirus Hu/NV/I/Hualien/LWT/2003/TWRiver/GI/Sungnae/May01/2006/KOR Norovirus Hu/Pune/PC01-GI/2005/IndiaNorovirus Han Norovirus oyster/cultured/GI/05/JPRiver/GI/Sungnae/May02/2006/KOR Norovirusoyster/cultured/GI/MAT/Apr05a/05/JP Norovirus Han Norovirusoyster/cultured/GI/MAT/Dec05/05/JP River/GI/Sungnae/May03/2006/KORNorovirus oyster/cultured/GI/MAT/May05a/05/JP Norovirus Han Norovirusoyster/cultured/GI/MAT05a/05/JP River/GI/Sungnae/May04/2006/KORNorovirus oyster/cultured/GI/MAT05b/05/JP Norovirus Han Norovirusoyster/cultured/GI/MAT05e/05/JP River/GI/Wangsuk/Aug01/2005/KORNorovirus oyster/cultured/GI/ONG05b/05/JP Norovirus Han Norovirusoyster/GI/BFDA-GI-01/2009/TAW River/GI/Wangsuk/Feb01/2006/KOR Norovirusoyster/GI/BFDA-GI-02/2009/TAW Norovirus Han Norovirusoyster/GI/BFDA-GI-04/2009/TAW River/GI/Wangsuk/Feb02/2006/KOR Norovirusoyster/GI/BFDA-GI-05/2009/TAW Norovirus Han Norovirusoyster/GI/BFDA-GI-06/2009/TAW River/GI/Wangsuk/Jan01/2006/KOR Norovirusoyster/GI/BFDA-GI-07/2009/TAW Norovirus Han Norovirusoyster/GI/BFDA-GI-08/2009/TAW River/GI/Wangsuk/Jul01/2005/KOR Norovirusoyster/GI/BFDA-GI-09/2008/TAW Norovirus Han Norovirusoyster/GI/BFDA-GI-10/2008/TAW River/GI/Wangsuk/Jul02/2005/KOR Norovirusoyster/GI/BFDA-GI-11/2008/TAW Norovirus Han Norovirusoyster/GI/BFDA-GI-12/2008/TAW River/GI/Wangsuk/May01/2006/KOR Norovirusoyster/GI/FP19A/2004/CAN Norovirus Hu/G1/2232/2006/BRA Norovirusoyster/GI/FP19D/2004/CAN Norovirus Hu/G1/2525/2006/BRA Norovirusoyster/GI/FP19F/2004/CAN Norovirus Hu/G1/Fin-Kauh/1999/Finland Norovirusoyster/GI/FP19J/2004/CAN Norovirus Hu/G1/Fin-Keur/1998/Finland Norovirusoyster/GI/FP50A/2004/CAN Norovirus Hu/G1/Fin-Kola/1999/Finland Norovirusoyster/GI/FP50C/2004/CAN Norovirus Hu/G1/Fin-Nurm/2000/Finland Norovirusoyster/GI/FP50J/2004/CAN Norovirus Hu/G1/Fin-Part/1999/Finland Norovirusoyster/GI/FP55A/2004/CAN Norovirus Hu/G1/Fin-Porv/1999/Finland Norovirusoyster/GI/FP55B/2004/CAN Norovirus Hu/G1/Fin-Sod/2003/Finland Norovirusoyster/GI/FP58A/2004/CAN Norovirus Hu/G1/Hamburg CN/2005 Norovirusoyster/GI/FP58D/2004/CAN Norovirus Hu/GGI/New Delhi/120/02/IND Norovirusoyster/GI/FP58G/2004/CAN Norovirus Hu/GGI/New Delhi/64/02/IND Norovirusoyster/GI/FP58J/2004/CAN Norovirus Hu/GGI/NL20010045/2001/NL Norovirusoyster/GI/FP67J/2004/CAN Norovirus Hu/GI/1/JPN Norovirusoyster/GI/FP68F/2004/CAN Norovirus Hu/GI/10B/2004/South Korea Norovirusoyster/GI/FP69B/2004/CAN Norovirus Hu/GI/11B/2004/South Korea Norovirusoyster/GI/FP72A/2004/CAN Norovirus Hu/GI/12/JPN Norovirusoyster/GI/FP72F/2004/CAN Norovirus Hu/GI/1278/2006/Ghana Norovirusoyster/GI/Hiroshimacity/29/02/JP Norovirus Hu/GI/12B/2004/South KoreaNorovirus oyster/GI/Hiroshimacity/36/03/JP NorovirusHu/GI/1313/2006/Ghana Norovirus oyster/GI/Yamaguchi/32B/03/JP NorovirusHu/GI/1370/2006/Ghana Norovirus oyster/GI/Yamaguchi/33C/03/JP NorovirusHu/GI/13B/2004/South Korea Norovirus oyster/GI/Yamaguchi/39B/03/JPNorovirus Hu/GI/14B/2004/South Korea Norovirusoyster/GI/Yamaguchi/43A/03/JP Norovirus Hu/GI/1507/2006/Ghana Norovirusoyster/GI/Yamaguchi/43C/03/JP Norovirus Hu/GI/15B/2004/South KoreaNorovirus oyster/GI/Yamaguchi/45C/03/JP Norovirus Hu/GI/16B/2004/SouthKorea Norovirus oyster/GI/Yamaguchi/57A/03/JP Norovirus Hu/GI/17/JPNNorovirus oyster/GI/Yamaguchi/57B/03/JP Norovirus Hu/GI/17B/2004/SouthKorea Norovirus oyster/GI/Yamaguchi/H16-105B/04/JP NorovirusHu/GI/18B/2004/South Korea Norovirus oyster/GI/Yamaguchi/H16-109B/04/JPNorovirus Hu/GI/19B/2004/South Korea Norovirusoyster/GI/Yamaguchi/H16-117B/04/JP Norovirus Hu/GI/1A/2004/South KoreaNorovirus oyster/GI/Yamaguchi/H16-21C/03/JP NorovirusHu/GI/1B/2004/South Korea Norovirus oyster/GI/Yamaguchi/H16-32B/03/JPNorovirus Hu/GI/2002/2222/Moscow/RUS Norovirusoyster/GI/Yamaguchi/H16-51A/04/JP Norovirus Hu/GI/2003/3168/Moscow/RUSNorovirus oyster/GI/Yamaguchi/H16-57C/04/JP NorovirusHu/GI/2005/5831/Moscow/RUS Norovirus oyster/GI/Yamaguchi/H17-105B/05/JPNorovirus Hu/GI/2005/6833/Chelyabinsk/RUS Norovirusoyster/GI/Yamaguchi/H17-110D/05/JP NorovirusHu/GI/2005/6835/Chelyabinsk/RUS Norovirusoyster/GI/Yamaguchi/H17-117A/05/JP NorovirusHu/GI/2005/6836/Chelyabinsk/RUS Norovirusoyster/GI/Yamaguchi/H17-123A/05/JP Norovirus Hu/GI/2005/7656/NizhnyNorovirus oyster/GI/Yamaguchi/H17-21B/04/JP Novgorod/RUS Norovirusoyster/GI/Yamaguchi/H17-25B/04/JP NorovirusHu/GI/2005/7987/Chelyabinsk/RUS Norovirusoyster/GI/Yamaguchi/H17-80A/05/JP NorovirusHu/GI/2005/8064/Chelyabinsk/RUS Norovirusoyster/GI/Yamaguchi/H17-81A/05/JP NorovirusHu/GI/2005/8086/Chelyabinsk/RUS Norovirusoyster/GI/Yamaguchi/H17-81B/05/JP NorovirusHu/GI/2005/8088/Chelyabinsk/RUS Norovirusoyster/GI/Yamaguchi/H17-97C/05/JP NorovirusHu/GI/2005/8388/Chelyabinsk/RUS Norovirusoyster/wild/GI/SHG/ST1/Mar05a/05/JP Norovirus Hu/GI/2005/8763/Tyumen/RUSNorovirus oyster/wild/GI/SHG/ST1/Mar05f/05/JP Norovirus Norovirusoyster/wild/GI/SHG/ST2/Mar05a/05/JP Hu/GI/2006/10882/Chelyabinsk/RUSNorovirus oyster/wild/GI/SHG/ST2/Mar05b/05/JP NorovirusHu/GI/2006/11227/Nizhny Norovirus oyster/wild/GI/SHG/ST2/Mar05e/05/JPNovgorod/RUS Norovirus oyster/wild/GI/SHG/ST2/Mar05f/05/JP NorovirusHu/GI/2006/9564/Chelyabinsk/RUS Norovirusoyster/wild/GI/SHG/ST3/Apr05a/05/JP NorovirusHu/GI/2006/9636/Chelyabinsk/RUS Norovirusoyster/wild/GI/SHG/ST3/Apr05c/05/JP Norovirus Hu/GI/20B/2004/South KoreaNorovirus oyster/wild/GI/SHG/ST3/Apr05 

 /05/JP Norovirus Hu/GI/21B/2004/South Korea Norovirusoyster/wild/GI/SHG/ST3/Dec05c/05/JP Norovirus Hu/GI/22B/2004/South KoreaNorovirus oyster/wild/GI/SHG/ST3/Feb06/06/JP NorovirusHu/GI/23B/2004/South Korea Norovirus oyster/wild/GI/SHG/ST3/Jan06a/06/JPNorovirus Hu/GI/24B/2004/South Korea Norovirusoyster/wild/GI/SHG/ST3/Jan06c/06/JP Norovirus Hu/GI/25B/2004/South KoreaNorovirus oyster/wild/GI/SHG/ST3/Mar05/05/JP Norovirus Hu/GI/28/JPNNorovirus oyster/wild/GI/SHG/ST3/Mar06a/06/JP NorovirusHu/GI/2A/2004/South Korea Norovirus oyster/wild/GI/SHG/ST3/Mar06c/06/JPNorovirus Hu/GI/2B/2004/South Korea Norovirussewage/GI/Toyama/Apr-1/2006/JP Norovirus Hu/GI/3A/2004/South KoreaNorovirus sewage/GI/Toyama/Apr-2/2006/JP Norovirus Hu/GI/3B/2004/SouthKorea Norovirus sewage/GI/Toyama/Apr/2007/JP NorovirusHu/GI/4B/2004/South Korea Norovirus sewage/GI/Toyama/Aug-1/2007/JPNorovirus Hu/GI/5B/2004/South Korea Norovirussewage/GI/Toyama/Aug-2/2007/JP Norovirus Hu/GI/6/8014/2005/BRA Norovirussewage/GI/Toyama/Aug/2006/JP Norovirus Hu/GI/6B/2004/South KoreaNorovirus sewage/GI/Toyama/Dec/2007/JP Norovirus Hu/GI/7/JPN Norovirussewage/GI/Toyama/Feb/2007/JP Norovirus Hu/GI/7B/2004/South KoreaNorovirus sewage/GI/Toyama/Feb/2008/JP Norovirus Hu/GI/8/JPN Norovirussewage/GI/Toyama/Jan-1/2008/JP Norovirus Hu/GI/8014/2004/BRA Norovirussewage/GI/Toyama/Jan-P2/2008/JP Norovirus Hu/GI/8B/2004/South KoreaNorovirus sewage/GI/Toyama/Jan/2007/JP Norovirus Hu/GI/9B/2004/SouthKorea Norovirus sewage/GI/Toyama/Jul/2006/JP NorovirusHu/GI/Babbacombe/1996/GBR Norovirus sewage/GI/Toyama/Jul/2007/JPNorovirus Hu/GI/BCCDC03028/2003/CAN Norovirussewage/GI/Toyama/Jun/2006/JP Norovirus Hu/GI/BCCDC04003/2004/CANNorovirus sewage/GI/Toyama/Jun/2007/JP NorovirusHu/GI/BCCDC04008/2004/CAN Norovirus sewage/GI/Toyama/Mar-1/2007/JPNorovirus Hu/GI/BE/200307/2007/SGP Norovirussewage/GI/Toyama/Mar-2/2007/JP Norovirus Hu/GI/BE/230107-1/2007/SGPNorovirus sewage/GI/Toyama/Mar-P2/2007/JP NorovirusHu/GI/BE/230107-2/2007/SGP Norovirus sewage/GI/Toyama/Mar/2008/JPNorovirus Hu/GI/BE/230107-3/2007/SGP Norovirussewage/GI/Toyama/May-2/2006/JP Norovirus Hu/GI/BE/230207-1/2007/SGPNorovirus sewage/GI/Toyama/May-P1/2006/JP NorovirusHu/GI/BE/230207-2/2007/SGP Norovirus sewage/GI/Toyama/May/2006/JPNorovirus Hu/GI/BE/240407-1/2007/SGP Norovirussewage/GI/Toyama/May/2007/JP Norovirus Hu/GI/BE/240407-2/2007/SGPNorovirus sewage/GI/Toyama/NoV-1/2006/JP NorovirusHu/GI/BE/240407-3/2007/SGP Norovirus sewage/GI/Toyama/NoV-P2/2006/JPNorovirus Hu/GI/BE/270607-1/2007/SGP Norovirussewage/GI/Toyama/NoV/2007/JP Norovirus Hu/GI/BE/270607-2/2007/SGPNorovirus sewage/GI/Toyama/Sep-1/2006/JP NorovirusHu/GI/BE/290507-1/2007/SGP Norovirus sewage/GI/Toyama/Sep-2/2006/JPNorovirus Hu/GI/BE/290507-2/2007/SGP Norovirussewage/GI/Toyama/Sep-P1/2006/JP Norovirus Hu/GI/BE/290507-3/2007/SGPNorovirus sewage/GI/Toyama/Sep/2007/JP Norovirus Hu/GI/Beijing/50/2007Norovirus sewage/GI/Toyama/SW0609-7/2006/JP NorovirusHu/GI/Beijing/60/2007 Norovirus sewage/GI/Toyama/SW0701-2/2006/JPNorovirus Hu/GI/BHL37/2000/Botswana Norovirussewage/GI/Toyama/SW0702-7/2007/JP Norovirus Hu/GI/BS/200307-1/2007/SGPNorovirus sewage/GI/Toyama/SW0703-18/2007/JP NorovirusHu/GI/BS/200307-2/2007/SGP Norovirus sewage/GI/Toyama/SW0705-9/2007/JPNorovirus Hu/GI/BS/230107-1/2007/SGP Norovirussewage/GI/Toyama/SW0708-1/2007/JP Norovirus Hu/GI/BS/230107-2/2007/SGPNorovirus water/GI/Gyeonggi/A12/2002/KOR NorovirusHu/GI/BS/230107-3/2007/SGP Norovirus water/GI/Gyeonggi/A14/2003/KORNorovirus Hu/GI/BS/230107-4/2007/SGP Noroviruswater/GI/Gyeonggi/A15/2003/KOR Norovirus Hu/GI/BS/230107-5/2007/SGPNorovirus water/GI/Gyeonggi/A2-1/2002/KOR NorovirusHu/GI/BS/230207-1/2007/SGP Norovirus water/GI/Gyeonggi/A2-2/2002/KORNorovirus Hu/GI/BS/230207-2/2007/SGP Noroviruswater/GI/Gyeonggi/A7/2002/KOR Norovirus Hu/GI/BS/240407-1/2007/SGPNorovirus water/GI/Gyeonggi/A8/2002/KOR NorovirusHu/GI/BS/240407-2/2007/SGP Norovirus water/GI/Gyeonggi/H10/2002/KORNorovirus Hu/GI/BS/240407-3/2007/SGP Noroviruswater/GI/Gyeonggi/H12/2002/KOR Norovirus Hu/GI/BS/270607-1/2007/SGPNorovirus water/GI/Gyeonggi/H13/2003/KOR NorovirusHu/GI/BS/270607-2/2007/SGP Norovirus water/GI/Gyeonggi/H14/2003/KORNorovirus Hu/GI/BS/270607-3/2007/SGP Noroviruswater/GI/Gyeonggi/H15/2003/KOR Norovirus Hu/GI/BS/290507-1/2007/SGPNorovirus water/GI/Gyeonggi/H2/2002/KOR NorovirusHu/GI/BS/290507-2/2007/SGP Norovirus water/GI/Gyeonggi/H3/2002/KORNorovirus Hu/GI/C1-011106-1/2006/SGP Noroviruswater/GI/Gyeonggi/H6/2002/KOR Norovirus Hu/GI/C1-011106-2/2006/SGPNorovirus water/GI/Gyeonggi/H7/2002/KOR NorovirusHu/GI/C1-111206/2006/SGP Norovirus water/GI/Gyeonggi/H8/2002/KORNorovirus Hu/GI/C1-150806/2006/SGP Noroviruswater/GI/Gyeonggi/H9/2002/KOR Norovirus Hu/GI/C1-201106/2006/SGPNorovirus water/GI/Gyeonggi/I14/2003/KOR NorovirusHu/GI/C1-220606/2006/SGP Norovirus water/GI/Gyeonggi/I15/2003/KORNorovirus Hu/GI/C1-240706-1/2006/SGP Noroviruswater/GI/Gyeonggi/I2/2002/KOR Norovirus Hu/GI/C1-240706-2/2006/SGPNorovirus water/GI/Gyeonggi/I8/2002/KOR NorovirusHu/GI/C1-271206/2006/SGP Norovirus water/GI/Gyeonggi/S1/2002/KORNorovirus Hu/GI/C2-230507/2007/SGP Noroviruswater/GI/Gyeonggi/S10/2002/KOR Norovirus Hu/GI/C7-157/2005/KOR Noroviruswater/GI/Gyeonggi/S11/2002/KOR Norovirus Hu/GI/C7-167/2005/KOR Noroviruswater/GI/Gyeonggi/S12/2002/KOR Norovirus Hu/GI/Cardrona/2006/NZLNorovirus water/GI/Gyeonggi/S14/2003/KOR NorovirusHu/GI/E-110407-1/2007/SGP Norovirus water/GI/Gyeonggi/S15/2003/KORNorovirus Hu/GI/E-110407-2/2007/SGP Noroviruswater/GI/Gyeonggi/S3/2002/KOR Norovirus Hu/GI/E-140307/2007/SGPNorovirus water/GI/Gyeonggi/S4/2002/KOR NorovirusHu/GI/Eiken/5587/2002/NOR Norovirus water/GI/Gyeonggi/S7-1/2002/KORNorovirus Hu/GI/FH-A/2004/South Korea Noroviruswater/GI/Gyeonggi/S7-2/2002/KOR Norovirus Hu/GI/FH-B/2004/South KoreaNorovirus water/GI/Gyeonggi/S8/2002/KOR NorovirusHu/GI/Furutangen/4200/2002/NOR Norovirus water/GI/Gyeonggi/S9/2002/KORNorovirus Hu/GI/GpN/2004/Irl Norovirus Hu/GI/ICB1159/1996/BrazilNorovirus Hu/GI/Guadalajara/TD1 Norovirus Hu/GI/ICB1230/1996/BrazilNorovirus Hu/GI/Guadalajara/TD12 Norovirus Hu/GI/ICB1242C2/1996/BrazilNorovirus Hu/GI/Guadalajara/TD7 Norovirus Hu/GI/ICB1346C2/1996/BrazilNorovirus Hu/GI/Guadalajara/TD8 Norovirus Hu/GI/ICB1436C2/1996/BrazilNorovirus Norovirus Hu/GI/ICB1918/1996/BrazilHu/GI/Guangxi/NN07230/2007/CHN Norovirus Hu/GI/ICB1969C2/1997/BrazilNorovirus Hu/GI/GuRIV/Caracas/2007/VEN NorovirusHu/GI/ICB2484/1998/Brazil Norovirus Hu/GI/GuRV/Caracas/2007/VENNorovirus Hu/GI/Jeju-43/2007/KOR Norovirus Hu/GI/GuRVII/Caracas/2008/VENNorovirus Hu/GI/Jeju-50/2007/KOR Norovirus Hu/GI/Hemsedal/114/2001/NORNorovirus Hu/GI/KD125/2005/Iraq Norovirus Hu/GI/Hiroshima/40-20/04/JPNorovirus Hu/GI/KD25/2005/Iraq Norovirus Hu/GI/Hiroshima/61-1/05/JPNorovirus Hu/GI/KD88/2005/Iraq Norovirus Hu/GI/HK/CU050101/2005/CHNNorovirus Hu/GI/KE/200307-1/2007/SGP NorovirusHu/GI/HK/CU050113/2005/CHN Norovirus Hu/GI/KE/200307-2/2007/SGPNorovirus Hu/GI/HK/CU050210/2005/CHN NorovirusHu/GI/KE/230107-1/2007/SGP Norovirus Hu/GI/HK/CU050335/2005/CHNNorovirus Hu/GI/KE/230107-2/2007/SGP NorovirusHu/GI/HK/CU050431/2005/CHN Norovirus Hu/GI/KE/230107-3/2007/SGPNorovirus Hu/GI/HK/CU050432/2005/CHN NorovirusHu/GI/HK/CU050448/2005/CHN Norovirus genogroup GI.1 NorovirusEnv/GGI.1/679/2006/IT Norovirus Norovirus Hu/GI-1/414003-3/2004/UKHu/GI.1/Mussels/M8nov2004/Foto/Sweden NorovirusHu/GI.1/2003/4529/Moscow/RUS Norovirus NorovirusHu/GI.1/2003/4580/Moscow/RUS Hu/GI.1/P2.Delsjo2004/Gothenburg/SwedenNorovirus Hu/GI.1/2003/4602/Moscow/RUS Norovirus NorovirusHu/GI.1/2003/4661/Moscow/RUS Hu/GI.1/P3.Delsjo2004/Gothenburg/SwedenNorovirus Hu/GI.1/2005/6067/Bishkek/RUS Norovirus NorovirusHu/GI.1/2005/7685/Nizhny Hu/GI.1/P4.Delsjo2004/Gothenburg/SwedenNovgorod/RUS Norovirus Norovirus Hu/GI.1/2005/8156/Moscow/RUSHu/GI.1/P5.Delsjo2004/Gothenburg/Sweden Norovirus Hu/GI.1/2005/8227/St.Norovirus Petersburg/RUS Hu/GI.1/P6.Delsjo2004/Gothenburg/SwedenNorovirus Hu/GI.1/2006/10246/Odessa/RUS NorovirusHu/GI.1/P7-587/2007/Stromstad/Sweden NorovirusHu/GI.1/2006/10305/Odessa/RUS Norovirus NorovirusHu/GI.1/2007/11580/Moscow/RUS Hu/GI.1/P7.Delsjo2004/Gothenburg/SwedenNorovirus Hu/GI.1/2007/2384/Moscow/RUS Norovirus NorovirusHu/GI.1/Beijing/45/2007 Hu/GI.1/P715.Delsjo2004/Gothenburg/SwedenNorovirus Norovirus Hu/GI.1/Cuernavaca/7183/2007/MEXHu/GI.1/P725.Delsjo2004/Gothenburg/Sweden NorovirusHu/GI.1/Dhaka234/2000/BGD Norovirus NorovirusHu/GI.1/P726.Delsjo2004/Gothenburg/SwedenHu/GI.1/Mussels/M10nov2004/Foto/Sweden Norovirus NorovirusHu/GI.1/P738.Delsjo2004/Gothenburg/SwedenHu/GI.1/Mussels/M127nov2004/Foto/Sweden Norovirus NorovirusHu/GI.1/P774.Delsjo2004/Gothenburg/SwedenHu/GI.1/Mussels/M28nov2004/Foto/Sweden NorovirusHu/GI.1/P8.Delsjo2004/Gothenburg/Sweden NorovirusHu/GI.1/P9.Delsjo2004/Gothenburg/Sweden NorovirusHu/GI.1/PI.Delsjo2004/Gothenburg/Sweden Norovirusoyster/GI.1/1A/Stromstad/Sweden Norovirusoyster/GI.1/1B/Stromstad/Sweden Norovirus oyster/GI.1/2/Stromstad/SwedenNorovirus genogroup GI.2 Norovirus Env/GGI.2/671/2006/IT NorovirusHu/GGI.2/patient M/2006/NLD Norovirus Env/GGI.2/677/2006/IT NorovirusHu/GGI.2/Southampton32609/2007/US Norovirus Env/GGI.2/680/2006/ITNorovirus Hu/GI-2/414003-1/2004/UK Norovirus Env/GGI.2/704/2006/ITNorovirus Hu/GI.2/13375/2007/RJ/BRA NorovirusHu/GG1-2/Berlin/90068.04-8- Norovirus Hu/GI.2/13397/2007/RJ/BRABA4/2004/DE Norovirus Hu/GI.2/Leuven/2003/BEL NorovirusHu/GG1-2/Berlin/90405.04-1- Norovirus BA1/2004/DEHu/GI.2/Mussels/M39nov2004/Foto/Sweden NorovirusHu/GG1-2/Berlin/90961.04-2- Norovirus septic BA1/2004/DEsystem/GGI.2/Southampton31845/2007/US NorovirusHu/GG1-2/Berlin/91192.05-7- Norovirus well BA3/2004/DEwater/GGI.2/Southampton31818/2007/US NorovirusHu/GG1-2/Berlin/91568.04-6- BA3/2004/DE Norovirus genogroup GI.3Norovirus Hu/GI-3/512057-1/2005/UK NorovirusHu/GI.3/P14.ASpen2004/Lerum/Sweden Norovirus Hu/GI.3/13440/2007/RJ/BRANorovirus Hu/GI.3/P15.ASpen2004/Lerum/Sweden NorovirusHu/GI.3/13484/2007/RJ/BRA Norovirus Hu/GI.3/P16.ASpen2004/Lerum/SwedenNorovirus Norovirus Hu/GI.3/P17.ASpen2004/Lerum/SwedenHu/GI.3/Guadalajara/50074v1/2007/MEX NorovirusHu/GI.3/P18.ASpen2004/Lerum/Sweden Norovirus Hu/GI.3/JKPG_881/SWE/2007Norovirus Hu/GI.3/P2.ASpen2004/Lerum/Sweden NorovirusHu/GI.3/JKPG_882/SWE/2007 Norovirus Hu/GI.3/P3.ASpen2004/Lerum/SwedenNorovirus Hu/GI.3/JKPG_883/SWE/2007 NorovirusHu/GI.3/P4.ASpen2004/Lerum/Sweden Norovirus NorovirusHu/GI.3/P5.ASpen2004/Lerum/Sweden Hu/GI.3/P1.ASpen2004/Lerum/SwedenNorovirus Hu/GI.3/P7.ASpen2004/Lerum/Sweden Norovirus NorovirusHu/GI.3/P8.ASpen2004/Lerum/Sweden Hu/GI.3/P10.ASpen2004/Lerum/SwedenNorovirus Hu/GI.3/P9.ASpen2004/Lerum/Sweden NorovirusHu/GI.3/P12.ASpen2004/Lerum/Sweden Hu/GI.3/P11.ASpen2004/Lerum/SwedenNorovirus Hu/GI.3/P13.ASpen2004/Lerum/Sweden Norovirus Norovirusgenogroup GI.4 Norovirus Env/GGI.4/678/2006/IT NorovirusHu/GI-4/E-1/2005/UK Norovirus Hu/GG1-4/Berlin/91568.04-6- NorovirusHu/GI-4/Inba/061217/2006/JP BA3/2004/DE Norovirus Hu/GI.4/1643/2008/USNorovirus Hu/GG1-4/Berlin/92617.04-3- Norovirus Hu/GI.4/pa-nov/2009/FINBA2/2004/DE Norovirus oyster A clone 1/GGI.2/2006/NLD NorovirusHu/GG1-4/Berlin/92672.04-4- Norovirus raspberries/GI.4/be-nov/2009/FINBA2/2004/DE Norovirus sewage/GI.4/Toyama/SW0702- NorovirusHu/GG1-4/Berlin/92674.04-5- 1/2007/JP BA2/2004/DE NorovirusHu/GI-4/612058-1/2006/UK Norovirus Hu/GI-4/612057-1/2006/UK NorovirusHu/GI-4/714124-1/2007/UK Norovirus genogroup GI.5 Norovirusenv/GGI.5/1120/2007/ITA Norovirus env/GGI.5/1160/2007/ITA Norovirusenv/GGI.5/1130/2007/ITA Norovirus Hu/GI-5/Newquay-1/2008/UK Norovirusenv/GGI.5/1132/2007/ITA Norovirus Norovirus env/GGI.5/1136/2007/ITAHu/GI.5/Cuernavaca/7253/2007/MEX Norovirus genogroup GI.6 NorovirusHu/GI-6/Q-1/2007/US Norovirus genogroup GI.7 NorovirusHu/GI.7/4349a/2008/ZAF Norovirus sewage/GI.7/Toyama/SW0703- Norovirussewage/GI.7/Toyama/SW0702- 10/2007/JP 11/2007/JP Norovirus genogroupGI.8 Norovirus Hu/GI-8/C6-48/South Korea NorovirusHu/GI.8/Cuernavaca/7162/2007/MEX Norovirus Hu/GI-8/C6-49/South KoreaNorovirus Hu/GI.8/Cuernavaca/7172/2007/MEX Norovirus Hu/GI-8/C6-52/SouthKorea Norovirus Hu/GI.8/Guadalajara/50061/2007/MEX NorovirusHu/GI-8/C6-53/South Korea Norovirus Norovirus Hu/GI-8/C7-157/South KoreaHu/GI.8/Guadalajara/50074v2/2008/MEX Norovirus Hu/GI-8/C7-163/SouthKorea Norovirus Hu/GI.8/Guadalajara/50081/2007/MEX NorovirusHu/GI-8/Kimitsu/060754/2006/JP Norovirus Hu/GI.8/HME-394/2005/TWNNorovirus Hu/GI.8/2008890321/2008/US Norovirus Hu/GI.8/HME-401/2005/TWNNorovirus Norovirus Hu/GI.8/HME-406/2005/TWNHu/GI.8/Cuernavaca/50416/2007/MEX Norovirus Hu/GI.8/HME-407/2005/TWNNorovirus Norovirus Hu/GI.8/HME-419/2005/TWNHu/GI.8/Cuernavaca/7125/2007/MEX Norovirus Hu/GI.8/HME-462/2005/TWNNorovirus Norovirus Hu/GI.8/HME-468/2005/TWNHu/GI.8/Cuernavaca/7145/2007/MEX NorovirusHu/GI.8/Cuernavaca/7158/2007/MEX Southampton virus Norovirus genogroup 2Lordsdale virus Norovirus Hu/GII/Farsund/2681/2002/NOR Norovirusgenogroup GII unidentified Norovirus Hu/GII/FH-A/2004/South Koreasubgroup Norovirus Hu/GII/flag1/nursing Human calcivirushome/Flagstaff/USA/2004 NV/GII/Bollnas/IV6650/2003/SE Norovirus Humancalcivirus Hu/GII/GI.3/P6.ASpen2004/Lerum/SwedenNV/GII/Falkoping/IV6744/2002/SE Norovirus Hu/GII/Goulburn Valley G5175Human calcivirus A/1983/AUS NV/GII/Karlstad/IV12375/2002/SE NorovirusHu/GII/Goulburn Valley G5175 Human calcivirus B/1983/AUSNV/GII/Lidkoping/IV6546/2003/SE Norovirus Hu/GII/Goulburn Valley G5175Human calcivirus C/1983/AUS NV/GII/Mariestad/IV12677/2002/SE NorovirusHu/GII/GpB/2004/Irl Human calcivirus Norovirus Hu/GII/GpC/2004/IrlNV/GII/Motala/IV3248/2002/SE Norovirus Hu/GII/GpD/2004/Irl Humancalcivirus Norovirus Hu/GII/GpE/2003/4/IrlNV/GII/Norrtalje/IV12537/2002/SE Norovirus Hu/GII/GpF/2004/Irl Humancalcivirus Norovirus Hu/GII/GpG/2004/Irl NV/GII/Norrtalje/IV1382/2003/SENorovirus Hu/GII/GpH/2003/4/Irl Human calcivirus NorovirusHu/GII/GPH56/1999/Botswana NV/GII/Norrtalje/IV1760/2002/SE NorovirusHu/GII/GpI/2004/Irl Human calcivirus Norovirus Hu/GII/GpJ/2004/IrlNV/GII/Norrtalje/IV2839/2002/SE Norovirus Hu/GII/GpK/2004/Irl Humancalcivirus Norovirus Hu/GII/GpL/2004/Irl NV/GII/Skovde/IV12503/2002/SENorovirus Hu/GII/GpM/2004/Irl Human calcivirus NorovirusHu/GII/Guadalajara/TDII1 NV/GII/Skovde/IV6547/2003/SE NorovirusHu/GII/GuRII/Caracas/2007/VEN Human calcivirus NorovirusHu/GII/GuRX/Caracas/2008/VEN NV/GII/Stockholm/IV1018/2001/SE NorovirusHu/GII/GuRXI/Caracas/2008/VEN Human calcivirus NorovirusHu/GII/GuRXII/Caracas/2008/VEN NV/GII/Stockholm/IV1124/2003/SE NorovirusHu/GII/GuRXIII/Caracas/2008/VEN Human calcivirus NorovirusHu/GII/GuRXIV/Caracas/2008/VEN NV/GII/Stockholm/IV11320/2002/SENorovirus Hu/GII/GuRXV/Caracas/2008/VEN Human calcivirus NorovirusHu/GII/GuRXVI/Caracas/2008/VEN NV/GII/Stockholm/IV1138/2003/SE NorovirusHu/GII/GuRXVII/Caracas/2008/VEN Human calcivirus NorovirusHu/GII/GuRXVIII/Caracas/2008/VEN NV/GII/Stockholm/IV1142/2003/SENorovirus Hu/GII/GZ-1/2008/CHN Human calcivirus NorovirusHu/GII/GZ-2/2008/CHN NV/GII/Stockholm/IV1163/2003/SE NorovirusHu/GII/GZ-3/2008/CHN Human calcivirus NorovirusHu/GII/Hamburg/1614/2006/Ger NV/GII/Stockholm/IV1167/2003/SE NorovirusHu/GII/Hamburg/21407/2006/Ger Human calcivirus NorovirusHu/GII/Hamburg/2241/2006/Ger NV/GII/Stockholm/IV11835/2002/SE NorovirusHu/GII/Hiroshima/2005/JP Human calcivirus NorovirusHu/GII/Hiroshima/33-2/03/JP NV/GII/Stockholm/IV12197/2002/SE NorovirusHu/GII/Hiroshima/39-6/03/JP Human calcivirus NorovirusHu/GII/Hiroshima/54-3/04/JP NV/GII/Stockholm/IV1229/2003/SE NorovirusHu/GII/Hiroshima/571-1/05/JP Human calcivirus NorovirusHu/GII/HK/CU041206/2004/CHN NV/GII/Stockholm/IV1259/2001/SE NorovirusHu/GII/HK/CU041213/2004/CHN Human calcivirus NorovirusHu/GII/HK/CU041220/2004/CHN NV/GII/Stockholm/IV12699/2002/SE NorovirusHu/GII/HK/CU041222/2004/CHN Human calcivirus NorovirusHu/GII/HK/CU041225/2004/CHN NV/GII/Stockholm/IV1273/2003/SE NorovirusHu/GII/HK/CU041245/2004/CHN Human calcivirus NorovirusHu/GII/HK/CU041247/2004/CHN NV/GII/Stockholm/IV13229/2002/SE NorovirusHu/GII/HK/CU050106/2005/CHN Human calcivirus NorovirusHu/GII/HK/CU050111/2005/CHN NV/GII/Stockholm/IV1342/2003/SE NorovirusHu/GII/HK/CU050113/2005/CHN Human calcivirus NorovirusHu/GII/HK/CU050118/2005/CHN NV/GII/Stockholm/IV1464/2001/SE NorovirusHu/GII/HK/CU050119/2005/CHN Human calcivirus NorovirusHu/GII/HK/CU050128/2005/CHN NV/GII/Stockholm/IV1472/2002/SE NorovirusHu/GII/HK/CU050130/2005/CHN Human calcivirus NorovirusHu/GII/HK/CU050135/2005/CHN NV/GII/Stockholm/IV1513/2002/SE NorovirusHu/GII/HK/CU050136/2005/CHN Human calcivirus NorovirusHu/GII/HK/CU050140/2005/CHN NV/GII/Stockholm/IV1526/2001/SE NorovirusHu/GII/HK/CU050141/2005/CHN Human calcivirus NorovirusHu/GII/HK/CU050149/2005/CHN NV/GII/Stockholm/IV1678/2002/SE NorovirusHu/GII/HK/CU050152/2005/CHN Human calcivirus NorovirusHu/GII/HK/CU050211/2005/CHN NV/GII/Stockholm/IV1759/2002/SE NorovirusHu/GII/HK/CU050214/2005/CHN Human calcivirus NorovirusHu/GII/HK/CU050217/2005/CHN NV/GII/Stockholm/IV1772/2001/SE NorovirusHu/GII/HK/CU050227/2005/CHN Human calcivirus NorovirusHu/GII/HK/CU050240/2005/CHN NV/GII/Stockholm/IV1813/2002/SE NorovirusHu/GII/HK/CU050403/2005/CHN Human calcivirus NorovirusHu/GII/HK/CU050431/2005/CHN NV/GII/Stockholm/IV2045/2001/SE NorovirusHu/GII/HK/CU050476/2005/CHN Human calcivirus NorovirusHu/GII/HK/CU050852/2005/CHN NV/GII/Stockholm/IV2168/2001/SE NorovirusHu/GII/HK/CU051013/2005/CHN Human calcivirus NorovirusHu/GII/HK/CU051039/2005/CHN NV/GII/Stockholm/IV2180/2001/SE NorovirusHu/GII/HK/CU051120/2005/CHN Human calcivirus NorovirusHu/GII/HK/CU051139/2005/CHN NV/GII/Stockholm/IV2182/2001/SE NorovirusHu/GII/HK/CU051146/2005/CHN Human calcivirus NorovirusHu/GII/HK/CU051149/2005/CHN NV/GII/Stockholm/IV2546/2001/SE NorovirusHu/GII/HK/CU051155/2005/CHN Human calcivirus NorovirusHu/GII/Hokkaido/2004/JP NV/GII/Stockholm/IV2682/2001/SE NorovirusHu/GII/Hokushin/03/JP Human calcivirus Norovirus Hu/GII/HS66/2001/USNV/GII/Stockholm/IV2763/2002/SE Norovirus Hu/GII/I1/JPN Human calcivirusNorovirus Hu/GII/I13/JPN NV/GII/Stockholm/IV2765/2002/SE NorovirusHu/GII/I14/JPN Human calcivirus Norovirus Hu/GII/I7/JPNNV/GII/Stockholm/IV2859/2001/SE Norovirus Hu/GII/IAl-C104/2004/BRA Humancalcivirus Norovirus Hu/GII/IAL-C112/2004/BRANV/GII/Stockholm/IV2863/2001/SE Norovirus Hu/GII/IAl-C152/2005/BRA Humancalcivirus Norovirus Hu/GII/IAL-C16/1995/BRANV/GII/Stockholm/IV2873/2002/SE Norovirus Hu/GII/IAl-C174/2005/BRA Humancalcivirus Norovirus Hu/GII/IAl-C176/2005/BRANV/GII/Stockholm/IV2877/2002/SE Norovirus Hu/GII/IAl-C178/2005/BRA Humancalcivirus Norovirus Hu/GII/IAl-C19/1995/BRANV/GII/Stockholm/IV2919/2001/SE Norovirus Hu/GII/IAl-C21/1995/BRA Humancalcivirus Norovirus Hu/GII/IAl-C22/1995/BRANV/GII/Stockholm/IV2925/2001/SE Norovirus Hu/GII/IAl-C65/1995/BRA Humancalcivirus Norovirus Hu/GII/IAl-C70/1995/BRANV/GII/Stockholm/IV3307/2001/SE Norovirus Hu/GII/ICB1200/1996/BrazilHuman calcivirus Norovirus Hu/GII/ICB1207/1996/BrazilNV/GII/Stockholm/IV3355/2002/SE Norovirus Hu/GII/ICB1208/1996/BrazilHuman calcivirus Norovirus Hu/GII/ICB1235/1996/BrazilNV/GII/Stockholm/IV3400/2002/SE Norovirus Hu/GII/ICB1241/1996/BrazilHuman calcivirus Norovirus Hu/GII/ICB1242C1/1996/BrazilNV/GII/Stockholm/IV3480/2002/SE Norovirus Hu/GII/ICB1244/1996/BrazilHuman calcivirus Norovirus Hu/GII/ICB1248/1996/BrazilNV/GII/Stockholm/IV3514/2002/SE Norovirus Hu/GII/ICB1257/1996/BrazilHuman calcivirus Norovirus Hu/GII/ICB1258/1996/BrazilNV/GII/Stockholm/IV3602/2001/SE Norovirus Hu/GII/ICB1261/1996/BrazilHuman calcivirus Norovirus Hu/GII/ICB1262/1996/BrazilNV/GII/Stockholm/IV3626/2001/SE Norovirus Hu/GII/ICB1263/1996/BrazilHuman calcivirus Norovirus Hu/GII/ICB1346C1/1996/BrazilNV/GII/Stockholm/IV3728/2001/SE Norovirus Hu/GII/ICB1429/1996/BrazilHuman calcivirus Norovirus Hu/GII/ICB1430/1996/BrazilNV/GII/Stockholm/IV3837/2001/SE Norovirus Hu/GII/ICB1431/1996/BrazilHuman calcivirus Norovirus Hu/GII/ICB1432/1996/BrazilNV/GII/Stockholm/IV3882/2001/SE Norovirus Hu/GII/ICB1434/1996/BrazilHuman calcivirus Norovirus Hu/GII/ICB1435/1996/BrazilNV/GII/Stockholm/IV3911/2001/SE Norovirus Hu/GII/ICB1436C1/1996/BrazilHuman calcivirus Norovirus Hu/GII/ICB1441/1996/BrazilNV/GII/Stockholm/IV4348/2001/SE Norovirus Hu/GII/ICB1443/1996/BrazilHuman calcivirus Norovirus Hu/GII/ICB1444/1996/BrazilNV/GII/Stockholm/IV4724/2001/SE Norovirus Hu/GII/ICB1445/1996/BrazilHuman calcivirus Norovirus Hu/GII/ICB1450/1996/BrazilNV/GII/Stockholm/IV478/2001/SE Norovirus Hu/GII/ICB1454/1996/BrazilHuman calcivirus Norovirus Hu/GII/ICB1456/1996/BrazilNV/GII/Stockholm/IV4884/2001/SE Norovirus Hu/GII/ICB1467/1996/BrazilHuman calcivirus Norovirus Hu/GII/ICB1521/1996/BrazilNV/GII/Stockholm/IV4902/2001/SE Norovirus Hu/GII/ICB1529/1996/BrazilHuman calcivirus Norovirus Hu/GII/ICB1530/1996/BrazilNV/GII/Stockholm/IV5350/2001/SE Norovirus Hu/GII/ICB1912/1996/BrazilHuman calcivirus Norovirus Hu/GII/ICB1913/1996/BrazilNV/GII/Stockholm/IV5366/2001/SE Norovirus Hu/GII/ICB1915/1996/BrazilHuman calcivirus Norovirus Hu/GII/ICB1925/1997/BrazilNV/GII/Stockholm/IV6189/2002/SE Norovirus Hu/GII/ICB1928/1997/BrazilHuman calcivirus Norovirus Hu/GII/ICB1929/1997/BrazilNV/GII/Stockholm/IV620/2001/SE Norovirus Hu/GII/ICB1932/1997/BrazilHuman calcivirus Norovirus Hu/GII/ICB1963/1997/BrazilNV/GII/Stockholm/IV6211/2002/SE Norovirus Hu/GII/ICB1969C1/1997/BrazilHuman calcivirus Norovirus Hu/GII/ICB1977/1997/BrazilNV/GII/Stockholm/IV6253/2003/SE Norovirus Hu/GII/ICB1983/1997/BrazilHuman calcivirus Norovirus Hu/GII/ICB1987C1/1997/BrazilNV/GII/Stockholm/IV6271/2002/SE Norovirus Hu/GII/ICB1987C2/1997/BrazilHuman calcivirus Norovirus Hu/GII/ICB1988/1997/BrazilNV/GII/Stockholm/IV6285/2002/SE Norovirus Hu/GII/ICB2109/1997/BrazilHuman calcivirus Norovirus Hu/GII/ICB2160/1997/BrazilNV/GII/Stockholm/IV6312/2003/SE Norovirus Hu/GII/ICB2162/1998/BrazilHuman calcivirus Norovirus Hu/GII/ICB2230/1998/BrazilNV/GII/Stockholm/IV6515/2002/SE Norovirus Hu/GII/ICB2482/1998/BrazilHuman calcivirus Norovirus Hu/GII/ICB2617/1999/BrazilNV/GII/Stockholm/IV6819/2003/SE Norovirus Hu/GII/ICB2620/1999/BrazilHuman calcivirus Norovirus Hu/GII/ICB2670/1999/BrazilNV/GII/Stockholm/IV6970/2003/SE Norovirus Hu/GII/ICB2784/1999/BrazilHuman calcivirus Norovirus Hu/GII/ICB2785/1999/BrazilNV/GII/Stockholm/IV6984/2003/SE Norovirus Hu/GII/ICB2787/1999/BrazilHuman calcivirus Norovirus Hu/GII/ICB2791/1999/BrazilNV/GII/Stockholm/IV6989/2002/SE Norovirus Hu/GII/ICB2891/1999/BrazilHuman calcivirus Norovirus Hu/GII/Ichimiya/04/JPNV/GII/Stockholm/IV6998/2003/SE Norovirus Hu/GII/Ina/02/JP Humancalcivirus Norovirus Hu/GII/J1/JPN NV/GII/Stockholm/IV7137/2002/SENorovirus Hu/GII/J2/JPN Human calcivirus Norovirus Hu/GII/K1/JPNNV/GII/Stockholm/IV76/2002/SE Norovirus Hu/GII/K2/JPN Human calcivirusNorovirus Hu/GII/K3/JPN NV/GII/Sundsvall/IV6891/2002/SE NorovirusHu/GII/Kamo/03/JP Human calcivirus Norovirus Hu/GII/KD106/2005/IraqNV/GII/Uppsala/IV1348/2003/SE Norovirus Hu/GII/KD142/2005/Iraq Humancalcivirus Norovirus Hu/GII/KD180/2005/IraqNV/GII/Uppsala/IV6477/2003/SE Norovirus Hu/GII/KD203/2005/Iraq Humancalicivirus HU/NLV/Bham132/95/UK Norovirus Hu/GII/KD22/2005/Iraq Humancalicivirus HU/NLV/Borna 185/00/DE Norovirus Hu/GII/KD244/2005/IraqHuman calicivirus Hu/NLV/GII/MD101- Norovirus Hu/GII/KD77/2005/Iraq2/1987/US Norovirus Hu/GII/KE/200307-1/2007/SGP Human calicivirusHu/NLV/GII/MD134- Norovirus Hu/GII/KE/200307-2/2007/SGP 10/1987/USNorovirus Hu/GII/KE/230107/2007/SGP Human calicivirus Hu/NLV/GII/MD134-Norovirus Hu/GII/KE/230207-1/2007/SGP 7/1987/US NorovirusHu/GII/KE/230207-2/2007/SGP Human calicivirus Hu/NLV/GII/MD145-Norovirus Hu/GII/KE/240407-1/2007/SGP 12/1987/US NorovirusHu/GII/KE/240407-2/2007/SGP Human calicivirus Hu/NLV/Hillingdon/90/UKNorovirus Hu/GII/KE/270607-1/2007/SGP Human calicivirusHu/NLV/Leeds/90/UK Norovirus Hu/GII/KE/270607-2/2007/SGP Humancalicivirus Hu/NLV/Parkroyal/95/UK Norovirus Hu/GII/KE/270607-3/2007/SGPHuman calicivirus Hu/NLV/Seacroft/90/UK NorovirusHu/GII/KE/290507-1/2007/SGP Human calicivirus Hu/NLV/Symgreen/95/UKNorovirus Hu/GII/KE/290507-2/2007/SGP Human calicivirusNLV/Aichi/124-89/JP Norovirus Hu/GII/KE/290507-3/2007/SGP Humancalicivirus NLV/Aichi/12A-94/JP Norovirus Hu/GII/KE/290507-4/2007/SGPHuman calicivirus NLV/Aichi/12B-94/JP NorovirusHu/GII/Kongsvinger/1793/2005/NOR Human calicivirus NLV/Aichi/12C-94/JPNorovirus Hu/GII/Kristiansand/1299/2001/NOR Human calicivirusNLV/Aichi/12D-94/JP Norovirus Hu/GII/KS/200307-1/2007/SGP Humancalicivirus NLV/Aichi/12E-94/JP Norovirus Hu/GII/KS/200307-2/2007/SGPHuman calicivirus NLV/Aichi/13A-95/JP NorovirusHu/GII/KS/200307-3/2007/SGP Human calicivirus NLV/Aichi/15A-96/JPNorovirus Hu/GII/KS/230107/2007/SGP Human calicivirusNLV/Aichi/16A-96/JP Norovirus Hu/GII/KS/230207-1/2007/SGP Humancalicivirus NLV/Aichi/4A-88/JP Norovirus Hu/GII/KS/230207-2/2007/SGPHuman calicivirus NLV/Aichi/8A-90/JP Norovirus Hu/GII/KS/240407/2007/SGPHuman calicivirus NLV/Beeskow/124/00/DE NorovirusHu/GII/KS/270607-1/2007/SGP Human calicivirus NLV/Berlin/491/00/DENorovirus Hu/GII/KS/270607-2/2007/SGP Human calicivirusNLV/Berlin/495/00/DE Norovirus Hu/GII/KS/270607-3/2007/SGP Humancalicivirus Norovirus Hu/GII/KS/290507-1/2007/SGPNLV/Chesterfield/434/1997/US Norovirus Hu/GII/KS/290507-2/2007/SGP Humancalicivirus NLV/DIJON171/96 Norovirus Hu/GII/KS/290507-3/2007/SGP Humancalicivirus NLV/Erfurt/007/00/DE Norovirus Hu/GII/KS/290507-4/2007/SGPHuman calicivirus NLV/Erfurt/546/00/DE NorovirusHu/GII/KSDA52/2006/Botswana Human calicivirus NorovirusHu/GII/KSDA63/2006/Botswana NLV/Frankfurt(Oder)/170/99/DE NorovirusHu/GII/KSDA74/2006/Botswana Human calicivirus NLV/Idaho NorovirusHu/GII/L1a/JPN Falls/378/1996/US Norovirus Hu/GII/L1b/JPN Humancalicivirus Norovirus Hu/GII/L3/JPN NLV/Koenigswusterhausen/130/00/DENorovirus Hu/GII/L4/JPN Human calicivirus NorovirusHu/GII/Leverkusen267/2005/DE NLV/Ludwigslust/218/99/DE NorovirusHu/GII/Luckenwalde591/2002/DE Human calicivirus NorovirusHu/GII/Maizuru/7714/2007/JPN NLV/Ludwigslust/221/99/DE NorovirusHu/GII/Maizuru/7718/2007/JPN Human calicivirus NorovirusHu/GII/Maizuru/7719/2007/JPN NLV/Oberschleissheim/112/99/DE NorovirusHu/GII/Maizuru/7723/2007/JPN Human calicivirus NLV/Pirna/110/00/DENorovirus Hu/GII/Maizuru/7724/2007/JPN Human calicivirus NorovirusHu/GII/Maizuru/7725/2007/JPN NLV/Wyoming/US/genogroup 2 NorovirusHu/GII/Maizuru/7727/2007/JPN Human calicivirus NV/Berlin029/02/DENorovirus Hu/GII/Maizuru/7731/2007/JPN Human calicivirusNV/Berlin040/02/DE Norovirus Hu/GII/Maizuru/7732/2007/JPN Humancalicivirus NV/Berlin131/01/DE Norovirus Hu/GII/Maizuru/7734/2007/JPNHuman calicivirus NV/Berlin159/01/DE NorovirusHu/GII/Maizuru/7744/2007/JPN Human calicivirus NV/Berlin245/01/DENorovirus Hu/GII/Maizuru/7748/2007/JPN Human calicivirusNV/Berlin264/01/DE Norovirus Hu/GII/Maizuru/7749/2007/JPN Humancalicivirus NV/Berlin376/01/DE Norovirus Hu/GII/Maizuru/7752/2007/JPNHuman calicivirus NV/Berlin428/01/DE NorovirusHu/GII/Maizuru/7755/2007/JPN Human calicivirus NV/Berlin642/01/DENorovirus Hu/GII/Maizuru/7759/2007/JPN Human calicivirusNV/Berlin750/01/DE Norovirus Hu/GII/Maizuru/7760/2007/JPN Humancalicivirus Norovirus Hu/GII/Maizuru/7761/2007/JPNNV/GII/Avesta/1817/2002/SE Norovirus Hu/GII/Maizuru/7764/2007/JPN Humancalicivirus NV/GII/Bollnas/1999/SE NorovirusHu/GII/Maizuru/7768/2007/JPN Human calicivirus NorovirusHu/GII/Maizuru/7770/2007/JPN NV/GII/Boras/0016/1998/SE NorovirusHu/GII/Marina58/2003/Botswana Human calicivirus NorovirusHu/GII/Melbourne/1998-06/AU NV/GII/Boras/0082/2003/SE NorovirusHu/GII/Melbourne/1998-07/AU Human calicivirus NorovirusHu/GII/Melbourne/1998-21/AU NV/GII/Boras/2076/2000/SE NorovirusHu/GII/Melbourne/1999-13/AU Human calicivirus NorovirusHu/GII/Melbourne/1999-14/AU NV/GII/Falun/0019/1998/SE NorovirusHu/GII/Melbourne/1999-15/AU Human calicivirus NorovirusHu/GII/Melbourne/1999-18/AU NV/GII/Falun/0036/2002/SE NorovirusHu/GII/Melbourne/2000-02/AU Human calicivirus NV/GII/Goteborg/1998/SENorovirus Hu/GII/Melbourne/2000-08/AU Human calicivirus NorovirusHu/GII/Melbourne/2000-10/AU NV/GII/Hudiksvall/0330/2000/SE NorovirusHu/GII/Melbourne/2000-12/AU Human calicivirus NorovirusHu/GII/Melbourne/2000-13/AU NV/GII/Jonkoping/0026/2002/SE NorovirusHu/GII/Melbourne/2001-01/AU Human calicivirus NorovirusHu/GII/Melbourne/2001-13/AU NV/GII/Kalmar/0220/1998/SE NorovirusHu/GII/Melbourne/2001-25/AU Human calicivirus NorovirusHu/GII/Melbourne/2002-33/AU NV/GII/Kristianstad/0553/2000/SE NorovirusHu/GII/Miyagi/03093/03/JP Human calicivirus NorovirusHu/GII/Miyagi/03219/03/JP NV/GII/Kristinehamn/0938/2001/SE NorovirusHu/GII/Miyagi/03375/03/JP Human calicivirus NorovirusHu/GII/Moscow/10514/2006/RUS NV/GII/Landskrona/0228/1998/SE NorovirusHu/GII/Moscow/10516/2006/RUS Human calicivirus NorovirusHu/GII/Moscow/10525/2006/RUS NV/GII/Linkoping/0227/1997/SE NorovirusHu/GII/Moscow/10526/2006/RUS Human calicivirus NorovirusHu/GII/Moscow/10539/2006/RUS NV/GII/Linkoping/0538/2000/SE NorovirusHu/GII/Moscow/10540/2006/RUS Human calicivirus NorovirusHu/GII/Moscow/10541/2006/RUS NV/GII/Linkoping/1020/1998/SE NorovirusHu/GII/Moscow/10555/2006/RUS Human calicivirus NorovirusHu/GII/Moscow/10557/2006/RUS NV/GII/Linkoping/1999/0440/SE NorovirusHu/GII/Moscow/10579/2006/RUS Human calicivirus NorovirusHu/GII/Moscow/10581/2006/RUS NV/GII/Ljusdal/1251/1997/SE NorovirusHu/GII/Moscow/10586/2006/RUS Human calicivirus NorovirusHu/GII/Moscow/10588/2006/RUS NV/GII/Ludvika/1001/2002/SE NorovirusHu/GII/Moscow/10598/2006/RUS Human calicivirus NorovirusHu/GII/Moscow/10652/2006/RUS NV/GII/Malmo/0144/2000/SE NorovirusHu/GII/Moscow/10654/2006/RUS Human calicivirus NorovirusHu/GII/Moscow/10664/2006/RUS NV/GII/Malmo/1229/1999/SE NorovirusHu/GII/Moscow/6395/2005/RUS Human calicivirus NorovirusHu/GII/Moscow/7844/2005/RUS NV/GII/Malmo/4708/2002/SE NorovirusHu/GII/Moscow/7971/2005/RUS Human calicivirus NorovirusHu/GII/Moscow/8558/2005/RUS NV/GII/Malmo/5092/2002/SE NorovirusHu/GII/Moscow/9062/2006/RUS Human calicivirus NorovirusHu/GII/Moscow/9088/2006/RUS NV/GII/Molndal/1651/1997/SE NorovirusHu/GII/Moscow/9156/2006/RUS Human calicivirus NorovirusNV/GII/Mora/1692/1997/SE Hu/GII/Mussels/M10mar2004/Foto/Sweden Humancalicivirus NV/GII/Mora/1999/SE Norovirus Human calicivirusHu/GII/Mussels/M2mar2004/Foto/Sweden NV/GII/Norrkoping/0081/2002/SENorovirus Human calicivirus Hu/GII/Mussels/M5mar2004/Foto/SwedenNV/GII/Norrkoping/0575/2001/SE Norovirus Human calicivirusHu/GII/Mussels/M7mar2004/Foto/Sweden NV/GII/Ostersund/0983/1998/SENorovirus Human calicivirus Hu/GII/Mussels/M8Amar2004/Foto/SwedenNV/GII/Ostersund/142501/1999/SE Norovirus Human calicivirusHu/GII/Mussels/M8Bmar2004/Foto/Sweden NV/GII/Sandviken/1062/1997/SENorovirus Human calicivirus Hu/GII/Mussels/M9mar2004/Foto/SwedenNV/GII/Solleftea/0898/2002/SE Norovirus Hu/GII/N147/2004/Irl Humancalicivirus Norovirus Hu/GII/N162/2004/Irl NV/GII/Stockholm/0551/2001/SENorovirus Hu/GII/N176/2004/Irl Human calicivirus NorovirusHu/GII/N189/2004/Irl NV/GII/Stockholm/0686/2001/SE NorovirusHu/GII/N26/2003/Irl Human calicivirus Norovirus Hu/GII/N314/2004/IrlNV/GII/Stockholm/0736/2003/SE Norovirus Hu/GII/N36/2003/Irl Humancalicivirus Norovirus Hu/GII/N390/2004/Irl NV/GII/Stockholm/0849/1997/SENorovirus Hu/GII/N430/2004/Irl Human Calicivirus NorovirusHu/GII/N438/2004/Irl NV/GII/Stockholm/2032/1999/SE NorovirusHu/GII/N477/2004/Irl Human calicivirus Norovirus Hu/GII/N79/2004/IrlNV/GII/Stockholm/82601/1999/SE Norovirus Hu/GII/N97/2004/Irl Humancalicivirus Norovirus Hu/GII/Nagano/2004/H/JPNV/GII/Trollhattan/0847/2002/SE Norovirus Hu/GII/Nagano/2004/JP Humancalicivirus Norovirus Hu/GII/Nagasaki/2004/H/Hokkaido/JPNV/GII/Uddevalla/0032/2002/SE Norovirus Hu/GII/New Delhi/183/IND Humancalicivirus Norovirus Hu/GII/New Delhi/209/INDNV/GII/Uppsala/0979/2002/SE Norovirus Hu/GII/New Delhi/228/IND Humancalicivirus NV/GII/Vara/1582/1997/SE NorovirusHu/GII/NFL26-2VR7/03-2005/CAN Human calicivirus NorovirusHu/GII/Nijmegen-Lourdes/81021- NV/GII/Vaxjo/0157/1998/SE 26069/2008/NLDHuman calicivirus Norovirus Hu/GII/Nizhny NV/GII/Vaxjo/0394/2000/SENovgorod/7691/2005/RUS Human calicivirus strain Mc100 NorovirusHu/GII/Nizhny Human calicivirus strain Mc124 Novgorod/7692/2005/RUSHuman calicivirus strain Mc17 Norovirus Hu/GII/Nizhny Human calicivirusstrain Mc24 Novgorod/8252/2005/RUS Human calicivirus strain Mc37Norovirus Hu/GII/Nizhny Human calicivirus strain Mc52Novgorod/8261//2005RUS Human calicivirus strain Mc99 NorovirusHu/GII/NoV296/2004/CAN Human calicivirus strain Melksham NorovirusHu/GII/NoV355/2004/CAN Human calicivirus strain St1 NorovirusHu/GII/NoV64/2004/CAN Norovirus ark Norovirus Hu/GII/NoV750/2004/CANclam/GII/YanTai/ZY319/China/2008 Norovirus Hu/GII/NoV752/2004/CANNorovirus bo/GII/CE-M-06-0532/2006/CAN Norovirus Hu/GII/NoV784/2004/CANNorovirus clam/GII/Shijimi1/JPN Norovirus Hu/GII/NoV79/2004/CANNorovirus clam/GII/Shijimi10a/JPN Norovirus Hu/GII/NoV793/2004/CANNorovirus clam/GII/Shijimi10b/JPN Norovirus Hu/GII/NoV804/2004/CANNorovirus clam/GII/Shijimi10c/JPN Norovirus Hu/GII/NoV809/2004/CANNorovirus clam/GII/Shijimi13/JPN Norovirus Hu/GII/NSC042/PA/1993/BRANorovirus clam/GII/Shijimi14/JPN Norovirus Hu/GII/NSC053/PA/1993/BRANorovirus clam/GII/Shijimi15/JPN Norovirus Hu/GII/NSC076/PA/1993/BRANorovirus clam/GII/Shijimi16a/JPN Norovirus Hu/GII/NSC081/PA/1993/BRANorovirus clam/GII/Shijimi16b/JPN Norovirus Hu/GII/NSC141/PA/1993/BRANorovirus clam/GII/Shijimi16c/JPN Norovirus Hu/GII/NSC183/PA/1993/BRANorovirus clam/GII/Shijimi17a/JPN Norovirus Hu/GII/NSC185/PA/1993/BRANorovirus clam/GII/Shijimi17b/JPN Norovirus Hu/GII/NSC225/PA/1993/BRANorovirus clam/GII/Shijimi18/JPN Norovirus Hu/GII/NSC253/PA/1993/BRANorovirus clam/GII/Shijimi19/JPN Norovirus Hu/GII/NSC281/PA/1993/BRANorovirus clam/GII/Shijimi2/JPN Norovirus Hu/GII/Nsk-688/2005/RUSNorovirus clam/GII/Shijimi22/JPN Norovirus Hu/GII/Nsk-701/2005/RUSNorovirus clam/GII/Shijimi24/JPN Norovirus Hu/GII/Nsk-K14/2006/RUSNorovirus clam/GII/Shijimi25/JPN Norovirus Hu/GII/Nsk-K15/2006/RUSNorovirus clam/GII/Shijimi26/JPN Norovirus Hu/GII/Nucci/2005/CO/USNorovirus clam/GII/Shijimi27/JPN Norovirus Hu/GII/nursing home Norovirusclam/GII/Shijimi28a/JPN flag2/Flagstaff/2004/USA Norovirusclam/GII/Shijimi28b/JPN Norovirus Hu/GII/O1/JPN Norovirusclam/GII/Shijimi28c/JPN Norovirus Hu/GII/O3a/JPN Norovirusclam/GII/Shijimi28d/JPN Norovirus Hu/GII/O3b/JPN Norovirusclam/GII/Shijimi29/JPN Norovirus Hu/GII/Osaka659/2006/JPN Norovirusclam/GII/Shijimi3/JPN Norovirus Hu/GII/Oslo/1024/2000/NOR Norovirusclam/GII/Shijimi30/JPN Norovirus Hu/GII/Oslo/148/2005/NOR Norovirusclam/GII/Shijimi4a/JPN Norovirus Hu/GII/Oslo/164/2004/NOR Norovirusclam/GII/Shijimi4b/JPN Norovirus Hu/GII/Oslo/2202/2001/NOR Norovirusclam/GII/Shijimi6/JPN Norovirus Hu/GII/Oslo/352/2001/NOR Norovirusclam/GII/Shijimi7a/JPN Norovirus Hu/GII/Oslo/477/2005/NOR Norovirusclam/GII/Shijimi7b/JPN Norovirus Hu/GII/Oslo/6498/2000/NOR Norovirusclam/GII/Shijimi8a/JPN Norovirus Hu/GII/Oslo/785/2005/NOR Norovirusclam/GII/Shijimi8b/JPN Norovirus Norovirus clam/GII/Shijimi8c/JPNHu/GII/P1.Confectionary2004/Gothenburg/Sweden Norovirusclam/GII/Shijimi8d/JPN Norovirus Norovirus clam/GII/Shijimi8e/JPNHu/GII/P2.Confectionary2004/Gothenburg/Sweden Norovirusclam/GII/Shijimi9a/JPN Norovirus Hu/GII/P2/JPN Norovirusclam/GII/Shijimi9b/JPN Norovirus NorovirusHu/GII/P3.Confectionary2004/Gothenburg/Swedenclam/GII/WeiHai/SD279/China/2008 Norovirus Hu/GII/P3/JPN NorovirusCor/Gunma/Apr-1/GII/2004/JP Norovirus NorovirusCor/Gunma/Apr-2/GII/2004/JPHu/GII/P4.Confectionary2004/Gothenburg/Sweden NorovirusCor/Gunma/Aug-1/GII/2004/JP Norovirus NorovirusCor/Gunma/Aug-2/GII/2004/JPHu/GII/P5.Confectionary2004/Gothenburg/Sweden NorovirusCor/Gunma/Dec-1/GII/2004/JP Norovirus Hu/GII/P5/JPN NorovirusCor/Gunma/Dec-2/GII/2004/JP Norovirus NorovirusCor/Gunma/Dec-3/GII/2004/JPHu/GII/P6.Confectionary2004/Gothenburg/Sweden NorovirusCor/Gunma/Dec-4/GII/2004/JP Norovirus NorovirusCor/Gunma/Feb-1/GII/2004/JPHu/GII/P7.Confectionary2004/Gothenburg/Sweden NorovirusCor/Gunma/Feb-3/GII/2004/JP Norovirus Hu/GII/PC12/2006/BotswanaNorovirus Cor/Gunma/Feb-4/GII/2004/JP NorovirusHu/GII/PC23/2006/Botswana Norovirus Cor/Gunma/Feb-5/GII/2004/JPNorovirus Hu/GII/PC28/2006/Botswana NorovirusCor/Gunma/Jan-1/GII/2004/JP Norovirus Hu/GII/PC5/2006/Botswana NorovirusCor/Gunma/Jan-2/GII/2004/JP Norovirus Hu/GII/Penza/10625/2006/RUSNorovirus Cor/Gunma/Jul-1/GII/2004/JP NorovirusHu/GII/Penza/10630/2006/RUS Norovirus Cor/Gunma/Jul-2/GII/2004/JPNorovirus Hu/GII/Penza/10631/2006/RUS NorovirusCor/Gunma/Jul-3/GII/2004/JP Norovirus Hu/GII/Podolsk/10604/2006/RUSNorovirus Cor/Gunma/Jul-4/GII/2004/JP NorovirusHu/GII/Podolsk/10609/2006/RUS Norovirus Cor/Gunma/Jun-1/GII/2004/JPNorovirus Hu/GII/Podolsk/10620/2006/RUS NorovirusCor/Gunma/Jun-2/GII/2004/JP Norovirus Hu/GII/R1D-111206/2006/SGPNorovirus Cor/Gunma/Mar-2/GII/2004/JP NorovirusHu/GII/R1D-150806/2006/SGP Norovirus Cor/Gunma/May-1/GII/2004/JPNorovirus Hu/GII/R1D-201106/2006/SGP NorovirusCor/Gunma/May-2/GII/2004/JP Norovirus Hu/GII/R1D-220606/2006/SGPNorovirus Cor/Gunma/May-3/GII/2004/JP NorovirusHu/GII/R1D-271206/2006/SGP Norovirus Cor/Gunma/May-4/GII/2004/JPNorovirus Hu/GII/R1U-011106/2006/SGP NorovirusCor/Gunma/Nov-2/GII/2004/JP Norovirus Hu/GII/R1U-031006/2006/SGPNorovirus Cor/Gunma/Oct-1/GII/2004/JP NorovirusHu/GII/R1U-111206/2006/SGP Norovirus Cor/Gunma/Oct-2/GII/2004/JPNorovirus Hu/GII/R1U-150806-1/2006/SGP NorovirusCor/Gunma/Oct-3/GII/2004/JP Norovirus Hu/GII/R1U-150806-2/2006/SGPNorovirus Env/GGII/670/2006/IT Norovirus Hu/GII/R1U-201106/2006/SGPNorovirus GII/103/2005/RJ/BRA Norovirus Hu/GII/R2D-011106/2006/SGPNorovirus GII/105/2005/RJ/BRA Norovirus Hu/GII/R2D-031006/2006/SGPNorovirus GII/107/2005/RJ/BRA Norovirus Hu/GII/R2D-111206/2006/SGPNorovirus GII/58/2005/RJ/BRA Norovirus Hu/GII/R2D-150806/2006/SGPNorovirus GII/60/2005/RJ/BRA Norovirus Hu/GII/R2D-201106/2006/SGPNorovirus GII/70/2005/RJ/BRA Norovirus Hu/GII/R2D-240706-1/2006/SGPNorovirus GII/71/2005/RJ/BRA Norovirus Hu/GII/R2D-240706-2/2006/SGPNorovirus GII/Lopburi020/2006/THA Norovirus Hu/GII/R2U-011106/2006/SGPNorovirus GII/Lopburi026/2006/THA Norovirus Hu/GII/R2U-031006/2006/SGPNorovirus GII/Lopburi043/2006/THA Norovirus Hu/GII/R2U-111206-1/2006/SGPNorovirus GII/Lopburi084/2006/THA Norovirus Hu/GII/R2U-111206-2/2006/SGPNorovirus GII/Lopburi085/2006/THA Norovirus Hu/GII/R2U-111206-3/2006/SGPNorovirus GII/Lopburi095/2006/THA Norovirus Hu/GII/R2U-150806/2006/SGPNorovirus GII/Lopburi102/2006/THA Norovirus Hu/GII/R2U-201106-1/2006/SGPNorovirus GII/Lopburi103/2006/THA Norovirus Hu/GII/R2U-201106-2/2006/SGPNorovirus GII/Lopburi109/2006/THA Norovirus Hu/GII/R2U-201106-3/2006/SGPNorovirus GII/Lopburi117/2006/THA Norovirus Hu/GII/R2U-240706/2006/SGPNorovirus GII/Lopburi127/2006/THA Norovirus Hu/GII/R2U-271206/2006/SGPNorovirus GII/Lopburi146/2006/THA Norovirus Hu/GII/R3D-251006/2006/SGPNorovirus GII/Lopburi147/2006/THA Norovirus Hu/GII/R3U-200607/2007/SGPNorovirus GII/Lopburi155/2006/THA Norovirus Hu/GII/R3U-251006/2006/SGPNorovirus GII/Lopburi159/2006/THA NorovirusHu/GII/Ramotswa73/2006/Botswana Norovirus groundwater/GII/Busan/BU01-Norovirus Hu/GII/Ramotswa92/2006/Botswana 04/2008/KOR NorovirusHu/GII/Rjukan/5577/2002/NOR Norovirus groundwater/GII/Busan/BU01-Norovirus Hu/GII/S10/JPN 08/2008/KOR Norovirus Hu/GII/S11/JPN Norovirusgroundwater/GII/Changwon/BU01- Norovirus Hu/GII/S12a/JPN 38/2008/KORNorovirus Hu/GII/S12b/JPN Norovirus groundwater/GII/Cheorwon/KA01-Norovirus Hu/GII/S2/JPN 19/2008/KOR Norovirus Hu/GII/S3/JPN Norovirusgroundwater/GII/Geochang/BU01- Norovirus Hu/GII/S4/JPN 42/2008/KORNorovirus Hu/GII/S5/JPN Norovirus groundwater/GII/Goseong/KA01-Norovirus Hu/GII/S8/JPN 28/2008/KOR Norovirus Hu/GII/S9/JPN Norovirusgroundwater/GII/Gyeongju/BU01- Norovirus Hu/GII/Salvador/B02/2006/BRA30/2008/KOR Norovirus Hu/GII/Salvador/B07/2006/BRA Norovirusgroundwater/GII/Gyeongsan/BU01- Norovirus Hu/GII/Salvador/D07/2006/BRA12/2008/KOR Norovirus Hu/GII/Salvador/E04/2006/BRA Norovirusgroundwater/GII/Hapcheon/BU01- Norovirus Hu/GII/Salvador/F02/2006/BRA45/2008/KOR Norovirus Hu/GII/Salvador/F05/2006/BRA Norovirusgroundwater/GII/JI-a-1/2007/KOR Norovirus Hu/GII/Seoul0006/2007/KRNorovirus groundwater/GII/JI-a/2007/KOR NorovirusHu/GII/Seoul0009/2007/KR Norovirus groundwater/GII/Pohang/BU01-Norovirus Hu/GII/Seoul0012/2007/KR 21/2008/KOR NorovirusHu/GII/Seoul0022/2007/KR Norovirus groundwater/GII/Uiryeong/BU01-Norovirus Hu/GII/Seoul0031/2007/KR 15/2008/KOR NorovirusHu/GII/Seoul0032/2007/KR Norovirus groundwater/GII/Uiryeong/BU01-Norovirus Hu/GII/Seoul0033/2007/KR 16/2008/KOR NorovirusHu/GII/Seoul0034/2007/KR Norovirus groundwater/GII/Uljin/BU01- NorovirusHu/GII/Seoul0037/2007/KR 23/2008/KOR Norovirus Hu/GII/Seoul0038/2007/KRNorovirus groundwater/GII/Ulju/BU01- Norovirus Hu/GII/Seoul0042/2007/KR34/2008/KOR Norovirus Hu/GII/Seoul0044/2007/KR Norovirus NorovirusHu/GII/Seoul0046/2007/KR groundwater/GII/Yeongcheon/BU01- NorovirusHu/GII/Seoul0048/2007/KR 19/2008/KOR Norovirus Hu/GII/Seoul0049/2007/KRNorovirus Norovirus Hu/GII/Seoul0052/2007/KRgroundwater/GII/Yeongcheon/BU01- Norovirus Hu/GII/Seoul0055/2007/KR20/2008/KOR Norovirus Hu/GII/Seoul0056/2007/KR Norovirus Han NorovirusHu/GII/Seoul0058/2008/KR River/GII/Dukpoong/Apr01/2006/KOR NorovirusHu/GII/Seoul0070/2008/KR Norovirus Han NorovirusHu/GII/Seoul0071/2008/KR River/GII/Dukpoong/Apr02/2006/KOR NorovirusHu/GII/Seoul0072/2008/KR Norovirus Han NorovirusHu/GII/Seoul0073/2008/KR River/GII/Dukpoong/Apr03/2006/KOR NorovirusHu/GII/Seoul0077/2008/KR Norovirus Han NorovirusHu/GII/Seoul0079/2008/KR River/GII/Dukpoong/Aug01/2005/KOR NorovirusHu/GII/Seoul0088/2008/KR Norovirus Han NorovirusHu/GII/Seoul0089/2008/KR River/GII/Dukpoong/Aug02/2005/KOR NorovirusHu/GII/Seoul0090/2008/KR Norovirus Han NorovirusHu/GII/Seoul0125/2008/KR River/GII/Dukpoong/Aug03/2005/KOR NorovirusHu/GII/Seoul0148/2008/KR Norovirus Han NorovirusHu/GII/Seoul0150/2008/KR River/GII/Dukpoong/Aug04/2005/KOR NorovirusHu/GII/Seoul0166/2008/KR Norovirus Han NorovirusHu/GII/Seoul0184/2007/KR River/GII/Dukpoong/Aug05/2005/KOR NorovirusHu/GII/Seoul0201/2007/KR Norovirus Han NorovirusHu/GII/Seoul0203/2007/KR River/GII/Dukpoong/Jan01/2006/KOR NorovirusHu/GII/Seoul0204/2007/KR Norovirus Han NorovirusHu/GII/Seoul0208/2007/KR River/GII/Dukpoong/Jan02/2006/KOR NorovirusHu/GII/Seoul0211/2007/KR Norovirus Han NorovirusHu/GII/Seoul0212/2007/KR River/GII/Dukpoong/Jan03/2006/KOR NorovirusHu/GII/Seoul0213/2007/KR Norovirus Han NorovirusHu/GII/Seoul0214/2007/KR River/GII/Dukpoong/Jan04/2006/KOR NorovirusHu/GII/Seoul0216/2007/KR Norovirus Han NorovirusHu/GII/Seoul0219/2007/KR River/GII/Dukpoong/Mar01/2006/KOR NorovirusHu/GII/Seoul0220/2007/KR Norovirus Han NorovirusHu/GII/Seoul0222/2007/KR River/GII/Dukpoong/Mar02/2006/KOR NorovirusHu/GII/Seoul0223/2007/KR Norovirus Han NorovirusHu/GII/Seoul0224/2007/KR River/GII/Dukpoong/May01/2006/KOR NorovirusHu/GII/Seoul0225/2007/KR Norovirus Han NorovirusHu/GII/Seoul0226/2008/KR River/GII/Dukpoong/May02/2006/KOR NorovirusHu/GII/Seoul0227/2008/KR Norovirus Han NorovirusHu/GII/Seoul0231/2008/KR River/GII/Dukpoong/Oct01/2005/KOR NorovirusHu/GII/Seoul0232/2008/KR Norovirus Han NorovirusHu/GII/Seoul0235/2008/KR River/GII/Jamsil/Jan01/2006/KOR NorovirusHu/GII/Seoul0236/2008/KR Norovirus Han NorovirusHu/GII/Seoul0238/2008/KR River/GII/Jamsil/Oct01/2005/KOR NorovirusHu/GII/Seoul0239/2008/KR Norovirus Han NorovirusHu/GII/Seoul0240/2008/KR River/GII/Jamsil/Oct02/2005/KOR NorovirusHu/GII/Seoul0241/2008/KR Norovirus Han NorovirusHu/GII/Seoul0242/2008/KR River/GII/Kyoungan/Apr01/2006/KOR NorovirusHu/GII/Seoul0243/2008/KR Norovirus Han NorovirusHu/GII/Seoul0505/2007/KR River/GII/Kyoungan/Apr02/2006/KOR NorovirusHu/GII/Seoul0506/2007/KR Norovirus Han NorovirusHu/GII/Seoul0507/2007/KR River/GII/Kyoungan/Jan01/2006/KOR NorovirusHu/GII/Seoul0508/2007/KR Norovirus Han NorovirusHu/GII/Seoul0509/2007/KR River/GII/Kyoungan/Jan02/2006/KOR NorovirusHu/GII/Seoul0510/2007/KR Norovirus Han NorovirusHu/GII/Seoul0511/2007/KR River/GII/Kyoungan/Mar01/2006/KOR NorovirusHu/GII/Seoul0512/2007/KR Norovirus Han NorovirusHu/GII/Seoul0513/2007/KR River/GII/Kyoungan/May01/2006/KOR NorovirusHu/GII/Seoul0514/2007/KR Norovirus Han NorovirusHu/GII/Seoul0515/2007/KR River/GII/Kyoungan/May02/2006/KOR NorovirusHu/GII/Seoul0516/2007/KR Norovirus Han NorovirusHu/GII/Seoul0517/2007/KR River/GII/Kyoungan/May03/2006/KOR NorovirusHu/GII/Seoul0518/2007/KR Norovirus Han NorovirusHu/GII/Seoul0519/2007/KR River/GII/Kyoungan/May04/2006/KOR NorovirusHu/GII/Seoul0520/2007/KR Norovirus Han NorovirusHu/GII/Seoul0521/2007/KR River/GII/Kyoungan/Oct01/2005/KOR NorovirusHu/GII/Seoul0522/2007/KR Norovirus Han NorovirusHu/GII/Seoul0523/2007/KR River/GII/Kyoungan/Oct02/2005/KOR NorovirusHu/GII/Seoul0524/2007/KR Norovirus Han NorovirusHu/GII/Seoul0525/2007/KR River/GII/Kyoungan/Oct03/2005/KOR NorovirusHu/GII/Seoul0526/2007/KR Norovirus Han NorovirusHu/GII/Seoul0527/2007/KR River/GII/Paldang/Oct01/2005/KOR NorovirusHu/GII/Seoul0528/2007/KR Norovirus Han NorovirusHu/GII/Seoul0529/2007/KR River/GII/Paldang/Oct02/2005/KOR NorovirusHu/GII/Seoul0530/2007/KR Norovirus Han NorovirusHu/GII/Seoul0531/2007/KR River/GII/Sungnae/Apr01/2006/KOR NorovirusHu/GII/Seoul0532/2007/KR Norovirus Han NorovirusHu/GII/Seoul0533/2007/KR River/GII/Sungnae/Jan01/2006/KOR NorovirusHu/GII/Seoul0534/2007/KR Norovirus Han NorovirusHu/GII/Seoul0535/2007/KR River/GII/Sungnae/Jan02/2006/KOR NorovirusHu/GII/Seoul0536/2007/KR Norovirus Han NorovirusHu/GII/Seoul0537/2007/KR River/GII/Sungnae/Jan03/2006/KOR NorovirusHu/GII/Seoul0538/2007/KR Norovirus Han NorovirusHu/GII/Seoul0539/2007/KR River/GII/Sungnae/Mar01/2006/KOR NorovirusHu/GII/Seoul0540/2007/KR Norovirus Han NorovirusHu/GII/Seoul0541/2007/KR River/GII/Sungnae/Mar02/2006/KOR NorovirusHu/GII/Seoul0542/2007/KR Norovirus Han NorovirusHu/GII/Seoul0543/2007/KR River/GII/Sungnae/Mar03/2006/KOR NorovirusHu/GII/Seoul0544/2007/KR Norovirus Han NorovirusHu/GII/Seoul0545/2007/KR River/GII/Sungnae/May01/2006/KOR NorovirusHu/GII/Seoul0546/2007/KR Norovirus Han NorovirusHu/GII/Seoul0547/2007/KR River/GII/Sungnae/May02/2006/KOR NorovirusHu/GII/Seoul0548/2007/KR Norovirus Han NorovirusHu/GII/Seoul0549/2007/KR River/GII/Sungnae/Oct01/2005/KOR NorovirusHu/GII/Seoul0550/2007/KR Norovirus Han NorovirusHu/GII/Seoul0551/2008/KR River/GII/Wangsuk/Apr01/2006/KOR NorovirusHu/GII/Seoul0552/2007/KR Norovirus Han NorovirusHu/GII/SewCCI/Caracas/2007/VEN River/GII/Wangsuk/Apr02/2006/KORNorovirus Hu/GII/SewCI/2007/VEN Norovirus Han NorovirusHu/GII/SewCIX/Caracas/2008/VEN River/GII/Wangsuk/Apr03/2006/KORNorovirus Hu/GII/SewIvicI/Caracas/2007/VEN Norovirus Han NorovirusHu/GII/SewVill/Caracas/2007/VEN River/GII/Wangsuk/Aug01/2005/KORNorovirus Hu/GII/SH18/2005/CA Norovirus Han NorovirusHu/GII/SH19/2005/CA River/GII/Wangsuk/Aug02/2005/KOR NorovirusHu/GII/SH20/2005/CA Norovirus Han Norovirus Hu/GII/SH23/2005/CARiver/GII/Wangsuk/Jan01/2006/KOR Norovirus Hu/GII/SH24/2005/CA NorovirusHan Norovirus Hu/GII/SH25/2005/CA River/GII/Wangsuk/Jan02/2006/KORNorovirus Hu/GII/SH26/2005/CA Norovirus Han NorovirusHu/GII/SH27/2005/CA River/GII/Wangsuk/Jan03/2006/KOR NorovirusHu/GII/SH28/2005/CA Norovirus Han Norovirus Hu/GII/SH29/2005/CARiver/GII/Wangsuk/Mar01/2006/KOR Norovirus Hu/GII/SH30/2005/CA NorovirusHan Norovirus Hu/GII/SH31/2005/CA River/GII/Wangsuk/May01/2006/KORNorovirus Hu/GII/SH32/2005/CA Norovirus Han NorovirusHu/GII/Shandong/TQ24/China River/GII/Wangsuk/May02/2006/KOR NorovirusHu/GII/Shandong/TQ3/China Norovirus Han NorovirusHu/GII/Shandong/TQ33/China River/GII/Wangsuk/Oct01/2005/KOR NorovirusHu/GII/Shandong/TQ36/China Norovirus Han NorovirusHu/GII/Shandong/TQ8/China River/GII/Wangsuk/Oct02/2005/KOR NorovirusHu/GII/Shandong/TR28/China Norovirus Han NorovirusHu/GII/Shandong/TR86/China River/GII/Wangsuk/Oct03/2005/KOR NorovirusHu/GII/Shandong/TR88/China Norovirus Hu/5032/2001/Bra NorovirusHu/GII/Shandong/TR92/China Norovirus Hu/5037/2001/Bra NorovirusHu/GII/Shandong/TT138/China Norovirus Hu/5046/2001/Bra NorovirusHu/GII/Shandong/TT147/China Norovirus Hu/5049/2001/Bra NorovirusHu/GII/Shandong/TT170/China Norovirus Hu/5095/2001/Bra NorovirusHu/GII/Shandong/TT19/China Norovirus Hu/5112/2001/Bra NorovirusHu/GII/Shandong/TT197/China Norovirus Hu/5118/2001/Bra NorovirusHu/GII/Shandong/TT37/China Norovirus Hu/Billings/2006/USA NorovirusHu/GII/Shandong/TT40/China Norovirus Hu/CL-CS/2006/USA NorovirusHu/GII/Shandong/TT50/China Norovirus Hu/Cumberland/2004/USA NorovirusHu/GII/Shandong/TT62/China Norovirus Hu/Duan/Beijing/2006/ChinaNorovirus Hu/GII/Shandong/TT66/China Norovirus Hu/FL04/2004/USANorovirus Hu/GII/Shandong/TT7/China Norovirus Hu/G2/1737/2006/BRANorovirus Hu/GII/Shandong/TT89/China Norovirus Hu/G2/2762/2006/BRANorovirus Hu/GII/Shandong/TT99/China Norovirus Hu/G2/2810/2006/BRANorovirus Hu/GII/Shizuoka/2005/JP Norovirus Hu/G2/916/2006/BRA NorovirusHu/GII/Sinaloa/Mexico/M1/2007 Norovirus Hu/G2/Fin-Beng/1998/FinlandNorovirus Hu/GII/Sinaloa/Mexico/NV1/2006 NorovirusHu/G2/Fin-Hank/2003/Finland Norovirus Hu/GII/Sinaloa/Mexico/NV10/2007Norovirus Hu/G2/Fin-Jana/2002/Finland NorovirusHu/GII/Sinaloa/Mexico/NV11/2007 Norovirus Hu/G2/Fin-Keur2/1998/FinlandNorovirus Hu/GII/Sinaloa/Mexico/NV12/2007 NorovirusHu/G2/Fin-Korp/2002/Finland Norovirus Hu/GII/Sinaloa/Mexico/NV13/2007Norovirus Hu/G2/Fin-Nauv/2003/Finland NorovirusHu/GII/Sinaloa/Mexico/NV16/2007 Norovirus Hu/G2/Fin-Pyha/2000/FinlandNorovirus Hu/GII/Sinaloa/Mexico/NV17/2007 NorovirusHu/G2/Fin-Pyha2/2000/Finland Norovirus Hu/GII/Sinaloa/Mexico/NV19/2007Norovirus Hu/G2/Fin-Savi/1999/Finland NorovirusHu/GII/Sinaloa/Mexico/NV2/2007 Norovirus Hu/GA04/2004/USA NorovirusHu/GII/Sinaloa/Mexico/NV20/2006 Norovirus Hu/GCanyon/2002/USA NorovirusHu/GII/Sinaloa/Mexico/NV20/2007 Norovirus Hu/GGI/Hamburg/744/2008/DEUNorovirus Hu/GII/Sinaloa/Mexico/NV21/2007 Norovirus Hu/GGII/NewDelhi/209/01/IND Norovirus Hu/GII/Sinaloa/Mexico/NV22/2007 NorovirusHu/GGII/NL19990014/1999/NL Norovirus Hu/GII/Sinaloa/Mexico/NV23/2007Norovirus Hu/GGII/NL20000047/2000/NL NorovirusHu/GII/Sinaloa/Mexico/NV24/2007 Norovirus Hu/GII.ne/Gothenburg/2005/SWENorovirus Hu/GII/Sinaloa/Mexico/NV25/2007 Norovirus Hu/GII/1/JPNNorovirus Hu/GII/Sinaloa/Mexico/NV3/2007 Norovirus Hu/GII/10/JPNNorovirus Hu/GII/Sinaloa/Mexico/NV4/2007 Norovirus Hu/GII/10015/2004/BRANorovirus Hu/GII/Sinaloa/Mexico/NV5/2007 Norovirus Hu/GII/10070/2004/BRANorovirus Hu/GII/Sinaloa/Mexico/NV6/2007 Norovirus Hu/GII/10076/2004/BRANorovirus Hu/GII/Sinaloa/Mexico/NV9/2007 Norovirus Hu/GII/10079/2004/BRANorovirus Hu/GII/Sinsiro/97/JP Norovirus Hu/GII/101/JPN NorovirusHu/GII/SL4452/2005/Arg Norovirus Hu/GII/103/JPN NorovirusHu/GII/Sofia166/2007/BGR Norovirus Hu/GII/106/JPN NorovirusHu/GII/Sofia663/2007/BGR Norovirus Hu/GII/10B/2004/South Korea NorovirusHu/GII/St Petersburg/6296/2006/RUS Norovirus Hu/GII/11/JPN NorovirusHu/GII/St Petersburg/9092/2006/RUS Norovirus Hu/GII/110/JPN NorovirusHu/GII/St Petersburg/9102/2006/RUS Norovirus Hu/GII/111/JPN NorovirusHu/GII/Stavanger/2851/2002/NOR Norovirus Hu/GII/112/JPN NorovirusHu/GII/T4/JPN Norovirus Hu/GII/114/JPN Norovirus Hu/GII/Tahara/04/JPNorovirus Hu/GII/115/JPN Norovirus Hu/GII/TF4618/2006/Arg NorovirusHu/GII/118/JPN Norovirus Hu/GII/Tianjin/1/2008/CHN NorovirusHu/GII/11B/2004/South Korea Norovirus Hu/GII/Tianjin/510/2009/CHNNorovirus Hu/GII/12/JPN Norovirus Hu/GII/Tianjin/53/2008/CHN NorovirusHu/GII/127/JPN Norovirus Hu/GII/Toronto/SK/2002/CAN NorovirusHu/GII/131/2004/HK Norovirus Hu/GII/Toronto/SK/2005/CAN NorovirusHu/GII/1329/2006/Ghana Norovirus Hu/GII/Toyama/106/2007/JP NorovirusHu/GII/1333/2006/Ghana Norovirus Hu/GII/Toyama/108/2007/JP NorovirusHu/GII/136/JPN Norovirus Hu/GII/Toyama/114/2007/JP NorovirusHu/GII/1364/2006/Ghana Norovirus Hu/GII/Toyama/115/2007/JP NorovirusHu/GII/1367/2006/Ghana Norovirus Hu/GII/Toyama/409/2006/JP NorovirusHu/GII/1407/2006/Ghana Norovirus Hu/GII/Toyama/52/2007/JP NorovirusHu/GII/143/JPN Norovirus Hu/GII/Toyama/54/2007/JP NorovirusHu/GII/1443/2006/Ghana Norovirus Hu/GII/Toyama/55/2007/JP NorovirusHu/GII/147/JPN Norovirus Hu/GII/Toyama/56/2007/JP NorovirusHu/GII/148/JPN Norovirus Hu/GII/Toyama/58/2007/JP NorovirusHu/GII/1495/2006/Ghana Norovirus Hu/GII/Toyama/59/2007/JP NorovirusHu/GII/15/JPN Norovirus Hu/GII/Toyama/60/2007/JP NorovirusHu/GII/150/JPN Norovirus Hu/GII/Toyama/61/2007/JP NorovirusHu/GII/1517/2006/Ghana Norovirus Hu/GII/Toyama/64/2007/JP NorovirusHu/GII/153/JPN Norovirus Hu/GII/Toyama/93/2007/JP NorovirusHu/GII/1559/2006/Ghana Norovirus Hu/GII/Toyama/98/2007/JP NorovirusHu/GII/156/JPN Norovirus Hu/GII/Toyama/99/2007/JP NorovirusHu/GII/1566/2006/Ghana Norovirus Hu/GII/Tromso/4266/2003/NOR NorovirusHu/GII/161/JPN Norovirus Hu/GII/Tromso/4398/2002/NOR NorovirusHu/GII/17/JPN Norovirus Hu/GII/Tromso/4469/2003/NOR NorovirusHu/GII/173/JPN Norovirus Hu/GII/TSPC18/2006/Botswana NorovirusHu/GII/174/JPN Norovirus Hu/GII/TSPC19/2006/Botswana NorovirusHu/GII/175/JPN Norovirus Hu/GII/TSPC22/2006/Botswana NorovirusHu/GII/177/JPN Norovirus Hu/GII/TSPC29/2006/Botswana NorovirusHu/GII/195/JPN Norovirus Hu/GII/Tynset/4117/2003/NOR NorovirusHu/GII/196/JPN Norovirus Hu/GII/Tyumen/9825/2006/RUS NorovirusHu/GII/197/JPN Norovirus Hu/GII/Tyumen/9830/2006/RUS NorovirusHu/GII/1B/2004/South Korea Norovirus Hu/GII/UE/200307-1/2007/SGPNorovirus Hu/GII/2002/2064/Moscow/RUS NorovirusHu/GII/UE/200307-2/2007/SGP Norovirus Hu/GII/2002/2325/Moscow/RUSNorovirus Hu/GII/UE/200307-3/2007/SGP NorovirusHu/GII/2003/3464/Moscow/RUS Norovirus Hu/GII/UE/230107-1/2007/SGPNorovirus Hu/GII/2003/3601/Moscow/RUS NorovirusHu/GII/UE/230107-2/2007/SGP Norovirus Hu/GII/2005/5844/Moscow/RUSNorovirus Hu/GII/UE/230207-1/2007/SGP Norovirus NorovirusHu/GII/UE/230207-2/2007/SGP Hu/GII/2005/6082/Chelyabinsk/RUS NorovirusHu/GII/UE/230207-3/2007/SGP Norovirus Hu/GII/2005/6297/St. NorovirusHu/GII/UE/240407-1/2007/SGP Petersburg/RUS NorovirusHu/GII/UE/240407-2/2007/SGP Norovirus Hu/GII/2005/6300/St. NorovirusHu/GII/UE/270607-1/2007/SGP Petersburg/RUS NorovirusHu/GII/UE/270607-2/2007/SGP Norovirus Hu/GII/2005/6315/St. NorovirusHu/GII/UE/270607-3/2007/SGP Petersburg/RUS NorovirusHu/GII/UE/290507-1/2007/SGP Norovirus Hu/GII/2005/6316/St. NorovirusHu/GII/UE/290507-2/2007/SGP Petersburg/RUS NorovirusHu/GII/UE/290507-3/2007/SGP Norovirus Hu/GII/2005/6336/Moscow/RUSNorovirus Hu/GII/US/200307-1/2007/SGP NorovirusHu/GII/2005/6373/Moscow/RUS Norovirus Hu/GII/US/200307-2/2007/SGPNorovirus Hu/GII/2005/6442/Nizhny Norovirus Hu/GII/US/200307-3/2007/SGPNovgorod/RUS Norovirus Hu/GII/US/230107-1/2007/SGP NorovirusHu/GII/2005/6451/Nizhny Norovirus Hu/GII/US/230107-2/2007/SGPNovgorod/RUS Norovirus Hu/GII/US/230207-1/2007/SGP NorovirusHu/GII/2005/6455/Nizhny Norovirus Hu/GII/US/230207-2/2007/SGPNovgorod/RUS Norovirus Hu/GII/US/230207-3/2007/SGP NorovirusHu/GII/2005/6457/Nizhny Norovirus Hu/GII/US/240407-1/2007/SGPNovgorod/RUS Norovirus Hu/GII/US/240407-2/2007/SGP NorovirusHu/GII/2005/6463/Nizhny Norovirus Hu/GII/US/270607/2007/SGP Novgorod/RUSNorovirus Hu/GII/US/290507-1/2007/SGP Norovirus NorovirusHu/GII/US/290507-2/2007/SGP Hu/GII/2005/6640/Chelyabinsk/RUS NorovirusHu/GII/Vagedalen/314/2004/NOR Norovirus Norovirus Hu/GII/VN10/2002/VNMHu/GII/2005/6655/Chelyabinsk/RUS Norovirus Hu/GII/VN190/2002/VNMNorovirus Norovirus Hu/GII/VN207/2003/VNMHu/GII/2005/6667/Chelyabinsk/RUS Norovirus Hu/GII/VN3/2002/VNM NorovirusNorovirus Hu/GII/VN433/2003/VNM Hu/GII/2005/6670/Chelyabinsk/RUSNorovirus Hu/GII/VN799/2003/VNM Norovirus NorovirusHu/GII/VN800/2003/VNM Hu/GII/2005/6671/Chelyabinsk/RUS NorovirusHu/GII/VN862/2003/VNM Norovirus Norovirus Hu/GII/VN915/2003/VNMHu/GII/2005/6672/Chelyabinsk/RUS Norovirus Hu/GII/VN981/2003/VNMNorovirus Norovirus Hu/GII/Water-A/2004/South KoreaHu/GII/2005/6675/Chelyabinsk/RUS Norovirus Hu/GII/Water-B/2004/SouthKorea Norovirus Norovirus Hu/GII/Yamaguchi/2003/JPHu/GII/2005/6727/Chelyabinsk/RUS Norovirus Hu/GII/Yamaguchi/2005/JPNorovirus Norovirus Hu/Gunma/1/GII/JP Hu/GII/2005/6733/Chelyabinsk/RUSNorovirus Hu/Gunma/2/GII/JP Norovirus Norovirus Hu/Gunma/6/GII/JPHu/GII/2005/6742/Chelyabinsk/RUS Norovirus Hu/Houston/1995/USA NorovirusNorovirus Hu/Lonaconing/2001/USA Hu/GII/2005/6743/Chelyabinsk/RUSNorovirus Hu/Mashhad1/GGII/Iran Norovirus NorovirusHu/Mashhad2/GGII/Iran Hu/GII/2005/6808/Chelyabinsk/RUS NorovirusHu/Mashhad3/GGII/Iran Norovirus Norovirus Hu/Minato/N1/10/99/JPHu/GII/2005/6894/Chelyabinsk/RUS Norovirus Hu/Minato/N1/14/99/JPNorovirus Hu/GII/2005/7137/Moscow/RUS Norovirus Hu/Minato/N1/33/99/JPNorovirus Hu/GII/2005/7579/Moscow/RUS Norovirus Hu/Minato/N1/6/99/JPNorovirus Hu/GII/2005/7586/Moscow/RUS Norovirus Hu/Mississip/2006/USANorovirus Hu/GII/2005/7594/Moscow/RUS Norovirus Hu/MT01/2006/USANorovirus Hu/GII/2005/7601/Nizhny NorovirusHu/NLV/GII/Neustrelitz260/2000/DE Novgorod/RUS NorovirusHu/NLV/II/Hualien/DY/2003/TW Norovirus Hu/GII/2005/7679/Nizhny NorovirusHu/NLV/VannesL169/2000/France Novgorod/RUS Norovirus Hu/OSD-CS/2006/USANorovirus Hu/GII/2005/7718/Moscow/RUS Norovirus Hu/Pune/OPD01/2007/IndiaNorovirus Hu/GII/2005/7725/Moscow/RUS Norovirus Hu/Pune/OPD02/2007/IndiaNorovirus Hu/GII/2005/7748/Moscow/RUS Norovirus Hu/Pune/OPD03/2007/IndiaNorovirus Hu/GII/2005/7749/Moscow/RUS Norovirus Hu/QM2-CS/2004/USANorovirus Hu/GII/2005/7764/Moscow/RUS Norovirus Hu/Richmond/1994/USANorovirus Hu/GII/2005/7821/Odessa/RUS Norovirus Hu/Ryndam/2005/USANorovirus Norovirus Hu/Warren/2002/USA Hu/GII/2005/8093/Chelyabinsk/RUSNorovirus NV/GII/Chiba1/2004/JP Norovirus Hu/GII/2005/8159/St. NorovirusNV/GII/Shizuoka31/2005/JP Petersburg/RUS NorovirusNV/GII/Yamaguchi13/2005/JP Norovirus Hu/GII/2005/8162/St. NorovirusNV/GII/Yamaguchi17/2003/JP Petersburg/RUS NorovirusNV/GII/Yamaguchi18/2004/JP Norovirus Hu/GII/2005/8254/Nizhny NorovirusNV/GII/Yamaguchi21/2004/JP Novgorod/RUS NorovirusNV/GII/Yamaguchi25/2005/JP Norovirus Hu/GII/2005/8256/Nizhny NorovirusNV/GII/Yamaguchi9/2003/JP Novgorod/RUS Norovirus NVA1 NorovirusNorovirus NVA3 Hu/GII/2005/8433/Chelyabinsk/RUS Norovirus NVM2 NorovirusHu/GII/2006/10584/Moscow/RUS Norovirus NVM3 NorovirusHu/GII/2006/8292/Moscow/RUS Norovirus NVM5 NorovirusHu/GII/2006/8791/Tyumen/RUS Norovirus NVN1 Norovirus Norovirus NVN2Hu/GII/2006/9442/Chelyabinsk/RUS Norovirus NVN3 Norovirus Norovirus NVN5Hu/GII/2006/9563/Chelyabinsk/RUS Norovirus NVNOV1 Norovirus NorovirusNVNOV4 Hu/GII/2006/9607/Chelyabinsk/RUS Norovirus NVO3 NorovirusHu/GII/2006/9895/St. Norovirus NVO5 Petersburg/RUS Norovirus oyster Aclone 2/GGII.2/2006/NLD Norovirus Norovirusoyster/cultured/GII/Is/Dec05/05/JP Hu/GII/2006/9942/Makhachkala/RUSNorovirus oyster/cultured/GII/ISDec05b/05/JP Norovirus Norovirusoyster/cultured/GII/ISDec05d/05/JP Hu/GII/2007/11976/Chelyabinsk/RUSNorovirus oyster/cultured/GII/ISJan06a/06/JP Norovirus Hu/GII/204/JPNNorovirus oyster/cultured/GII/ISJan06b/06/JP Norovirus Hu/GII/209/JPNNorovirus oyster/cultured/GII/ISJan06c/06/JP Norovirus Hu/GII/21/JPNNorovirus oyster/cultured/GII/ISJan06d/06/JP Norovirus Hu/GII/210/JPNNorovirus oyster/cultured/GII/ISJan06e/06/JP Norovirus Hu/GII/213/JPNNorovirus oyster/cultured/GII/ISMar06a/06/JP Norovirus Hu/GII/224/JPNNorovirus oyster/cultured/GII/ISMar06b/06/JP Norovirus Hu/GII/229/JPNNorovirus oyster/cultured/GII/MAApr05a/05/JP Norovirus Hu/GII/233/JPNNorovirus oyster/cultured/GII/MAApr05b/05/JP Norovirus Hu/GII/234/JPNNorovirus oyster/cultured/GII/MADec05a/05/JP Norovirus Hu/GII/235/JPNNorovirus oyster/cultured/GII/MADec05b/05/JP Norovirus Hu/GII/236/JPNNorovirus oyster/cultured/GII/MAFeb05/05/JP Norovirus Hu/GII/237/JPNNorovirus oyster/cultured/GII/MAJan06c/06/JP Norovirus Hu/GII/239/JPNNorovirus oyster/cultured/GII/MAJan06d/06/JP Norovirus Hu/GII/241/JPNNorovirus oyster/cultured/GII/MAJan06f/06/JP Norovirus Hu/GII/251/JPNNorovirus oyster/cultured/GII/MAMar05a/05/JP Norovirus Hu/GII/256/JPNNorovirus oyster/cultured/GII/MAMar05b/05/JP Norovirus Hu/GII/260/JPNNorovirus oyster/cultured/GII/MAMar05d/05/JP Norovirus Hu/GII/268/JPNNorovirus oyster/cultured/GII/MAMar05f/05/JP Norovirus Hu/GII/27/JPNNorovirus oyster/cultured/GII/MAMar06a/06/JP Norovirus Hu/GII/276/JPNNorovirus oyster/cultured/GII/MAMar06b/06/JP Norovirus Hu/GII/277/JPNNorovirus oyster/cultured/GII/MAMar06c/06/JP Norovirus Hu/GII/28/JPNNorovirus oyster/cultured/GII/MAMar06e/06/JP NorovirusHu/GII/281/2006/HKG Norovirus oyster/cultured/GII/ON/Dec05/05/JPNorovirus Hu/GII/281/JPN Norovirus oyster/cultured/GII/ON/Jan06/06/JPNorovirus Hu/GII/283/JPN Norovirus oyster/GII/Aomori/1-1/03/JP NorovirusHu/GII/288/JPN Norovirus oyster/GII/Aomori/1-2/03/JP NorovirusHu/GII/290/JPN Norovirus oyster/GII/Aomori/1-3/03/JP NorovirusHu/GII/292/JPN Norovirus oyster/GII/Aomori/1-4/03/JP NorovirusHu/GII/293/JPN Norovirus oyster/GII/Aomori/10-1/03/JP NorovirusHu/GII/299/JPN Norovirus oyster/GII/Aomori/10-2/03/JP NorovirusHu/GII/2B/2004/South Korea Norovirus oyster/GII/Aomori/11-3/04/JPNorovirus Hu/GII/3/8165/2004/BRA Norovirus oyster/GII/Aomori/12-1/04/JPNorovirus Hu/GII/300/JPN Norovirus oyster/GII/Aomori/12-2/04/JPNorovirus Hu/GII/304/JPN Norovirus oyster/GII/Aomori/13-1/04/JPNorovirus Hu/GII/313/JPN Norovirus oyster/GII/Aomori/13-2/04/JPNorovirus Hu/GII/315/JPN Norovirus oyster/GII/Aomori/13-3/04/JPNorovirus Hu/GII/32/JPN Norovirus oyster/GII/Aomori/18/02/JP NorovirusHu/GII/33/JPN Norovirus oyster/GII/Aomori/2-3/03/JP NorovirusHu/GII/37/JPN Norovirus oyster/GII/Aomori/3-3/03/JP NorovirusHu/GII/39/JPN Norovirus oyster/GII/Aomori/4-1/03/JP NorovirusHu/GII/3B/2004/South Korea Norovirus oyster/GII/Aomori/4-2/03/JPNorovirus Hu/GII/4/10076/2004/BRA Norovirus oyster/GII/Aomori/43/02/JPNorovirus Hu/GII/4/10840/2005/BRA Norovirus oyster/GII/Aomori/5-1/03/JPNorovirus Hu/GII/4/10842/2005/BRA Norovirus oyster/GII/Aomori/5-3/03/JPNorovirus Hu/GII/4/9491/2004/BRA Norovirus oyster/GII/Aomori/7-1/03/JPNorovirus Hu/GII/4/9546/2004/BRA Norovirus oyster/GII/Aomori/7-2/03/JPNorovirus Hu/GII/401/JPN Norovirus oyster/GII/Aomori/7-3/03/JP NorovirusHu/GII/402/JPN Norovirus oyster/GII/Aomori/8-1/03/JP NorovirusHu/GII/403/JPN Norovirus oyster/GII/Aomori/8-2/03/JP NorovirusHu/GII/404/JPN Norovirus oyster/GII/FP55H/2004/CAN NorovirusHu/GII/407/JPN Norovirus oyster/GII/FP68G/2004/CAN NorovirusHu/GII/410/JPN Norovirus oyster/GII/FP69A/2004/CAN NorovirusHu/GII/411/JPN Norovirus oyster/GII/Hiroshimacity/122/03/JP NorovirusHu/GII/413/JPN Norovirus oyster/GII/Hiroshimacity/35/03/JP NorovirusHu/GII/419/JPN Norovirus oyster/GII/Osakacity/15-3/02/JP NorovirusHu/GII/420/JPN Norovirus oyster/GII/Osakacity/4-3/02/JP NorovirusHu/GII/427/JPN Norovirus oyster/GII/Osakacity/OY051-2/02/JP NorovirusHu/GII/428/JPN Norovirus oyster/GII/Osakacity/OY302-1/03/JP NorovirusHu/GII/430/JPN Norovirus oyster/GII/Osakacity/OY319-1/03/JP NorovirusHu/GII/486/2004/HK Norovirus oyster/GII/QingDao/CS327/China/2008Norovirus Hu/GII/4B/2004/South Korea Norovirusoyster/GII/Saitama/S3/03/JP Norovirus Hu/GII/52/JPN Norovirusoyster/GII/Saitama/S4/03/JP Norovirus Hu/GII/53/JPN Norovirusoyster/GII/Saitama/S5/03/JP Norovirus Hu/GII/56/JPN Norovirusoyster/GII/Saitama/S7-2/03/JP Norovirus Hu/GII/57/JPN Norovirusoyster/GII/Saitama/S7/03/JP Norovirus Hu/GII/5B/2004/South KoreaNorovirus oyster/GII/Saitama/S8/03/JP Norovirus Hu/GII/6/8169/2004/BRANorovirus oyster/GII/Yamaguchi/24B/02/JP Norovirus Hu/GII/67/JPNNorovirus oyster/GII/Yamaguchi/24C/02/JP Norovirus Hu/GII/6B/2004/SouthKorea Norovirus oyster/GII/Yamaguchi/34A/03/JP Norovirus Hu/GII/70/JPNNorovirus oyster/GII/Yamaguchi/34C/03/JP Norovirus Hu/GII/733/2006/HKGNorovirus oyster/GII/Yamaguchi/38B/03/JP Norovirus Hu/GII/74/JPNNorovirus oyster/GII/Yamaguchi/38C/03/JP Norovirus Hu/GII/75/JPNNorovirus oyster/GII/Yamaguchi/43A/03/JP Norovirus Hu/GII/77/JPNNorovirus oyster/GII/Yamaguchi/46A/03/JP Norovirus Hu/GII/7886/2004/BRANorovirus oyster/GII/Yamaguchi/H17-97B/05/JP Norovirus Hu/GII/79/JPNNorovirus oyster/GII/Yamaguchi/H17-97C/05/JP NorovirusHu/GII/7B/2004/South Korea Norovirus oyster/wild/GII/SST1Mar05b/05/JPNorovirus Hu/GII/80/JPN Norovirus oyster/wild/GII/SST1Mar05c/05/JPNorovirus Hu/GII/8040/2004/BRA Norovirusoyster/wild/GII/SST1Mar05e/05/JP Norovirus Hu/GII/81/JPN Norovirusoyster/wild/GII/SST1Mar05g/05/JP Norovirus Hu/GII/8165/2004/BRANorovirus oyster/wild/GII/SST1Mar05h/05/JP NorovirusHu/GII/8169/2004/BRA Norovirus oyster/wild/GII/SST1Mar05i/05/JPNorovirus Hu/GII/8187/2004/BRA Norovirusoyster/wild/GII/SST2Mar05a/05/JP Norovirus Hu/GII/8193/2004/BRANorovirus oyster/wild/GII/SST2Mar05b/05/JP NorovirusHu/GII/8195/2004/BRA Norovirus oyster/wild/GII/SST2Mar05i/05/JPNorovirus Hu/GII/8198/2004/BRA Norovirusoyster/wild/GII/SST3Apr05a/05/JP Norovirus Hu/GII/8211/2004/BRANorovirus oyster/wild/GII/SST3Apr05b/05/JP Norovirus Hu/GII/83/JPNNorovirus oyster/wild/GII/SST3Apr05c/05/JP Norovirus Hu/GII/84/JPNNorovirus oyster/wild/GII/SST3Apr05d/05/JP NorovirusHu/GII/8405/2004/BRA Norovirus oyster/wild/GII/SST3Dec05a/05/JPNorovirus Hu/GII/8489/2004/BRA Norovirusoyster/wild/GII/SST3Dec05b/05/JP Norovirus Hu/GII/85/JPN Norovirusoyster/wild/GII/SST3Dec05c/05/JP Norovirus Hu/GII/86/JPN Norovirusoyster/wild/GII/SST3Feb06a/06/JP Norovirus Hu/GII/8618/2004/BRANorovirus oyster/wild/GII/SST3Feb06b/06/JP NorovirusHu/GII/8619/2004/BRA Norovirus oyster/wild/GII/SST3Feb06d/06/JPNorovirus Hu/GII/8626/2004/BRA Norovirusoyster/wild/GII/SST3Feb06e/06/JP Norovirus Hu/GII/8632/2004/BRANorovirus oyster/wild/GII/SST3Feb06f/06/JP NorovirusHu/GII/8740/2004/BRA Norovirus oyster/wild/GII/SST3Feb06g/06/JPNorovirus Hu/GII/8B/2004/South Korea Norovirusoyster/wild/GII/SST3Jan06a/06/JP Norovirus Hu/GII/9/JPN Norovirusoyster/wild/GII/SST3Jan06d/06/JP Norovirus Hu/GII/90/JPN Norovirusoyster/wild/GII/SST3Jan06e/06/JP Norovirus Hu/GII/92/JPN Norovirusoyster/wild/GII/SST3Jan06f/06/JP Norovirus Hu/GII/9275/2004/BRANorovirus oyster/wild/GII/SST3Jan06g/06/JP Norovirus Hu/GII/93/JPNNorovirus oyster/wild/GII/SST3Jan06h/06/JP Norovirus Hu/GII/94/JPNNorovirus oyster/wild/GII/SST3Mar05a/05/JP NorovirusHu/GII/9475/2004/BRA Norovirus oyster/wild/GII/SST3Mar05b/05/JPNorovirus Hu/GII/9491/2004/BRA Norovirusoyster/wild/GII/SST3Mar05c/05/JP Norovirus Hu/GII/9546/2004/BRANorovirus oyster/wild/GII/SST3Mar05d/05/JP NorovirusHu/GII/9547/2004/BRA Norovirus oyster/wild/GII/SST3Mar05e/05/JPNorovirus Hu/GII/97/JPN Norovirus oyster/wild/GII/SST3Mar06b/06/JPNorovirus Hu/GII/9739/2004/BRA Norovirusoyster/wild/GII/SST3Mar06d/06/JP Norovirus Hu/GII/9740/2004/BRANorovirus razor Norovirus Hu/GII/9B/2004/South Koreaclam/GII/LaiZhou/LZ271/China/2008 Norovirus Hu/GII/AH040/2006/UKNorovirus scallop/GII/RiZhao/RZ276/China/2008 NorovirusHu/GII/AH050/2006/UK Norovirus sewage/GII/Toyama/Apr/2006/JP NorovirusHu/GII/AH097/2006/UK Norovirus sewage/GII/Toyama/Apr/2007/JP NorovirusHu/GII/AH107/2006/UK Norovirus sewage/GII/Toyama/Aug-4a/2006/JPNorovirus Hu/GII/AH109/2006/UK Norovirus sewage/GII/Toyama/Aug-6/2006/JPNorovirus Hu/GII/AH187/2006/UK Norovirus sewage/GII/Toyama/Aug/2007/JPNorovirus Hu/GII/AH192/2006/UK Norovirus sewage/GII/Toyama/Dec/2006/JPNorovirus Hu/GII/AH225/2006/UK Norovirus sewage/GII/Toyama/Dec/2007/JPNorovirus Hu/GII/AH387/2006/UK Norovirus sewage/GII/Toyama/Feb/2007/JPNorovirus Hu/GII/AH395/2006/UK Norovirus sewage/GII/Toyama/Feb/2008/JPNorovirus Hu/GII/AH397/2006/UK Norovirus sewage/GII/Toyama/Jan/2007/JPNorovirus Hu/GII/AH402/2006/UK Norovirus sewage/GII/Toyama/Jan/2008/JPNorovirus Hu/GII/AH406/2006/UK Norovirus sewage/GII/Toyama/Jul-3/2006/JPNorovirus Hu/GII/AH408/2006/UK Norovirussewage/GII/Toyama/Jul-4a/2006/JP Norovirus Hu/GII/AH410/2006/UKNorovirus sewage/GII/Toyama/Jul-4b/2006/JP NorovirusHu/GII/AH448/2007/UK Norovirus sewage/GII/Toyama/Jul/2006/JP NorovirusHu/GII/AH509/2007/UK Norovirus sewage/GII/Toyama/Jul/2007/JP NorovirusHu/GII/AH517/2007/UK Norovirus sewage/GII/Toyama/Jun-1/2006/JP NorovirusHu/GII/AH525/2007/UK Norovirus sewage/GII/Toyama/Jun-2/2006/JP NorovirusHu/GII/AH551/2007/UK Norovirus sewage/GII/Toyama/Jun-P1/2006/JPNorovirus Hu/GII/AH570/2007/UK Norovirus sewage/GII/Toyama/Jun/2007/JPNorovirus Hu/GII/AH571/2007/UK Norovirus sewage/GII/Toyama/Mar/2007/JPNorovirus Hu/GII/AH579/2007/UK Norovirus sewage/GII/Toyama/Mar/2008/JPNorovirus Hu/GII/AH590/2007/UK Norovirus sewage/GII/Toyama/May/2006/JPNorovirus Hu/GII/AH602/2007/UK Norovirus sewage/GII/Toyama/May/2007/JPNorovirus Hu/GII/AH604/2007/UK Norovirus sewage/GII/Toyama/Nov/2006/JPNorovirus Hu/GII/AH611/2007/UK Norovirus sewage/GII/Toyama/Nov/2007/JPNorovirus Hu/GII/AH612/2007/UK Norovirussewage/GII/Toyama/Oct-14/2006/JP Norovirus Hu/GII/AH616/2007/UKNorovirus sewage/GII/Toyama/Oct/2006/JP Norovirus Hu/GII/AH619/2007/UKNorovirus sewage/GII/Toyama/Oct/2007/JP Norovirus Hu/GII/AH623/2007/UKNorovirus sewage/GII/Toyama/Sep-3/2006/JP Norovirus Hu/GII/AH633/2007/UKNorovirus sewage/GII/Toyama/Sep-4b/2006/JP NorovirusHu/GII/AH642/2007/UK Norovirus sewage/GII/Toyama/Sep-7/2006/JP NorovirusHu/GII/AH643/2007/UK Norovirus sewage/GII/Toyama/Sep/2007/JP NorovirusHu/GII/AH651/2007/UK Norovirus spinach/GII/Hanam/2007/KOR NorovirusHu/GII/AH653/2007/UK Norovirus sw/GII/CE-06-0036/2006/CAN NorovirusHu/GII/AH654/2007/UK Norovirus sw/GII/CE-M-05-0047/2005/CAN NorovirusHu/GII/Algard/886/2001/NOR Norovirus sw/GII/CE-M-05-0076/2005/CANNorovirus Hu/GII/AM39/2005/BRA Norovirus sw/GII/CE-M-05-0108/2005/CANNorovirus Hu/GII/Arrowpark1B/2008/UK Norovirussw/GII/CE-M-05-0111/2005/CAN Norovirus Hu/GII/Athlone11/2006/BotswanaNorovirus sw/GII/CE-M-05-0112/2005/CAN NorovirusHu/GII/Athlone24/2006/Botswana Norovirus sw/GII/CE-M-05-0116/2005/CANNorovirus Hu/GII/Athlone64/2006/Botswana Norovirussw/GII/CE-M-06-0003/2006/CAN Norovirus Hu/GII/Athlone75/2006/BotswanaNorovirus sw/GII/CE-M-06-0011/2006/CAN NorovirusHu/GII/Athlone79/2006/Botswana Norovirus sw/GII/CE-M-06-0016/2006/CANNorovirus Hu/GII/BA4521/2005/Arg Norovirus sw/GII/CE-M-06-0020/2006/CANNorovirus Hu/GII/BC728/07-2007/CAN Norovirussw/GII/CE-M-06-0028/2006/CAN Norovirus Hu/GII/BCCDC03008/2003/CANNorovirus swine/GII/MI-QW48/02/US Norovirus Hu/GII/BCCDC03013/2003/CANNorovirus swine/GII/OH-QW101/03/US Norovirus Hu/GII/BCCDC03020/2004/CANNorovirus swine/GII/OH-QW125/03/US Norovirus Hu/GII/BCCDC03032/2003/CANNorovirus swine/GII/OH-QW170/03/US Norovirus Hu/GII/BCCDC04002/2004/CANNorovirus swine/GII/OH-QW218/03/US Norovirus Hu/GII/BCCDC04006/2004/CANNorovirus swine/GII/rj14008/2007/BRA NorovirusHu/GII/BCCDC04007/2004/CAN Norovirus Sydney 2212 NorovirusHu/GII/BE/200307-1/2007/SGP Norovirus water/GII/Gyeonggi/A11/2002/KORNorovirus Hu/GII/BE/200307-2/2007/SGP Noroviruswater/GII/Gyeonggi/A12/2002/KOR Norovirus Hu/GII/BE/230107-1/2007/SGPNorovirus water/GII/Gyeonggi/A13/2003/KOR NorovirusHu/GII/BE/230107-2/2007/SGP Norovirus water/GII/Gyeonggi/A14/2003/KORNorovirus Hu/GII/BE/230107-3/2007/SGP Noroviruswater/GII/Gyeonggi/A15/2003/KOR Norovirus Hu/GII/BE/230207-1/2007/SGPNorovirus water/GII/Gyeonggi/A8/2002/KOR NorovirusHu/GII/BE/230207-2/2007/SGP Norovirus water/GII/Gyeonggi/A9/2002/KORNorovirus Hu/GII/BE/230207-3/2007/SGP Noroviruswater/GII/Gyeonggi/H12-1/2002/KOR Norovirus Hu/GII/BE/240407/2007/SGPNorovirus water/GII/Gyeonggi/H12-2/2002/KOR NorovirusHu/GII/BE/270607-1/2007/SGP Norovirus water/GII/Gyeonggi/H13/2003/KORNorovirus Hu/GII/BE/270607-2/2007/SGP Noroviruswater/GII/Gyeonggi/H14/2003/KOR Norovirus Hu/GII/BE/270607-3/2007/SGPNorovirus water/GII/Gyeonggi/H15/2003/KOR NorovirusHu/GII/BE/290507-1/2007/SGP Norovirus water/GII/Gyeonggi/H8/2002/KORNorovirus Hu/GII/BE/290507-2/2007/SGP Noroviruswater/GII/Gyeonggi/H9/2002/KOR Norovirus Hu/GII/BE/290507-3/2007/SGPNorovirus water/GII/Gyeonggi/I12/2002/KOR NorovirusHu/GII/BE/290507-4/2007/SGP Norovirus water/GII/Gyeonggi/I14/2003/KORNorovirus Hu/GII/Beijing/01/2004/CHN Noroviruswater/GII/Gyeonggi/I15/2003/KOR Norovirus Hu/GII/Beijing/06/2005/CHNNorovirus water/GII/Gyeonggi/I5/2002/KOR NorovirusHu/GII/Beijing/07/2005/CHN Norovirus water/GII/Gyeonggi/S10/2002/KORNorovirus Hu/GII/Beijing/07/2006/CHN Noroviruswater/GII/Gyeonggi/S11-1/2002/KOR Norovirus Hu/GII/Beijing/10/2005/CHNNorovirus water/GII/Gyeonggi/S11-2/2002/KOR NorovirusHu/GII/Beijing/10/2006/CHN Norovirus water/GII/Gyeonggi/S12/2002/KORNorovirus Hu/GII/Beijing/101/2005/CHN Noroviruswater/GII/Gyeonggi/S14/2003/KOR Norovirus Hu/GII/Beijing/101/2007/CHNNorovirus water/GII/Gyeonggi/S15/2003/KOR NorovirusHu/GII/Beijing/102/2005/CHN Norovirus water/GII/Gyeonggi/S4/2002/KORNorovirus Hu/GII/Beijing/115/2004/CHN Noroviruswater/GII/Gyeonggi/S5/2002/KOR Norovirus Hu/GII/Beijing/116/2007/CHNNorovirus water/GII/Gyeonggi/S8/2002/KOR NorovirusHu/GII/Beijing/125/2007/CHN Norovirus water/GII/Gyeonggi/S9/2002/KORNorovirus Hu/GII/Beijing/127/2007/CHN NorovirusHu/GII/C3-040407/2007/SGP Norovirus Hu/GII/Beijing/133/2005/CHNNorovirus Hu/GII/C4-19/2005/KOR Norovirus Hu/GII/Beijing/133/2007/CHNNorovirus Hu/GII/C5-59/2006/KOR Norovirus Hu/GII/Beijing/139/2005/CHNNorovirus Hu/GII/C6-39/2005/KOR Norovirus Hu/GII/Beijing/14/2006/CHNNorovirus Hu/GII/C6-80/2006/KOR Norovirus Hu/GII/Beijing/148/2005/CHNNorovirus Hu/GII/C7-130/2005/KOR Norovirus Hu/GII/Beijing/148/2007/CHNNorovirus Hu/GII/C7-171/2005/KOR Norovirus Hu/GII/Beijing/153/2005/CHNNorovirus Hu/GII/C7-182/2005/KOR Norovirus Hu/GII/Beijing/156/2007/CHNNorovirus Hu/GII/C7-212/2005/KOR Norovirus Hu/GII/Beijing/162/2007/CHNNorovirus Hu/GII/C7-307/2006/KOR Norovirus Hu/GII/Beijing/165/2004/CHNNorovirus Hu/GII/C7-394/2006/KOR Norovirus Hu/GII/Beijing/169/2005/CHNNorovirus Hu/GII/Carlow/2002/Ire Norovirus Hu/GII/Beijing/175/2004/CHNNorovirus Hu/GII/CE-M-05-0045/2005/CAN NorovirusHu/GII/Beijing/178/2004/CHN Norovirus Hu/GII/CE-R1-06-027/2006/CANNorovirus Hu/GII/Beijing/178/2005/CHN NorovirusHu/GII/Chelyabinsk/8020/2005/RUS Norovirus Hu/GII/Beijing/19/2004/CHNNorovirus Hu/GII/Chelyabinsk/8031/2005/RUS NorovirusHu/GII/Beijing/191/2005/CHN Norovirus Hu/GII/Chelyabinsk/8361/2005/RUSNorovirus Hu/GII/Beijing/196/2007/CHN NorovirusHu/GII/Chelyabinsk/8398/2005/RUS Norovirus Hu/GII/Beijing/197/2005/CHNNorovirus Hu/GII/Chelyabinsk/8919/2006/RUS NorovirusHu/GII/Beijing/208/2006/CHN Norovirus Hu/GII/Chelyabinsk/9418/2006/RUSNorovirus Hu/GII/Beijing/215/2005/CHN NorovirusHu/GII/Chelyabinsk/9425/2006/RUS Norovirus Hu/GII/Beijing/221/2005/CHNNorovirus Hu/GII/Chelyabinsk/9459/2006/RUS NorovirusHu/GII/Beijing/228/2005/CHN Norovirus Hu/GII/Chelyabinsk/9471/2006/RUSNorovirus Hu/GII/Beijing/229/2005/CHN NorovirusHu/GII/Chelyabinsk/9475/2006/RUS Norovirus Hu/GII/Beijing/235/2006/CHNNorovirus Hu/GII/Chelyabinsk/9479/2006/RUS NorovirusHu/GII/Beijing/248/2006/CHN Norovirus Hu/GII/Chelyabinsk/9548/2006/RUSNorovirus Hu/GII/Beijing/259/2005/CHN Norovirus Hu/GII/Chiba/2004/JPNorovirus Hu/GII/Beijing/26/2006/CHN NorovirusHu/GII/CL4006-1309/2006/SGP Norovirus Hu/GII/Beijing/262/2007/CHNNorovirus Hu/GII/CL4007-1409/2006/SGP NorovirusHu/GII/Beijing/266/2006/CHN Norovirus Hu/GII/CL4008-1309/2006/SGPNorovirus Hu/GII/Beijing/27/2004/CHN NorovirusHu/GII/CL4009-1309/2006/SGP Norovirus Hu/GII/Beijing/271/2007/CHNNorovirus Hu/GII/CL4010-1409/2006/SGP NorovirusHu/GII/Beijing/274/2005/CHN Norovirus Hu/GII/CL4015-2909/2006/SGPNorovirus Hu/GII/Beijing/275/2005/CHN NorovirusHu/GII/CL4016-2909/2006/SGP Norovirus Hu/GII/Beijing/275/2007 NorovirusHu/GII/CL4018-2909/2006/SGP Norovirus Hu/GII/Beijing/277/2005/CHNNorovirus Hu/GII/CL4021-0310/2006/SGP NorovirusHu/GII/Beijing/282/2005/CHN Norovirus Hu/GII/CL4025-0310/2006/SGPNorovirus Hu/GII/Beijing/289/2005/CHN NorovirusHu/GII/CL4029-0310/2006/SGP Norovirus Hu/GII/Beijing/290/2007/CHNNorovirus Hu/GII/CL4031-0610/2006/SGP NorovirusHu/GII/Beijing/30/2004/CHN Norovirus Hu/GII/CL4033-0610/2006/SGPNorovirus Hu/GII/Beijing/300/2007/CHN NorovirusHu/GII/CL4035-0610/2006/SGP Norovirus Hu/GII/Beijing/303/2007/CHNNorovirus Hu/GII/CL4056-1110/2006/SGP NorovirusHu/GII/Beijing/307/2005/CHN Norovirus Hu/GII/CL4095-2010/2006/SGPNorovirus Hu/GII/Beijing/308/2005/CHN NorovirusHu/GII/CL4096-2010/2006/SGP Norovirus Hu/GII/Beijing/310/2007/CHNNorovirus Hu/GII/CL4097-2010/2006/SGP NorovirusHu/GII/Beijing/313/2007/CHN Norovirus Hu/GII/CL4097-3108/2006/SGPNorovirus Hu/GII/Beijing/321/2007/CHN NorovirusHu/GII/CL4098-3108/2006/SGP Norovirus Hu/GII/Beijing/323/2007/CHNNorovirus Hu/GII/CL4099-3108/2006/SGP NorovirusHu/GII/Beijing/33/2006/CHN Norovirus Hu/GII/CUHK3020/2008/HKG NorovirusHu/GII/Beijing/334/2007/CHN Norovirus Hu/GII/CUHK3205/2008/HKG NorovirusHu/GII/Beijing/34/2006/CHN Norovirus Hu/GII/CUHK3214/2008/HKG NorovirusHu/GII/Beijing/352/2007/CHN Norovirus Hu/GII/CUHK3229/2008/HKG NorovirusHu/GII/Beijing/352/2008 Norovirus Hu/GII/CUHK3286/2008/HKG NorovirusHu/GII/Beijing/357/2008 Norovirus Hu/GII/CUHK3330/2008/HKG NorovirusHu/GII/Beijing/361/2007/CHN Norovirus Hu/GII/CUHK3383/2008/HKG NorovirusHu/GII/Beijing/362/2007/CHN Norovirus Hu/GII/CUHK3452/2008/HKG NorovirusHu/GII/Beijing/371/2007/CHN Norovirus Hu/GII/CUHK3469/2008/HKG NorovirusHu/GII/Beijing/374/2007/CHN Norovirus Hu/GII/CUHK3497/2008/HKG NorovirusHu/GII/Beijing/375/2005/CHN Norovirus Hu/GII/CUHK3540/2008/HKG NorovirusHu/GII/Beijing/377/2007/CHN Norovirus Hu/GII/CUHK3578/2008/HKG NorovirusHu/GII/Beijing/38/2006/CHN Norovirus Hu/GII/CUHK3723/2008/HKG NorovirusHu/GII/Beijing/39/2004/CHN Norovirus Hu/GII/CUHK3895/2008/HKG NorovirusHu/GII/Beijing/398/2008 Norovirus Hu/GII/CUHK3918/2008/HKG NorovirusHu/GII/Beijing/401/2005/CHN Norovirus Hu/GII/CUHK3925/2008/HKG NorovirusHu/GII/Beijing/402/2005/CHN Norovirus Hu/GII/CUHK4071/2008/HKG NorovirusHu/GII/Beijing/430/2005/CHN Norovirus Hu/GII/CUHK4372/2008/HKG NorovirusHu/GII/Beijing/439/2005/CHN Norovirus Hu/GII/CUHK4389/2008/HKG NorovirusHu/GII/Beijing/45/2004/CHN Norovirus Hu/GII/CUHK4577/2008/HKG NorovirusHu/GII/Beijing/45/2005/CHN Norovirus Hu/GII/CUHK4636/2008/HKG NorovirusHu/GII/Beijing/455/2005/CHN Norovirus Hu/GII/CUHK4785/2008/HKG NorovirusHu/GII/Beijing/46/2005/CHN Norovirus Hu/GII/CUHK4844/2008/HKG NorovirusHu/GII/Beijing/466/2005/CHN Norovirus Hu/GII/CUHK4850/2008/HKG NorovirusHu/GII/Beijing/479/2005/CHN Norovirus Hu/GII/CUHK4870/2008/HKG NorovirusHu/GII/Beijing/48/2005/CHN Norovirus Hu/GII/CUHK4877/2008/HKG NorovirusHu/GII/Beijing/48/2007/CHN Norovirus Hu/GII/CUHK5054/2008/HKG NorovirusHu/GII/Beijing/484/2005/CHN Norovirus Hu/GII/CUHK5079/2008/HKG NorovirusHu/GII/Beijing/49/2007/CHN Norovirus Hu/GII/CUHK5120/2008/HKG NorovirusHu/GII/Beijing/492/2005/CHN Norovirus Hu/GII/CUHK5200/2008/HKG NorovirusHu/GII/Beijing/493/2005/CHN Norovirus Hu/GII/CUHK5324/2008/HKG NorovirusHu/GII/Beijing/495/2005/CHN Norovirus Hu/GII/CUHK5330/2008/HKG NorovirusHu/GII/Beijing/496/2005/CHN Norovirus Hu/GII/CUHK5355/2008/HKG NorovirusHu/GII/Beijing/498/2005/CHN Norovirus Hu/GII/CUHK5550/2008/HKG NorovirusHu/GII/Beijing/509/2005/CHN Norovirus Hu/GII/CUHK5573/2008/HKG NorovirusHu/GII/Beijing/518/2005/CHN Norovirus Hu/GII/CUHK5761/2008/HKG NorovirusHu/GII/Beijing/55/2004/CHN Norovirus Hu/GII/CUHK5815/2008/HKG NorovirusHu/GII/Beijing/57/2005/CHN Norovirus Hu/GII/CUHK5822/2008/HKG NorovirusHu/GII/Beijing/589/2008 Norovirus Hu/GII/CUHK5987/2008/HKG NorovirusHu/GII/Beijing/63/2007/CHN Norovirus Hu/GII/CUHK6075/2008/HKG NorovirusHu/GII/Beijing/66/2005/CHN Norovirus Hu/GII/CUHK6202/2008/HKG NorovirusHu/GII/Beijing/71/2007/CHN Norovirus Hu/GII/CUHK6252/2008/HKG NorovirusHu/GII/Beijing/74/2004/CHN Norovirus Hu/GII/CUHK6346/2008/HKG NorovirusHu/GII/Beijing/74/2007/CHN Norovirus Hu/GII/CUHK6412/2008/HKG NorovirusHu/GII/Beijing/79/2004/CHN Norovirus Hu/GII/CUHK6501/2008/HKG NorovirusHu/GII/Beijing/82/2004/CHN Norovirus Hu/GII/CUHK6518/2008/HKG NorovirusHu/GII/Beijing/88/2004/CHN Norovirus Hu/GII/CUHK6581/2008/HKG NorovirusHu/GII/Beijing/90/2004/CHN Norovirus Hu/GII/CUHK6766/2008/HKG NorovirusHu/GII/Beijing/95/2005/CHN Norovirus Hu/GII/E-090507/2007/SGP NorovirusHu/GII/Beijing/96/2007/CHN Norovirus Hu/GII/E-140307/2007/SGP NorovirusHu/GII/Bergen/7105/2002/NOR Norovirus Hu/GII/Ehime/2005/JP NorovirusHu/GII/BHL44/2000/Botswana Norovirus Hu/GII/Elverum/4167/2003/NORNorovirus Hu/GII/Brisbane/01/2004/AU NorovirusHu/GII/BS/200307-1/2007/SGP Norovirus Hu/GII/BS/200307-2/2007/SGPNorovirus Hu/GII/BS/230107-1/2007/SGP NorovirusHu/GII/BS/230107-2/2007/SGP Norovirus Hu/GII/BS/230207/2007/SGPNorovirus Hu/GII/BS/240407-1/2007/SGP NorovirusHu/GII/BS/240407-2/2007/SGP Norovirus Hu/GII/BS/270607-1/2007/SGPNorovirus Hu/GII/BS/270607-2/2007/SGP NorovirusHu/GII/BS/290507-1/2007/SGP Norovirus Hu/GII/BS/290507-2/2007/SGPNorovirus Hu/GII/C1-011106/2006/SGP Norovirus Hu/GII/C1-040706/2006/SGPNorovirus Hu/GII/C1-111206/2006/SGP Norovirus Hu/GII/C1-120/2006/KORNorovirus Hu/GII/C1-143/2006/KOR Norovirus Hu/GII/C1-144/2006/KORNorovirus Hu/GII/C1-149/2006/KOR Norovirus Hu/GII/C1-150806/2006/SGPNorovirus Hu/GII/C1-180706/2006/SGP Norovirus Hu/GII/C1-201106/2006/SGPNorovirus Hu/GII/C1-220606/2006/SGP Norovirus Hu/GII/C1-240706/2006/SGPNorovirus Hu/GII/C1-263/2006/KOR Norovirus Hu/GII/C1-271206/2006/SGPNorovirus Hu/GII/C1-307/2005/KOR Norovirus Hu/GII/C2-230507/2007/SGPNorovirus Hu/GII/C2-55/2006/KOR Norovirus genogroup GII.1 Norovirusenv/GGI.2/958/2007/ITA Norovirus Hu/GII.1/3445/2008/ZAF NorovirusHu/GII-1/FN1-Newc/2006/UK Norovirus Hu/GII.1/8738/2008/ZAF NorovirusHu/GII-12/Inba/060839/2006/JP Norovirus Hu/GII.1/CanteenA/Pirkanmaa-Norovirus Hu/GII.1/03155665/2003/AUS 15/2006/FIN NorovirusHu/GII.1/04113024/2004/AUS Norovirus Hu/GII.1/CanteenB/Pirkanmaa-Norovirus Hu/GII.1/04113825/2004/AUS 19/2006/FIN NorovirusHu/GII.1/04116150/2004/AUS Norovirus Hu/GII.1/CanteenC/Pirkanmaa-Norovirus Hu/GII.1/04144544/2004/AUS 18/2006/FIN NorovirusHu/GII.13/Miyagi/26/2006/JP Norovirus Hu/GII.13/Miyagi/4/2007/JPNorovirus genogroup GII.11 Norovirus pig/GII-11/AB117/CAN Noroviruspig/GII-11/F16-8/CAN Norovirus pig/GII-11/F12-8/05/CAN Noroviruspig/GII-11/F18-10/05/CAN Norovirus pig/GII-11/F12-8/CAN Noroviruspig/GII-11/F18-10/CAN Norovirus genogroup GII.13 NorovirusHu/GII.13/04150102/2004/AUS Norovirus Hu/GII.13/8591/Maizuru/2008/JPNNorovirus Hu/GII.13/8434/Maizuru/2007/JPN NorovirusHu/GII.13/8594/Maizuru/2008/JPN NorovirusHu/GII.13/8533/Maizuru/2008/JPN NorovirusHu/GII.13/8599/Maizuru/2008/JPN NorovirusHu/GII.13/8542/Maizuru/2008/JPN Norovirus Hu/GII.13/9513/2008/ZAFNorovirus Hu/GII.13/8559/Maizuru/2008/JPN Norovirussewage/GII.13/Toyama/SW0703- Norovirus Hu/GII.13/8560/Maizuru/2008/JPN6/2007/JP Norovirus sewage/GII.13/Toyama/SW0709- 11/2007/JP Norovirusgenogroup GII.14 Norovirus Hu/GII-14/ES071/2003/BRA NorovirusHu/GII.14/13501/2007/BRA Norovirus Hu/GII.14/13436/2007/BRA NorovirusHu/GII.14/3607/2008/ZAF Norovirus Hu/GII.14/13453/2007/BRA Norovirusgenogroup GII.16 Norovirus Hu/GII.16/4349b/2008/ZAF NorovirusHu/GII.16/Nsk-410/2005/RUS Norovirus genogroup GII.17 NorovirusHu/GGII.17/696Nica/2005 Norovirus genogroup GII.18 NorovirusHu/GGII.18/166Nica/2005 Norovirus Hu/GGII.18/36Nica/2005 NorovirusHu/GGII.18/186Nica/2005 Norovirus pig/GII-18/F15-10nv/CAN NorovirusHu/GGII.18/213Nica/2005 Norovirus swine/GII.18/rj14008/2007/BR NorovirusHu/GGII.18/231Nica/2005 Norovirus genogroup GII.2 Norovirusenv/GGI.2/1044/2007/ITA Norovirus Hu/GII-3/ES203/2003/BRA Norovirusenv/GGI.2/1046/2007/ITA Norovirus Hu/GII-3/ES265/2003/BRA Norovirusenv/GGI.2/1052/2007/ITA Norovirus Hu/GII-3/food handler 2/OB1/2007/UKNorovirus env/GGI.2/1054/2007/ITA Norovirus Hu/GII-3/food handler6/OB1/2007/UK Norovirus env/GGI.2/1056/2007/ITA NorovirusHu/GII-3/Morriston/2007/UK Norovirus env/GGI.2/1084/2007/ITA NorovirusHu/GII-3/NMH/2007/UK Norovirus env/GGI.2/1088/2007/ITA NorovirusHu/GII-3/Patient 1-01/2007/UK Norovirus env/GGI.2/1092/2007/ITANorovirus Hu/GII-3/Patient 2-01/2007/UK Norovirusenv/GGI.2/1110/2007/ITA Norovirus Hu/GII-3/Patient1-01/2007/UK Norovirusenv/GGI.2/1112/2007/ITA Norovirus Hu/GII-3/Patient1-02/2007/UK Norovirusenv/GGI.2/1134/2007/ITA Norovirus Hu/GII-3/Patient1-05/2007/UK Norovirusenv/GGI.2/1138/2007/ITA Norovirus Hu/GII-3/Patient2-01/2007/UK Norovirusenv/GGI.2/1158/2007/ITA Norovirus Hu/GII-3/Patient2-02/2007/UK Norovirusenv/GGI.2/950/2007/ITA Norovirus Hu/GII-3/Patient2-05/2007/UK Norovirusenv/GGI.2/952/2007/ITA Norovirus Hu/GII.3/02108181/2002/AUS Norovirusenv/GGI.2/954/2007/ITA Norovirus Hu/GII.3/02115422/2002/AUS Norovirusenv/GGI.2/964/2007/ITA Norovirus Hu/GII.3/02115428/2002/AUS Norovirusenv/GGI.2/968/2007/ITA Norovirus Hu/GII.3/02115441/2002/AUS Norovirusenv/GGI.2/976/2007/ITA Norovirus Hu/GII.3/03157163/2003/AUS Norovirusenv/GGI.2/980/2007/ITA Norovirus Hu/GII.3/03157169/2003/AUS Norovirusenv/GGI.2/982/2007/ITA Norovirus Hu/GII.3/04107624/2004/AUS Norovirusenv/GGI.2/984/2007/ITA Norovirus Hu/GII.3/04155699/2004/AUS Norovirusenv/GGI.2/986/2007/ITA Norovirus Hu/GII.3/05100687/2004/AUS Norovirusenv/GGI.2/992/2007/ITA Norovirus Hu/GII.3/05143926/2005/AUS Norovirusenv/GGI.2/994/2007/ITA Norovirus Hu/GII.3/1508/1/2008/RJ/BRA NorovirusHu/GGI.2/oyster8491OB/77351/FR Norovirus Hu/GII.3/15645/2008/RJ/BRANorovirus Hu/GGII.2/32Nica/2005 Norovirus Hu/GII.3/15737/2008/RJ/BRANorovirus Hu/GII-2/C1-263/South Korea NorovirusHu/GII.3/Cuernavaca/50317/2007/MEX Norovirus Hu/GII-2/C1-268/South KoreaNorovirus Hu/GII.3/Cuernavaca/7358/2008/MEX NorovirusHu/GII-2/Kashiwa/060771/2006/JP NorovirusHu/GII.3/Cuernavaca/7360/2008/MEX Norovirus Hu/GII-2/teacher1/OB4/2007/UK Norovirus Hu/GII.3/GE29/IRN NorovirusHu/GII.2/10488/2004/IRL Norovirus Hu/GII.3/Novosibirsk/s2835/2007/RuNorovirus Hu/GII.2/4447/2007/IRL NorovirusHu/GII.3/Novosibirsk/s2842/2007/Ru NorovirusHu/GII.2/Coevorden191S/1999/NL NorovirusHu/GII.3/Novosibirsk/s890/2006/Ru Norovirus NorovirusHu/GII.3/Novosibirsk/s891/2006/Ru Hu/GII.2/Cuernavaca/50031/2007/MEXNorovirus Hu/GII.3/Nsk-158/2005/RUS Norovirus Hu/GII.2/Delft48M/2000/NLNorovirus Hu/GII.3/Nsk-28/2005/RUS Norovirus Hu/GII.2/DenHaag37/2000/NLNorovirus Hu/GII.3/Nsk-2870/2008/RUS NorovirusHu/GII.2/Esslingen/3878/05/DE Norovirus Hu/GII.3/Nsk-2872/2008/RUSNorovirus Hu/GII.2/Goes28/2005/NL Norovirus Hu/GII.3/Nsk-2877/2008/RUSNorovirus Hu/GII.2/Heerlen7E/2002/NL NorovirusHu/GII.3/Nsk-2887/2008/RUS Norovirus Hu/GII.2/Heidenheim/3478/05/DENorovirus Hu/GII.3/Nsk-2891/2008/RUS NorovirusHu/GII.2/Kuenzelsau/3870/05/DE Norovirus Hu/GII.3/Nsk-2987/2008/RUSNorovirus Hu/GII.2/Leeuwarden15/2001/NL NorovirusHu/GII.3/Nsk-3018/2008/RUS Norovirus Hu/GII.2/Leeuwarden71/2003/NLNorovirus Hu/GII.3/Nsk-3071/2008/RUS NorovirusHu/GII.2/Mannheim/3343/05/DE Norovirus Hu/GII.3/Nsk-3076/2008/RUSNorovirus Norovirus Hu/GII.3/Nsk-3077/2008/RUSHu/GII.2/Mussels/M12nov2004/Foto/Sweden NorovirusHu/GII.3/Nsk-3203/2008/RUS Norovirus NorovirusHu/GII.3/Nsk-3290/2008/RUS Hu/GII.2/Mussels/M40nov2004/Foto/SwedenNorovirus Hu/GII.3/Nsk-3418/2008/RUS NorovirusHu/GII.2/OC080306/2008/JPN Norovirus Hu/GII.3/Nsk-3489/2008/RUSNorovirus Hu/GII.2/Rotterdam39E/2002/NL NorovirusHu/GII.3/Nsk-3501/2008/RUS Norovirus Hu/GII.2/Sigmaringen/3669/05/DENorovirus Hu/GII.3/Nsk-3515/2008/RUS Norovirus Hu/GII.2/Vaals87/2005/NLNorovirus Hu/GII.3/Nsk-76/2005/RUS NorovirusHu/GII.2/Waiblingen/3853/05/DE Norovirus Hu/GII.3/Nsk-B69/2009/RUSNorovirus Hu/GII.2/Wertheim/3501/05/DE NorovirusHu/GII.3/Nsk-B93/2009/RUS Norovirus Hu/GII.2/Zwolle25E/2001/NL NorovirusHu/GII.3/Nsk-B94/2009/RUS Norovirus genogroup G▪.3 NorovirusHu/GII.3/Nsk-D138/2009/RUS Norovirus Env/GGII.3/699/2006/IT NorovirusHu/GII.3/Nsk-D175/2009/RUS Norovirus env/GGII.3/972/2007/ITA NorovirusHu/GII.3/Nsk-D195/2009/RUS Norovirus environmental/GII-3/O04- NorovirusHu/GII.3/Nsk-D204/2009/RUS HBT/2008/UK NorovirusHu/GII.3/Nsk-D218/2009/RUS Norovirus environmental/GII-3/O18- NorovirusHu/GII.3/Nsk-D219/2009/RUS TDH/2008/UK NorovirusHu/GII.3/Nsk-D224/2009/RUS Norovirus environmental/GII-3/O28- NorovirusHu/GII.3/Nsk-D229/2009/RUS TFH/2008/UK NorovirusHu/GII.3/Nsk-D256/2009/RUS Norovirus environmental/GII-3/O31- NorovirusHu/GII.3/Nsk-D277/2009/RUS HBT/2008/UK NorovirusHu/GII.3/Nsk-D89/2009/RUS Norovirus Hu/GGII.3/691/2006/IT NorovirusHu/GII.3/Nsk-H276/2004/RUS Norovirus Hu/GII-3/613104/2006/UK NorovirusHu/GII.3/Nsk-H379/2004/RUS Norovirus Hu/GII-3/6479/2007/UK NorovirusHu/GII.3/Nsk-H418/2004/RUS Norovirus Hu/GII-3/6482/2007/UK NorovirusHu/GII.3/Nsk-H425/2004/RUS Norovirus Hu/GII-3/713092-3/2007/UK NorovirusHu/GII.3/Nsk-H470/2004/RUS Norovirus Hu/GII-3/Awa/060890/2006/JPNorovirus Hu/GII.3/Nsk-H487/2004/RUS Norovirus Hu/GII-3/B7316/2007/UKNorovirus Hu/GII.3/Nsk-H538/2004/RUS NorovirusHu/GII-3/Batch1-Swab10/2007/UK Norovirus Hu/GII.3/Nsk-H573/2004/RUSNorovirus Hu/GII-3/Batch1-Swab19/2007/UK NorovirusHu/GII.3/Nsk-H580/2004/RUS Norovirus Hu/GII-3/Batch2-Swab06/2007/UKNorovirus Hu/GII.3/Nsk-H617/2004/RUS NorovirusHu/GII-3/Batch2-Swab12/2007/UK Norovirus Hu/GII.3/Nsk-H677/2004/RUSNorovirus Hu/GII-3/Batch2-Swab16/2007/UK NorovirusHu/GII.3/O450/2008/RUS Norovirus Hu/GII-3/Batch2-Swab20/2007/UKNorovirus Hu/GII.3/RotterdamP1D0/2006/NL NorovirusHu/GII-3/Batch4-Swab03/2007/UK Norovirus Hu/GII.3/RotterdamP1D88/2006/NLNorovirus Hu/GII-3/Batch4-Swab10/2007/UK NorovirusHu/GII.3/RotterdamP5D0/2005/NL Norovirus Hu/GII-3/Batch4-Swab15/2007/UKNorovirus Hu/GII.3/RotterdamP8D0/2006/NL NorovirusHu/GII-3/Batch4-Swab16/2007/UK Norovirus Hu/GII.3/RotterdamP8D31/2006/NLNorovirus Hu/GII-3/Batch4-Swab20/2007/UK NorovirusHu/GII.3/Salvador/B10/2006/BRA Norovirus Hu/GII-3/Batch5-Swab14/2007/UKNorovirus Hu/GII.3/Salvador/C08/2006/BRA NorovirusHu/GII-3/Batch5-Swab15/2007/UK Norovirus Hu/GII.3/Salvador/D10/2006/BRANorovirus Hu/GII-3/Batch5-Swab20/2007/UK NorovirusHu/GII.3/Salvador/G06/2006/BRA Norovirus Hu/GII-3/Batch5-Swab23/2007/UKNorovirus Hu/GII.3/Salvador/G10/2006/BRA NorovirusHu/GII-3/Batch6-Swab03/2007/UK Norovirus Hu/GII.3/Salvador/H02/2006/BRANorovirus Hu/GII-3/Batch6-Swab10/2007/UK NorovirusHu/GII.3/Salvador/H08/2006/BRA Norovirus Hu/GII-3/Batch6-Swab13/2007/UKNorovirus Hu/GII.3/Salvador/H10/2006/BRA Norovirus Hu/GII-3/C1-139/SouthKorea Norovirus Hu/GII3/49167/Henan/06/CHN NorovirusHu/GII-3/Chosei/060920/2006/JP Norovirus Hu/GII3/52088/Shanghai/06/CHNNorovirus Hu/GII-3/customer 1/OB1/2007/UK NorovirusHu/GII3/52403/Jilin/07/CHN Norovirus Hu/GII-3/customer 1/OB2/2007/UKNorovirus oyster/GII.3/4/Stromstad/Sweden Norovirus Hu/GII-3/customer1/OB3/2007/UK Norovirus Hu/GII-3/ES149/2003/BRA NorovirusHu/GII-3/customer 2/OB1/2006/UK Norovirus Hu/GII-3/ES180/2003/BRANorovirus Hu/GII-3/ES096/2003/BRA Norovirus Hu/GII-3/ES198/2003/BRANorovirus Hu/GII-3/ES130/2003/BRA Norovirus genogroup GII.4 Norovirusenv/GGII.4/1034/2007/ITA Norovirus Hu/GII.4/Hiroshima/91/2006/JPNNorovirus env/GGII.4/1162a/2007/ITA NorovirusHu/GII.4/Hiroshima/92/2006/JPN Norovirus Env/GGII.4/645/2005/ITNorovirus Hu/GII.4/HK/CU09N10/2009/CHN Norovirus Env/GGII.4/649/2005/ITNorovirus Hu/GII.4/HK/CU09N11/2009/CHN Norovirus Env/GGII.4/650/2005/ITNorovirus Hu/GII.4/HK/CU09N12/2009/CHN Norovirus Env/GGII.4/671/2006/ITNorovirus Hu/GII.4/HK/CU09N24/2009/CHN Norovirus Env/GGII.4/672/2006/ITNorovirus Hu/GII.4/HK/CU09N4/2009/CHN Norovirus Env/GGII.4/677/2006Norovirus Hu/GII.4/HK/CU09N5/2009/CHN Norovirus Env/GGII.4/677/2006/ITNorovirus Hu/GII.4/HK/CU09N6/2009/CHN Norovirus Env/GGII.4/680/2006/ITNorovirus Hu/GII.4/HK/CU09N7/2009/CHN Norovirus Env/GGII.4/704/2006/ITNorovirus Hu/GII.4/HK/CU09N8/2009/CHN Norovirus env/GGII.4/954/2007/ITANorovirus Hu/GII.4/HK/CU09N9/2009/CHN Norovirus env/GGII.4/956/2007/ITANorovirus Hu/GII.4/HK/CU09S42/2009/CHN Norovirus env/GGII.4/960/2007/ITANorovirus Hu/GII.4/HK/CU09T10/2009/CHN Norovirus env/GGII.4/968/2007/ITANorovirus Hu/GII.4/HK/CU09T12/2009/CHN Norovirus env/GGII.4/976/2007/ITANorovirus Hu/GII.4/HME-407/2005/TWN Norovirus env/GGII.4/980/2007/ITANorovirus Hu/GII.4/HME-417/2005/TWN Norovirus env/GGII.4/992/2007/ITANorovirus Hu/GII.4/HME-434/2005/TWN Norovirus env/GGII.4/994/2007/ITANorovirus Hu/GII.4/HME-465/2005/TWN Norovirus env/GGII.4/996/2007/ITANorovirus Hu/GII.4/HME-467/2005/TWN Norovirus environmental/GII-4/O01-Norovirus Hu/GII.4/HME-618/2006/TWN FDH/2008/UK NorovirusHu/GII.4/HME-620/2006/TWN Norovirus environmental/GII-4/O01- NorovirusHu/GII.4/HME-622/2006/TWN HBT/2008/UK NorovirusHu/GII.4/HME-624/2006/TWN Norovirus environmental/GII-4/O04- NorovirusHu/GII.4/HME-627/2006/TWN TDH/2008/UK NorovirusHu/GII.4/HME-631/2006/TWN Norovirus environmental/GII-4/O10- NorovirusHu/GII.4/HME-633/2006/TWN TFH/2008/UK Norovirus Hu/GII.4/HS194/2009/USNorovirus environmental/GII-4/O19- Norovirus Hu/GII.4/Hunter 284E/04O/AUHBT/2008/UK Norovirus Hu/GII.4/Hunter 532D/04O/AU Norovirusenvironmental/GII-4/O27- Norovirus Hu/GII.4/Hunter120A/04O/AUTFH/2008/UK Norovirus Hu/GII.4/Hunter273C/04O/AU Norovirusenvironmental/GII-4/O31- Norovirus Hu/GII.4/Hunter4288/04S/AUTDH/2008/UK Norovirus Hu/GII.4/Hunter504D/04O/AU NorovirusHu/GGI.4/1735OB/77351/FR Norovirus Hu/GII.4/Hunter882M/04S/AU NorovirusHu/GGI.4/oyster1735OA/77351/FR Norovirus Hu/GII.4/Hunter913K/04O/AUNorovirus Hu/GGII-4/Alzira/1695/06/Sp NorovirusHu/GII.4/Hunter956S/04O/AU Norovirus Hu/GGII- NorovirusHu/GII.4/Hunter990O/04O/AU 4/Badalona/1586/BNM_05/06/Sp NorovirusHu/GII.4/I/2006/FIN Norovirus Hu/GGII- Norovirus Hu/GII.4/II/2006/FIN4/Banyoles/1474/Gi_10/06/Sp Norovirus Hu/GII.4/III/2006/FIN NorovirusHu/GGII- Norovirus Hu/GII.4/Isehara1/2006/JP 4/Barcelona/1258/BNM_08/05Norovirus Hu/GII.4/Isehara2/2006/JP NorovirusHu/GGII-4/Benicarlo/1226/04 Norovirus Hu/GII.4/Jannali611C/04O/AUNorovirus Hu/GGII-4/Benidorm/1222/05 NorovirusHu/GII.4/Jannali670H/04O/AU Norovirus Hu/GGII-4/Benidorm/1680/06Norovirus Hu/GII.4/Kobe034/2006/JP NorovirusHu/GGII-4/Benidorm/1707/06/Sp Norovirus Hu/GII.4/Kogarah393H/04O/AUNorovirus Hu/GGII- Norovirus Hu/GII.4/Kogarah4006/04O/AU4/Blanes/1483/Gi_22/06/Sp Norovirus Hu/GII.4/Longbay/00O/AU NorovirusHu/GGII- Norovirus Hu/GII.4/Manly388P/04O/AU 4/Cabrera/1590/RCSP_01/SpNorovirus Hu/GII.4/ManlyVale098M/04O/AU NorovirusHu/GGII-4/Calonge/Gi_03/1216/05 Norovirus Hu/GII.4/Mc17/2002/ThNorovirus Hu/GGII- Norovirus Hu/GII.4/MD-2004/2004/US4/Cambrils/1105/TA_10/05 Norovirus Hu/GII.4/Miyagi/1/2006/JP NorovirusHu/GGII- Norovirus Hu/GII.4/Miyagi/1/2007/JP 4/Corbera/RCSP_68/1134/04Norovirus Hu/GII.4/Miyagi/10/2006/JP Norovirus Hu/GGII- NorovirusHu/GII.4/Miyagi/11/2006/JP 4/Els_Pallers/1617/TA_02/06/Sp NorovirusHu/GII.4/Miyagi/12/2006/JP Norovirus Hu/GGII-4/Peniscola/1227/05Norovirus Hu/GII.4/Miyagi/13/2006/JP NorovirusHu/GGII-4/Rosas/1078/Gi59/04 Norovirus Hu/GII.4/Miyagi/14/2006/JPNorovirus Hu/GGII- Norovirus Hu/GII.4/Miyagi/15/2006/JP4/Roses/1491/Gi_23/06/Sp Norovirus Hu/GII.4/Miyagi/16/2006/JP NorovirusHu/GGII- Norovirus Hu/GII.4/Miyagi/17/2006/JP 4/Sabadell/1196/RC94_04/04Norovirus Hu/GII.4/Miyagi/18/2006/JP Norovirus Hu/GGII- NorovirusHu/GII.4/Miyagi/19/2006/JP 4/Sabadell/1236/RC_08/05 NorovirusHu/GII.4/Miyagi/2/2006/JP Norovirus Hu/GGII- NorovirusHu/GII.4/Miyagi/2/2007/JP 4/Sabadell/1510/RC_02/06/Sp NorovirusHu/GII.4/Miyagi/20/2006/JP Norovirus Hu/GGII- NorovirusHu/GII.4/Miyagi/21/2006/JP 4/Sant_Cugat/1527/RC_06/06/Sp NorovirusHu/GII.4/Miyagi/22/2006/JP Norovirus Hu/GGII- NorovirusHu/GII.4/Miyagi/23/2006/JP 4/Sant_Quirze/1092/RC_80/04 NorovirusHu/GII.4/Miyagi/24/2006/JP Norovirus Hu/GGII- NorovirusHu/GII.4/Miyagi/3/2006/JP 4/Sant_Sadurni/1087/RC_84/04 NorovirusHu/GII.4/Miyagi/3/2007/JP Norovirus Hu/GGII- NorovirusHu/GII.4/Miyagi/4/2007/JP 4/Tarragona/1613/TA_01/06/Sp NorovirusHu/GII.4/Miyagi/5/2006/JP Norovirus Hu/GGII- NorovirusHu/GII.4/Miyagi/5/2007/JP 4/Tarragona/1624/TA_03/06/Sp NorovirusHu/GII.4/Miyagi/6/2006/JP Norovirus Hu/GGII- NorovirusHu/GII.4/Miyagi/6/2007/JP 4/Tarragona/1636/TA_05/06/Sp NorovirusHu/GII.4/Miyagi/7/2006/JP Norovirus Hu/GGII- NorovirusHu/GII.4/Miyagi/7/2007/JP 4/Tremp/1567/Lleida_03/06/Sp NorovirusHu/GII.4/Miyagi/8/2006/JP Norovirus Hu/GGII-4/Valencia_HCUV/593/02Norovirus Hu/GII.4/Miyagi/8/2007/JP Norovirus Hu/GGII- NorovirusHu/GII.4/Miyagi/9/2006/JP 4/Vall_de_Bianya/1477/Gi_19/06/Sp NorovirusHu/GII.4/Miyagi/9/2007/JP Norovirus Hu/GGII-4/Villareal/1669/06Norovirus Hu/GII.4/Miyagi/HM050413/2005/JP NorovirusHu/GGII.4/0029A/69787/2006/NLD NorovirusHu/GII.4/Miyagi/HM050426/2005/JP NorovirusHu/GGII.4/0029B/69787/2006/NLD NorovirusHu/GII.4/Miyagi/HM050511/2005/JP NorovirusHu/GGII.4/0518B/68592/2006/NLD NorovirusHu/GII.4/Miyagi/HM050525/2005/JP Norovirus Hu/GGII.4/190Nica/2005Norovirus Norovirus Hu/GGII.4/256Nica/2005Hu/GII.4/Mussels/M29nov2004/Foto/Sweden NorovirusHu/GGII.4/2639B/66430/2006/NLD Norovirus NorovirusHu/GGII.4/2936A/66430/2006/NLD Hu/GII.4/Mussels/M33nov2004/Foto/SwedenNorovirus Hu/GGII.4/322Nica/2005 Norovirus Hu/GII.4/NewOrleans1500/2008/USA Norovirus Hu/GGII.4/324Nica/2005 NorovirusHu/GII.4/Nijmegen/2007/NL Norovirus Hu/GGII.4/330Nica/2005 NorovirusHu/GII.4/Nijmegen/81230-R/2008/NLD Norovirus Hu/GGII.4/3474A/2006/NLDNorovirus Hu/GII.4/Nijmegen/90106- Norovirus Hu/GGII.4/3474Ab/2006/NLD42472/2008/NLD Norovirus Hu/GGII.4/355Nica/2005 NorovirusHu/GII.4/Nijmegen115/2006/NL Norovirus Hu/GGII.4/380Nica/2005 NorovirusHu/GII.4/Novosibirsk/s1218/2006/Ru Norovirus Hu/GGII.4/382Nica/2005Norovirus Hu/GII.4/Novosibirsk/s1416/2006/Ru NorovirusHu/GGII.4/392Nica/2005 Norovirus Hu/GII.4/Novosibirsk/s1475/2006/RuNorovirus Hu/GGII.4/410Nica/2005 NorovirusHu/GII.4/Novosibirsk/s16/2005/Ru Norovirus Hu/GGII.4/413Nica/2005Norovirus Hu/GII.4/Novosibirsk/s164/2005/Ru NorovirusHu/GGII.4/414Nica/2005 Norovirus Hu/GII.4/Novosibirsk/s1640/2006/RuNorovirus Hu/GGII.4/42Nica/2005 NorovirusHu/GII.4/Novosibirsk/s1735/2006/Ru Norovirus Hu/GGII.4/432Nica/2005Norovirus Hu/GII.4/Novosibirsk/s1744/2007/Ru NorovirusHu/GGII.4/448Nica/2005 Norovirus Hu/GII.4/Novosibirsk/s1747/2007/RuNorovirus Hu/GGII.4/482Nica/2005 NorovirusHu/GII.4/Novosibirsk/s1764/2007/Ru NorovirusHu/GGII.4/4992A/65902/2006/NLD NorovirusHu/GII.4/Novosibirsk/s1768/2007/Ru NorovirusHu/GGII.4/4992B/65902/2006/NLD NorovirusHu/GII.4/Novosibirsk/s1770/2007/Ru NorovirusHu/GGII.4/5357A/67071/2006/NLD NorovirusHu/GII.4/Novosibirsk/s1784/2007/Ru NorovirusHu/GGII.4/5357B/67071/2006/NLD NorovirusHu/GII.4/Novosibirsk/s1792/2007/Ru NorovirusHu/GGII.4/5391A/66878/2006/NLD NorovirusHu/GII.4/Novosibirsk/s1795/2007/Ru NorovirusHu/GGII.4/5391B/66878/2006/NLD NorovirusHu/GII.4/Novosibirsk/s1798/2007/Ru Norovirus Hu/GGII.4/567Nica/2005Norovirus Hu/GII.4/Novosibirsk/s1830/2007/Ru NorovirusHu/GGII.4/577Nica/2005 Norovirus Hu/GII.4/Novosibirsk/s1837/2007/RuNorovirus Hu/GGII.4/586Nica/2005 NorovirusHu/GII.4/Novosibirsk/s1843/2007/Ru Norovirus Hu/GGII.4/593Nica/2005Norovirus Hu/GII.4/Novosibirsk/s1862/2007/Ru NorovirusHu/GGII.4/623Nica/2005 Norovirus Hu/GII.4/Novosibirsk/s1918/2007/RuNorovirus Hu/GGII.4/6282A/69479/2006/NLD NorovirusHu/GII.4/Novosibirsk/s1925/2007/Ru Norovirus Hu/GGII.4/634Nica/2005Norovirus Hu/GII.4/Novosibirsk/s1985/2007/Ru NorovirusHu/GGII.4/668/2006/IT Norovirus Hu/GII.4/Novosibirsk/s2085/2007/RuNorovirus Hu/GGII.4/669/2006/IT NorovirusHu/GII.4/Novosibirsk/s2093/2007/Ru Norovirus Hu/GGII.4/692/2006/ITNorovirus Hu/GII.4/Novosibirsk/s2184/2007/Ru NorovirusHu/GGII.4/720Nica/2006 Norovirus Hu/GII.4/Novosibirsk/s23/2005/RuNorovirus Hu/GGII.4/723Nica/2006 NorovirusHu/GII.4/Novosibirsk/s2369/2007/Ru Norovirus Hu/GGII.4/729Nica/2006Norovirus Hu/GII.4/Novosibirsk/s2629/2007/Ru NorovirusHu/GGII.4/735Nica/2006 Norovirus Hu/GII.4/Novosibirsk/s2862/2008/RuNorovirus Hu/GGII.4/7366A/63808/NLD NorovirusHu/GII.4/Novosibirsk/s290/2005/Ru Norovirus Hu/GGII.4/7366B/63808/NLDNorovirus Hu/GII.4/Novosibirsk/s2980/2008/Ru NorovirusHu/GGII.4/8956A/66842/2006/NLD NorovirusHu/GII.4/Novosibirsk/s317/2005/Ru NorovirusHu/GGII.4/9893B/67814/2006/NLD NorovirusHu/GII.4/Novosibirsk/s345/2005/Ru Norovirus Hu/GGII.4/Almelo039/2004/NLNorovirus Hu/GII.4/Novosibirsk/s383/2005/Ru NorovirusHu/GGII.4/Apeldoorn023/2003/NL NorovirusHu/GII.4/Novosibirsk/s416/2005/Ru Norovirus Hu/GGII.4/B1/2002/DNKNorovirus Hu/GII.4/Novosibirsk/s625/2005/Ru NorovirusHu/GGII.4/B11/2003/DNK Norovirus Hu/GII.4/Nsk-1/2005/RUS NorovirusHu/GGII.4/B12/2003/DNK Norovirus Hu/GII.4/Nsk-1973/2007/RUS NorovirusHu/GGII.4/B13/2002/DNK Norovirus Hu/GII.4/Nsk-2111/2007/RUS NorovirusHu/GGII.4/B1O/2003/DNK Norovirus Hu/GII.4/Nsk-2501/2007/RUS NorovirusHu/GGII.4/B2/2002/DNK Norovirus Hu/GII.4/Nsk-2518/2007/RUS NorovirusHu/GGII.4/B3/2002/DNK Norovirus Hu/GII.4/Nsk-2523/2007/RUS NorovirusHu/GGII.4/B4/2002/DNK Norovirus Hu/GII.4/Nsk-2578/2007/RUS NorovirusHu/GGII.4/B5/2002/DNK Norovirus Hu/GII.4/Nsk-2853/2008/RUS NorovirusHu/GGII.4/B6/2002/DNK Norovirus Hu/GII.4/Nsk-2862/2008/RUS NorovirusHu/GGII.4/B7/2003/DNK Norovirus Hu/GII.4/Nsk-2980/2008/RUS NorovirusHu/GGII.4/B8/2002/DNK Norovirus Hu/GII.4/Nsk-3096/2008/RUS NorovirusHu/GGII.4/B9/2002/DNK Norovirus Hu/GII.4/Nsk-3147/2008/RUS NorovirusHu/GGII.4/Cairo1/2006/EGY Norovirus Hu/GII.4/Nsk-3175/2008/RUS NorovirusHu/GGII.4/Cairo10/2007/EGY Norovirus Hu/GII.4/Nsk-3255/2008/RUSNorovirus Hu/GGII.4/Cairo2/2006/EGY Norovirus Hu/GII.4/Nsk-3288/2008/RUSNorovirus Hu/GGII.4/Cairo3/2006/EGY Norovirus Hu/GII.4/Nsk-3315/2008/RUSNorovirus Hu/GGII.4/Cairo4/2006/EGY Norovirus Hu/GII.4/Nsk-3363/2008/RUSNorovirus Hu/GGII.4/Cairo5/2006/EGY Norovirus Hu/GII.4/Nsk-3392/2008/RUSNorovirus Hu/GGII.4/Cairo6/2006/EGY Norovirus Hu/GII.4/Nsk-3396/2008/RUSNorovirus Hu/GGII.4/Cairo7/2007/EGY Norovirus Hu/GII.4/Nsk-3412/2008/RUSNorovirus Hu/GGII.4/Cairo8/2007/EGY Norovirus Hu/GII.4/Nsk-3445/2008/RUSNorovirus Hu/GGII.4/Cairo9/2007/EGY Norovirus Hu/GII.4/Nsk-3469/2008/RUSNorovirus Hu/GGII.4/DenBosch028/2004/NL NorovirusHu/GII.4/Nsk-3481/2008/RUS Norovirus Hu/GGII.4/DenHaag001/2003/NLNorovirus Hu/GII.4/Nsk-38/2005/RUS NorovirusHu/GGII.4/DenHaag015/2000/NL Norovirus Hu/GII.4/Nsk-6/2005/RUS NorovirusHu/GGII.4/DenHelder003/2004/NL Norovirus Hu/GII.4/Nsk-B20/2009/RUSNorovirus Hu/GGII.4/Dijon-E1057/2002/FRA NorovirusHu/GII.4/Nsk-B30/2009/RUS Norovirus Hu/GGII.4/Dijon-E1267/2006/FRANorovirus Hu/GII.4/Nsk-B38/2009/RUS NorovirusHu/GGII.4/Dijon-E1501/2006/FRA Norovirus Hu/GII.4/Nsk-B42/2009/RUSNorovirus Hu/GGII.4/Dijon-E2703/2008/FRA NorovirusHu/GII.4/Nsk-B67/2009/RUS Norovirus Hu/GGII.4/E1/2002/DNK NorovirusHu/GII.4/Nsk-B8/2009/RUS Norovirus Hu/GGII.4/E2/2002/DNK NorovirusHu/GII.4/Nsk-D118/2009/RUS Norovirus Hu/GGII.4/E3/2002/DNK NorovirusHu/GII.4/Nsk-D173/2009/RUS Norovirus Hu/GGII.4/E4/2003/DNK NorovirusHu/GII.4/Nsk-D183/2009/RUS Norovirus Hu/GGII.4/E5/2003/DNK NorovirusHu/GII.4/Nsk-D186/2009/RUS Norovirus Hu/GGII.4/E6/2003/DNK NorovirusHu/GII.4/Nsk-D191/2009/RUS Norovirus Hu/GGII.4/E7/2003/DNK NorovirusHu/GII.4/Nsk-D211/2009/RUS Norovirus Hu/GGII.4/E8/2003/DNK NorovirusHu/GII.4/Nsk-D270/2009/RUS Norovirus Hu/GGII.4/E9/2003/DNK NorovirusHu/GII.4/Nsk-D43/2009/RUS Norovirus Hu/GGII.4/Elsloo012/2004/NLNorovirus Hu/GII.4/Nsk-D45/2009/RUS NorovirusHu/GGII.4/EmmenE006/2002/NL Norovirus Hu/GII.4/Nsk-H445/2004/RUSNorovirus Hu/GGII.4/Haarlem457/2003/NL NorovirusHu/GII.4/Nsk-H472/2004/RUS Norovirus Hu/GGII.4/Heerlen003/2003/NLNorovirus Hu/GII.4/Nsk-H486/2004/RUS Norovirus NorovirusHu/GII.4/Nsk-K17/2005/RUS Hu/GGII.4/Leeuwarden043/2000/NL NorovirusHu/GII.4/Nsk-K25/2005/RUS Norovirus Hu/GGII.4/Liempde048/2004/NLNorovirus Hu/GII.4/NSW001P/2008/AU NorovirusHu/GGII.4/Middelburg007/2004/NL Norovirus Hu/GII.4/NSW017I/2008/AUNorovirus Hu/GGII.4/New Delhi/150/02/IND NorovirusHu/GII.4/NSW023C/2008/AUS Norovirus Hu/GGII.4/New Delhi/188/01/INDNorovirus Hu/GII.4/NSW042H/2008/AU Norovirus Hu/GGII.4/NewDelhi/203/01/IND Norovirus Hu/GII.4/NSW071I/2008/AU NorovirusHu/GGII.4/New Delhi/219/01/IND Norovirus Hu/GII.4/NSW088L/2007/AUSNorovirus Hu/GGII.4/Nijmegen083/2004/NL NorovirusHu/GII.4/NSW132C/2007/AU Norovirus Hu/GGII.4/OA1/2002/DNK NorovirusHu/GII.4/NSW137F/2007/AU Norovirus Hu/GGII.4/OA2/2002/DNK NorovirusHu/GII.4/NSW146P/2007/AU Norovirus Hu/GGII.4/OA3/2002/DNK NorovirusHu/GII.4/NSW161F/2007/AU Norovirus Hu/GGII.4/OA4/2002/DNK NorovirusHu/GII.4/NSW199U/2008/AU Norovirus Hu/GGII.4/OC1/2002/DNK NorovirusHu/GII.4/NSW2218/2008/AU Norovirus Hu/GGII.4/OG1/2002/DNK NorovirusHu/GII.4/NSW227C/2006/AU Norovirus Hu/GGII.4/OG2/2002/DNK NorovirusHu/GII.4/NSW252E/2007/AU Norovirus Hu/GGII.4/OG3/2002/DNK NorovirusHu/GII.4/NSW264P/2007/AU Norovirus Hu/GGII.4/OG4/2002/DNK NorovirusHu/GII.4/NSW287R/2007/AUS Norovirus Hu/GGII.4/OG5/2002/DNK NorovirusHu/GII.4/NSW3639/2008/AU Norovirus Hu/GGII.4/OG6/2002/DNK NorovirusHu/GII.4/NSW3645/2008/AU Norovirus Hu/GGII.4/OL1/2002/DNK NorovirusHu/GII.4/NSW3722/2008/AU Norovirus Hu/GGII.4/OM11/2003/DNK NorovirusHu/GII.4/NSW390I/2008/AU Norovirus Hu/GGII.4/OM12/2003/DNK NorovirusHu/GII.4/NSW401B/2008/AU Norovirus Hu/GGII.4/OM13/2003/DNK NorovirusHu/GII.4/NSW4140/2008/AU Norovirus Hu/GGII.4/OM14/2002/DNK NorovirusHu/GII.4/NSW422H/2008/AU Norovirus Hu/GGII.4/OM15/2003/DNK NorovirusHu/GII.4/NSW505G/2007/AU Norovirus Hu/GGII.4/OM2/2002/DNK NorovirusHu/GII.4/NSW515L/2007/AU Norovirus Hu/GGII.4/OM3/2002/DNK NorovirusHu/GII.4/NSW519M/2008/AU Norovirus Hu/GGII.4/OM4/2002/DNK NorovirusHu/GII.4/NSW522G/2008/AU Norovirus Hu/GGII.4/OM5/2002/DNK NorovirusHu/GII.4/NSW523R/2007/AU Norovirus Hu/GGII.4/OM6/2003/DNK NorovirusHu/GII.4/NSW536S/2008/AU Norovirus Hu/GGII.4/OM7/2003/DNK NorovirusHu/GII.4/NSW544K/2008/AUS Norovirus Hu/GGII.4/OM8/2003/DNK NorovirusHu/GII.4/NSW587V/2007/AU Norovirus Hu/GGII.4/ON1/2002/DNK NorovirusHu/GII.4/NSW609H/2007/AU Norovirus Hu/GGII.4/OO1/2002/DNK NorovirusHu/GII.4/NSW618P/2008/AU Norovirus Hu/GGII.4/OO2/2002/DNK NorovirusHu/GII.4/NSW625N/2008/AU Norovirus Hu/GGII.4/OO4/2002/DNK NorovirusHu/GII.4/NSW647Q/2007/AU Norovirus Hu/GGII.4/OO5/2002/DNK NorovirusHu/GII.4/NSW682R/2007/AU Norovirus Hu/GGII.4/patient F/2006/NLDNorovirus Hu/GII.4/NSW710L/2007/AU Norovirus Hu/GGII.4/S1/2002/DNKNorovirus Hu/GII.4/NSW743L/2008/AUS Norovirus Hu/GGII.4/S2/2003/DNKNorovirus Hu/GII.4/NSW774W/2007/AU Norovirus Hu/GGII.4/S3/2003/DNKNorovirus Hu/GII.4/NSW806J/2008/AU Norovirus Hu/GGII.4/S4/2003/DNKNorovirus Hu/GII.4/NSW8891/2007/AU Norovirus Hu/GGII.4/S5/2003/DNKNorovirus Hu/GII.4/NSW889Z/2007/AU Norovirus Hu/GGII.4/S7/2003/DNKNorovirus Hu/GII.4/NSW9282/2008/AU Norovirus Hu/GGII.4/S8/2003/DNKNorovirus Hu/GII.4/NSW961W/2007/AU NorovirusHu/GGII.4/Schiedam018/2001/NL Norovirus Hu/GII.4/OC090053/2009/JPNNorovirus Hu/GGII.4/Tiel001/1995/NL Norovirus Hu/GII.4/PA1/2004/ITNorovirus Hu/GGII.4/Tilburg059/2004/NL Norovirus Hu/GII.4/PA118/2006/ITNorovirus Hu/GGII.4/Utrecht058/2001/NL NorovirusHu/GII.4/PA118R-/2004/IT Norovirus Hu/GGII.4/V10/2003/DNK NorovirusHu/GII.4/PA121/2006/IT Norovirus Hu/GGII.4/V11/2003/DNK NorovirusHu/GII.4/PA125R-/2004/IT Norovirus Hu/GGII.4/V12/2002/DNK NorovirusHu/GII.4/PA128R-/2004/IT Norovirus Hu/GGII.4/V13/2003/DNK NorovirusHu/GII.4/PA129R-/2004/IT Norovirus Hu/GGII.4/V15/2002/DNK NorovirusHu/GII.4/PA130R-/2004/IT Norovirus Hu/GGII.4/V4/2002/DNK NorovirusHu/GII.4/PA133/2006/IT Norovirus Hu/GGII.4/V5/2003/DNK NorovirusHu/GII.4/PA134R-/2004/IT Norovirus Hu/GGII.4/V8/2003/DNK NorovirusHu/GII.4/PA135R-/2004/IT Norovirus Hu/GGII.4/Valencia/2004/ES NorovirusHu/GII.4/PA138R-/2004/IT Norovirus Norovirus Hu/GII.4/PA14/2006/ITHu/GGII.4/Waddinxveen016/2000/NL Norovirus Hu/GII.4/PA143/2005/ITNorovirus Hu/GGII.4/WeertE022/2002/NL Norovirus Hu/GII.4/PA147/2006/ITNorovirus Hu/GII-4 vUC/M/2006/US Norovirus Hu/GII.4/PA148/2006/ITNorovirus Hu/GII-4/10641/2005/Bra Norovirus Hu/GII.4/PA15R-/2002/ITNorovirus Hu/GII-4/10668/2005/Bra Norovirus Hu/GII.4/PA163/2006/ITNorovirus Hu/GII-4/10689/2005/Bra Norovirus Hu/GII.4/PA173/2006/ITNorovirus Hu/GII-4/10831/2005/Bra Norovirus Hu/GII.4/PA175/2006/ITNorovirus Hu/GII-4/10942/2005/Bra Norovirus Hu/GII.4/PA178/2006/ITNorovirus Hu/GII-4/123027/2001/UK Norovirus Hu/GII.4/PA179/2006/ITNorovirus Hu/GII-4/414055/2004/UK Norovirus Hu/GII.4/PA180/2006/ITNorovirus Hu/GII-4/422031/2004/UK Norovirus Hu/GII.4/PA189/2006/ITNorovirus Hu/GII-4/588/2008/UK Norovirus Hu/GII.4/PA2/2005/IT NorovirusHu/GII-4/613123/2006/UK Norovirus Hu/GII.4/PA29R-/2002/IT NorovirusHu/GII-4/614025/2006/UK Norovirus Hu/GII.4/PA31/2006/IT NorovirusHu/GII-4/AC3-1/2006/UK Norovirus Hu/GII.4/PA37/2006/IT NorovirusHu/GII-4/Aichi3/2006/JP Norovirus Hu/GII.4/PA39/2005/IT NorovirusHu/GII-4/Aichi4/2006/JP Norovirus Hu/GII.4/PA53/2006/IT NorovirusHu/GII-4/Akita1/2006/JP Norovirus Hu/GII.4/PA56/2005/IT NorovirusHu/GII-4/Akita2/2006/JP Norovirus Hu/GII.4/PA57/2004/IT NorovirusHu/GII-4/Akita4/2006/JP Norovirus Hu/GII.4/PA58R-/2004/IT NorovirusHu/GII-4/Akita5/2006/JP Norovirus Hu/GII.4/PA71/2006/IT NorovirusHu/GII-4/AN6-Newc/2005/UK Norovirus Hu/GII.4/PA9R-/2004/IT NorovirusHu/GII-4/Aomori1/2006/JP Norovirus Hu/GII.4/Parma/1875/2008/ITANorovirus Hu/GII-4/Aomori2/2006/JP NorovirusHu/GII.4/Parma/1896/2008/ITA Norovirus Hu/GII-4/Aomori4/2006/JPNorovirus Hu/GII.4/Picton037/03O/AU Norovirus Hu/GII-4/Aomori5/2006/JPNorovirus Hu/GII.4/Picton081/03O/AU Norovirus Hu/GII-4/Aqualand/1015/04Norovirus Hu/GII.4/Ramsgate336I/04O/AU NorovirusHu/GII-4/Awa/040354/2004/JP Norovirus Hu/GII.4/Rhyl440/2005/UK NorovirusHu/GII-4/Awa/061288/2006/JP Norovirus Hu/GII.4/RIS/2006/USA NorovirusHu/GII-4/Barcelona/985/03 Norovirus Hu/GII.4/Riviera1590/2008/USNorovirus Hu/GII-4/Beijing/h1/2005/CHN NorovirusHu/GII.4/Riviera1635/2008/US Norovirus Hu/GII-4/Beijing145/2007/ChinaNorovirus Hu/GII.4/RotterdamP2D0/2005/NL NorovirusHu/GII-4/Beijing151/2007/China NorovirusHu/GII.4/RotterdamP2D182/2005/NL NorovirusHu/GII-4/Beijing157/2007/China Norovirus Hu/GII.4/RotterdamP3D0/2006/NLNorovirus Hu/GII-4/Benidorm/812/02/Sp NorovirusHu/GII.4/RotterdamP3D21/2006/NL Norovirus Hu/GII-4/Benidorm/858/02/SpNorovirus Hu/GII.4/RotterdamP4D0/2006/NL NorovirusHu/GII-4/Benidorm/901/03/Sp Norovirus Hu/GII.4/RotterdamP4D33/2006/NLNorovirus Hu/GII-4/Berga/759/02/Sp NorovirusHu/GII.4/RotterdamP5D36/2005/NL Norovirus Hu/GII- NorovirusHu/GII.4/RotterdamP5D51/2005/NL 4/Berga/RC69_02/926/03/Sp NorovirusHu/GII.4/RotterdamP6D0/2006/NL Norovirus Hu/GII-4/Brynhaven/2003/UKNorovirus Hu/GII.4/RotterdamP6D33/2006/NL NorovirusHu/GII-4/C1-158/South Korea Norovirus Hu/GII.4/RotterdamP7D0/2006/NLNorovirus Hu/GII-4/C1-163/South Korea NorovirusHu/GII.4/RotterdamP7D119/2007/NL Norovirus Hu/GII-4/C1-164/South KoreaNorovirus Hu/GII.4/RotterdamP8D65/2006/NL NorovirusHu/GII-4/C1-183/South Korea Norovirus Hu/GII.4/Salvador/A01/2006/BRANorovirus Hu/GII-4/C1-184/South Korea NorovirusHu/GII.4/Salvador/A02/2006/BRA Norovirus Hu/GII-4/C1-185/South KoreaNorovirus Hu/GII.4/Salvador/A05/2006/BRA Norovirus Hu/GII-4/C1-186/SouthKorea Norovirus Hu/GII.4/Salvador/A09/2006/BRA NorovirusHu/GII-4/C1-188/South Korea Norovirus Hu/GII.4/Salvador/A10/2006/BRANorovirus Hu/GII-4/C1-198/South Korea NorovirusHu/GII.4/Salvador/A11/2006/BRA Norovirus Hu/GII-4/C1-199/South KoreaNorovirus Hu/GII.4/Salvador/A12/2006/BRA Norovirus Hu/GII-4/C1-200/SouthKorea Norovirus Hu/GII.4/Salvador/B01/2006/BRA NorovirusHu/GII-4/C1-258/South Korea Norovirus Hu/GII.4/Salvador/B06/2006/BRANorovirus Hu/GII-4/C1-275/South Korea NorovirusHu/GII.4/Salvador/B08/2006/BRA Norovirus Hu/GII-4/C1-307/South KoreaNorovirus Hu/GII.4/Salvador/B09/2006/BRA Norovirus Hu/GII-4/C1-308/SouthKorea Norovirus Hu/GII.4/Salvador/B11/2006/BRA NorovirusHu/GII-4/C1-309/South Korea Norovirus Hu/GII.4/Salvador/B12/2006/BRANorovirus Hu/GII-4/C3-89/South Korea NorovirusHu/GII.4/Salvador/C01/2006/BRA Norovirus Hu/GII-4/C3-92/South KoreaNorovirus Hu/GII.4/Salvador/C02/2006/BRA Norovirus Hu/GII-4/C4-26/SouthKorea Norovirus Hu/GII.4/Salvador/C03/2006/BRA NorovirusHu/GII-4/C5-105/South Korea Norovirus Hu/GII.4/Salvador/C04/2006/BRANorovirus Hu/GII-4/C5-107/South Korea NorovirusHu/GII.4/Salvador/C06/2006/BRA Norovirus Hu/GII-4/C5-113/South KoreaNorovirus Hu/GII.4/Salvador/C07/2006/BRA Norovirus Hu/GII-4/C5-150/SouthKorea Norovirus Hu/GII.4/Salvador/C09/2006/BRA NorovirusHu/GII-4/C5-159/South Korea Norovirus Hu/GII.4/Salvador/C10/2006/BRANorovirus Hu/GII-4/C5-76/South Korea NorovirusHu/GII.4/Salvador/C11/2006/BRA Norovirus Hu/GII-4/C6-107/South KoreaNorovirus Hu/GII.4/Salvador/C12/2006/BRA Norovirus Hu/GII-4/C6-108/SouthKorea Norovirus Hu/GII.4/Salvador/D01/2006/BRA NorovirusHu/GII-4/C7-429/South Korea Norovirus Hu/GII.4/Salvador/D02/2006/BRANorovirus Hu/GII-4/c7-446/South Korea NorovirusHu/GII.4/Salvador/D03/2006/BRA Norovirus Hu/GII-4/C7-481/South KoreaNorovirus Hu/GII.4/Salvador/D04/2006/BRA Norovirus Hu/GII-4/C7-486/SouthKorea Norovirus Hu/GII.4/Salvador/D05/2006/BRA NorovirusHu/GII-4/C7-487/South Korea Norovirus Hu/GII.4/Salvador/D08/2006/BRANorovirus Hu/GII-4/Can_Sans/787/02/Sp NorovirusHu/GII.4/Salvador/D09/2006/BRA NorovirusHu/GII-4/Centelles/RC05-03/909/03 NorovirusHu/GII.4/Salvador/D11/2006/BRA Norovirus Hu/GII-4/Chester/2006/UKNorovirus Hu/GII.4/Salvador/D12/2006/BRA NorovirusHu/GII-4/Chiba/040095/2003/JP Norovirus Hu/GII.4/Salvador/E01/2006/BRANorovirus Hu/GII-4/Chiba/040974/2004/JP NorovirusHu/GII.4/Salvador/E02/2006/BRA Norovirus Hu/GII-4/Chosei/061333/2006/JPNorovirus Hu/GII.4/Salvador/E03/2006/BRA NorovirusHu/GII-4/CUK-3/2008/KR Norovirus Hu/GII.4/Salvador/E06/2006/BRANorovirus Hu/GII-4/EAUS Wd/2008/UK NorovirusHu/GII.4/Salvador/E09/2006/BRA Norovirus Hu/GII-4/Ehime1/2006/JPNorovirus Hu/GII.4/Salvador/E10/2006/BRA NorovirusHu/GII-4/Ehime2/2006/JP Norovirus Hu/GII.4/Salvador/F01/2006/BRANorovirus Hu/GII-4/Ehime5/2006/JP NorovirusHu/GII.4/Salvador/F06/2006/BRA Norovirus Hu/GII-4/ES001/2003/BRANorovirus Hu/GII.4/Salvador/F08/2006/BRA NorovirusHu/GII-4/ES003/2003/BRA Norovirus Hu/GII.4/Salvador/F09/2006/BRANorovirus Hu/GII-4/ES008/2003/BRA NorovirusHu/GII.4/Salvador/F10/2006/BRA Norovirus Hu/GII-4/ES014/2003/BRANorovirus Hu/GII.4/Salvador/F11/2006/BRA NorovirusHu/GII-4/ES017/2003/BRA Norovirus Hu/GII.4/Salvador/F12/2006/BRANorovirus Hu/GII-4/ES020/2003/BRA NorovirusHu/GII.4/Salvador/G01/2006/BRA Norovirus Hu/GII-4/ES029/2003/BRANorovirus Hu/GII.4/Salvador/G02/2006/BRA NorovirusHu/GII-4/ES035/2003/BRA Norovirus Hu/GII.4/Salvador/G03/2006/BRANorovirus Hu/GII-4/ES040/2003/BRA NorovirusHu/GII.4/Salvador/G05/2006/BRA Norovirus Hu/GII-4/ES272/2003/BRANorovirus Hu/GII.4/Salvador/G07/2006/BRA Norovirus Hu/GII-4/FUMI/2010/JPNorovirus Hu/GII.4/Salvador/G08/2006/BRA Norovirus Hu/GII- NorovirusHu/GII.4/Salvador/G09/2006/BRA 4/Funabashi/050601/2005/JP NorovirusHu/GII.4/Salvador/H05/2006/BRA Norovirus Hu/GII- NorovirusHu/GII.4/Salvador/H06/2006/BRA 4/Funabashi/060548/2006/JP NorovirusHu/GII.4/Salvador/H07/2006/BRA Norovirus Hu/GII-4/He Wd/2008/UKNorovirus Hu/GII.4/Salvador/H09/2006/BRA NorovirusHu/GII-4/Hiroshima1/2006/JP Norovirus Hu/GII.4/Salvador/H11/2006/BRANorovirus Hu/GII-4/Hiroshima2/2006/JP NorovirusHu/GII.4/Salvador/H12/2006/BRA Norovirus Hu/GII-4/Ho Wd/2008/UKNorovirus Hu/GII.4/Samokov172/2007/BGR NorovirusHu/GII-4/Hokkaido1/2006/JP Norovirus Hu/GII.4/Seoul/0015/2007/KORNorovirus Hu/GII-4/Hokkaido2/2006/JP NorovirusHu/GII.4/Seoul/0017/2007/KOR Norovirus Hu/GII-4/Hokkaido3/2006/JPNorovirus Hu/GII.4/Seoul/0023/2007/KOR NorovirusHu/GII-4/Hokkaido4/2006/JP Norovirus Hu/GII.4/Seoul/0039/2007/KORNorovirus Hu/GII-4/Hokkaido5/2006/JP NorovirusHu/GII.4/Seoul/0040/2007/KOR Norovirus Hu/GII-4/Ichikawa/050701/2005/JPNorovirus Hu/GII.4/Seoul/0045/2007/KOR NorovirusHu/GII-4/Ichikawa/060832/2006/JP Norovirus Hu/GII.4/Seoul/0053/2007/KORNorovirus Hu/GII-4/Ichikawa/061159/2006/JP NorovirusHu/GII.4/Seoul/0059/2008/KOR Norovirus Hu/GII-4/Inba/050590/2005/JPNorovirus Hu/GII.4/Seoul/0065/2008/KOR NorovirusHu/GII-4/Inba/060946/2006/JP Norovirus Hu/GII.4/Seoul/0066/2008/KORNorovirus Hu/GII-4/Inba/060966/2006/JP NorovirusHu/GII.4/Seoul/0068/2008/KOR Norovirus Hu/GII-4/Inba/061099/2006/JPNorovirus Hu/GII.4/Seoul/0074/2008/KOR NorovirusHu/GII-4/Inba/061224/2006/JP Norovirus Hu/GII.4/Seoul/0093/2008/KORNorovirus Hu/GII-4/Inba/061365/2006/JP NorovirusHu/GII.4/Seoul/0097/2008/KOR Norovirus Hu/GII-4/Inba/061367/2006/JPNorovirus Hu/GII.4/Seoul/0104/2008/KOR NorovirusHu/GII-4/Inba/061421/2006/JP Norovirus Hu/GII.4/Seoul/0106/2008/KORNorovirus Hu/GII-4/Isumi/060936/2006/JP NorovirusHu/GII.4/Seoul/0120/2008/KOR Norovirus Hu/GII-4/Jeju-1/2007/KORNorovirus Hu/GII.4/Seoul/0134/2008/KOR NorovirusHu/GII-4/Jeju-10/2007/KOR Norovirus Hu/GII.4/Seoul/0136/2008/KORNorovirus Hu/GII-4/Jeju-11/2007/KOR NorovirusHu/GII.4/Seoul/0176/2008/KOR Norovirus Hu/GII-4/Jeju-12/2007/KORNorovirus Hu/GII.4/Seoul/0183/2008/KOR NorovirusHu/GII-4/Jeju-14/2007/KOR Norovirus Hu/GII.4/Seoul/0199/2007/KORNorovirus Hu/GII-4/Jeju-15/2007/KOR NorovirusHu/GII.4/Seoul/0200/2007/KOR Norovirus Hu/GII-4/Jeju-16/2007/KORNorovirus Hu/GII.4/Seoul/0202/2007/KOR NorovirusHu/GII-4/Jeju-19/2007/KOR Norovirus Hu/GII.4/Seoul/0205/2007/KORNorovirus Hu/GII-4/Jeju-2/2007/KOR NorovirusHu/GII.4/Seoul/0206/2007/KOR Norovirus Hu/GII-4/Jeju-21/2007/KORNorovirus Hu/GII.4/Seoul/0207/2007/KOR NorovirusHu/GII-4/Jeju-22/2007/KOR Norovirus Hu/GII.4/Seoul/0209/2007/KORNorovirus Hu/GII-4/Jeju-27/2007/KOR NorovirusHu/GII.4/Seoul/0210/2007/KOR Norovirus Hu/GII-4/Jeju-29/2007/KORNorovirus Hu/GII.4/Seoul/0215/2007/KOR NorovirusHu/GII-4/Jeju-32/2007/KOR Norovirus Hu/GII.4/Seoul/0217/2007/KORNorovirus Hu/GII-4/Jeju-34/2007/KOR NorovirusHu/GII.4/Seoul/0218/2007/KOR Norovirus Hu/GII-4/Jeju-4/2007/KORNorovirus Hu/GII.4/Seoul/0221/2007/KOR NorovirusHu/GII-4/Jeju-41/2007/KOR Norovirus Hu/GII.4/Seoul/0228/2008/KORNorovirus Hu/GII-4/Jeju-47/2007/KOR NorovirusHu/GII.4/Seoul/0229/2008/KOR Norovirus Hu/GII-4/Jeju-9/2007/KORNorovirus Hu/GII.4/Seoul/0230/2008/KOR NorovirusHu/GII-4/JN15-Newc/2006/UK Norovirus Hu/GII.4/Seoul/0233/2008/KORNorovirus Hu/GII-4/JN3-Newc/2006/UK NorovirusHu/GII.4/Seoul/0234/2008/KOR Norovirus Hu/GII-4/Kaiso/030556/2003/JPNorovirus Hu/GII.4/Seoul/0237/2008/KOR NorovirusHu/GII-4/Kaiso/060848/2006/JP Norovirus Hu/GII.4/Seoul/0244/2008/KORNorovirus Hu/GII-4/Kaiso/061318/2006/JP NorovirusHu/GII.4/Seoul/0245/2008/KOR Norovirus Hu/GII-4/Kashiwa/060802/2006/JPNorovirus Hu/GII.4/Shenzhen104-06/2006/CHN NorovirusHu/GII-4/Kashiwa/061256/2006/JP NorovirusHu/GII.4/Shenzhen12-06/2006/CHN Norovirus Hu/GII-4/Katori/041008/2004/JPNorovirus Hu/GII.4/Shenzhen120-06/2006/CHN NorovirusHu/GII-4/Katori/061002/2006/JP NorovirusHu/GII.4/Shenzhen122-06/2006/CHN NorovirusHu/GII-4/Katori/061492/2006/JP NorovirusHu/GII.4/Shenzhen124-06/2006/CHN NorovirusHu/GII-4/Kimitsu/041440/2005/JP NorovirusHu/GII.4/Shenzhen166-06/2006/CHN NorovirusHu/GII-4/Kimitsu/061146/2006/JP NorovirusHu/GII.4/Shenzhen172-06/2006/CHN NorovirusHu/GII-4/Kimitsu/061427/2006/JP NorovirusHu/GII.4/Shenzhen173-06/2006/CHN Norovirus Hu/GII-4/Kumamoto1/2006/JPNorovirus Hu/GII.4/Shenzhen176-06/2006/CHN NorovirusHu/GII-4/Kumamoto2/2006/JP Norovirus Hu/GII.4/Shenzhen178-06/2006/CHNNorovirus Hu/GII-4/Kumamoto3/2006/JP NorovirusHu/GII.4/Shenzhen179-06/2006/CHN Norovirus Hu/GII-4/Kumamoto4/2006/JPNorovirus Hu/GII.4/Shenzhen181-06/2006/CHN NorovirusHu/GII-4/Kumamoto5/2006/JP Norovirus Hu/GII.4/Shenzhen196-06/2006/CHNNorovirus Hu/GII-4/Lincoln House/2006/UK NorovirusHu/GII.4/Shenzhen21-06/2006/CHN NorovirusHu/GII-4/Manresa/81_02/914/02/Sp NorovirusHu/GII.4/Shenzhen27-06/2006/CHN NorovirusHu/GII-4/Matsudo/021071/2002/JP NorovirusHu/GII.4/Shenzhen44-06/2006/CHN NorovirusHu/GII-4/Matsudo/060907/2006/JP NorovirusHu/GII.4/Shenzhen63-06/2006/CHN NorovirusHu/GII-4/Matsudo/061442/2006/JP NorovirusHu/GII.4/Shenzhen66-06/2006/CHN NorovirusHu/GII-4/Matsudo/061495/2006/JP NorovirusHu/GII.4/Shenzhen76-06/2006/CHN Norovirus Hu/GII-4/Miyagi2/2006/JPNorovirus Hu/GII.4/Shenzhen79-06/2006/CHN NorovirusHu/GII-4/Miyagi4/2006/JP Norovirus Hu/GII.4/Shenzhen85-06/2006/CHNNorovirus Hu/GII-4/Miyagi5/2006/JP NorovirusHu/GII.4/Shenzhen95-06/2006/CHN Norovirus Hu/GII-4/Morella/867/03/SpNorovirus Hu/GII.4/SHZH004/2007/CHN Norovirus Hu/GII- NorovirusHu/GII.4/SHZH009/2007/CHN 4/Narashino/060903/2006/JP NorovirusHu/GII.4/SHZH012/2007/CHN Norovirus Hu/GII- NorovirusHu/GII.4/SHZH154/2007/CHN 4/Narashino/061281/2006/JP NorovirusHu/GII.4/SHZH166/2007/CHN Norovirus Hu/GII-4/NFL-1602VR88/02- NorovirusHu/GII.4/SHZH168/2007/CHN 2005/CAN Norovirus Hu/GII.4/SSCS/2005/USANorovirus Hu/GII-4/NFL1903/VR13/02- NorovirusHu/GII.4/Stockholm/19865/2008/SE 2005/CAN NorovirusHu/GII.4/Su2445/03O/AU Norovirus Hu/GII-4/Noda/061126/2006/JP NorovirusHu/GII.4/Sydney1145/98S/AU Norovirus Hu/GII-4/OM06213/2006/UK NorovirusHu/GII.4/Sydney1347/98S/AU Norovirus Hu/GII-4/Osaka/1998/JPN NorovirusHu/GII.4/Sydney1696/98S/AU Norovirus Hu/GII-4/passenger NorovirusHu/GII.4/Sydney198N/04S/AU 1/OB6/2007/UK NorovirusHu/GII.4/Sydney2086/98S/AU Norovirus Hu/GII-4/Patient1/2004/UK NorovirusHu/GII.4/Sydney2113/98S/AU Norovirus Hu/GII-4/Patient10/2007/UKNorovirus Hu/GII.4/Sydney2145/98O/AU NorovirusHu/GII-4/Patient11/2007/UK Norovirus Hu/GII.4/Sydney267J/04S/AUNorovirus Hu/GII-4/Patient2-1/2006/UK NorovirusHu/GII.4/Sydney284/97S/AU Norovirus Hu/GII-4/Patient2-4/2006/UKNorovirus Hu/GII.4/Sydney348/97O/AU Norovirus Hu/GII-4/Patient5/2006/UKNorovirus Hu/GII.4/Sydney4012/02S/AU Norovirus Hu/GII-4/Patient6/2006/UKNorovirus Hu/GII.4/Sydney4134/01S/AU NorovirusHu/GII-4/Patient7-1/2006/UK Norovirus Hu/GII.4/Sydney4136/01S/AUNorovirus Hu/GII-4/Patient7-2/2006/UK NorovirusHu/GII.4/Sydney4209/01S/AU Norovirus Hu/GII-4/Patient8/2006/UK NorovirusHu/GII.4/Sydney4237/01S/AU Norovirus Hu/GII-4/Patient9/2006/UK NorovirusHu/GII.4/Sydney4262/01S/AU Norovirus Hu/GII-4/Peniscola/583/02/SpNorovirus Hu/GII.4/Sydney4264/01S/AU NorovirusHu/GII-4/Peniscola/852/02/Sp Norovirus Hu/GII.4/Sydney4266/01S/AUNorovirus Hu/GII-4/Pineda_de_Mar/792/02/Sp NorovirusHu/GII.4/Sydney4288/02S/AU Norovirus Hu/GII-4/Portsmouth/2004/UKNorovirus Hu/GII.4/Sydney4337/02S/AU NorovirusHu/GII-4/Res._S.Patricio/757/02/Sp Norovirus Hu/GII.4/Sydney4360/02S/AUNorovirus Hu/GII- Norovirus Hu/GII.4/Sydney4384/02S/AU4/Res_Enbellpuig/793/02/Sp Norovirus Hu/GII.4/Sydney4416/02S/AUNorovirus Hu/GII-4/RH488/2008/UK Norovirus Hu/GII.4/Sydney4477/02S/AUNorovirus Hu/GII-4/Rhyl-FCH/2008/UK Norovirus Hu/GII.4/Sydney4480/02S/AUNorovirus Hu/GII-4/Rhyl440/2004/UK Norovirus Hu/GII.4/Sydney591/97S/AUNorovirus Hu/GII-4/Saga1/2006/JP Norovirus Hu/GII.4/Sydney625K/04O/AUNorovirus Hu/GII-4/Saga4/2006/JP Norovirus Hu/GII.4/Sydney642/97S/AUNorovirus Hu/GII-4/Saga5/2006/JP Norovirus Hu/GII.4/Sydney715D/04S/AUNorovirus Hu/GII-4/Sakai2/2006/JP Norovirus Hu/GII.4/Sydney740C/2006/AUSNorovirus Hu/GII-4/Sakai3/2006/JP Norovirus Hu/GII.4/Sydney755/97S/AUNorovirus Hu/GII-4/Sakai4/2006/JP Norovirus Hu/GII.4/Sydney762I/04S/AUNorovirus Hu/GII- Norovirus Hu/GII.4/Sydney776/99O/AU4/Sallent/RC_73_02/921/02/Sp Norovirus Hu/GII.4/Sydney812J/02O/AUNorovirus Hu/GII-4/Sanbu/050878/2006/JP NorovirusHu/GII.4/Sydney917J/02O/AU Norovirus Hu/GII-4/STDGH/2008/UK NorovirusHu/GII.4/Taipei-AB/06/TW Norovirus Hu/GII-4/Tarrasa/772/02/Sp NorovirusHu/GII.4/Taipei-AD/06/TW Norovirus Hu/GII-4/Toyama1/2006/JP NorovirusHu/GII.4/Taipei-AE/06/TW Norovirus Hu/GII-4/Toyama4/2006/JP NorovirusHu/GII.4/Taipei-AN/06/TW Norovirus Hu/GII-4/Toyama5/2006/JP NorovirusHu/GII.4/Taipei-AN1/06/TW Norovirus Hu/GII-4/U/2004/UK NorovirusHu/GII.4/Taipei-AP/06/TW Norovirus Hu/GII-4/Valencia/530i/01/SpNorovirus Hu/GII.4/Taipei-AR/06/TW Norovirus Hu/GII-4/Vilanova/767/02/SpNorovirus Hu/GII.4/Taipei-AS/06/TW Norovirus Hu/GII.4/10468/2005/BRANorovirus Hu/GII.4/Taipei-AW/06/TW Norovirus Hu/GII.4/10513/2005/BRANorovirus Hu/GII.4/Taipei-AZ/06/TW Norovirus Hu/GII.4/10526/2004/IRLNorovirus Hu/GII.4/Taipei-BB/06/TW Norovirus Hu/GII.4/10624/2005/BRANorovirus Hu/GII.4/Taipei-BD/06/TW Norovirus Hu/GII.4/10641/2005/BRANorovirus Hu/GII.4/Taipei-BG/06/TW Norovirus Hu/GII.4/10661/2005/BRANorovirus Hu/GII.4/Taipei-D/06/TW Norovirus Hu/GII.4/10668/2005/BRANorovirus Hu/GII.4/Taipei-U/06/TW Norovirus Hu/GII.4/10801/2005/BRANorovirus Hu/GII.4/Taipei-V/06/TW Norovirus Hu/GII.4/10852/2005/BRANorovirus Hu/GII.4/Terneuzen70/2006/NL Norovirus Hu/GII.4/10897/2005/BRANorovirus Hu/GII.4/Tianjin/2/2008/CHN Norovirus Hu/GII.4/10942/2005/BRANorovirus Hu/GII.4/Tianjin/26/2008/CHN Norovirus Hu/GII.4/10962/2005/BRANorovirus Hu/GII.4/Tianjin/27/2008/CHN Norovirus Hu/GII.4/11779/2005/BRANorovirus Hu/GII.4/Tianjin/28/2008/CHN Norovirus Hu/GII.4/11869/2006/BRANorovirus Hu/GII.4/Tianjin/29/2008/CHN Norovirus Hu/GII.4/11952/2006/BRANorovirus Hu/GII.4/Tianjin/30/2008/CHN Norovirus Hu/GII.4/12016/2006/BRANorovirus Hu/GII.4/Tianjin/31/2008/CHN Norovirus Hu/GII.4/12044/2006/BRANorovirus Hu/GII.4/Tianjin/33/2008/CHN Norovirus Hu/GII.4/12079/2006/BRANorovirus Hu/GII.4/Tianjin/34/2008/CHN Norovirus Hu/GII.4/12090/2006/BRANorovirus Hu/GII.4/Tianjin/36/2008/CHN Norovirus Hu/GII.4/12091/2006/BRANorovirus Hu/GII.4/Tianjin/42/2008/CHN Norovirus Hu/GII.4/12098/2006/BRANorovirus Hu/GII.4/Tianjin/50/2008/CHN Norovirus Hu/GII.4/12103/2006/BRANorovirus Hu/GII.4/Tianjin/55/2008/CHN Norovirus Hu/GII.4/12155/2006/BRANorovirus Hu/GII.4/Tianjin/62/2008/CHN Norovirus Hu/GII.4/12161/2006/BRANorovirus Hu/GII.4/Tianjin/66/2008/CHN NorovirusHu/GII.4/122/17/2006/RJ/BRA Norovirus Hu/GII.4/Tianjin/68/2008/CHNNorovirus Hu/GII.4/124/12/2006/RJ/BRA NorovirusHu/GII.4/Tianjin/72/2008/CHN Norovirus Hu/GII.4/124/16/2006/RJ/BRANorovirus Hu/GII.4/Tianjin/75/2008/CHN NorovirusHu/GII.4/130/13/2006/RJ/BRA Norovirus Hu/GII.4/Tianjin/9/2008/CHNNorovirus Hu/GII.4/13370/2007/BRA Norovirus Hu/GII.4/Tianjin/90/2008/CHNNorovirus Hu/GII.4/13473/2007/BRA Norovirus Hu/GII.4/Tianjin/91/2008/CHNNorovirus Hu/GII.4/13504/2007/BRA NorovirusHu/GII.4/Turramurra597U/04O/AU Norovirus Hu/GII.4/13531/2007/BRANorovirus Hu/GII.4/Turramurra604J/04O/AU NorovirusHu/GII.4/13563/2007/BRA Norovirus Hu/GII.4/VIC0682/2007/AU NorovirusHu/GII.4/13693/2007/BRA Norovirus Hu/GII.4/VIC3850/2007/AU NorovirusHu/GII.4/13707/2007/BRA Norovirus Hu/GII.4/VIC3852/2007/AU NorovirusHu/GII.4/13822/2007/BRA Norovirus Hu/GII.4/VIC3863/2007/AU NorovirusHu/GII.4/13827/2007/BRA Norovirus Hu/GII.4/VIC4670/2007/AU NorovirusHu/GII.4/13930/2007/BRA Norovirus Hu/GII.4/VIC4681/2007/AU NorovirusHu/GII.4/13945/2007/BRA Norovirus Hu/GII.4/VIC4906/2007/AU NorovirusHu/GII.4/14/1/19/2007/RJ/BRA Norovirus Hu/GII.4/VIC4911/2007/AUNorovirus Hu/GII.4/14013/2007/BRA Norovirus Hu/GII.4/VIC8188/2007/AUNorovirus Hu/GII.4/14865/2008/RJ/BRA Norovirus Hu/GII.4/VIC8193/2007/AUNorovirus Hu/GII.4/2004/NL Norovirus Hu/GII.4/WA001D/2007/AU NorovirusHu/GII.4/2006b/AS2/2007/CHN Norovirus Hu/GII.4/WA080B/2008/AU NorovirusHu/GII.4/2006b/AS6/2007/CHN Norovirus Hu/GII.4/WA125C/2007/AU NorovirusHu/GII.4/2006b/AS7/2007/CHN Norovirus Hu/GII.4/WA178J/2007/AU NorovirusHu/GII.4/2006b/BX7/2007/CHN Norovirus Hu/GII.4/WA229F/2007/AU NorovirusHu/GII.4/2006b/DD6/2007/CHN Norovirus Hu/GII.4/WA432N/2007/AU NorovirusHu/GII.4/2006b/DD9/2007/CHN Norovirus Hu/GII.4/WA476G/2007/AU NorovirusHu/GII.4/2006b/DL2/2007/CHN Norovirus Hu/GII.4/WA530G/2007/AU NorovirusHu/GII.4/2006b/DL4/2007/CHN Norovirus Hu/GII.4/WA670N/2007/AU NorovirusHu/GII.4/2006b/FS7/2007/CHN Norovirus Hu/GII.4/WA971W/2007/AU NorovirusHu/GII.4/2006b/FX2/2007/CHN Norovirus Hu/GII.4/WA988N/2007/AU NorovirusHu/GII.4/2006b/FX3/2007/CHN Norovirus Hu/GII.4/Wellington/1995/USANorovirus Hu/GII.4/2006b/FX8/2007/CHN NorovirusHu/GII.4/Yerseke38/2006/NL Norovirus Hu/GII.4/2006b/JZ7/2007/CHNNorovirus Hu/GII.4a/Sofia367/2007/BGR NorovirusHu/GII.4/2006b/JZ8/2007/CHN Norovirus Hu/GII4/47836/Hainan/06/CHNNorovirus Hu/GII.4/2006b/LY10/2007/CHN NorovirusHu/GII4/47847/Hainan/06/CHN Norovirus Hu/GII.4/2006b/LY2/2007/CHNNorovirus Hu/GII4/47925/Hebei/06/CHN NorovirusHu/GII.4/2006b/LY4/2007/CHN Norovirus Hu/GII4/48178/Shanxi/06/CHNNorovirus Hu/GII.4/2006b/LY6/2007/CHN NorovirusHu/GII4/49613/Shaanxi/06/CHN Norovirus Hu/GII.4/2006b/LY7/2007/CHNNorovirus Hu/GII4/50143/Jilin/06/CHN NorovirusHu/GII.4/2006b/PJ4/2007/CHN Norovirus Hu/GII4/50318/Hebei/06/CHNNorovirus Hu/GII.4/2006b/SY2/2007/CHN NorovirusHu/GII4/50483/Jilin/06/CHN Norovirus Hu/GII.4/4336/2007/IRL NorovirusHu/GII4/50496/Jilin/06/CHN Norovirus Hu/GII.4/754 NorovirusHu/GII4/50503/Jilin/06/CHN N.Novgorod/2008/RUS NorovirusHu/GII4/50510/Jilin/06/CHN Norovirus Hu/GII.4/7883/2006/IRL NorovirusHu/GII4/50511/Jilin/06/CHN Norovirus Hu/GII.4/866 NorovirusHu/GII4/50512/Jilin/06/CHN N.Novgorod/2008/RUS NorovirusHu/GII4/50514/Jilin/06/CHN Norovirus Hu/GII.4/884 NorovirusHu/GII4/50515/Jilin/06/CHN N.Novgorod/2008/RUS NorovirusHu/GII4/50516/Jilin/06/CHN Norovirus Hu/GII.4/8854/2004/IRL NorovirusHu/GII4/50523/Jilin/06/CHN Norovirus Hu/GII.4/Apeldoorn317/2007/NLNorovirus Hu/GII4/50524/Jilin/06/CHN Norovirus Hu/GII.4/Beijing/167/2007Norovirus Hu/GII4/50535/Jilin/06/CHN Norovirus Hu/GII.4/Beijing/170/2007Norovirus Hu/GII4/50540/Jilin/06/CHN Norovirus Hu/GII.4/Beijing/194/2007Norovirus Hu/GII4/50559/Jilin/06/CHN Norovirus Hu/GII.4/Beijing/212/2007Norovirus Hu/GII4/50562/Jilin/06/CHN Norovirus Hu/GII.4/Beijing/222/2007Norovirus Hu/GII4/50564/Jilin/06/CHN Norovirus Hu/GII.4/Beijing/225/2007Norovirus Hu/GII4/50566/Jilin/06/CHN Norovirus Hu/GII.4/BJ172/2007/CHNNorovirus Hu/GII4/50567/Jilin/06/CHN Norovirus Hu/GII.4/BJ222/2008/CHNNorovirus Hu/GII4/50569/Jilin/06/CHN Norovirus Hu/GII.4/BJ225/2008/CHNNorovirus Hu/GII4/50580/Jilin/06/CHN Norovirus Hu/GII.4/BJ226/2008/CHNNorovirus Hu/GII4/51002/Jilin/06/CHN Norovirus Hu/GII.4/BJ228/2008/CHNNorovirus Hu/GII4/51031/Jilin/06/CHN Norovirus Hu/GII.4/BJ231/2008/CHNNorovirus Hu/GII4/51074/Jilin/06/CHN Norovirus Hu/GII.4/BJ238/2008/CHNNorovirus Hu/GII4/51078/Jilin/06/CHN Norovirus Hu/GII.4/BJ240/2008/CHNNorovirus Hu/GII4/51079/Jilin/06/CHN Norovirus Hu/GII.4/BJ244/2008/CHNNorovirus Hu/GII4/51267/Anhui/06/CHN Norovirus Hu/GII.4/BJ245/2008/CHNNorovirus Hu/GII4/51268/Anhui/06/CHN Norovirus Hu/GII.4/BJ299/2008/CHNNorovirus Hu/GII4/51270/Anhui/06/CHN Norovirus Hu/GII.4/Boxmeer/90104-Norovirus Hu/GII4/51273/Anhui/06/CHN 42217/2009/NLD NorovirusHu/GII4/51275/Anhui/06/CHN Norovirus Hu/GII.4/CHDC2094/1974/US NorovirusHu/GII4/51850/Hebei/07/CHN Norovirus Hu/GII.4/CHDC3967/1988/US NorovirusHu/GII4/51856/Hebei/07/CHN Norovirus Hu/GII.4/CHDC4108/1987/US NorovirusHu/GII4/51873/Hebei/07/CHN Norovirus Hu/GII.4/CHDC4871/1977/US NorovirusHu/GII4/51875/Hebei/07/CHN Norovirus Hu/GII.4/CHDC5191/1974/US NorovirusHu/GII4/52066/Shanghai/06/CHN Norovirus Hu/GII.4/Chungnam(1- NorovirusHu/GII4/52217/Shanghai/06/CHN 32)/2008/Kor NorovirusHu/GII4/52240/Shanghai/06/CHN Norovirus Hu/GII.4/Chungnam(10- NorovirusHu/GII4/52398/Jilin/07/CHN 70)/2008/Kor NorovirusHu/GII4/52415/Jilin/07/CHN Norovirus Hu/GII.4/Chungnam(10- NorovirusHu/GII4/52416/Jilin/07/CHN 88)/2008/Kor NorovirusHu/GII4/52421/Jilin/07/CHN Norovirus Hu/GII.4/Chungnam(11- NorovirusHu/GII4/52422/Jilin/07/CHN 100)/2008/Kor NorovirusHu/Houston/TCH186/2002/US Norovirus Hu/GII.4/Chungnam(11- NorovirusHu/Norovirus/GII- 104)/2008/Kor 4/Cegled1603/2002/HUN NorovirusHu/GII.4/Chungnam(11- Norovirus Hu/Norovirus/GII- 91)/2008/Kor4/Dunaujvaros2477/2006/HUN Norovirus Hu/GII.4/Chungnam(11- NorovirusHu/Norovirus/GII- 94)/2008/Kor 4/Gyor2872/2006/HUN NorovirusHu/GII.4/Chungnam(12- Norovirus Hu/Norovirus/GII- 107)/2008/Kor4/Kapuvar3029/2007/HUN Norovirus Hu/GII.4/Chungnam(12- NorovirusHu/Norovirus/GII- 170)/2008/Kor 4/Kiskunhalas1264/2002/HUN NorovirusHu/GII.4/Chungnam(12- Norovirus Hu/Norovirus/GII- 176)/2008/Kor4/Mohacs1147/2002/HUN Norovirus Hu/GII.4/Chungnam(12- NorovirusHu/Norovirus/GII- 77)/2008/Kor 4/Mosonmagyarovar2594/2006/HUN NorovirusHu/GII.4/Chungnam(4- Norovirus Hu/Norovirus/GII- 29)/2008/Kor4/Nagykoru2098/2004/HUN Norovirus Hu/GII.4/Chungnam(6- NorovirusHu/Norovirus/GII-4/Ocsa923/2002/HUN 85)/2008/Kor NorovirusHu/Norovirus/GII- Norovirus Hu/GII.4/Chungnam(9- 4/Pecs2967/2007/HUN34)/2008/Kor Norovirus Hu/Norovirus/GII- NorovirusHu/GII.4/Chungnam(out- 4/Sopron1562/2002/HUN ag5)/2008/Kor NorovirusHu/Norovirus/GII- Norovirus Hu/GII.4/Chungnam(out-4/Tiszatelek982/2002/HUN as6)/2008/Kor Norovirus oyster/GII.4/2007/USANorovirus Hu/GII.4/Chungnam(out- Norovirus sea water/GII.4/HME-371/TWNbr1)/2008/Kor Norovirus sea water/GII.4/HME-493/TWN NorovirusHu/GII.4/Chungnam(out- Norovirus sea water/GII.4/HME-527/TWNbr15)/2008/Kor Norovirus sewage/GII.4/Toyama/SW0610- NorovirusHu/GII.4/Chungnam(out- 1/2006/JP br17)/2008/Kor Norovirussewage/GII.4/Toyama/SW0611- Norovirus Hu/GII.4/Chungnam(out- 1/2006/JPbr25)/2008/Kor Norovirus sewage/GII.4/Toyama/SW0612- NorovirusHu/GII.4/Chungnam(out- 7/2006/JP ns9)/2008/Kor Norovirussewage/GII.4/Toyama/SW0701- Norovirus Hu/GII.4/Chungnam(out- 5/2007/JPsc8)/2008/Kor Norovirus sewage/GII.4/Toyama/SW0702- NorovirusHu/GII.4/Chungnam(out- 4/2007/JP sc9)/2008/Kor Norovirussewage/GII.4/Toyama/SW0703- Norovirus Hu/GII.4/Chungnam(out- 1/2007/JPss13)/2008/Kor Norovirus sewage/GII.4/Toyama/SW0704- NorovirusHu/GII.4/Chungnam(out- 2/2007/JP ss20)/2008/Kor Norovirussewage/GII.4/Toyama/SW0706- Norovirus Hu/GII.4/Chungnam(out- 1/2007/JPss23)/2008/Kor Norovirus sewage/GII.4/Toyama/SW0707- NorovirusHu/GII.4/Chungnam(out- 1/2007/JP ss33)/2008/Kor Norovirussewage/GII.4/Toyama/SW0708- Norovirus Hu/GII.4/Chungnam(out- 19/2007/JPss38)/2008/Kor Norovirus sewage/GII.4/Toyama/SW0710- NorovirusHu/GII.4/Chungnam(out- 1/2007/JP ssh1)/2008/Kor Norovirussewage/GII.4/Toyama/SW0711- Norovirus Hu/GII.4/cruise 10/2007/JPship/VS122/2006/USA Norovirus sewage/GII.4/Toyama/SW0712- NorovirusHu/GII.4/cruiseship/2007/ZAF 13/2007/JP Norovirus NorovirusHu/GII.4/Hiroshima/115/2007/JPN Hu/GII.4/Cuernavaca/50318/2007/MEXNorovirus Hu/GII.4/Hiroshima/129/2007/JPN Norovirus NorovirusHu/GII.4/Hiroshima/134/2007/JPN Hu/GII.4/Cuernavaca/50320/2007/MEXNorovirus Hu/GII.4/Hiroshima/139/2007/JPN Norovirus NorovirusHu/GII.4/Hiroshima/151/2008/JPN Hu/GII.4/Cuernavaca/7366/2008/MEXNorovirus Hu/GII.4/Hiroshima/154/2008/JPN Norovirus NorovirusHu/GII.4/Hiroshima/19/2001/JPN Hu/GII.4/Cuernavaca/7366v4/2008/MEXNorovirus Hu/GII.4/Hiroshima/42/2004/JPN Norovirus NorovirusHu/GII.4/Hiroshima/44/2004/JPN Hu/GII.4/Cuernavaca/8030/2008/MEXNorovirus Hu/GII.4/Hiroshima/48/2004/JPN Norovirus NorovirusHu/GII.4/Hiroshima/55/2005/JPN Hu/GII.4/Cuernavaca/8034/2008/MEXNorovirus Hu/GII.4/Hiroshima/56/2005/JPN NorovirusHu/GII.4/DenHaag54/2006/NL Norovirus Hu/GII.4/Hiroshima/57/2005/JPNNorovirus Hu/GII.4/DenHaag89/2006/NL NorovirusHu/GII.4/Hiroshima/58/2005/JPN Norovirus Hu/GII.4/Dhaka8/2004/BGDNorovirus Hu/GII.4/Hiroshima/59/2005/JPN NorovirusHu/GII.4/Dijon/E872/2002/FRA Norovirus Hu/GII.4/Hiroshima/63/2006/JPNNorovirus Hu/GII.4/DilwichHill203D/04O/AU NorovirusHu/GII.4/Hiroshima/67/2006/JPN Norovirus Hu/GII.4/Dongen46/2006/NLNorovirus Hu/GII.4/Hiroshima/68/2006/JPN NorovirusHu/GII.4/DulwichHil1190I/04O/AU Norovirus Hu/GII.4/Hiroshima/69/2006/JPNNorovirus Norovirus Hu/GII.4/Hiroshima/74/2006/JPNHu/GII.4/DulwichHil1194M/04O/AU NorovirusHu/GII.4/DulwichHil1197P/04O/AU Norovirus Hu/GII.4/GE14/IRN NorovirusHu/GII.4/GE28/IRN Norovirus Hu/GII.4/GE3/IRN Norovirus Hu/GII.4/GE31/IRNNorovirus Hu/GII.4/GE44/IRN Norovirus Hu/GII.4/GE8/IRN NorovirusHu/GII.4/GE9/IRN Norovirus Hu/GII.4/Henry/2000/USA NorovirusHu/GII.4/Hiroshima/108/2007/JPN NorovirusHu/GII.4/Hiroshima/109/2007/JPN NorovirusHu/GII.4/Hiroshima/110/2007/JPN Norovirus genogroup GII.5 NorovirusNorovirus Hu/GII.5/Guadalajara/50051/2007/MEXHu/GII.5/Cuernavaca/8039/2008/MEX Norovirus genogroup GII.6 NorovirusHu/GII-6/ES315/2003/BRA Norovirus Hu/GII.6/Cuernavaca/50335/2007/MEXNorovirus Hu/GII-6/ES332/2003/BRA Norovirus Hu/GII.6/Dhaka233/2000/BGDNorovirus Hu/GII.6/13573/2007/RJ/BRA Norovirussewage/GII.6/Toyama/SW0701- Norovirus Hu/GII.6/46048/2006/IRL 35/2007/JPNorovirus Hu/GII.6/47747/2006/IRL Norovirus sewage/GII.6/Toyama/SW0705-2/2007/JP Norovirus genogroup GII.7 Norovirus Hu/GII-8/ES343/2003/BRANorovirus Norovirus Hu/GII.8/Cuernavaca/50364v2/2007/MEXHu/GII.8/Cuernavaca/50364v1/2007/MEX Norovirus genogroup GII.8 NorovirusHu/GII-8/ES343/2003/BRA Norovirus NorovirusHu/GII.8/Cuernavaca/50364v2/2007/MEXHu/GII.8/Cuernavaca/50364v1/2007/MEX Norovirus genogroup GII.9 NorovirusHu/GII.9/10775/2005/BRA Norovirus Hu/GII.9/Salvador/A07/2006/BRANorovirus Hu/GII.9/Alingsas/p1/2009/SWE NorovirusHu/GII.9/Salvador/A08/2006/BRA Norovirus NorovirusHu/GII.9/Salvador/B03/2006/BRA Hu/GII.9/Cuernavaca/7315/2007/MEXNorovirus Hu/GII.9/Salvador/B04/2006/BRA NorovirusHu/GII.9/Salvador/A04/2006/BRA Norovirus Hu/GII.9/Salvador/B05/2006/BRANorovirus Hu/GII.9/Salvador/A06/2006/BRA NorovirusHu/GII.9/Salvador/F03/2006/BRA Norovirus genogroup GII.b Humancalicivirus Norovirus Hu/GIIb/02115441/2002/AUSNLV/Gourdon78/2000/France Norovirus Hu/GIIb/03155665/2003/AUS Norovirusenv/GGII.b/1036/2007/ITA Norovirus Hu/GIIb/03157163/2003/AUS Norovirusenv/GGII.b/1161a/2007/ITA Norovirus Hu/GIIb/03157169/2003/AUS Norovirusenv/GGII.b/1161b/2007/ITA Norovirus Hu/GIIb/04107624/2004/AUS Norovirusenv/GGII.b/1162b/2007/ITA Norovirus Hu/GIIb/04113824/2004/AUS NorovirusEnv/GGII.b/678/2006/IT Norovirus Hu/GIIb/04113843/2004/AUS NorovirusEnv/GGII.b/679/2006/IT Norovirus Hu/GIIb/04114779/2004/AUS NorovirusHu/GGII.b/670/2006/IT Norovirus Hu/GIIb/04121605/2004/AUS NorovirusHu/GGIIb/oyster1735OA/77351/FR Norovirus Hu/GIIb/04134701/2004/AUSNorovirus Hu/GGIIb/oyster1786OA/77351/FR NorovirusHu/GIIb/04144544/2004/AUS Norovirus Hu/GII.b/50602/2006/IRL NorovirusHu/GIIb/04150102/2004/AUS Norovirus Hu/GII.b/8503/2007/IRL NorovirusHu/GIIb/04155699/2004/AUS Norovirus Hu/GII.b/9590/2004/IRL NorovirusHu/GIIb/05100687/2004/AUS Norovirus Hu/GII.b/9614/2004/IRL NorovirusHu/GIIb/05143926/2005/AUS Norovirus Hu/GIIb/02106590/2002/AUS NorovirusHu/GIIb/02115422/2002/AUS Snow Mountain virus Norovirus genogroup 3Norovirus Bo/GIII.1/Aba-Z5/2002/HUN Norovirusbovine/GIII.2/541_0448/2005/NOR Norovirus Bo/GIII.1/Norsewood/2006/NZLNorovirus bovine/GIII.2/584_3248/2005/NOR NorovirusBo/GIII.2/Aba-4736/2008/HUN Norovirus bovine/GIII.2/670_0799/2006/NORNorovirus Bo/GIII.2/Aba-Z2/2002/HUN Norovirusbovine/GIII.2/718_0785/2006/NOR Norovirusbovine/GIII.2/216_0114/2006/NOR Norovirus Norovirusbovine/GIII.2/240_0243/2005/NOR bovine/GIII/chimeric/107_0485/2005/NORNorovirus bovine/GIII.2/300_0250/2006/NOR Norovirus Norovirusbovine/GIII.2/312_0529/2006/NOR bovine/GIII/chimeric/661_1570/2006/NORNorovirus bovine/GIII.2/340_1235/2006/NOR Norovirus Norovirusbovine/GIII.2/471_0790/2005/NOR bovine/GIII/chimeric/752_3024/2006/NORNorovirus bovine/GIII/chimeric/785_0449/2006/NOR NorovirusHu/G3/C5-106/South Korea Norovirus genogroup 4 Human calcivirusNorovirus dog/GIV.2/Bari/91/2007/ITA NV/GIV/Stockholm/IV1680/2002/SENorovirus Hu/GIV.1/Italy/980/2007/ITA Norovirus dog/170/07/Ita Noroviruslion/GGIV.2/Pistoia/387/06/ITA Norovirus isolates Human calicivirusHu/NLV/Berlin/226/01/DE Norovirus Hu/NFLV4641/Terre-Neuve/06- Humancalicivirus 2004/CAN Hu/NLV/Bitburg/289/01/DE NorovirusHu/NLV/BA4231/2004/Arg Human calicivirus NorovirusHu/NLV/Banbury/B9S23/2003/UK Hu/NLV/Leverkusen451/2000/DE NorovirusHu/NLV/ChippingNorton/2003/UK Human calicivirus NorovirusHu/NLV/Didcot/B9S2/2003/UK Hu/NLV/Leverkusen476/2000/DE NorovirusHu/NLV/DjiboutiVdG5/2003/Djibouti Human calicivirus NorovirusHu/NLV/DjiboutiVdG50/2003/Djibouti Hu/NLV/Oxford/B5S22/2003/UK NorovirusHu/NLV/DjiboutiVdG66/2003/Djibouti Human calicivirus Hu/NLV/Queen'sNorovirus Hu/NLV/Dresden174/pUS- Arms/Leeds/92/UK NorII/1997/GE Humancalicivirus Hu/SaV4895/2001/Bra Norovirus Hu/NLV/E3/1997/Crete Humancalicivirus Mc10 Norovirus Hu/NLV/ER4424/2004/Arg Human calicivirusNLV/1157-01/SWE Norovirus Hu/NLV/ER4426/2004/Arg Human calicivirusNLV/1312-01/SWE Norovirus Hu/NLV/II/Hualien/2004/TW Human calicivirusNLV/1464-01/SWE Norovirus Hu/NLV/LP4392/2004/Arg Human calicivirusNLV/1581-00/SWE Norovirus Hu/NLV/LP4395/2004/Arg Human calicivirusNLV/1581-01/SWE Norovirus Hu/NLV/NE4208/2004/Arg Human calicivirusNLV/186-01/SWE Norovirus Hu/NLV/Oxford/B1S1/2002/UK Human calicivirusNLV/1937-00/SWE Norovirus Hu/NLV/Oxford/B1S11/2002/UK Human calicivirusNLV/2004-00/SWE Norovirus Hu/NLV/Oxford/B1S12/2002/UK Human calicivirusNLV/2102-00/SWE Norovirus Hu/NLV/Oxford/B1S16/2002/UK Human calicivirusNLV/2115-00/SWE Norovirus Hu/NLV/Oxford/B1S2/2002/UK Human calicivirusNLV/2197-00/SWE Norovirus Hu/NLV/Oxford/B1S21/2002/UK Human calicivirusNLV/2366-00/SWE Norovirus Hu/NLV/Oxford/B1S4/2002/UK Human calicivirusNLV/500-01/SWE Norovirus Hu/NLV/Oxford/B2S10/2002/UK Human calicivirusNLV/Albacete70/01/SP Norovirus Hu/NLV/Oxford/B2S11/2002/UK Humancalicivirus NLV/Altenkirchen Norovirus Hu/NLV/Oxford/B2S14/2002/UK140/01/DE Norovirus Hu/NLV/Oxford/B2S15/2002/UK Human calicivirusNLV/Avila112/02/SP Norovirus Hu/NLV/Oxford/B2S16/2002/UK Humancalicivirus NLV/BA1026 Norovirus Hu/NLV/Oxford/B2S17/2002/UK Humancalicivirus Norovirus Hu/NLV/Oxford/B2S18/2002/UKNLV/Bacsborsod/1542/2002/HUN Norovirus Hu/NLV/Oxford/B2S20/2002/UK Humancalicivirus NLV/Bad Berleburg/477/01 NorovirusHu/NLV/Oxford/B2S23/2002/UK Human calicivirus NorovirusHu/NLV/Oxford/B2S24/2002/UK NLV/Balatonlelle/680/2001/HUN NorovirusHu/NLV/Oxford/B2S25/2002/UK Human calicivirus NLV/Basel/2001/CHNorovirus Hu/NLV/Oxford/B2S26/2002/UK Human calicivirus NorovirusHu/NLV/Oxford/B3S16/2003/UK NLV/Batonyterenye/1436/2002/HUN NorovirusHu/NLV/Oxford/B3S18/2003/UK Human calicivirus NLV/Beijing/cr840/ChinaNorovirus Hu/NLV/Oxford/B3S19/2003/UK Human calicivirus NorovirusHu/NLV/Oxford/B3S20/2003/UK NLV/Benetusser/453/2002/Sp NorovirusHu/NLV/Oxford/B3S4/2003/UK Human calicivirus NLV/Berlin 146/2000/DENorovirus Hu/NLV/Oxford/B4S1/2002/UK Human calicivirus NLV/Berlin210-1/1999/DE Norovirus Hu/NLV/Oxford/B4S2/2002/UK Human calicivirusNLV/Berlin 210-2/1999/DE Norovirus Hu/NLV/Oxford/B4S4/2002/UK Humancalicivirus NLV/Berlin 211-1/1999/DE NorovirusHu/NLV/Oxford/B4S5/2002/UK Human calicivirus NLV/Berlin 211-2/1999/DENorovirus Hu/NLV/Oxford/B4S6/2002/UK Human calicivirus NLV/Berlin248/1999/DE Norovirus Hu/NLV/Oxford/B4S7/2002/UK Human calicivirusNLV/Berlin 348/2000/DE Norovirus Hu/NLV/Oxford/B5S1/22002/UK Humancalicivirus NLV/Berlin 363/2000/DE Norovirus Hu/NLV/Oxford/B5S10/2002/UKHuman calicivirus NLV/Berlin 385/2000/DE NorovirusHu/NLV/Oxford/B5S13/2002/UK Human calicivirus NLV/Berlin/159/98/DENorovirus Hu/NLV/Oxford/B5S19/2002/UK Human calicivirusNLV/Berlin/238/98/DE Norovirus Hu/NLV/Oxford/B5S23/2003/UK Humancalicivirus NLV/Berne/2001/CH Norovirus Hu/NLV/Oxford/B5S7/2002/UK Humancalicivirus Norovirus Hu/NLV/Oxford/B5S8/2002/UKNLV/Bicske/1225/2002/HUN Norovirus Hu/NLV/Oxford/B5S9/2002/UK Humancalicivirus NLV/Boxer/2001/US Norovirus Hu/NLV/Oxford/B6S2/2003/UK Humancalicivirus NLV/Brandenburg Norovirus Hu/NLV/Oxford/B6S3/2003/UK40/1999/DE Norovirus Hu/NLV/Oxford/B6S4/2003/UK Human calicivirusNorovirus Hu/NLV/Oxford/B6S5/2003/UK NLV/Budapest/1095/2002/HUNNorovirus Hu/NLV/Oxford/B6S6/2003/UK Human calicivirus NorovirusHu/NLV/Oxford/B8S5/2002/UK NLV/Budapest/HUNs1/1997/HUN NorovirusHu/NLV/Pont de Roide 671/2004/France Human calicivirus NLV/C59/99Norovirus Hu/NLV/Pont de Roide 673/2004/France Human calicivirusNLV/Castell/2001/Sp Norovirus Hu/NLV/RN4372/2004/Arg Human calicivirusNLV/Coruna90/02/SP Norovirus Hu/NLV/RN4379/2004/Arg Human calicivirusNorovirus Hu/NLV/S63/1999/France NLV/Csakvar/877/2001/HUN NorovirusHu/NLV/SAG4237/2004/Arg Human calicivirus NorovirusHu/NLV/SAG4238/2004/Arg NLV/Csanadapaca/1868/2003/HUN NorovirusHu/NLV/SAG4241/2004/Arg Human calicivirus NorovirusHu/NLV/SF4413/2004/Arg NLV/Debrecen/1721/2003/HUN NorovirusHu/NLV/SF4420/2004/Arg Human calicivirus NorovirusHu/NLV/VannesL23/1999/France NLV/Debrecen/897/2001/HUN NorovirusHu/NLV/Witney/B7S2/2003/UK Human calicivirus NLV/Dillingen 259/01/DENorovirus Hu/Noguchi-1/2000/GH Human calicivirus NLV/Dillingen 391/01/DENorovirus Hu/Noguchi-10/2000/GH Human calicivirus NLV/Egeln 399/1999/DENorovirus Hu/Noguchi-2/2000/GH Human calicivirus NLV/Eger/1650/2002/HUNNorovirus Hu/Noguchi-3/2000/GH Human calicivirus NorovirusHu/Noguchi-4/2000/GH NLV/Eger/HUNs19/2000/HUN NorovirusHu/Noguchi-5/2000/GH Human calicivirus Norovirus Hu/Noguchi-6/2000/GHNLV/Eger/HUNs6/2000/HUN Norovirus Hu/Noguchi-7/2000/GH Human calicivirusNLV/Erd/967/2002/HUN Norovirus Hu/Noguchi-8/2000/GH Human calicivirusNLV/Erfurt 007/2000/DE Norovirus Hu/Noguchi-9/2000/GH Human calicivirusNLV/Erfurt 232/2000/DE Norovirus Hu/Noshiro/1/2007/JP Human calicivirusNLV/Erlangen Norovirus Hu/NoV/01/2004/SE 155/2000/DE NorovirusHu/NoV/02/2002/SE Human calicivirus NLV/Frankfurt(Oder) NorovirusHu/NoV/02/2006/SE 168/1999/DE Norovirus Hu/NoV/03/2002/SE Humancalicivirus NLV/Frankfurt(Oder) Norovirus Hu/NoV/03/2004/SE 170/1999/DENorovirus Hu/NoV/03/2006/SE Human calicivirus NLV/Frankfurt(Oder)Norovirus Hu/NoV/04/2004/SE 176/1999/DE Norovirus Hu/NoV/04/2005/SEHuman calicivirus Norovirus Hu/NoV/04/2006/SE NLV/FrankfurtO.386/1999/DENorovirus Hu/NoV/05/2004/SE Human calicivirus NorovirusHu/NoV/05/2005/SE NLV/Fuzesabony/1253/2002/HUN NorovirusHu/NoV/05/2006/SE Human calicivirus NLV/Geesthacht NorovirusHu/NoV/05_1/2002/SE 410/2000/DE Norovirus Hu/NoV/05_2/2002/SE Humancalicivirus NLV/Gelsenkirchen Norovirus Hu/NoV/06/2002/SE 468/2000/DENorovirus Hu/NoV/06/2004/SE Human calicivirus NLV/GGII/NDV1/99/INDNorovirus Hu/NoV/06/2005/SE Human calicivirus NLV/GGII/NDV2/99/INDNorovirus Hu/NoV/06/2006/SE Human calicivirus NLV/GGII/NDV3/99/INDNorovirus Hu/NoV/07/2002/SE Human calicivirus NorovirusHu/NoV/07/2004/SE NLV/GII/Langen1061/2002/DE Norovirus Hu/NoV/07/2006/SEHuman calicivirus Norovirus Hu/NoV/07_1/2005/SENLV/Gothenburg1/2001/Sweden Norovirus Hu/NoV/07_2/2005/SE Humancalicivirus NLV/Granada60i/02/SP Norovirus Hu/NoV/08/2002/SE Humancalicivirus Norovirus Hu/NoV/08/2003/SE NLV/Gyongyos/1255/2002/HUNNorovirus Hu/NoV/08/2004/SE Human calicivirus NorovirusHu/NoV/08/2005/SE NLV/Gyongyos/1467/2002/HUN Norovirus Hu/NoV/08/2006/SEHuman calicivirus NLV/Gyor/1734/2003/HUN Norovirus Hu/NoV/09/2002/SEHuman calicivirus Norovirus Hu/NoV/09/2003/SE NLV/Hajmasker/487/2001/HUNNorovirus Hu/NoV/09/2004/SE Human calicivirus NLV/Halle 445/1999/DENorovirus Hu/NoV/09/2005/SE Human calicivirus NLV/Hamburg NorovirusHu/NoV/09/2006/SE 347/2000/DE Norovirus Hu/NoV/10/2003/SE Humancalicivirus NLV/Herzberg 385/01/DE Norovirus Hu/NoV/10/2004/SE Humancalicivirus NLV/Ibiza67/01/SP Norovirus Hu/NoV/10_1/2006/SE Humancalicivirus Norovirus Hu/NoV/10_2/2006/SE NLV/Intahaza/1621/2003/HUNNorovirus Hu/NoV/11/2002/SE Human calicivirus NLV/J23/1999/US NorovirusHu/NoV/11/2003/SE Human calicivirus Norovirus Hu/NoV/11/2006/SENLV/Kaposvar/1505/2002/HUN Norovirus Hu/NoV/12/2002/SE Human calicivirusNorovirus Hu/NoV/12/2003/SE NLV/Kecskemet/1657/2003/HUN NorovirusHu/NoV/12/2004/SE Human calicivirus Norovirus Hu/NoV/13/2002/SENLV/Kiskunhalas/HUNo2/1999/HUN Norovirus Hu/NoV/13/2004/SE Humancalicivirus Norovirus Hu/NoV/13/2005/SE NLV/Kisujbanya/650/2001/HUNNorovirus Hu/NoV/13_1/2006/SE Human calicivirus NLV/Koblenz 229/2000/DENorovirus Hu/NoV/13_2/2006/SE Human calicivirus NLV/Laucha 403/1999/DENorovirus Hu/NoV/14/2002/SE Human calicivirus NLV/Leon55/00/SP NorovirusHu/NoV/15/2002/SE Human calicivirus Norovirus Hu/NoV/15/2003/SENLV/LesBorges/319/2001/Sp Norovirus Hu/NoV/15/2004/SE Human calicivirusNLV/Lleida/327/2001/Sp Norovirus Hu/NoV/15/2006/SE Human calicivirusNLV/Lugo37i/00/SP Norovirus Hu/NoV/16/2002/SE Human calicivirusNLV/Lugo73i/02/SP Norovirus Hu/NoV/16/2003/SE Human calicivirusNLV/M7/1999/US Norovirus Hu/NoV/17/2002/SE Human calicivirusNLV/Madrid106/02/SP Norovirus Hu/NoV/17/2006/SE Human calicivirusNLV/Madrid33/00/SP Norovirus Hu/NoV/18/2002/SE Human calicivirusNLV/Madrid36i/01/SP Norovirus Hu/NoV/18/2004/SE Human calicivirusNLV/Madrid63/01/SP Norovirus Hu/NoV/18/2006/SE Human calicivirusNLV/Madrid79/00/SP Norovirus Hu/NoV/19/2002/SE Human calicivirusNLV/Madrid94/02/SP Norovirus Hu/NoV/19/2006/SE Human calicivirusNLV/Magdeburg Norovirus Hu/NoV/21/2002/SE 171/1999/DE NorovirusHu/NoV/21/2006/SE Human calicivirus NLV/Magdeburg NorovirusHu/NoV/22/2002/SE 225/1999/DE Norovirus Hu/NoV/22_1/2006/SE Humancalicivirus NLV/Magdeburg Norovirus Hu/NoV/22_2/2006/SE 401/2000/DENorovirus Hu/NoV/23/2002/SE Human calicivirus NLV/Magdeburg NorovirusHu/NoV/23_1/2006/SE 460/1999/DE Norovirus Hu/NoV/23_2/2006/SE Humancalicivirus NLV/Magdeburg Norovirus Hu/NoV/24/2002/SE 514/1999/DENorovirus Hu/NoV/24/2006/SE Human calicivirus NLV/Magdeburg NorovirusHu/NoV/25/2002/SE 548/1999/DE Norovirus Hu/NoV/25/2006/SE Humancalicivirus NLV/Magdeburg Norovirus Hu/NoV/26/2002/SE 62/1999/DENorovirus Hu/NoV/26/2006/SE Human calicivirus NLV/Mallorca43/00/SPNorovirus Hu/NoV/27/2002/SE Human calicivirus NLV/Meliana/230/2001/SpNorovirus Hu/NoV/28/2002/SE Human calicivirus NLV/Mex7076/1999 NorovirusHu/NoV/29/2002/SE Human calicivirus Norovirus Hu/NoV/Dover/2000/UKNLV/Mogyoroska/671/2001/HUN Norovirus Hu/NR2176/1998/US Humancalicivirus NLV/MOH/99 Norovirus Hu/NR2210/1998/US Human calicivirusNorovirus Hu/NR2225/1999/US NLV/Mohacs/1064/2002/HUN NorovirusHu/NR2342/1997/US Human calicivirus Norovirus Hu/NR2443/1998/USNLV/Montblanc/287/2001/Sp Norovirus Hu/NR2459/1998/US Human calicivirusNLV/Mora/97/SE Norovirus Hu/NR2482/1998/US Human calicivirusNLV/Murcia103/02/SP Norovirus Hu/NR2486/1999/US Human calicivirusNLV/Murcia60/00/SP Norovirus Hu/NR2512/1999/US Human calicivirusNorovirus Hu/NR2531/1999/US NLV/Nagykovacsi/1918/2003/HUN NorovirusHu/NR2552/1999/US Human calicivirus Norovirus Hu/NSW021E/2006/AUSNLV/Nagykozar/623/2001/HUN Norovirus Hu/NSW022G/2006/AUS Humancalicivirus Norovirus Hu/NSW027B/2006/AUS NLV/Nemesgulacs/418/2001/HUNNorovirus Hu/NSW036B/2006/AUS Human calicivirus NLV/NeustrelitzNorovirus Hu/NSW065F/2006/AUS 163/1999/DE Norovirus Hu/NSW072D/2006/AUSHuman calicivirus Norovirus Hu/NSW095B/2006/AUSNLV/Nyiradony/793/2001/HUN Norovirus Hu/NSW108C/2006/AUS Humancalicivirus Norovirus Hu/NSW138H/2006/AUS NLV/Nyiregyhaza/1057/2002/HUNNorovirus Hu/NSW147I/2006/AUS Human calicivirus NLV/Oberhausen NorovirusHu/NSW159U/2006/AUS 455/01/DE Norovirus Hu/NSW162I/2006/AUS Humancalicivirus Norovirus Hu/NSW176K/2006/AUS NLV/Paks/HUNo4/1999/HUNNorovirus Hu/NSW182K/2006/AUS Human calicivirus NLV/Palencia69i/02/SPNorovirus Hu/NSW193M/2006/AUS Human calicivirus NLV/Papa/1476/2002/HUNNorovirus Hu/NSW195L/2006/AUS Human calicivirus NLV/Papa/1576/2002/HUNNorovirus Hu/NSW203I/2006/AUS Human calicivirus NorovirusHu/NSW212E/2006/AUS NLV/Patalom/HUNo10/2000/HUN NorovirusHu/NSW216C/2006/AUS Human calicivirus Norovirus Hu/NSW220I/2006/AUSNLV/Patapoklosi/HUNs3/1999/HUN Norovirus Hu/NSW248Q/2006/AUS Humancalicivirus Norovirus Hu/NSW287S/2006/AUS NLV/Pecel/1779/2003/HUNNorovirus Hu/NSW304I/2006/AUS Human calicivirus NLV/Pecs/571/2001/HUNNorovirus Hu/NSW306G/2006/AUS Human calicivirus NorovirusHu/NSW3137/2006/AUS NLV/Pecs/HUNs4/1999/HUN NorovirusHu/NSW322H/2006/AUS Human calicivirus NLV/Peleliu/1999 NorovirusHu/NSW324J/2006/AUS Human calicivirus NLV/Pfaffenhofen NorovirusHu/NSW330F/2006/AUS 028/2000/DE Norovirus Hu/NSW340C/2006/AUS Humancalicivirus NLV/Potsdam 196/2000/DE Norovirus Hu/NSW346E/2006/AUS Humancalicivirus NLV/Potsdam 384/2000/DE Norovirus Hu/NSW356Q/2006/AUS Humancalicivirus Norovirus Hu/NSW397R/2006/AUS NLV/Rarospuszta/778/2001/HUNNorovirus Hu/NSW4138/2006/AUS Human calicivirus NLV/Rostock 039/2000/DENorovirus Hu/NSW415F/2006/AUS Human calicivirus NLV/Sagunt/116/2000/SpNorovirus Hu/NSW415N/2006/AUS Human calicivirus NLV/Sagunt/181/2001/SpNorovirus Hu/NSW419Q/2006/AUS Human calicivirus NLV/Sagunt/222/2001/SpNorovirus Hu/NSW426I/2006/AUS Human calicivirus NLV/Sagunt/258/2001/SpNorovirus Hu/NSW432F/2006/AUS Human calicivirus NLV/Sagunt/364/2001/SpNorovirus Hu/NSW453O/2006/AUS Human calicivirus NorovirusHu/NSW510G/2006/AUS NLV/Sarospatak/1172/2002/HUN NorovirusHu/NSW517Q/2006/AUS Human calicivirus NLV/Schwerin NorovirusHu/NSW527Q/2006/AUS 002/2000/DE Norovirus Hu/NSW555L/2006/AUS Humancalicivirus NLV/Schwerin 003/00/DE Norovirus Hu/NSW608R/2006/AUS Humancalicivirus NLV/Schwerin Norovirus Hu/NSW611K/2006/AUS 218/1999/DENorovirus Hu/NSW627Q/2006/AUS Human calicivirus NLV/Segovia53i/02/SPNorovirus Hu/NSW629R/2006/AUS Human calicivirus NLV/Segovia97/02/SPNorovirus Hu/NSW659Y/2006/AUS Human calicivirus NorovirusHu/NSW689S/2006/AUS NLV/Sopron/1137/2002/HUN NorovirusHu/NSW689Y/2006/AUS Human calicivirus Norovirus Hu/NSW695Q/2006/AUSNLV/Sopron/1562/2002/HUN Norovirus Hu/NSW696T/2006/AUS Human calicivirusNorovirus Hu/NSW700I/2006/AUS NLV/Sopron/952/2002/HUN NorovirusHu/NSW710H/2006/AUS Human calicivirus NLV/St.Feliu/255/2001/Sp NorovirusHu/NSW716H/2006/AUS Human calicivirus Norovirus Hu/NSW717P/2006/AUSNLV/Steinbach/EG/2001/CA Norovirus Hu/NSW725O/2006/AUS Human calicivirusNLV/Stockholm/genotype Norovirus Hu/NSW751J/2006/AUS GGIIb NorovirusHu/NSW763N/2006/AUS Human calicivirus NLV/Suria/312/2001/Sp NorovirusHu/NSW768Y/2006/AUS Human calicivirus Norovirus Hu/NSW776R/2006/AUSNLV/Szava/HUNs13/2000/HUN Norovirus Hu/NSW779W/2006/AUS Humancalicivirus NLV/Szeged- Norovirus Hu/NSW779Y/2006/AUSAlgyo/HUNo1/1998/HUN Norovirus Hu/NSW782O/2006/AUS Human calicivirusNorovirus Hu/NSW821N/2006/AUS NLV/Szeged/1237/2002/HUN NorovirusHu/NSW827U/2006/AUS Human calicivirus Norovirus Hu/NSW855V/2006/AUSNLV/Szekesfehervar/1851/2003/HUN Norovirus Hu/NSW857X/2006/AUS Humancalicivirus Norovirus Hu/NSW870K/2006/AUS NLV/Szigetvar/HUNs7/2000/HUNNorovirus Hu/NSW890Q/2006/AUS Human calicivirus NLV/Szoc/806/2001/HUNNorovirus Hu/NSW892Q/2006/AUS Human calicivirus NorovirusHu/NSW897Z/2006/AUS NLV/Szolnok/1904/2003/HUN NorovirusHu/NSW944I/2006/AUS Human calicivirus Norovirus Hu/NSW953I/2006/AUSNLV/Szombathely/413/2001/HUN Norovirus Hu/NSW974O/2006/AUS Humancalicivirus Norovirus Hu/Nursing-home_A/28-12-2001/NLNLV/Tapioszentmarton/1909/2003/HUN NorovirusHu/Nursing-home_B/05-05-2002/NL Human calicivirus NLV/Tarrag/238/2001/SpNorovirus Hu/Nursing-home_C/06-06-2002/NL Human calicivirusNLV/Tata/1525/2002/HUN Norovirus Hu/Nursing-home_D/19-11-2002/NL Humancalicivirus NLV/Tenerife41i/01/SP NorovirusHu/Nursing-home_E_pat_1/08-01- Human calicivirus NLV/Tiefwarensee2003/NL/ 304/1999/DE Norovirus Hu/Nursing-home_E_pat_2/10-01- Humancalicivirus NLV/Tiefwarensee 2003/NL 305/1999/DE NorovirusHu/Nursing-home_F/22-01-2003/NL Human calicivirus NLV/Toddin 242/1999/DENorovirus Hu/Nursing-home_G/27-01-2003/NL Human calicivirusNLV/Toledo35/00/SP Norovirus Hu/Nursing-home_H/03-02-2003/NL Humancalicivirus Norovirus Hu/NV/Hokkaido/118/2002/JPNLV/Totkomlos/1798/2003/HUN Norovirus Hu/NV/Hokkaido/127/2002/JP Humancalicivirus NLV/Utiel/371/2001/Sp Norovirus Hu/NV/Hokkaido/130/2002/JPHuman calicivirus NLV/VA497/1999/US Norovirus Hu/NV/Hokkaido/135/2003/JPHuman calicivirus NLV/VA97207/1997 Norovirus Hu/NV/Hokkaido/183/2004/JPHuman calicivirus NLV/VA98115/1998 Norovirus Hu/NV/Hokkaido/186/2004/JPHuman calicivirus NLV/VA98387/1998 Norovirus Hu/NV/Hokkaido/192/2004/JPHuman calicivirus NLV/Valencia/123/2000/Sp NorovirusHu/NV/Hokkaido/194/2004/JP Human calicivirus NLV/Valencia/213/2001/SpNorovirus Hu/NV/Hokkaido/198/2004/JP Human calicivirusNLV/Valencia/256/2001/Sp Norovirus Hu/NV/Hokkaido/222/2004/JP Humancalicivi rus NLV/Valencia/261/2001/Sp NorovirusHu/NV/Hokkaido/231/2004/JP Human calicivirus NLV/Valencia/426/2002/SpNorovirus Hu/NV/Hokkaido/284/2004/JP Human calicivirus NorovirusHu/NV/Hokkaido/286/2005/JP NLV/Varalja/1898/2003/HUN NorovirusHu/NV/Hokkaido/300/2005/JP Human calicivirus NorovirusHu/NV/Hokkaido/306/2005/JP NLV/Veszprem/1023/2002/HUN NorovirusHu/NV/Hokkaido/307/2005/JP Human calicivirus NorovirusHu/NV/Hokkaido/322/2005/JP NLV/Veszprem/HUNo11a/2000/HUN NorovirusHu/NV/Hokkaido/332/2005/JP Human calicivirus NorovirusHu/NV/Hokkaido/44/2000/JP NLV/Veszprem/HUNo11b/2000/HUN NorovirusHu/NV/Hokkaido/47/2000/JP Human calicivirus NorovirusHu/NV/Osaka/F140/2006/JP NLV/Vilafranca/269/2001/Sp NorovirusHu/NV/Weymouth/2004/UK Human calicivirus NLV/Wiesbaden 294/01/DENorovirus Hu/NZ176/2006/NZL Human calicivirus NLV/Zaragoza77/00/SPNorovirus Hu/NZ186/2006/NZL Human calicivirus NLV/Zaragoza80/01/SPNorovirus Hu/NZ225/2006/NZL Human calicivirus NLV/Zaragoza83/01/SPNorovirus Hu/NZ309/2006/NZL Human calicivirus NV/Aubel/H252/2002/BeNorovirus Hu/NZ313/2006/NZL Human calicivirus NorovirusHu/NZ327/2006/NZL NV/Beaufays/H361/2002/Be Norovirus Hu/NZ330/2006/NZLHuman calicivirus NV/BQT648/2000/VE Norovirus Hu/NZ373/2005/NZL Humancalicivirus NV/CCS114/1996/VE Norovirus Hu/NZ460/2006/NZL Humancalicivirus NV/CCS14/1997/VE Norovirus Hu/NZ467/2006/NZL Humancalicivirus NV/CCS17/1997/VE Norovirus Hu/NZ500/2006/NZL Humancalicivirus NV/CCS207/1995/VE Norovirus Hu/NZ51/2006/NZL Humancalicivirus NV/CCS21/1997/VE Norovirus Hu/NZ530/2006/NZL Humancalicivirus NV/CCS215/1996/VE Norovirus Hu/NZ535/2006/NZL Humancalicivirus NV/CCS227/1998/VE Norovirus Hu/NZ536/2006/NZL Humancalicivirus NV/CCS39/1998/VE Norovirus Hu/NZ587/2006/NZL Humancalicivirus NV/Gentbrugge/ Norovirus Hu/O1/JPN H496/2003/Be NorovirusHu/O2a/JPN Human calicivirus Norovirus Hu/O2b/JPNNV/Gentbrugge/H494/2003/Be Norovirus Hu/Oberschleissheim 102/1999/DEHuman calicivirus Norovirus Hu/Oberschleissheim 108/1999/DENV/Gentbrugge/H497/2003/Be Norovirus Hu/Oberschleissheim 112/1999/DEHuman calicivirus NV/Grace- Norovirus Hu/Oberschleissheim 149/1999/DEHollogne/H384/2002/Be Norovirus Hu/Oberschleissheim 92/1999/DE Humancalicivirus Norovirus Hu/OC01243/2001/JP NV/Grivegnee/H501/2003/BeNorovirus Hu/OC02012/2002/JP Human calicivirus NV/H011/2002/Be NorovirusHu/OC02022/2002/JP Human calicivirus NV/H325/2002/Be NorovirusHu/OC02198/2002/JP Human calicivirus NV/Heusden/H492/2003/Be NorovirusHu/OC02202/2002/JP Human calicivirus NV/Kristianstad- NorovirusHu/OC03199-1/2003/JP Pat/2001/SE Norovirus Hu/OC03199-2/2003/JP Humancalicivirus NV/Kristianstad- Norovirus Hu/OC04038/2004/JP Ras/2001/SENorovirus Hu/OC04039/2004/JP Human calicivirus NV/Liege/H302/2002/BeNorovirus Hu/OC04042/2004/JP Human calicivirus NV/Lontzen/H556/2003/BeNorovirus Hu/OC04043/2004/JP Human calicivirus NorovirusHu/OC04056-1/2004/JP NV/Mariakerke/H514/2003/Be NorovirusHu/OC04056-2/2004/JP Human calicivirus NV/Oupeye/H007/2002/Be NorovirusHu/OC04059/2004/JP Human calicivirus NV/Romsee/H010/2002/Be NorovirusHu/OC04067/2004/JP Human calicivirus NV/Schoten/H473/2003/Be NorovirusHu/OC04071/2004/JP Human calicivirus NV/Sint NorovirusHu/OC04073/2004/JP Amanddeg/H493/2003/Be Norovirus Hu/OC04075/2004/JPHuman calicivirus NV/St Norovirus Hu/OC04076/2004/JPNicolas/H367/2002/Be Norovirus Hu/OC04169/2004/JP Human calicivirusNV/Tilff/H479/2003/Be Norovirus Hu/OC05010/2005/JP Human calicivirusNV/Zelzate/H495/2003/Be Norovirus Hu/OC07138/07/JP Human calicivirusstrain Arg320 Norovirus Hu/OC08086/08/JP Human calicivirus strainBAV/2.1/98/DEU Norovirus Hu/OC97007/97/JP Human calicivirus strainBRA/2.1/98/DEU Norovirus Hu/OC97049/1997/JP Human calicivirus strainHSS/2/98/DEU Norovirus Hu/OCS000564/2001/JP Human calicivirus strainNorovirus Hu/OCS020289/2002/JP Hu/NLV/Amsterdam/98-18/1998/NET NorovirusHu/OCS030697/2004/JP Human calicivirus strain NorovirusHu/OCS040035/2004/JP Hu/SLV/Stockholm/318/97/SE NorovirusHu/OCS040100/2004/JP Human norovirus CHN38109/SZ03 NorovirusHu/OCS980705/1998/JP Human norovirus CHN38111/SZ03 NorovirusHu/Odate/1/06/JP Human norovirus CHN38112/SZ03 NorovirusHu/Odate/2/2006/JP Human norovirus CHN38113/SZ03 NorovirusHu/Odate/3/2006/JP Human norovirus CHN38114/SZ03 NorovirusHu/Offenburg10550/2002/DE Human norovirus CHN4841/SZ03 NorovirusHu/Offenburg1155/2004/DE Human norovirus NorovirusHu/Offenburg216/2003/DE Hu/NV/I/Hualien/CYC/2003/TW NorovirusHu/Offenburg2620/2002/DE Maryland calicivirus 6 NorovirusHu/Offenburg4224/2004/DE Norovirus Bo/Aulendorf20/2003/DE NorovirusHu/Offenburg726/02/DE/2002/DE Norovirus Bo/Aulendorf22/2003/DE NorovirusHu/OLHSC-1/IRL Norovirus Bo/DijonA173/2006/FR Norovirus Hu/OLHSC-10/IRLNorovirus Bo/DijonA247/2007/FR Norovirus Hu/OLHSC-11/IRL NorovirusBo/DijonA273/2007/FR Norovirus Hu/OLHSC-12/IRL NorovirusBo/DijonA344/2007/FR Norovirus Hu/OLHSC-13/IRL NorovirusBo/DijonA428/2008/FR Norovirus Hu/OLHSC-14/IRL NorovirusBo/DijonA430/2008/FR Norovirus Hu/OLHSC-15/IRL NorovirusBo/Newbury2/1976/UK Norovirus Hu/OLHSC-16/IRL NorovirusBochum024/1998/GE Norovirus Hu/OLHSC-2/IRL Norovirus Bochum026/1997/GENorovirus Hu/OLHSC-3/IRL Norovirus Bochum031/1997/GE NorovirusHu/OLHSC-4/IRL Norovirus Bochum108/1997/GE Norovirus Hu/OLHSC-5/IRLNorovirus Bochum136/1998/GE Norovirus Hu/OLHSC-6/IRL NorovirusBochum220/1997/GE Norovirus Hu/OLHSC-7/IRL Norovirus Bochum224/1998/GENorovirus Hu/OLHSC-8/IRL Norovirus Bochum272/1998/GE NorovirusHu/OLHSC-9/IRL Norovirus Bochum339/1997/GE NorovirusHu/Omonogawa/1/1993/JP Norovirus bovine/125/2005/SVN NorovirusHu/Osaka/000321/2000/JP/3006 Norovirus bovine/Belgium/B102/2002/BeNorovirus Hu/Osaka/010203/2001/JP/3611 Norovirusbovine/Belgium/B128/2002/Be Norovirus Hu/Osaka/010203/2001/JP/3612Norovirus bovine/Belgium/B164/2002/Be NorovirusHu/Osaka/010228/2001/JP/3625 Norovirus bovine/Belgium/B173/2003/BeNorovirus Hu/Osaka/010314/2001/JP/3634 Norovirusbovine/Belgium/B307/2003/Be Norovirus Hu/Osaka/03-132/2003/JP Norovirusbovine/Belgium/B309/2003/Be Norovirus Hu/Osaka/05-1059/2006/JP Norovirusbovine/Belgium/B52/2002/Be Norovirus Hu/Osaka/05-1086/2006/JP Norovirusbovine/BV119/2007/BEL Norovirus Hu/Osaka/05-1180/2006/JP Norovirusbovine/BV120/2007/BEL Norovirus Hu/Osaka/05-365/2005/JP Norovirusbovine/BV129/2007/BEL Norovirus Hu/Osaka/101/05/JP Norovirusbovine/BV133/2007/BEL Norovirus Hu/Osaka/110/05/JP Norovirusbovine/BV15/2007/BEL Norovirus Hu/Osaka/133/05/JP Norovirusbovine/BV18/2007/BEL Norovirus Hu/Osaka/137/05/JP Norovirusbovine/BV24/2007/BEL Norovirus Hu/Osaka/146/05/JP Norovirusbovine/BV52/2007/BEL Norovirus Hu/Osaka/161/05/JP Norovirusbovine/BV9/2007/BEL Norovirus Hu/Osaka/177/04/JP Norovirusbovine/BV99/2007/BEL Norovirus Hu/Osaka/189/04/JP Norovirusbovine/Corroy/B37/2002/Be Norovirus Hu/Osaka/337/04/JP Norovirusbovine/Dalhem/B214/2003/Be Norovirus Hu/Osaka/36/05/JP Norovirusbovine/Florennes/B242/2003/Be Norovirus Hu/Osaka/49/05/JP Norovirusbovine/KT17/2004/SVN Norovirus Hu/Osaka/52/05/JP Norovirusbovine/Mohiville/B123/2002/Be Norovirus Hu/Osaka/61/05/JP Norovirusbovine/Wasma/B199/2003/Be Norovirus Hu/Osaka/7075/2005/JP Norovirusbovine/Wasme/B199/2003/Be Norovirus Hu/Osaka/7107/2006/JP Norovirusbovine/Wasme/B200/2003/Be Norovirus Hu/Osaka/724/04/JP Noroviruscarrot/Offenburg/2004/DE Norovirus Hu/Osaka/786/04/JP Noroviruscattle/BV416/2008/BEL Norovirus Hu/Osaka/840/04/JP NorovirusChanthaburi-75/Thailand Norovirus Hu/OsakaNI/2004/JP Norovirusclam/Shimane/Asari1- Norovirus Hu/oysters/CR17F2000/France DT/Jun2008/JPNorovirus Hu/oysters/CR91NL2000/Netherlands Norovirusclam/Shimane/Asari1- Norovirus Hu/oysters/O04-16/2004/NLLiquid/Jun2008/JP Norovirus Hu/oysters/O04-45/2004/NL Norovirusclam/Shimane/Asari3- Norovirus Hu/oysters/O6NL2002/NetherlandsDT/Jun2008/JP Norovirus Hu/oysters/oes16NL2001/Netherlands Noroviruscleaning Norovirus Hu/P1-1/2000/SWE rag/Enzkofen40942/2007/DEU NorovirusHu/P1-10/2000/SWE Norovirus cow/125/2005/SVN Norovirus Hu/P1-11/2000/SWENorovirus cow/KT17/2004/SVN Norovirus Hu/P1-12/2000/SWE NorovirusDhaka/167/2004/BGD Norovirus Hu/P1-13/2000/SWE NorovirusDhaka/176/2004/BGD Norovirus Hu/P1-14/2000/SWE NorovirusDhaka/196/2004/BGD Norovirus Hu/P1-15/2000/SWE NorovirusDhaka/262/2004/BGD Norovirus Hu/P1-16/2000/SWE NorovirusDhaka/267/2004/BGD Norovirus Hu/P1-17/2000/SWE NorovirusDhaka/270/2004/BGD Norovirus Hu/P1-18/2000/SWE NorovirusDhaka/289/2005/BGD Norovirus Hu/P1-19/2000/SWE NorovirusDhaka/295/2005/BGD Norovirus Hu/P1-20/2000/SWE NorovirusDhaka/305/2005/BGD Norovirus Hu/P1-3/2000/SWE NorovirusDhaka/335/2005/BGD Norovirus Hu/P1-6/2000/SWE NorovirusDhaka/361/2005/BGD Norovirus Hu/P1-7/2000/SWE NorovirusDhaka/367/2005/BGD Norovirus Hu/P1-8/2000/SWE NorovirusDhaka/373/2005/BGD Norovirus Hu/P1-9/2000/SWE NorovirusDhaka/389/2005/BGD Norovirus Hu/P10/JPN Norovirus Dhaka/401/2005/BGDNorovirus Hu/P11-10/2001/SWE Norovirus Dhaka/415/2005/BGD NorovirusHu/P11-12/2001/SWE Norovirus Dhaka/417/2005/BGD NorovirusHu/P11-13/2001/SWE Norovirus Dhaka/423/2005/BGD NorovirusHu/P11-14/2001/SWE Norovirus Dhaka/427/2005/BGD NorovirusHu/P11-16/2001/SWE Norovirus Dhaka/455/2005/BGD NorovirusHu/P11-19/2001/SWE Norovirus Dhaka/471/2005/BGD NorovirusHu/P11-2/2001/SWE Norovirus Dhaka/473/2005/BGD NorovirusHu/P11-20/2001/SWE Norovirus Dhaka/478/2005/BGD NorovirusHu/P11-21/2001/SWE Norovirus Dhaka/481/2005/BGD NorovirusHu/P11-211/2001/SWE Norovirus Dhaka/493/2005/BGD NorovirusHu/P11-23/2001/SWE Norovirus Dhaka/497/2005/BGD NorovrrusHu/P11-24/2001/SWE Norovirus Dhaka/501/2005/BGD NorovirusHu/P11-25/2001/SWE Norovirus Dhaka/503/2005/BGD NorovirusHu/P11-26/2001/SWE Norovirus Dhaka/527/2005/BGD NorovirusHu/P11-27/2001/SWE Norovirus Dhaka/617/2005/BGD NorovirusHu/P11-3/2001/SWE Norovirus Dhaka/665/2005/BGD NorovirusHu/P11-5/2001/SWE Norovirus Dhaka/717/2005/BGD NorovirusHu/P11-7/2001/SWE Norovirus Dhaka/750/2005/BGD NorovirusHu/P13-1/2001/SWE Norovirus Dhaka/759/2005/BGD NorovirusHu/P13-10/2001/SWE Norovirus Dhaka/767/2005/BGD NorovirusHu/P13-11/2001/SWE Norovirus Dhaka/791/2005/BGD NorovirusHu/P13-12/2001/SWE Norovirus Dhaka/817/2005/BGD NorovirusHu/P13-13/2001/SWE Norovirus Dhaka/861/2005/BGD NorovirusHu/P13-14/2001/SWE Norovirus Dhaka/881/2005/BGD NorovirusHu/P13-15/2001/SWE Norovirus Dhaka/893/2005/BGD NorovirusHu/P13-16/2001/SWE Norovirus Dhaka/904/2005/BGD NorovirusHu/P13-17/2001/SWE Norovirus dog/C33/Viseu/2007/PRT NorovirusHu/P13-19/2001/SWE Norovirus dog/Thessaloniki/30/2008/GRC NorovirusHu/P13-2/2001/SWE Norovirus Dresden153/1997/GE NorovirusHu/P13-3/2001/SWE Norovirus Dresden245/1997/GE NorovirusHu/P13-4/2001/SWE Norovirus Dresden267/1997/GE NorovirusHu/P13-6/2001/SWE Norovirus Dresden319/1997/GE NorovirusHu/P13-7/2001/SWE Norovirus Erlangen195/1997/GE NorovirusHu/P13-8/2001/SWE Norovirus Freiburg024/1997/GE NorovirusHu/P13-9/2001/SWE Norovirus Freiburg057/1997/GE Norovirus Hu/P14/JPNNorovirus Freiburg253/1998/GE Norovirus Hu/P15-1/2001/SWE NorovirusHamburg048/1997/GE Norovirus Hu/P15-10/2001/SWE NorovirusHamburg135/1998/GE Norovirus Hu/P15-12/2001/SWE NorovirusHamburg137/1997/GE Norovirus Hu/P15-14/2001/SWE NorovirusHamburg139/1997/GE Norovirus Hu/P15-15/2001/SWE NorovirusHamburg180/1997/GE Norovirus Hu/P15-18/2001/SWE NorovirusHamburg189/1997/GE Norovirus Hu/P15-2/2001/SWE NorovirusHamburg236/1997/GE Norovirus Hu/P15-22/2001/SWE NorovirusHamburg316/1998/GE Norovirus Hu/P15-25/2001/SWE Norovirus Hu/01/05/DRNorovirus Hu/P15-3/2001/SWE Norovirus Hu/0137/2004/NL NorovirusHu/P15-30/2001/SWE Norovirus Hu/0672HA/2004/NL NorovirusHu/P15-5/2001/SWE Norovirus Hu/1064A/73292/2007/NLD NorovirusHu/P15-6/2001/SWE Norovirus Hu/1064B/73292/2007/NLD NorovirusHu/P15-9/2001/SWE Norovirus Hu/1968/US Norovirus Hu/P17-1/2003/SWENorovirus Hu/4476A/64317/2006/NLD Norovirus Hu/P17-10/2003/SWE NorovirusHu/5013/JPN Norovirus Hu/P17-11/2003/SWE Norovirus Hu/5014/JPN NorovirusHu/P17-12/2003/SWE Norovirus Hu/5015/JPN Norovirus Hu/P17-13/2003/SWENorovirus Hu/5017.34/2003/JPN Norovirus Hu/P17-14/2003/SWE NorovirusHu/5069/JPN Norovirus Hu/P17-15/2003/SWE Norovirus Hu/5128/JPN NorovirusHu/P17-17/2003/SWE Norovirus Hu/5722/JPN Norovirus Hu/P17-18/2003/SWENorovirus Hu/5723/JPN Norovirus Hu/P17-19/2003/SWE NorovirusHu/5735/2004/JPN Norovirus Hu/P17-2/2003/SWE Norovirus Hu/5740/JPNNorovirus Hu/P17-20/2003/SWE Norovirus Hu/5828/JPN NorovirusHu/P17-3/2003/SWE Norovirus Hu/6136/JPN Norovirus Hu/P17-6/2003/SWENorovirus Hu/6819/2005/JPN Norovirus Hu/P17-8/2003/SWE NorovirusHu/6820/2005/JPN Norovirus Hu/P17-9/2003/SWE Norovirus Hu/6822/2005/JPNNorovirus Hu/P1a/JPN Norovirus Hu/6824/2005/JPN Norovirus Hu/P1b/JPNNorovirus Hu/6825/2005/JPN Norovirus Hu/P2/JPN NorovirusHu/6828/2005/JPN Norovirus Hu/P3-10/2000/SWE Norovirus Hu/6892/2005/JPNNorovirus Hu/P3-11/2000/SWE Norovirus Hu/6960/2005/JPN NorovirusHu/P3-14/2000/SWE Norovirus Hu/7300/2005/JPN Norovirus Hu/P3-15/2000/SWENorovirus Hu/771/2005/IRL Norovirus Hu/P3-16/2000/SWE NorovirusHu/78/04/Ru Norovirus Hu/P3-17/2000/SWE Norovirus Hu/8533/Maizuru/08/JPNNorovirus Hu/P3-18/2000/SWE Norovirus Hu/Aalen2506/2003/DE NorovirusHu/P3-19/2000/SWE Norovirus Hu/Accra/2000/GH Norovirus Hu/P3-2/2000/SWENorovirus Hu/Afyon/14/2007/TR Norovirus Hu/P3-20/2000/SWE NorovirusHu/Afyon/22/2007/TR Norovirus Hu/P3-3/2000/SWE NorovirusHu/Afyon/34/2007/TR Norovirus Hu/P3-4/2000/SWE NorovirusHu/Afyon/44/2007/TR Norovirus Hu/P3-5/2000/SWE NorovirusHu/Afyon/49/2007/TR Norovirus Hu/P3-6/2000/SWE NorovirusHu/Afyon/65/2007/TR Norovirus Hu/P3-7/2000/SWE NorovirusHu/Afyon/7/2007/TR Norovirus Hu/P3-8/2000/SWE NorovirusHu/Afyon/70/2007/TR Norovirus Hu/P3-9/2000/SWE NorovirusHu/Afyon/72/2007/TR Norovirus Hu/P4a/JPN Norovirus Hu/Afyon/74/2007/TRNorovirus Hu/P4b/JPN Norovirus Hu/Afyon/79/2007/TR NorovirusHu/P5-1/2000/SWE Norovirus Hu/Afyon/88/2007/TR NorovirusHu/P5-11/2000/SWE Norovirus Hu/Ahm/PC03/2006/India NorovirusHu/P5-14/2000/SWE Norovirus Hu/Akabane/990206/1999/JP/2087 NorovirusHu/P5-15/2000/SWE Norovirus Hu/Akabane/991130/1999/JP/2258 NorovirusHu/P5-16/2000/SWE Norovirus Hu/Akita-City/1/2006/JP NorovirusHu/P5-18/2000/SWE Norovirus Hu/Akita-City/1/2007/JP NorovirusHu/P5-19/2000/SWE Norovirus Hu/Akita-City/1/2008/JP NorovirusHu/P5-2/2000/SWE Norovirus Hu/Akita-City/2/2008/JP NorovirusHu/P5-20/2000/SWE Norovirus Hu/Akita-City/3/2008/JP NorovirusHu/P5-3/2000/SWE Norovirus Hu/Akita-City/4/2008/JP NorovirusHu/P5-4/2000/SWE Norovirus Hu/Aur/A822/2006/India NorovirusHu/P5-5/2000/SWE Norovirus Hu/Aur/A832/2006/India NorovirusHu/P5-7/2000/SWE Norovirus Hu/Balingen2573/2004/DE NorovirusHu/P5-8/2000/SWE Norovirus Hu/Balingen633/2002/DE NorovirusHu/P7-10/2001/SWE Norovirus Hu/Beijing/06/2005/CHN NorovirusHu/P7-11/2001/SWE Norovirus Hu/Beijing/148/2005/CHN NorovirusHu/P7-12/2001/SWE Norovirus Hu/Beijing/169/2005/CHN NorovirusHu/P7-14/2001/SWE Norovirus Hu/Beijing/375/2005/CHN NorovirusHu/P7-15/2001/SWE Norovirus Hu/Beijing/48/2005/CHN NorovirusHu/P7-16/2001/SWE Norovirus Hu/Beijing/BJ1/2002/CHN NorovirusHu/P7-17/2001/SWE Norovirus Hu/Beijing/BJ12/2002/CHN NorovirusHu/P7-18/2001/SWE Norovirus Hu/Beijing/BJ14/2002/CHN NorovirusHu/P7-19/2001/SWE Norovirus Hu/Beijing/BJ21/2002/CHN NorovirusHu/P7-2/2001/SWE Norovirus Hu/Beijing/CR2905/2004/CHN NorovirusHu/P7-20/2001/SWE Norovirus Hu/Beijing/CR2932/2004/CHN NorovirusHu/P7-3/2001/SWE Norovirus Hu/Beijing/CR2987/2004/CHN NorovirusHu/P7-4/2001/SWE Norovirus Hu/Berlin/11/03/Germany NorovirusHu/P7-5/2001/SWE Norovirus Hu/Boeblingen13203/2002/DE NorovirusHu/P7-6/2001/SWE Norovirus Hu/Boeblingen13295/2002/DE NorovirusHu/P7-7/2001/SWE Norovirus Hu/Boeblingen2108/2003/DE NorovirusHu/P9-1/2001/SWE Norovirus Hu/Briancon870/2004/France NorovirusHu/P9-10/2001/SWE Norovirus Hu/C14/2002/AU Norovirus Hu/P9-11/2001/SWENorovirus Hu/Calw132712/2002/DE Norovirus Hu/P9-12/2001/SWE NorovirusHu/Calw13843/2002/DE Norovirus Hu/P9-18/2001/SWE NorovirusHu/Calw1452/2003/DE Norovirus Hu/P9-2/2001/SWE NorovirusHu/Calw2169/2003/DE Norovirus Hu/P9-21/2001/SWE NorovirusHu/Calw2563/2003/DE Norovirus Hu/P9-23/2001/SWE NorovirusHu/Calw3453/2002/DE Norovirus Hu/P9-24/2001/SWE NorovirusHu/Calw5194/2002/DE Norovirus Hu/P9-26/2001/SWE NorovirusHu/Caterer_Company_1_pat_1/10- Norovirus Hu/P9-27/2001/SWE 04-2003/NLNorovirus Hu/P9-30/2001/SWE Norovirus Hu/Caterer_Company_1_pat_2/10-Norovirus Hu/P9-5/2001/SWE 04-2003/NL Norovirus Hu/P9-6/2001/SWENorovirus Hu/Caterer_Company_2_pat_1/12- Norovirus Hu/P9-7/2001/SWE04-2003/NL Norovirus Hu/P9-8/2001/SWE NorovirusHu/Caterer_Company_2_pat_2/12- Norovirus Hu/P9-9/2001/SWE 04-2003/NLNorovirus Hu/Picton/2003/AU Norovirus Hu/Caterer_personel_1/16-04-Norovirus Hu/PontdeRoide682/2004/France 2003/NL NorovirusHu/ptAdam/64815/2006/NLD Norovirus Hu/Caterer_personel_2/16-04-Norovirus Hu/ptAdam/64815b/2006/NLD 2003/NL NorovirusHu/Pune/OPD04/2007/India Norovirus Hu/Caterer_personel_3/16-04-Norovirus Hu/Pune/OPD05/2007/India 2003/NL NorovirusHu/Pune/PC01/2005/India Norovirus Hu/Caterer_personel_4/16-04- NorovirusHu/Pune/PC02/2006/India 2003/NL Norovirus Hu/Pune/PC04/2005/IndiaNorovirus Hu/Caterer_personel_5/16-04- Norovirus Hu/Pune/PC05/2005/India2003/NL Norovirus Hu/Pune/PC06/2005/India NorovirusHu/Chatellerault709/2004/France Norovirus Hu/Pune/PC07/2005/IndiaNorovirus Hu/Chiba/000010/2000/JP Norovirus Hu/Pune/PC08/2005/IndiaNorovirus Hu/Chiba/000016G1/1999/JP Norovirus Hu/Pune/PC09/2005/IndiaNorovirus Hu/Chiba/000016G2/1999/JP Norovirus Hu/Pune/PC10/2005/IndiaNorovirus Hu/Chiba/000022/2000/JP Norovirus Hu/Pune/PC11/2006/IndiaNorovirus Hu/Chiba/000325/2000/JP Norovirus Hu/Pune/PC12/2006/IndiaNorovirus Hu/Chiba/000335/2000/JP Norovirus Hu/Pune/PC13/2006/IndiaNorovirus Hu/Chiba/000336/2000/JP Norovirus Hu/Pune/PC14/2006/IndiaNorovirus Hu/Chiba/000337/2000/JP Norovirus Hu/Pune/PC15/2006/IndiaNorovirus Hu/Chiba/000344/2000/JP Norovirus Hu/Pune/PC16/2006/IndiaNorovirus Hu/Chiba/000459/2000/JP Norovirus Hu/Pune/PC17/2006/IndiaNorovirus Hu/Chiba/000468/2000/JP Norovirus Hu/Pune/PC18/2006/IndiaNorovirus Hu/Chiba/000485/2000/JP Norovirus Hu/Pune/PC19/2006/IndiaNorovirus Hu/Chiba/000516/2000/JP Norovirus Hu/Pune/PC20/2006/IndiaNorovirus Hu/Chiba/000520/2000/JP Norovirus Hu/Pune/PC21/2006/IndiaNorovirus Hu/Chiba/000600/2000/JP Norovirus Hu/Pune/PC22/2006/IndiaNorovirus Hu/Chiba/000661/2000/JP Norovirus Hu/Pune/PC23/2006/IndiaNorovirus Hu/Chiba/000782/2000/JP Norovirus Hu/Pune/PC24/2006/IndiaNorovirus Hu/Chiba/001049/2000/JP Norovirus Hu/Pune/PC25/2006/IndiaNorovirus Hu/Chiba/001080/2000/JP Norovirus Hu/Pune/PC26/2006/IndiaNorovirus Hu/Chiba/010006/2001/JP Norovirus Hu/Pune/PC27/2006/IndiaNorovirus Hu/Chiba/010045/2001/JP Norovirus Hu/Pune/PC28/2006/IndiaNorovirus Hu/Chiba/010105/2001/JP Norovirus Hu/Pune/PC29/2006/IndiaNorovirus Hu/Chiba/010108/2001/JP Norovirus Hu/Pune/PC30/2007/IndiaNorovirus Hu/Chiba/010390/2001/JP Norovirus Hu/Pune/PC31/2007/IndiaNorovirus Hu/Chiba/010433/2001/JP Norovirus Hu/Pune/PC32/2007/IndiaNorovirus Hu/Chiba/010442/2001/JP Norovirus Hu/Pune/PC33/2007/IndiaNorovirus Hu/Chiba/010465/2001/JP Norovirus Hu/Pune/PC34/2007/IndiaNorovirus Hu/Chiba/010510/2001/JP Norovirus Hu/Pune/PC35/2007/IndiaNorovirus Hu/Chiba/010522/2001/JP Norovirus Hu/Pune/PC36/2007/IndiaNorovirus Hu/Chiba/010526/2001/JP Norovirus Hu/Pune/PC37/2007/IndiaNorovirus Hu/Chiba/010539/2001/JP Norovirus Hu/Pune/PC38/2007/IndiaNorovirus Hu/Chiba/010587/2001/JP Norovirus Hu/Pune/PC39/2007/IndiaNorovirus Hu/Chiba/010621/2001/JP Norovirus Hu/Pune/PC40/2007/IndiaNorovirus Hu/Chiba/010751/2001/JP Norovirus Hu/Pune/PC41/2007/IndiaNorovirus Hu/Chiba/010998/2001/JP Norovirus Hu/Pune/PC42/2007/IndiaNorovirus Hu/Chiba/020015/2002/JP Norovirus Hu/Pune/PC43/2007/IndiaNorovirus Hu/Chiba/020040/2002/JP Norovirus Hu/Pune/PC44/2007/IndiaNorovirus Hu/Chiba/020042/2002/JP Norovirus Hu/Pune/PC45/2007/IndiaNorovirus Hu/Chiba/020062/2002/JP Norovirus Hu/Pune/PC46/2007/IndiaNorovirus Hu/Chiba/020096G1/2002/JP Norovirus Hu/Pune/PC47/2007/IndiaNorovirus Hu/Chiba/020096G2/2002/JP Norovirus Hu/Pune/PC48/2007/IndiaNorovirus Hu/Chiba/020097/2002/JP Norovirus Hu/Pune/PC49/2007/IndiaNorovirus Hu/Chiba/020198/2002/JP Norovirus Hu/Pune/PC50/2007/IndiaNorovirus Hu/Chiba/020247/2002/JP Norovirus Hu/Pune/PC51/2007/IndiaNorovirus Hu/Chiba/020250/2002/JP Norovirus Hu/Pune/PC52/2007/IndiaNorovirus Hu/Chiba/020251/2002/JP Norovirus Hu/Pune/PC53/2007/IndiaNorovirus Hu/Chiba/020267/2002/JP Norovirus Hu/Pune/PC54/2007/IndiaNorovirus Hu/Chiba/020301/2002/JP Norovirus Hu/Pune/PC55/2007/IndiaNorovirus Hu/Chiba/020475/2002/JP Norovirus Hu/Pune/PC56/2007/IndiaNorovirus Hu/Chiba/020555/2002/JP Norovirus Hu/Pune/PC57/2007/IndiaNorovirus Hu/Chiba/020984/2002/JP Norovirus Hu/Pune/PC58/2007/IndiaNorovirus Hu/Chiba/021022/2002/JP Norovirus Hu/QLD059/2006/AUS NorovirusHu/Chiba/021026/2002/JP Norovirus Hu/QLD466/2006/AUS NorovirusHu/Chiba/021050/2002/JP Norovirus Hu/QLD497/2006/AUS NorovirusHu/Chiba/021068/2002/JP Norovirus Hu/QLD900/2006/AUS NorovirusHu/Chiba/021071/2002/JP Norovirus Hu/QLD946/2006/AUS NorovirusHu/Chiba/030100/2003/JP Norovirus Hu/QLD987/2006/AUS NorovirusHu/Chiba/030305/2003/JP Norovirus Hu/R1/JPN NorovirusHu/Chiba/030308/2003/JP Norovirus Hu/R2/JPN NorovirusHu/Chiba/030322/2003/JP Norovirus Hu/R3/JPN NorovirusHu/Chiba/030335/2003/JP Norovirus Hu/Rastatt724/2003/DE NorovirusHu/Chiba/030358/2003/JP Norovirus Hu/Ravensburg12859/2001/DE NorovirusHu/Chiba/030360/2003/JP Norovirus Hu/Ravensburg6690/2001/DE NorovirusHu/Chiba/030399/2003/JP Norovirus Hu/reference/2000/SWE NorovirusHu/Chiba/030403/2003/JP Norovirus Hu/RemsMurr3910/2002/DE NorovirusHu/Chiba/030412/2003/JP Norovirus Hu/Reutlingen1302/2002/DE NorovirusHu/Chiba/030429/2003/JP Norovirus Hu/Reutlingen1402/2002/DE NorovirusHu/Chiba/030474/2003/JP Norovirus Hu/Reutlingen2844/2002/DE NorovirusHu/Chiba/030486/2003/JP Norovirus Hu/River_Cruising_ship_1/16-05-Norovirus Hu/Chiba/030510/2003/JP 2001/NL NorovirusHu/Chiba/030517/2003/JP Norovirus Hu/River_Cruising_Ship_2/08-04-Norovirus Hu/Chiba/030522/2003/JP 2003/NL NorovirusHu/Chiba/030541/2003/JP Norovirus Hu/S1/JPN NorovirusHu/Chiba/030542/2003/JP Norovirus Hu/S10/JPN NorovirusHu/Chiba/030546/2003/JP Norovirus Hu/S12a/JPN NorovirusHu/Chiba/030547G1/2003/JP Norovirus Hu/S12b/JPN NorovirusHu/Chiba/030547G2/2003/JP Norovirus Hu/S14/JPN NorovirusHu/Chiba/030556/2003/JP Norovirus Hu/S2/JPN NorovirusHu/Chiba/030603/2003/JP Norovirus Hu/S4/JPN NorovirusHu/Chiba/030654/2003/JP Norovirus Hu/S6/JPN NorovirusHu/Chiba/030658/2003/JP Norovirus Hu/S7/JPN NorovirusHu/Chiba/030910/2003/JP Norovirus Hu/S8/JPN NorovirusHu/Chiba/030968/2003/JP Norovirus Hu/Saarbruecken/04/03/GermanyNorovirus Hu/Chiba/030981/2003/JP Norovirus Hu/Saga/000313/2000/JP/2876Norovirus Hu/Chiba/031038/2003/JP Norovirus Hu/Saga/001215/2000/JP/3101Norovirus Hu/Chiba/04-1008/2004/JP Norovirus Hu/Saga/5424/03/JPNorovirus Hu/Chiba/04-1050/2005/JP Norovirus Hu/Sakai/04-179/2005/JPNorovirus Hu/Chiba/04-899/2004/JP Norovirus Hu/Samokov414/2007/BGRNorovirus Hu/Chiba/04-974/2004/JP NorovirusHu/SchwaebischHall11120/2002/DE Norovirus Hu/Chiba/040001/2004/JPNorovirus Hu/Serian/GE0241/2001/MYS Norovirus Hu/Chiba/040002/2004/JPNorovirus Hu/Serian/GE0431/2001/MYS Norovirus Hu/Chiba/040003/2004/JPNorovirus Hu/Serian/GE0433/2001/MYS Norovirus Hu/Chiba/040045/2004/JPNorovirus Hu/Serian/GE0861/2001/MYS Norovirus Hu/Chiba/040092/2004/JPNorovirus Hu/Shaanxi/49576/2006/CHN Norovirus Hu/Chiba/040096/2004/JPNorovirus Hu/Shaanxi/49586/2006/CHN Norovirus Hu/Chiba/040110/2004/JPNorovirus Hu/Shaanxi/49595/2006/CHN Norovirus Hu/Chiba/040140/2004/JPNorovirus Hu/Shaanxi/49596/2006/CHN Norovirus Hu/Chiba/040230/2004/JPNorovirus Hu/Shaanxi/49597/2006/CHN Norovirus Hu/Chiba/040252/2004/JPNorovirus Hu/Shaanxi/49598/2006/CHN Norovirus Hu/Chiba/040277/2004/JPNorovirus Hu/Shaanxi/49599/2006/CHN Norovirus Hu/Chiba/040300/2004/JPNorovirus Hu/Shaanxi/49600/2006/CHN Norovirus Hu/Chiba/040309/2004/JPNorovirus Hu/Shaanxi/49601/2006/CHN Norovirus Hu/Chiba/040311/2004/JPNorovirus Hu/Shaanxi/49606/2006/CHN Norovirus Hu/Chiba/040493/2004/JPNorovirus Hu/Shaanxi/49607/2006/CHN Norovirus Hu/Chiba/040500/2004/JPNorovirus Hu/Shaanxi/49610/2006/CHN Norovirus Hu/Chiba/040501/2004/JPNorovirus Hu/Shaibah-1/2007/IRQ Norovirus Hu/Chiba/040502/2004/JPNorovirus Hu/Shaibah-2/2007/IRQ Norovirus Hu/Chiba/040545/2004/JPNorovirus Hu/Shanghai/49798/2006/CHN Norovirus Hu/Chiba/040554/2004/JPNorovirus Hu/Shanghai/49800/2006/CHN Norovirus Hu/Chiba/040589/2004/JPNorovirus Hu/Shanghai/49803/2006/CHN Norovirus Hu/Chiba/990897/1999/JPNorovirus Hu/Shanxi/49709/2006/CHN Norovirus Hu/Chiba/990900/1999/JPNorovirus Hu/Shanxi/49716/2006/CHN Norovirus Hu/Chiba/990969/1999/JPNorovirus Hu/Shanxi/50106/2006/CHN Norovirus Hu/Chiba/991012/1999/JPNorovirus Hu/Shimane/D1712-A-a/Jun2008/JP NorovirusHu/Chiba/991013/1999/JP Norovirus Hu/Shimane/D1712-A-b/Jun2008/JPNorovirus Hu/Chiba/991118/1999/JP NorovirusHu/Shimane/D1714-B/Jun2008/JP Norovirus Hu/Chiba/991120/1999/JPNorovirus Hu/Shimane/D1715-B-a/Jun2008/JP NorovirusHu/Chiba/991173/1999/JP Norovirus Hu/Shimane/D1715-B-b/Jun2008/JPNorovirus Hu/Chiba/991180/1999/JP NorovirusHu/Shimane/D1716-B/Jun2008/JP Norovirus Hu/CHN2119/CC99 NorovirusHu/Shimane/D1725/Jun2008/JP Norovirus Hu/CHN2121/CC99 NorovirusHu/Shimane/D1730-A/Jun2008/JP Norovirus Hu/CHN2122/CC99 NorovirusHu/Shimane/D1731-A/Jun2008/JP Norovirus Hu/CHN2127/CC99 NorovirusHu/Shimane/D1734-D/Jun2008/JP Norovirus Hu/CHN2136/CC99 NorovirusHu/Shimane/D1739-A/Jun2008/JP Norovirus Hu/CHN2139/CC99 NorovirusHu/Shimane/D1741-D-a/Jun2008/JP Norovirus Hu/CHN2140/CC99 NorovirusHu/Shimane/D1741-D-b/Jun2008/JP Norovirus Hu/CHN2168/LL99 NorovirusHu/Shimane/D1742-D/Jun2008/JP Norovirus Hu/CHN2183/LL99 NorovirusHu/Shimane/D1743-D/Jun2008/JP Norovirus Hu/CHN2514/HN99 NorovirusHu/Shinshiro/1/2006/JP Norovirus Hu/CHN2553/HN99 NorovirusHu/Showa/1/05/JP Norovirus Hu/CHN2576/HN99 NorovirusHu/SI001386/Slovenia Norovirus Hu/CHN2625/GZH99 NorovirusHu/Sigmaringen13187/2002/DE Norovirus Hu/CHN2749/GZH99 NorovirusHu/Sigmaringen4557/2001/DE Norovirus Hu/CHN2792/LZH99 NorovirusHu/Sigmaringen687/2003/DE Norovirus Hu/CHN2799/LZH99 NorovirusHu/Sofia156/2007/BGR Norovirus Hu/CHN2807/KM00 NorovirusHu/Sofia578/2007/BGR Norovirus Hu/CHN2809/KM00 NorovirusHu/Sofia661/2007/BGR Norovirus Hu/CHN2841/KM99 NorovirusHu/Sommieres1203/2006/France Norovirus Hu/CHN2842/KM99 NorovirusHu/SteColette658/2004/France Norovirus Hu/CHN2844/KM99 NorovirusHu/Stuttgart02184/2002/DE Norovirus Hu/CHN2851/KM99 NorovirusHu/Stuttgart7528/2002/DE Norovirus Hu/CHN2929/GZH00 Norovirus Hu/T2a/JPNNorovirus Hu/CHN302/BJ99 Norovirus Hu/T2b/JPN Norovirus Hu/CHN3055/FJ99Norovirus Hu/T3/JPN Norovirus Hu/CHN3111/FJ99 Norovirus Hu/T4/JPNNorovirus Hu/CHN3156/FJ99 Norovirus Hu/Taipei-1/04/TW NorovirusHu/CHN3181/HZH99 Norovirus Hu/Taipei-11/04/TW Norovirus Hu/CHN3191/HZH99Norovirus Hu/Taipei-24/04/TW Norovirus Hu/CHN3198/HZH99 NorovirusHu/Taipei-32/04/TW Norovirus Hu/CHN3202/HZH99 NorovirusHu/Taipei-33/04/TW Norovirus Hu/CHN3241/HZH99 NorovirusHu/Taipei-52/04/TW Norovirus Hu/CHN3256/HZH99 NorovirusHu/Taipei-53/04/TW Norovirus Hu/CHN3258/HZH99 NorovirusHu/Taipei-57/04/TW Norovirus Hu/CHN3263/HZH99 NorovirusHu/Taipei-63/04/TW Norovirus Hu/CHN3275/HZH99 NorovirusHu/Taipei-69/04/TW Norovirus Hu/CHN3298/HZH99 NorovirusHu/Taipei-70/04/TW Norovirus Hu/CHN3299/HZH99 NorovirusHu/Taipei-73/04/TW Norovirus Hu/CHN3309/HZH99 NorovirusHu/Taipei-76/04/TW Norovirus Hu/CHN3477/LL00 NorovirusHu/Taipei-78/04/TW Norovirus Hu/CHN360/BJ99 Norovirus Hu/Taipei-81/04/TWNorovirus Hu/CHN3755/CC00 Norovirus Hu/Taipei-82/04/TW NorovirusHu/CHN3786/CC00 Norovirus Hu/Taipei-84/04/TW Norovirus Hu/CHN3787/CC00Norovirus Hu/Taipei-91/04/TW Norovirus Hu/CHN3822/CC00 NorovirusHu/Taipei-93GI/04/TW Norovirus Hu/CHN3824/CC99 NorovirusHu/Taipei-93GII/04/TW Norovirus Hu/CHN3826/CC99 NorovirusHu/Takanosu/1/2008/JP Norovirus Hu/CHN3838/LL00 NorovirusHu/Tamagawa/1/05/JP Norovirus Hu/CHN38456/BJ04 NorovirusHu/Tamagawa/1/06/JP Norovirus Hu/CHN3852/LL00 NorovirusHu/Tamagawa/2/05/JP Norovirus Hu/CHN38588/BJ04 NorovirusHu/Tamagawa/2/2006/JP Norovirus Hu/CHN38791/XJ04 NorovirusHu/Tauberbischofsheim14175/2001/DE Norovirus Hu/CHN388/BJ00 NorovirusHu/Tauberbischofsheim6245/2002/DE Norovirus Hu/CHN38812/XJ04 NorovirusHu/TE5/2003/ITA Norovirus Hu/CHN38816/XJ04 NorovirusHu/Texas/TCH04-577/2004/US Norovirus Hu/CHN3898/KM00 NorovirusHu/TL206/1999/MEX Norovirus Hu/CHN39186/CC04 Norovirus Hu/TL24/1998/MEXNorovirus Hu/CHN39240/CC04 Norovirus Hu/TL354/2000/MEX NorovirusHu/CHN39246/CC04 Norovirus Hu/Tokyo/1Se/2005/JPN NorovirusHu/CHN39280/CC04 Norovirus Hu/Tokyo/216DCC/2005/JPN NorovirusHu/CHN3931/KM00 Norovirus Hu/Tokyo/272DCC/2006/JPN NorovirusHu/CHN39386/SZ04 Norovirus Hu/Tokyo/276DCC/2006/JPN NorovirusHu/CHN39428/SZ04 Norovirus Hu/Tokyo/285DCC/2006/JPN NorovirusHu/CHN39462/SZ04 Norovirus Hu/Tokyo/286DCC/2006/JPN NorovirusHu/CHN39540/SZ04 Norovirus Hu/Tokyo/2Se/2006/JPN NorovirusHu/CHN3963/LL00 Norovirus Hu/Tokyo/306DCC/2006/JPN NorovirusHu/CHN3973/LL00 Norovirus Hu/Tokyo/390DCC/2006/JPN NorovirusHu/CHN40048/KM04 Norovirus Hu/Tokyo/391DCC/2006/JPN NorovirusHu/CHN40078/KM04 Norovirus Hu/Tokyo/392DCC/2006/JPN NorovirusHu/CHN40092/KM04 Norovirus Hu/Tokyo/393DCC/2006/JPN NorovirusHu/CHN401/BJ●0 Norovirus Hu/Tokyo/396DCC/2006/JPN NorovirusHu/CHN40182/KM04 Norovirus Hu/Tokyo/398DCC/2006/JPN NorovirusHu/CHN40482/SH04 Norovirus Hu/Tokyo/3Se/2006/JPN NorovirusHu/CHN40496/SH04 Norovirus Hu/Tokyo/400DCC/2006/JPN NorovirusHu/CHN40538/SH04 Norovirus Hu/Tokyo/401DCC/2006/JPN NorovirusHu/CHN40600/SH04 Norovirus Hu/Tokyo/402DCC/2006/JPN NorovirusHu/CHN40656/CZ04 Norovirus Hu/Tokyo/403DCC/2006/JPN NorovirusHu/CHN40685/CZ04 Norovirus Hu/Tokyo/405DCC/2006/JPN NorovirusHu/CHN40737/CZ04 Norovirus Hu/Tokyo/406DCC/2006/JPN NorovirusHu/CHN40763/CZ04 Norovirus Hu/Tokyo/411DCC/2006/JPN NorovirusHu/CHN40896/SZ04 Norovirus Hu/Tokyo/414DCC/2006/JPN NorovirusHu/CHN40998/SZ04 Norovirus Hu/Tokyo/418DCC/2006/JPN NorovirusHu/CHN41779/XJ04 Norovirus Hu/Tokyo/419DCC/2006/JPN NorovirusHu/CHN41808/LL04 Norovirus Hu/Tokyo/51Se/2005/JPN NorovirusHu/CHN42018/LL05 Norovirus Hu/Tokyo/56Se/2005/JPN NorovirusHu/CHN42164/CC04 Norovirus Hu/Tokyo/61Se/2005/JPN NorovirusHu/CHN42224/LL05 Norovirus Hu/Tokyo/6602St/2005/JPN NorovirusHu/CHN42269/LL05 Norovirus Hu/Tokyo/6789St/2006/JPN NorovirusHu/CHN4253/LL01 Norovirus Hu/Tokyo/6801St/2006/JPN NorovirusHu/CHN42548/LL05 Norovirus Hu/Tokyo/7391St/2005/JPN NorovirusHu/CHN42572/LL05 Norovirus Hu/Tokyo/7395St/2005/JPN NorovirusHu/CHN42814/CZ04 Norovirus Hu/Tokyo/7403St/2005/JPN NorovirusHu/CHN42846/CZ04 Norovirus Hu/Tokyo/7860/2007/JPN NorovirusHu/CHN42936/CZ04 Norovirus Hu/Tokyo/7882/2007/JPN NorovirusHu/CHN42951/CZ05 Norovirus Hu/Tsushima/1/2006/JP NorovirusHu/CHN42973/CZ05 Norovirus Hu/Tuebingen4259/2002/DE NorovirusHu/CHN42982/XJ05 Norovirus Hu/Tuebingen7827/2001/DE NorovirusHu/CHN4300/LL01 Norovirus Hu/Tuebingen9261/2001/DE NorovirusHu/CHN43098/CC05 Noroviius Hu/UK11/1998/GBR Norovirus Hu/CHN43160/CC05Norovirus Hu/UK12/2001/GBR Norovirus Hu/CHN43172/CC05 NorovirusHu/UK14/1998/GBR Norovirus Hu/CHN43202/LZ04 Norovirus Hu/Ulm2451/2002/DENorovirus Hu/CHN43262/LZ05 Norovirus Hu/Ulm70/2003/DE NorovirusHu/CHN43266/LZ05 Norovirus Hu/V1607/06/IND Norovirus Hu/CHN43283/LZ05Norovirus Hu/V1622/06/IND Norovirus Hu/CHN43301/LZ05 NorovirusHu/V1628/06/IND Norovirus Hu/CHN43303/LZ05 Norovirus Hu/V1656/06/INDNorovirus Hu/CHN43320/LZ05 Norovirus Hu/V1668/06/IND NorovirusHu/CHN43321/LZ05 Norovirus Hu/V1682/07/IND Norovirus Hu/CHN43324/LZ05Norovirus Hu/V1699/07/IND Norovirus Hu/CHN43330/LZ05 NorovirusHu/V1702/07/IND Norovirus Hu/CHN43332/LZ05 Norovirus Hu/V1706/07/INDNorovirus Hu/CHN43338/LZ05 Norovirus Hu/V1707/07/IND NorovirusHu/CHN43342/LZ05 Norovirus Hu/V1714/07/IND Norovirus Hu/CHN43364/LZ04Norovirus Hu/V1737/07/IND Norovirus Hu/CHN43367/LZ04 NorovirusHu/V1749/07/IND Norovirus Hu/CHN43466/SH04 Norovirus Hu/V1750/07/INDNorovirus Hu/CHN43502/SH04 Norovirus Hu/V1760/07/IND NorovirusHu/CHN43512/SH05 Norovirus Hu/V1766/07/IND Norovirus Hu/CHN43552/SH05Norovirus Hu/V1772/07/IND Norovirus Hu/CHN43568/SH05 NorovirusHu/V1774/07/IND Norovirus Hu/CHN4359/LL01 Norovirus Hu/V1776/07/INDNorovirus Hu/CHN43594/SH05 Norovirus Hu/V1783/07/IND NorovirusHu/CHN4369/LL01 Norovirus Hu/VC192/2000/MEX Norovirus Hu/CHN43949/LZ04Norovirus Hu/VC193/2000/MEX Norovirus Hu/CHN43964/LZ04 NorovirusHu/VC66/1999/MEX Norovirus Hu/CHN43989/LZ04 NorovirusHu/Vesoul576/2003/France Norovirus Hu/CHN4411/CC01 NorovirusHu/VIC080/2006/AUS Norovirus Hu/CHN4412/CC01 NorovirusHu/VIC248/2006/AUS Norovirus Hu/CHN44123/LZ05 NorovirusHu/VIC397/2006/AUS Norovirus Hu/CHN44124/LZ05 NorovirusHu/VIC399/2006/AUS Norovirus Hu/CHN44126/LZ05 NorovirusHu/VIC458/2006/AUS Norovirus Hu/CHN44128/LZ05 NorovirusHu/VIC534/2006/AUS Norovirus Hu/CHN44134/LZ05 NorovirusHu/VIC544/2006/AUS Norovirus Hu/CHN44136/LZ05 NorovirusHu/VIC545/2006/AUS Norovirus Hu/CHN44692/KM04 NorovirusHu/VIC584/2006/AUS Norovirus Hu/CHN4474/CC01 NorovirusHu/VIC595/2006/AUS Norovirus Hu/CHN44812/LZ05 NorovirusHu/VIC644/2006/AUS Norovirus Hu/CHN44821/LZ05 NorovirusHu/VIC647/2006/AUS Norovirus Hu/CHN44858/KM04 NorovirusHu/VIC885/2006/AUS Norovirus Hu/CHN44898/KM04 NorovirusHu/VIC886/2006/AUS Norovirus Hu/CHN459/BJ00 NorovirusHu/Vigneux1379/2006/France Norovirus Hu/CHN4617/CC00 NorovirusHu/Villingen2309/2004/DE Norovirus Hu/CHN462/BJ00 NorovirusHu/Villingen311/2003/DE Norovirus Hu/CHN465/BJ00 NorovirusHu/VN1/2006/VNM Norovirus Hu/CHN4709/LL01 Norovirus Hu/VN26/2006/VNMNorovirus Hu/CHN4711/LL01 Norovirus Hu/VN41/2006/VNM NorovirusHu/CHN4748/LL01 Norovirus Hu/VN59/2006/VNM Norovirus Hu/CHN4789/LL01Norovirus Hu/VN73/2006/VNM Norovirus Hu/CHN5450/KM01 NorovirusHu/VN74/2006/VNM Norovirus Hu/CHN5531/KM01 Norovirus Hu/VN75/2006/VNMNorovirus Hu/CMH001/03/2003/THA Norovirus Hu/VN77/2006/VNM NorovirusHu/CMH002/05/2005/THA Norovirus Hu/VN78/2006/VNM NorovirusHu/CMH005/05/2005/THA Norovirus Hu/VN79/2006/VNM NorovirusHu/CMH006/04/2004/THA Norovirus Hu/VN80/2006/VNM NorovirusHu/CMH010/00/2000/THA Norovirus Hu/VN82/2006/VNM NorovirusHu/CMH010/05/2005/THA Norovirus Hu/VN84/2006/VNM NorovirusHu/CMH011/02/2002/THA Norovirus Hu/VN85/2006/VNM NorovirusHu/CMH011/04/2004/THA Norovirus Hu/VN87/2006/VNM NorovirusHu/CMH015/03/2003/THA Norovirus Hu/VN88/2006/VNM NorovirusHu/CMH018/04/2004/THA Norovirus Hu/VN89/2006/VNM NorovirusHu/CMH025/04/2004/THA Norovirus Hu/VN9/2006/VNM NorovirusHu/CMH028/03/2003/THA Norovirus Hu/VN95/2006/VNM NorovirusHu/CMH034/03/2003/THA Norovirus Hu/Waiblingen26/2003/DE NorovirusHu/CMH034/04/2004/THA Norovirus Hu/Waiblingen5141/2002/DE NorovirusHu/CMH037/00/2000/THA Norovirus Hu/Waiblingen6509/2001/DE NorovirusHu/CMH037/04/2004/THA Norovirus Hu/Waldshut5564/2003/DE NorovirusHu/CMH038/02/2002/THA Norovirus Hu/Waldshut7877/2002/DE NorovirusHu/CMH038/04/2004/THA Norovirus Hu/WKDHaussach8968/2003/DE NorovirusHu/CMH040/02/2002/THA Norovirus Hu/Yokohama/y04-161-16/2004/JP NorovirusHu/CMH041/02/2002/THA Norovirus Hu/Yokohama/y04-198-13/2005/JP NorovirusHu/CMH042/02/2002/THA Norovirus Hu/Yokohama/y04-200-11/2005/JP NorovirusHu/CMH042/05/2005/THA Norovirus Hu/Yokohama/y04-208-1/2005/JP NorovirusHu/CMH043/02/2002/THA Norovirus Hu/Yokohama/y04-V10-1/2005/JP NorovirusHu/CMH043/03/2003/THA Norovirus Hu/Yokohama/y05-153-40/2005/JP NorovirusHu/CMH045/04/2004/THA Norovirus Hu/Yokohama/y05-V14-5/2005/JP NorovirusHu/CMH049/04/2004/THA Norovirus Hu/Yokohama/y05-V17-8/2005/JP NorovirusHu/CMH052/01/2001/THA Norovirus Hu/Yokohama/y06-V110-5/2007/JP NorovirusHu/CMH063/04/2004/THA Norovirus Hu/Yokohama/y06-V111-3/2007/JP NorovirusHu/CMH064/04/2004/THA Norovirus Hu/Yokohama/y06-V114-14/2007/JPNorovirus Hu/CMH068/01/2001/THA Norovirus Hu/Yokohama/y06-V117-2/2007/JPNorovirus Hu/CMH076/04/2004/THA Norovirus Hu/Yokohama/y06-V34-5/2006/JPNorovirus Hu/CMH076/05/2005/THA Norovirus Hu/Yokohama/y06-V37-21/2006/JPNorovirus Hu/CMH079/04/2004/THA Norovirus Hu/Yokohama/y06-V44-2/2006/JPNorovirus Hu/CMH083/05/2005/THA Norovirus Hu/Yokohama/y06-V55-3/2006/JPNorovirus Hu/CMH090/04/2004/THA Norovirus Hu/Yokohama/y06-V67-5/2006/JPNorovirus Hu/CMH091/01/2001/THA Norovirus Hu/Yokohama/y06-V82-2/2007/JPNorovirus Hu/CMH091/04/2004/THA Norovirus Hu/Yokote/1/2008/JP NorovirusHu/CMH092/04/2004/THA Norovirus Hu/Yokote/2/2008/JP NorovirusHu/CMH096/01/2001/THA Norovirus Hu/Yokote/3/2008/JP NorovirusHu/CMH097/01/2001/THA Norovirus Hu/Yonaizawa/1/05/JP NorovirusHu/CMH104/05/2005/THA Norovirus Hu/Yuri/1/2007/JP NorovirusHu/CMH112/01/2001/THA Norovirus Hu/Zuerich/P3d1/2006 NorovirusHu/CMH113/05/2005/THA Norovirus Hu/Zuerich/P3d683/2008 NorovirusHu/CMH120/01/2001/THA Norovirus Hu/Zuerich/P4d1/2007 NorovirusHu/CMH126/01/2001/THA Norovirus Hu/Zuerich/P4d281/2007 NorovirusHu/CMH133/04/2004/THA Norovirus Hu/Zuerich/P5d1/2008 NorovirusHu/CMH138/04/2004/THA Norovirus Hu/Zuerich/P5d161/2009 NorovirusHu/CMH139/04/2004/THA Norovirus Hu/Zuerich/P7d1/2008 NorovirusHu/CMH140/04/2004/THA Norovirus Hu/Zuerich/P7d384/2009 NorovirusHu/CMH142/05/2005/THA Norovirus human feces/CIT N002/IRL NorovirusHu/CMH145/04/2004/THA Norovirus human feces/CIT N005/IRL NorovirusHu/CMH145/05/2005/THA Norovirus human feces/CIT N008/IRL NorovirusHu/CMH148/01/2001/THA Norovirus human feces/CIT N018/IRL NorovirusHu/CMH153/04/2004/THA Norovirus human feces/CIT N030/IRL NorovirusHu/CMH158/04/2004/THA Norovirus human feces/CIT N032/IRL NorovirusHu/CMH159/04/2004/THA Norovirus human feces/CIT N034/IRL NorovirusHu/CMH183/00/2000/THA Norovirus human feces/CIT N073/IRL NorovirusHu/CMH241/01/2001/THA Norovirus human feces/CIT N078/IRL NorovirusHu/CMH247/01/2001/THA Norovirus Kandy/101/2005/LKA NorovirusHu/CMH251/01/2001/THA Norovirus Kandy/108/2005/LKA NorovirusHu/CMH262/01/2001/THA Norovirus Kandy/115/2005/LKA NorovirusHu/CMH298/01/2001/THA Norovirus Kandy/117/2005/LKA NorovirusHu/CMH308/01/2001/THA Norovirus Kandy/131/2005/LKA NorovirusHu/CMH309/01/2001/THA Norovirus Kandy/133/2005/LKA NorovirusHu/CMH323/02/2002/THA Norovirus Kandy/140/2005/LKA NorovirusHu/CMH329/02/2002/THA Norovirus Kandy/142/2005/LKA NorovirusHu/CMH344/02/2002/THA Norovirus Kandy/145/2005/LKA NorovirusHu/CMH357/00/2000/THA Norovirus Kandy/148/2005/LKA NorovirusHu/CMH359/00/2000/THA Norovirus Kandy/152/2005/LKA NorovirusHu/CN244/1998/US Norovirus Kandy/159/2005/LKA NorovirusHu/CN2686/1997/US Norovirus Kandy/174/2005/LKA NorovirusHu/CN2693/1997/US Norovirus Kandy/180/2005/LKA NorovirusHu/CN2694/1997/US Norovirus Kandy/185/2005/LKA NorovirusHu/CN2716/1998/US Norovirus Kandy/193/2005/LKA NorovirusHu/CN2753/1998/US Norovirus Kandy/197/2005/LKA NorovirusHu/CN2765/1998/US Norovirus Kandy/20/2005/LKA NorovirusHu/CN2819/1998/US Norovirus Kandy/209/2005/LKA NorovirusHu/CN2841/1998/US Norovirus Kandy/210/2005/LKA NorovirusHu/CN2849/1998/US Norovirus Kandy/213/2005/LKA NorovirusHu/CN2856/1998/US Norovirus Kandy/221/2005/LKA NorovirusHu/CN2887/1998/US Norovirus Kandy/234/2005/LKA NorovirusHu/CN2957/1998/US Norovirus Kandy/239/2005/LKA NorovirusHu/CN2976/1998/US Norovirus Kandy/245/2005/LKA NorovirusHu/CN2982/1998/US Norovirus Kandy/258/2005/LKA NorovirusHu/CN2990/1998/US Norovirus Kandy/270/2005/LKA NorovirusHu/CN2996/1998/US Norovirus Kandy/280/2005/LKA NorovirusHu/CN3015/1998/US Norovirus Kandy/298/2005/LKA NorovirusHu/CN3016/1998/US Norovirus Kandy/326/2005/LKA NorovirusHu/CN3038/1998/US Norovirus Kandy/332/2005/LKA NorovirusHu/CN3041/1998/US Norovirus Kandy/341/2005/LKA NorovirusHu/CN3044/1998/US Norovirus Kandy/353/2005/LKA NorovirusHu/CN3050/1998/US Norovirus Kandy/354/2005/LKA NorovirusHu/CN3052/1998/US Norovirus Kandy/362/2005/LKA NorovirusHu/CN3071/1998/US Norovirus Kandy/369/2005/LKA NorovirusHu/CN3108/1999/US Norovirus Kandy/370/2005/LKA NorovirusHu/CN3117/1999/US Norovirus Kandy/4/2005/LKA Norovirus Hu/CN3135/1999/USNorovirus Mex7076/1999 Norovirus Hu/CN3147/1999/US Norovirus mincedmeat/Stuttgart554/2007/DEU Norovirus Hu/CN3171/1999/US Norovirusmouse/Hannover1/2007/DEU Norovirus Hu/CN3202/1999/US Norovirusmouse/TW2006/TWN Norovirus Hu/CN3204/1999/US Norovirus mouse/TW2007/TWNNorovirus Hu/CN3221/1999/US Norovirus mussels/Korntal8335/2007/DEUNorovirus Hu/CN3244/1999/US Norovirus Nagano/7-29/Apr2008/JPN NorovirusHu/CN3246/1999/US Norovirus Nagasaki/03/JP Norovirus Hu/CN3260/1999/USNorovirus Nizhny Novgorod/14072/RUS/2006 Norovirus Hu/CN3273/1999/USNorovirus Nizhny Novgorod/14342/RUS/2006 Norovirus Hu/CN3321/1999/USNorovirus Nizhny Novgorod/14726/RUS/2007 Norovirus Hu/CN3341/1999/USNorovirus Nizhny Novgorod/14780/RUS/2007 Norovirus Hu/CN438/1999/USNorovirus Nizhny Novgorod/14995/RUS/2007 Norovirus Hu/CN88/1998/USNorovirus Nizhny Novgorod/2461/RUS/2007 Norovirus Norovirus NizhnyNovgorod/2549/RUS/2007 Hu/cockles/KOK1QNL/2000/Netherlands NorovirusNizhny Novgorod/2557/RUS/2007 Norovirus Hu/Daycare-center_A/21-02-Norovirus NLV/BUDS/2002/USA 2002/NL Norovirus NLV/IF1998/2003/IraqNorovirus Hu/Daycare-center_B/12-12- Norovirus NLV/IF2036/2003/Iraq2002/NL Norovirus NLV/Paris Island/2003/USA NorovirusHu/DC2022-Madag04/2004/MDG Norovirus NongKhai-22/Thailand NorovirusHu/DC2048-Madag04/2004/MDG Norovirus NongKhai-51/Thailand NorovirusHu/DC2054-Madag04/2004/MDG Norovirus noodlesalad/Stuttgart21334/2006/DEU Norovirus Hu/DG6003-Madag04/2004/MDGNorovirus NV/aomori/C13/03/JP Norovirus Hu/DG6004-Madag04/2004/MDGNorovirus NV/ehime/C11/04/JP Norovirus Hu/DG6020-Madag04/2004/MDGNorovirus NV/ehime/C3/02/JP Norovirus Hu/Diner_Amsterdam/08-07-Norovirus NV/Futatsui/1/05/JP 2002/NL Norovirus NV/hiroshima/C1/03/JPNorovirus Hu/DM4025-Madag05/2005/MDG Norovirus NV/hokkaido/C37/04/JPNorovirus Hu/DR0011-Madag04/2004/MDG Norovirus NV/hokkaido/C38/04/JPNorovirus Hu/DR0023-Madag04/2004/MDG Norovirus NV/kagoshima/C20/03/JPNorovirus Hu/DR0025-Madag04/2004/MDG Norovirus NV/kagoshima/C31/03/JPNorovirus Hu/DR0045-Madag04/2004/MDG Norovirus NV/kagoshima/C6/04/JPNorovirus Hu/DR0046-Madag04/2004/MDG Norovirus NV/kanagawa/C10/03/JPNorovirus Hu/DT1020-Magad04/2004/MDG Norovirus NV/kanagawa/C36/04/JPNorovirus Hu/DT1032-Madag04/2004/MDG Norovirus NV/mie/C18/03/JPNorovirus Hu/Ehime/05-30/2005/JP Norovirus NV/mie/C27/04/JP NorovirusHu/Emmendingen13186/2002/DE Norovirus NV/mie/C33/03/JP NorovirusHu/Emmendingen13848/2002/DE Norovirus NV/mie/C4/03/JP NorovirusHu/Emmendingen154/2003/DE Norovirus NV/nagano/C14/03/JP NorovirusHu/Esslingen5791/2003/DE Norovirus NV/nagano/C17/03/JP NorovirusHu/Freiburg3308/2002/DE Norovirus NV/nagano/C22/03/JP NorovirusHu/Freudenstadt13147/2001/DE Norovirus NV/nagano/C5/03/JP NorovirusHu/Freudenstadt2011/2004/DE Norovirus NV/nagano/C9/03/JP NorovirusHu/Friedrichshafen1104/2004/DE NorovirusNV/sediment/Maracaibo1/2003/VENorovirus Hu/Friedrichshafen8054/2002/DE Norovirus NV/shizuoka/C30/04/JPNorovirus Hu/Fujian/49737/2006/CHN Norovirus NV/water/Maracaibo1/2003/VENorovirus Hu/Fujian/49745/2006/CHN Norovirus NV/yamaguchi/C16/03/JPNorovirus Hu/Fujian/49747/2006/CHN Norovirus NV/Yuri/1/95/JP NorovirusHu/Fujian/50255/2006/CHN Norovirus oyster clone NorovirusHu/Fujian/50257/2006/CHN A/Mannheim11815/2006/DEU NorovirusHu/Fujian/50260/2006/CHN Norovirus oyster clone NorovirusHu/Fujian/50264/2006/CHN B/Mannheim11815/2006/DEU NorovirusHu/G2/Fin-Upinniemi/1998/Finland Norovirus oyster/4433O/64317/2006/FRNorovirus Hu/Ghana-1/2000/GH Norovirus oyster/GII-4/BC-12/2009/CANNorovirus Hu/Ghana-2/2000/GH Norovirus oyster/GII-4/BC-13/2009/CANNorovirus Hu/GI/New Delhi/120/IND Norovirus oyster/GII-4/H-149/2008/CANNorovirus Hu/GI/Otofuke/1979/JP Norovirus oyster/Guangzhou 2/CHNNorovirus Norovirus oyster/oes7/64815b/2006/FRHu/GII/Hannover20132624/2006/DE Norovirus oyster/oes8a/64815/2006/FRNorovirus Hu/GM245/2000/MEX Norovirus oyster/oes8b/64815/2006/FRNorovirus Hu/GM260/2000/MEX Norovirus oyster/Zhuhai 5/CHN NorovirusHu/GM268/2000/MEX Norovirus pasta/Waldshut11487/2007/DEU NorovirusHu/GM272/2000/MEX Norovirus pig/30/2004/SVN Norovirus Hu/GM93/1999/MEXNorovirus pig/31/2004/SVN Norovirus Hu/Goeppingen12959/2002/DE Noroviruspig/36/2004/SVN Norovirus Hu/Goeppingen4251/2003/DE Noroviruspig/AB169/CAN Norovirus Hu/Graz/10/03/Austria Norovirus pig/AB276/CANNorovirus Hu/Groetzingen995/2003/DE Norovirus pig/F15-7/CAN NorovirusHu/Guangzhou/NV- Norovirus pig/F16-8/CAN VP1/2006/China Noroviruspig/F16-9/CAN Norovirus Hu/Guangzhou/NV- Norovirus pig/F18-8/CANVP2/2006/China Norovirus pig/F18-9/CAN Norovirus Hu/Guangzhou/NVgz01/CHNNorovirus pig/KT7/2004/SVN Norovirus Hu/Gunma/11-01/2005/JP Noroviruspig/P15_2/2004/SVN Norovirus Hu/Gunma/12-02/2006/JP Noroviruspig/Vet10-S08108/DNK Norovirus Hu/Gunma/8-01/2004/JP Noroviruspig/Vet14-S08257/DNK Norovirus Hu/Gunma/9-01/2004/JP Noroviruspig/Vet18-S08131/DNK Norovirus Hu/H1/JPN Norovirus pig/Vet41-S08288/DNKNorovirus Hu/H2/JPN Norovirus pig/Vet53-S08140/DNK Norovirus Hu/H3/JPNNorovirus pig/ZP-0711/2007/NZL Norovirus Hu/Hainan/47840/2006/CHNNorovirus potato/Boeblingen/2003/DE Norovirus Hu/Hainan/47841/2006/CHNNorovirus raw sewage/Monastir/14/2005/TUN Norovirus Hu/HCMC131/2006/VNMNorovirus raw sewage/Monastir/15/2006/TUN Norovirus Hu/HCMC204/2006/VNMNorovirus raw sewage/Monastir/25/2004/TUN Norovirus Hu/HCMC298/2006/VNMNorovirus raw sewage/Monastir/29/2005/TUN Norovirus Hu/HCMC311/2006/VNMNorovirus raw sewage/Monastir/32/2006/TUN Norovirus Hu/HCMC318/2006/VNMNorovirus raw sewage/Monastir/64/2005/TUN Norovirus Hu/HCMC91/2006/VNMNorovirus raw sewage/Monastir/9/2006/TUN NorovirusHu/Hebei/47931/2006/CHN Norovirus rice/Stuttgart7008/2006/DEU NorovirusHu/Hebei/48574/2006/CHN Norovirus SaKaeo-14/Thailand NorovirusHu/Hebei/48578/2006/CHN Norovirus SaKaeo-52/Thailand NorovirusHu/Hebei/48580/2006/CHN Norovirus SaKaeo-53/Thailand NorovirusHu/Hebei/48588/2006/CHN Norovirus SaKaeo-54/Thailand NorovirusHu/Hebei/48962/2006/CHN Norovirus SaKaeo-57/Thailand NorovirusHu/Hebei/48963/2006/CHN Norovirus SaKaeo-61/Thailand NorovirusHu/Hebei/48966/2006/CHN Norovirus salami/Wiesental40521/2007/DEUNorovirus Hu/Hebei/50033/2006/CHN Norovirusschnitzel/Stuehlingen37112/2007/DEU Norovirus Hu/Hebei/50034/2006/CHNNorovirus shashlik/Stuttgart76/2007/DEU NorovirusHu/Hebei/50036/2006/CHN Norovirus sheep/Norsewood11/2007/NZL NorovirusHu/Hebei/50038/2006/CHN Norovirus sheep/Norsewood30/2007/NZL NorovirusHu/Hebei/50039/2006/CHN Norovirus shellfish/Monastir/3/2003/TUNNorovirus Hu/Hebei/50040/2006/CHN Norovirus Songkhla-34/ThailandNorovirus Hu/Hebei/50302/2006/CHN Norovirus Songkhla-36/ThailandNorovirus Hu/Hebei/50307/2006/CHN Norovirus Songkhla-37/ThailandNorovirus Hu/Hebei/50316/2006/CHN Norovirus Suminoe oyster/BeibuGulf/2004/China Norovirus Hu/Hebei/50322/2006/CHN NorovirusSw/PC23/2007/BEL Norovirus Hu/Heidelberg13373/2002/DE NorovirusSw/PC26/2007/BEL Norovirus Hu/Heidelberg13908/2002/DE Norovirusswab/Rottenburg/40728/2005/DE Norovirus Hu/Heidelberg1884/2003/DENorovirus swab/Stuttgart/38663/2006/DE NorovirusHu/Heidenheim3796/2002/DE Norovirus swine/IV-2/2005/HUN NorovirusHu/Heilbronn2647/2004/DE Norovirus swine/K5/JP NorovirusHu/Heilbronn2846/2002/DE Norovirus Tak-62/Thailand NorovirusHu/Heilbronn4983/2001/DE Norovirus Tak-69/Thailand NorovirusHu/Henan/49166/2006/CHN Norovirus treated sewage/Monastir/24/2005/TUNNorovirus Hu/Henan/49189/2006/CHN Norovirus treatedsewage/Monastir/28/2005/TUN Norovirus Hu/Hiroshima/20-507/2001/JPNorovirus treated sewage/Monastir/48/2005/TUN NorovirusHu/Hiroshima/21-517/2002/JP Norovirus treatedsewage/Monastir/60/2005/TUN Norovirus Hu/Hiroshima/25-583/2002/JPNorwalk virus (Hu/NLV/OC00003/2000/JP) NorovirusHu/Hiroshima/26-623/2002/JP Norwalk virus (Hu/NLV/OC00018/2000/JP)Norovirus Hu/Hiroshima/32-754/2003/JP Norwalk virus(Hu/NLV/OC00019/2000/JP) Norovirus Hu/Hiroshima/38-840/2003/JP Norwalkvirus (Hu/NLV/OC96065/1996/JP) Norovirus Hu/Hiroshima/39-852/2003/JPNorwalk virus (Hu/NLV/OC98008/1998/JP) NorovirusHu/Hiroshima/43-886/2004/JP Norwalk virus (Hu/NLV/OC99288/1999/JP)Norovirus Hu/Hiroshima/48-936/2004/JP Norwalk virusHu/NV/Chiba/001049/2000/JP Norovirus Hu/Hiroshima/48-938/2004/JP Norwalkvirus Hu/NV/Chiba/010105/2001/JP Norovirus Hu/Hiroshima/60-1015/2005/JPNorwalk virus Hu/NV/Chiba/021071/2002/JP NorovirusHu/Hiroshima/62-1046/2006/JP Norwalk virus Hu/NV/Chiba/030100/2003/JPNorovirus Hu/Hiroshima/66-1110/2006/JP Norwalk virusHu/NV/Chiba/030556/2003/JP Norovirus Hu/Hokkaido/10-13/2004/JP Norwalkvirus Hu/NV/Chiba/030910/2003/JP Norovirus Hu/Hokkaido/109/2002/JPNorwalk virus Hu/NV/Chiba/031038/2003/JP NorovirusHu/Hokkaido/110/2002/JP Norwalk virus Hu/NV/Chiba/040092/2004/JPNorovirus Hu/Hokkaido/111A/2002/JP Norwalk virusHu/NV/Chiba/040110/2004/JP Norovirus Hu/Hokkaido/112/2002/JP Norwalkvirus Hu/NV/Chiba/040277/2004/JP Norovirus Hu/Hokkaido/133/2003/JPNorwalk virus Hu/NV/Chiba/040502/2004/JP NorovirusHu/Hokkaido/134/2003/JP Norwalk virus Hu/NV/Chiba/991002/1999/JPNorovirus Hu/Hokkaido/139/2003/JP Norwalk virus Hu/NV/Karachi/1001/1990Norovirus Hu/Hokkaido/141/2003/JP Norwalk virus NLV/Carousel/1998/UKNorovirus Hu/Hokkaido/146A/2003/JP Norwalk virus NLV/Driffield/1999/UKNorovirus Hu/Hokkaido/157/2003/JP Norwalk virus NLV/Luton/1999/UKNorovirus Hu/Hokkaido/160/2003/JP Norwalk virus NLV/Ramridge/1998/UKNorovirus Hu/Hokkaido/182/2004/JP Norwalk virus NLV/Windlesham/1998/UKNorovirus Hu/Hokkaido/190/2004/JP Norwalk virus NV/hokkaido/C-39/04/JPNorovirus Hu/Hokkaido/203A/2004/JP Norwalk virus NV/hokkaido/C-40/04/JPNorovirus Hu/Hokkaido/211/2004/JP Norwalk-like virus Hu/NLV/GI/464/USNorovirus Hu/Hokkaido/228/2004/JP Norwalk-like virus Hu/NLV/GI/487/USNorovirus Hu/Hokkaido/28/1999/JP Norwalk-like virus Hu/NLV/GI/488/USNorovirus Hu/Hokkaido/34B/2000/JP Norwalk-like virus Hu/NLV/GI/560/USNorovirus Hu/Hokkaido/5-05/2003/JP Norwalk-like virus Hu/NLV/GI/579/USNorovirus Hu/Hokkaido/60/2001/JP Norwalk-like virus Hu/NLV/GI/611/USNorovirus Hu/Hokkaido/7-07/2004/JP Norwalk-like virus Hu/NLV/GI/615/USNorovirus Hu/Hokkaido/74/2001/JP Norwalk-like virus Hu/NLV/GI/629/USNorovirus Hu/Hokkaido/77/2001/JP Norwalk-like virus Hu/NLV/GI/653/USNorovirus Hu/Hokkaido/82/2001/JP Norwalk-like virus Hu/NLV/GI/661/USNorovirus Hu/Hokkaido/83/2001/JP Norwalk-like virus Hu/NLV/GI/665/USNorovirus Hu/Hokkaido/86B/2001/JP Norwalk-like virus Hu/NLV/GI/684/USNorovirus Hu/Hokkaido/87/2001/JP Norwalk-like virus Hu/NLV/GI/736/USNorovirus Hu/Hokkaido/88/2001/JP Norwalk-like virus Hu/NLV/GI/772/USNorovirus Hu/Hokkaido/90/2001/JP Norwalk-like virus Hu/NLV/GII/506/USNorovirus Hu/Hokkaido/91/2001/JP Norwalk-like virus Hu/NLV/GII/514/USNorovirus Hu/Hokkaido/92/2002/JP Norwalk-like virus Hu/NLV/GII/535/USNorovirus Hu/Hokkaido/94/2002/JP Norwalk-like virus Hu/NLV/GII/542/USNorovirus Hu/Hokkaido/96B/2002/JP Norwalk-like virus Hu/NLV/GII/549/USNorovirus Hu/Hospital_AA_ PAAZ_pat_1/15- Norwalk-like virusHu/NLV/GII/562/US 07-2002/NL Norwalk-like virus Hu/NLV/GII/564/USNorovirus Norwalk-like virus Hu/NLV/GII/565/USHu/Hospital_AA_PAAZ_personel_1/18-07- Norwalk-like virusHu/NLV/GII/567/US 2002/NL Norwalk-like virus Hu/NLV/GII/577/US NorovirusHu/Hospital_AB_A1_pat_104-02- Norwalk-like virus Hu/NLV/GII/580/US2003/NL Norwalk-like virus Hu/NLV/GII/586/US NorovirusHu/Hospital_AB_A1_pat_205-03- Norwalk-like virus Hu/NLV/GII/596/US2003/NL Norwalk-like virus Hu/NLV/GII/604/US NorovirusHu/Hospital_AB_A3_pat_1/10-02- Norwalk-like virus Hu/NLV/GII/607/US2003/NL Norwalk-like virus Hu/NLV/GII/634/US Norovirus Norwalk-likevirus Hu/NLV/GII/642/US Hu/Hospital_AB_A3_personel_1/10-02- Norwalk-likevirus Hu/NLV/GII/643/US 2003/NL Norwalk-like virus Hu/NLV/GII/649/USNorovirus Hu/Hospital_AB_A7_pat_1/06-01- Norwalk-like virusHu/NLV/GII/654/US 2003/NL Norwalk-like virus Hu/NLV/GII/663/US NorovirusHu/Hospital_AB_A8_pat_1/21-01- Norwalk-like virus Hu/NLV/GII/668/US2003/NL Norwalk-like virus Hu/NLV/GII/677/US NorovirusHu/Hospital_AB_A9_pat_1/18-12- Norwalk-like virus Hu/NLV/GII/682/US2002/NL Norwalk-like virus Hu/NLV/GII/683/US NorovirusHu/Hospital_AB_B1_pat_1/22-01- Norwalk-like virus Hu/NLV/GII/691/US2003/NL Norwalk-like virus Hu/NLV/GII/692/US NorovirusHu/Hospital_AB_B1_pat_2/28-02- Norwalk-like virus Hu/NLV/GII/707/US2003/NL Norwalk-like virus Hu/NLV/GII/708/US Norovirus Norwalk-likevirus Hu/NLV/GII/710/US Hu/Hospital_AB_B1_personel_1/27-01- Norwalk-likevirus Hu/NLV/GII/712/US 2003/NL Norwalk-like virus Hu/NLV/GII/715/USNorovirus Hu/Hospital_AB_PAAZ_pat07-02- Norwalk-like virusHu/NLV/GII/723/US 2003/NL2. Norwalk-like virus Hu/NLV/GII/733/USNorovirus Hu/Hospital_AB_PAAZ_pat_3/11- Norwalk-like virusHu/NLV/GII/734/US 02-2003/NL Norwalk-like virus Hu/NLV/GII/737/USNorovirus Hu/I10a/JPN Norwalk-like virus Hu/NLV/GII/740/US NorovirusHu/I10b/JPN Norwalk-like virus Hu/NLV/GII/741/US Norovirus Hu/I3a/JPNNorwalk-like virus Hu/NLV/GII/759/US Norovirus Hu/I3b/JPN Norwalk-likevirus Hu/NLV/GII/762/US Norovirus Hu/I4/JPN Norwalk-like virusHu/NLV/GIV/765/US Norovirus Hu/IR-112/2006/Iran Norwalk-like virusHu/NV/03012-2/GII/2003/JP Norovirus Hu/IR-115/2006/Iran Norwalk-likevirus Hu/NV/OC02065/2002/JP Norovirus Hu/IR-117/2006/Iran Norwalk-likevirus Hu/NV/OC02172- Norovirus Hu/IR-186/2006/Iran 1/GII/2002/JapanNorovirus Hu/IR-197/2006/Iran Norwalk-like virus Hu/NV/OC02172-Norovirus Hu/IR-198/2006/Iran 2/GII/2002/Japan NorovirusHu/IR-202/2006/Iran Norwalk-like virus Hu/NV/OC02172- NorovirusHu/IR-240/2006/Iran 3/GII/2002/Japan Norovirus Hu/IR-41/2006/IranNorwalk-like virus Hu/NV/OC02172- Norovirus Hu/J1/JPN 4/GII/2002/JapanNorovirus Hu/Jilin/48344/2006/CHN Norwalk-like virusHu/NV/OC02189/2002/Japan Norovirus Hu/Jilin/48352/2006/CHN Norwalk-likevirus Hu/NV/OC02198-2/2002/JP Norovirus Hu/Jilin/48354/2006/CHNNorwalk-like virus Hu/NV/OC03006/2002/JP NorovirusHu/Jilin/48356/2006/CHN Norwalk-like virus Hu/NV/OC03008/2003/JPNorovirus Hu/Jilin/48358/2006/CHN Norwalk-like virusHu/NV/OC03009/GI/2003/JP Norovirus Hu/Jilin/49129/2006/CHN Norwalk-likevirus Hu/NV/OC03009/GII/2003/JP Norovirus Hu/Jilin/49133/2006/CHNNorwalk-like virus Hu/NV/OC03011/2003/JP NorovirusHu/Jilin/49137/2006/CHN Norwalk-like virus Hu/NV/OC03012-1/GII/2003/JPNorovirus Hu/Jilin/49141/2006/CHN Norwalk-like virusHu/NV/OC03012-3/GII/2003/JP Norovirus Hu/Jilin/50143/2006/CHNNorwalk-like virus Hu/NV/OC03012/GI/2003/JP NorovirusHu/Jilin/50145/2006/CHN Norwalk-like virus Hu/NV/OC03017/2003/JPNorovirus Hu/Jilin/50148/2006/CHN Norwalk-like virusHu/NV/OC03020/2003/JP Norovirus Hu/Jilin/50151/2006/CHN Norwalk-likevirus Hu/NV/OC03021-1/2003/JP Norovirus Hu/Jilin/50156/2006/CHNNorwalk-like virus Hu/NV/OC03021-2/2003/JP Norovirus Hu/K13830/05/INDNorwalk-like virus Hu/NV/OC03022-1/GI/2003/JP Norovirus Hu/K4/JPNNorwalk-like virus Hu/NV/OC03022-1/GII/2003/JP NorovirusHu/Kagoshima/6-04/2003/JP Norwalk-like virus Hu/NV/OC03022-2/GI/2003/JPNorovirus Hu/Kakunodate/1/2008/JP Norwalk-like virusHu/NV/OC03022-2/GII/2003/JP Norovirus Hu/Karlsruhe10567/2002/DENorwalk-like virus Hu/NV/OC03024/2003/JP NorovirusHu/Karlsruhe2527/2004/DE Norwalk-like virus Hu/NV/OC03026/GI/2003/JPNorovirus Hu/Karlsruhe892/2002/DE Norwalk-like virusHu/NV/OC03026/GII/2003/JP Norovirus Hu/Kawabe/1/05/JP Norwalk-like virusHu/NV/OC03027/2003/JP Norovirus Hu/Kazuno/1/2007/JP Norwalk-like virusHu/NV/OC03028/2003/JP Norovirus Hu/KL1009/1998/US Norwalk-like virusHu/NV/OC03034-1/GI/2003/JP Norovirus Hu/KL1327/1999/US Norwalk-likevirus Hu/NV/OC03034-1/GII/2003/JP Norovirus Hu/KL1353/1998/USNorwalk-like virus Hu/NV/OC03034-2/GI/2003/JP NorovirusHu/KL1372/1999/US Norwalk-like virus Hu/NV/OC03034-2/GII/2003/JPNorovirus Hu/KL1404/1998/US Norwalk-like virusHu/NV/OC03034-3/GI/2003/JP Norovirus Hu/KL1418/1998/US Norwalk-likevirus Hu/NV/OC03035/2003/JP Norovirus Hu/KL1454/1999/US Norwalk-likevirus Hu/NV/OC03036/2003/JP Norovirus Hu/KL1461/1998/US Norwalk-likevirus Hu/NV/OC03037/2003/JP Norovirus Hu/KL1486/1998/US Norwalk-likevirus Hu/NV/OC03039-1/GII/2003/JP Norovirus Hu/KL1494/1998/USNorwalk-like virus Hu/NV/OC03039-2/GII/2003/JP NorovirusHu/KL1512/1998/US Norwalk-like virus Hu/NV/OC03039/GI/2003/JP NorovirusHu/KL1522/1998/US Norwalk-like virus Hu/NV/OC03040/2003/JP NorovirusHu/KL1553/1998/US Norwalk-like virus Hu/NV/OC03042/2003/JP NorovirusHu/KL1574/1999/US Norwalk-like virus Hu/NV/OC03047/GI/2003/JP NorovirusHu/KL1620/1998/US Norwalk-like virus Hu/NV/OC03047/GII/2003/JP NorovirusHu/KL1682/1998/US Norwalk-like virus Hu/NV/OC03048/2003/JP NorovirusHu/KL1733/1999/US Norwalk-like virus Hu/NV/OC03050/2003/JP NorovirusHu/KL1798/1998/US Norwalk-like virus Hu/NV/OC03053/2003/JP NorovirusHu/KL1823/1999/US Norwalk-like virus Hu/NV/OC03054/2003/JP NorovirusHu/KL1852/1999/US Norwalk-like virus Hu/NV/OC03055/2003/JP NorovirusHu/KL1872/1999/US Norwalk-like virus NLV/Appalachicola NorovirusHu/KL1884/1999/US Bay/318/1995/US Norovirus Hu/KL1912/1999/USNorwalk-like virus NLV/Baltimore/274/1993/US Norovirus Hu/KL1943/1999/USNorwalk-like virus NLV/Baltimore/277/1993/US Norovirus Hu/KL1974/1999/USNorwalk-like virus NLV/Brattleboro/321/1995/US NorovirusHu/KL2018/1999/US Norwalk-like virus NLV/Burwash NorovirusHu/KL2022/1999/US Landing/331/1995/US Norovirus Hu/KL2030/1999/USNorwalk-like virus NLV/Florida/269/1993/US Norovirus Hu/KL2033/1999/USNorwalk-like virus NLV/Fort Norovirus Hu/KL2059/1999/USLauderdale/560/1998/US Norovirus Hu/KL2089/1999/US Norwalk-like virusNLV/Gwynedd/273/1994/US Norovirus Hu/KL2092/1999/US Norwalk-like virusNLV/Honolulu/219/1992/US Norovirus Hu/KL2146/1999/US Norwalk-like virusNLV/Honolulu/314/1994/US Norovirus Hu/KL2162/1999/US Norwalk-like virusNLV/Lionville/247/1993/US Norovirus Hu/KL714/1999/US Norwalk-like virusNLV/Little Rock/316/1994/US Norovirus Hu/KL724/1998/US Norwalk-likevirus NLV/Miami Norovirus Hu/KL755/1998/US Beach/326/1995/US NorovirusHu/KL759/1997/US Norwalk-like virus NLV/Miami/292/1994/US NorovirusHu/KL771/1998/US Norwalk-like virus NLV/Miami/81/1986/US NorovirusHu/KL817/1998/US Norwalk-like virus Norovirus Hu/KL824/1998/USNLV/Montgomery/312/1994/US Norovirus Hu/KL828/1998/US Norwalk-like virusNLV/New Norovirus Hu/KL874/1999/US Orleans/266/1993/US NorovirusHu/KL942/1998/US Norwalk-like virus NLV/New NorovirusHu/Kolkata/L8775/2006/IND Orleans/279/1994/US Norovirus Hu/Kolkata/V1041Norwalk-like virus NLV/New Norovirus Hu/Kolkata/V1370Orleans/306/1994/US Norovirus Hu/Kolkata/V518 Norwalk-like virusNLV/Port Norovirus Hu/Komaki/1/2006/JP Canaveral/301/1994/US NorovirusHu/Kuala Norwalk-like virus NLV/Richmond/283/1994/USLumpur/NB2824/1998/MYS Norwalk-like virus NLV/Saint Cloud/624/1998/USNorovirus Hu/Kuala Norwalk-like virus NLV/Towson/313/1994/USLumpur/NB2834/1998/MYS Norwalk-like virus NLV/UK3-17/12700/1992/GBNorovirus Hu/Kuala Norwalk-like virus NLV/Westover/302/1994/USLumpur/NB2857/1998/MYS Norwalk-like virus NLV/White River/290/1994/USNorovirus Hu/Kuala Norwalk-like virus Sw/NLV/VA34/1998/NLLumpur/NB2875/1998/MYS Saratoga calicivirus 7 Norovirus Hu/KualaNorwalk-like virus sp. Lumpur/NB2895/1998/MYS Norwalk-like virusNorovirus Hu/Kuala Small round structured virus Lumpur/NB2922/1998/MYSHuman calicivirus SRSV-Ba/98/CH Norovirus Hu/Kuala Human calicivirusSRSV-Gst/98/CH Lumpur/NB2969/1998/MYS Human calicivirus SRSV/MI1/94/JPNorovirus Hu/Kuala Human calicivirus SRSV/SA1/89/JPLumpur/NB2978/1998/MYS Human calicivirus SRSV/SA2/91/JP NorovirusHu/Kuala Human calicivirus SRSV1-LaN/98/CH Lumpur/NB4464/1999/MYS Humancalicivirus SRSV2-LaN/98/CH Norovirus Hu/Kuala unclassified NorovirusLumpur/NB4467/1999/MYS Bovine enteric calicivirus Norovirus Hu/KualaHuman norovirus - Alphatron Lumpur/NB4469/1999/MYS Human norovirusSaitama Norovirus Hu/Kuala Minireovirus Lumpur/NB4492/1999/MYS Murinenorovirus Norovirus Hu/Kuala Murine norovirus 1 Lumpur/NB4495/1999/MYSMurine norovirus 2 Norovirus Hu/Kuala Murine norovirus 3Lumpur/NB4529/1999/MYS Murine norovirus 4 Norovirus Hu/Kuala Murinenorovirus 5 Lumpur/NB4532/1999/MYS Murine norovirus 6 Norovirus Hu/KualaMurine norovirus 7 Lumpur/NB4540/1999/MYS NorovirusHu/Monastir/249/2003/TUN Norovirus Hu/Kuala NorovirusHu/Monastir/273/2003/TUN Lumpur/NB4543/1999/MYS NorovirusHu/Monastir/294/2003/TUN Norovirus Hu/Kuala NorovirusHu/Monastir/310/2003/TUN Lumpur/NB4550/1999/MYS NorovirusHu/Monastir/375/2003/TUN Norovirus Hu/Kuala NorovirusHu/Monastir/389/2003/TUN Lumpur/NB4552/1999/MYS NorovirusHu/Monastir/8655/2007/TUN Norovirus Hu/Kuala NorovirusHu/Mougon692/2004/France Lumpur/NB4577/1999/MYS NorovirusHu/Mum/M004/2006/India Norovirus Hu/Kuala Lumpur/NR26/1994/MYS NorovirusHu/Mum/M633/2006/India Norovirus Hu/Kuala Lumpur/NR94/1994/MYS NorovirusHu/Mum/M685/2006/India Norovirus Hu/Kuenzelsau16836/2001/DE NorovirusHu/Mum/M689/2006/India Norovirus Hu/Kunming/146/2004/China NorovirusHu/Mum/M777/2006/India Norovirus Hu/Kurume/951228/1995/JP/419 NorovirusHu/Mum/M780/2006/India Norovirus Hu/L154/2000/France NorovirusHu/Mum/M802/2006/India Norovirus Hu/L1a/JPN NorovirusHu/Mum/M844/2006/India Norovirus Hu/L1b/JPN NorovirusHu/Mum/M853/2006/India Norovirus Hu/L2a/JPN NorovirusHu/Mum/M860/2006/India Norovirus Hu/L2b/JPN NorovirusHu/mussels/Mo04-05/2004b/UK Norovirus Hu/L2c/JPN NorovirusHu/mussels/Mo04-07/2004/IE Norovirus Hu/L3/JPN NorovirusHu/mussels/Mo04-08/2004/UK Norovirus Hu/L4/JPN NorovirusHu/mussels/Mo04-10/2004b/UK Norovirus Hu/Leipzig/CE1/2009/DEU NorovirusHu/mussels/Mo04-14/2004c/IE Norovirus Hu/Leipzig/CE2/2009/DEU NorovirusHu/mussels/Mo04-15/2004/IE Norovirus Hu/Leipzig/P1-5/2009/DEU NorovirusHu/mussels/Mo04-21/2004b/UK Norovirus Hu/Lelystad_Hospital/16-01-Norovirus Hu/mussels/Mo04-21/2004c/UK 2003/NL NorovirusHu/mussels/Mo04-22/2004/IE Norovirus Hu/Lelystad_Nursing-home/21-07-Norovirus Hu/mussels/Mo04-22/2004b/IE 2002/NL NorovirusHu/mussels/Mo04-23/2004/UK Norovirus Hu/Lelystad_Nursing-home/22-07-Norovirus Hu/mussels/Mo04-25/2004c/IE 2002/NL NorovirusHu/mussels/Mo04-32/2004b/IE Norovirus Hu/Leonberg1098/2003/DE NorovirusHu/mussels/Mo19NL2000a/Netherlands Norovirus Hu/Leonberg1661/2003/DENorovirus Hu/mussels/Mos11GB2003/United Norovirus Hu/Loerrach11869/02/DEKingdom Norovirus Hu/Loerrach5230/2001/DE NorovirusHu/mussels/Mos18I2004b/UK Norovirus Hu/Loerrach840/2002/DE NorovirusHu/mussels/Mos2GB2003/United Norovirus Hu/Ludwigsburg0211/2002/DEKingdom Norovirus Hu/Ludwigsburg13253/2002/DE NorovirusHu/mussels/Mos9I2003a/Ireland Norovirus Hu/Ludwigsburg1472/2004/DENorovirus Hu/mussels/Mos9I2003b/Ireland NorovirusHu/Ludwigsburg7563/2002/DE Norovirus Hu/mussels/Mos9I2003c/IrelandNorovirus Hu/Ludwigsburg781/2003/DE Norovirus Hu/N1/JPN NorovirusHu/LuoCheng17/Sep2006/CHN Norovirus Hu/N2/JPN NorovirusHu/Maastricht/03-01-2003/NL Norovirus Hu/N3/JPN NorovirusHu/Maizuru/000324/2000/JP/2468 Norovirus Hu/Nag/N230/2006/IndiaNorovirus Hu/Maizuru/000602/2000/JP/2840 NorovirusHu/Nag/N248/2006/India Norovirus Hu/Maizuru/010426/2001/JP/3385Norovirus Hu/Nag/N259/2006/India NorovirusHu/Maizuru/010524/2001/JP/3229 Norovirus Hu/Nag/N273/2007/IndiaNorovirus Hu/Maizuru/030512/2003/JP/4656 NorovirusHu/Nag/N363/2007/India Norovirus Hu/Maizuru/5017/04/JP NorovirusHu/Nag/N381/2007/India Norovirus Hu/Maizuru/6448/2005/JP NorovirusHu/Nag/N387/2007/India Norovirus Hu/Maizuru/6449/2005/JP NorovirusHu/Nag/N410/2007/India Norovirus Hu/Maizuru/7179/2005/JP NorovirusHu/Nag/N416/2007/India Norovirus Hu/Maizuru/7297/2006/JP NorovirusHu/Nag/N457/2007/India Norovirus Hu/Manitoba/4205/2003/CAN NorovirusHu/Nagano/1-01/2002/JP Norovirus Hu/Mannheim1265/2003/DE NorovirusHu/Nagano/2-01/2002/JP Norovirus Hu/Mannheim131/2009/DE NorovirusHu/Nagano/3-01/2002/JP Norovirus Hu/Mannheim1706/2003/DE NorovirusHu/Nagano/37-3/Feb2008/JPN Norovirus Hu/Mannheim2491/2004/DE NorovirusHu/Nagano/4-04/2003/JP Norovirus Hu/Mannheim51912/2002/DE NorovirusHu/Nagano/7-19/Apr2008/JPN Norovirus Hu/Mannheim61209/2001/DE NorovirusHu/Mihama/1/2006/JP Norovirus Hu/Minase/1/05/JP NorovirusHu/MK04/2004/JP Norovirus Hu/Monastir 113/2003/TUN Norovirus Hu/Monastir127/2003/TUN Norovirus Hu/Monastir 3968/2004/TUN Norovirus Hu/Monastir493/2003/TUN Norovirus Hu/Monastir 529/2003/TUN Norovirus Hu/Monastir715/2003/TUN Norovirus Hu/Monastir 8655/2007/TUN NorovirusHu/Monastir/03/2003/TUN Norovirus Hu/Monastir/127/2003/TUN NorovirusHu/Monastir/13562/2004/TUN Norovirus Hu/Monastir/17285/2004/TUNNorovirus Hu/Monastir/17291/2006/TUN NorovirusHu/Monastir/17736/2005/TUN Norovirus Hu/Monastir/1795/2004/TUN NorovirusHu/Monastir/18/2003/TUN Norovirus Hu/Monastir/39/2004/TUN NorovirusHu/Monastir/430/2003/TUN Norovirus Hu/Monastir/4456/2005/TUN NorovirusHu/Monastir/474/2003/TUN Norovirus Hu/Monastir/519/2003/TUN NorovirusHu/Monastir/578/2003/TUN Norovirus Hu/Monastir/862/2003/TUN Murinenorovirus GV Oyster norovirus Oyster norovirus HK-W498-02 Oysternorovirus HK-W423-02 Oyster norovirus HK-W507-02 Oyster norovirusHK-W426-02 Oyster norovirus HK-W539-02 Oyster norovirus HK-W464-02 Swinenorovirus Oyster norovirus HK-W469-02

What is claimed is:
 1. A chimeric norovirus viral protein 1 (VP1)comprising the S-domain of the VP1 from a first norovirus strain and atleast a portion of the P-domain of the VP1 from a second norovirusstrain, wherein the VP1 protein has the formula:A-S-L-P-B wherein A and B are independently absent or comprise anydesired amino acid sequence; S is the S-domain of VP1 from a firstnorovirus strain; P is a norovirus VP1 P-domain; wherein at least aportion of the P-domain is from a second norovirus strain; L is absentor a linker peptide selected from the group consisting of a linkerpeptide of the VP1 from the first norovirus strain, from the secondnorovirus strain, or from a third norovirus strain; a polyglycine linkerof formula (Gly)n wherein n=2, 3, 4, 5, 6, 7, 8, 9, 10 or more (SEQ IDNO:5); a linker of formula (GGGS)n wherein n=1, 2, 3 or 4 (SEQ ID NO:6);and a charged linker of formula (SRSK)n wherein n=1, 2, 3 or 4 (SEQ IDNO:7).
 2. The chimeric norovirus VP1 of claim 1, wherein the linkerpeptide is a linker peptide of the VP1 from the first norovirus strain,from the second norovirus strain, or from a third norovirus strain. 3.The chimeric VP1 of claim 1, wherein L is the linker peptide of VP1 fromthe first norovirus strain, from the second norovirus strain or from athird norovirus strain.
 4. The chimeric VP1 of claim 1, wherein P is theentire P-domain from a second norovirus strain.
 5. The chimeric VP1 ofclaim 1, wherein P comprises a P1-subdomain, or portion thereof, fromthe first norovirus strain and a P2-subdomain from a second norovirusstrain.
 6. The chimeric VP1 protein according to claim 1, wherein thefirst norovirus strain is selected from the group consisting of thenorovirus strains listed in Table
 1. 7. The chimeric VP1 proteinaccording to claim 1, wherein the first norovirus strain is the SnowMountain strain.
 8. The chimeric VP1 protein according to claim 1,wherein the second norovirus strain is selected from the groupconsisting of the norovirus strains listed in Table
 1. 9. The chimericVP1 protein according to claim 7, wherein the second norovirus strain isa strain selected from the group consisting of genogroup GII, anorovirus strain from genogroup GI and a norovirus strain from genogroupGIV.
 10. The chimeric VP1 protein according to claim 7, wherein thesecond norovirus strain is selected from the group consisting of anorovirus strain from genogroup GII, and a norovirus strain fromgenogroup GI.
 11. The chimeric VP1 protein according to claim 10,wherein the second norovirus strain is Norwalk virus, GII.4.2006a, orNew Orleans.
 12. A norovirus virus like particle (VLP) comprising achimeric VP1 protein according to claim
 1. 13. A monovalent norovirusvirus like particle (VLP) comprising a chimeric VP1 protein according toclaim
 1. 14. A multivalent norovirus virus like particle (VLP)comprising a chimeric VP1 protein is according to claim
 1. 15. Themultivalent VLP according to claim 14, wherein the VLP comprises two ormore different chimeric VP1 proteins.
 16. An immunogenic compositioncomprising a chimeric VP1 protein according to claim
 1. 17. Animmunogenic composition comprising a VLP according to claim
 12. 18. Animmunogenic composition comprising a monovalent VLP according to claim13.
 19. An immunogenic composition comprising a multivalent VLPaccording to claim
 14. 20. An immunogenic composition, comprising two ormore different monovalent VLPs according to claim
 13. 21. A recombinantnucleic acid encoding a chimeric VP1 protein according to claim
 1. 22.The recombinant nucleic acid according to claim 21, wherein therecombinant nucleic acid comprises a vector.
 23. The recombinant nucleicacid according to claim 21, wherein the recombinant nucleic acid isself-replicating.
 24. An immunogenic composition comprising arecombinant nucleic acid of claim
 21. 25. A recombinant host cellcomprising a recombinant nucleic acid of claim
 21. 26. The recombinanthost cell according to claim 25, wherein the host cell is selected fromthe group consisting of insect cells, mammalian cells, avian cells,bacteria, yeast cells, Tetrahymena cells and combinations thereof.